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1. 发明申请

WO2011161093A1 ACYLTRANSFERASES AND USES THEROF IN FATTY ACID PRODUCTION 审中-公开
标题翻译： ACYLTRANSFERASES及其在脂肪酸生产中的应用
公开(公告)号：WO2011161093A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060315
申请日：2011-06-21
申请人： BASF PLANT SCIENCE COMPANY GMBH , SENGER, Toralf , MARTY, Laurent , STYMNE, Sten , LINDBERG YILMAZ, Jenny , NAPIER, Johnathan A. , SAYANOVA, Olga , HASLAM, Richard , NOEMI, Ruiz Lopez
发明人： SENGER, Toralf , MARTY, Laurent , STYMNE, Sten , LINDBERG YILMAZ, Jenny , NAPIER, Johnathan A. , SAYANOVA, Olga , HASLAM, Richard , NOEMI, Ruiz Lopez
IPC分类号： C12N15/82 , C12P7/64
CPC分类号： C12N9/1029 , A23D9/02 , A23K20/158 , A23L33/105 , A23L33/115 , A23L33/12 , A23V2002/00 , A23V2250/1862 , A23V2250/1868 , A23V2250/187 , A23V2250/1882 , C11C1/045 , C12N15/8247 , C12P7/6427 , C12Y203/0102 , Y02P20/52
摘要： The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucletides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
摘要翻译：本发明涉及多不饱和脂肪酸的重组制造。具体地说，它涉及酰基转移酶多肽，编码所述酰基转移酶的多核苷酸以及载体，宿主细胞，含有所述多核苷酸的非人转基因生物。此外，本发明考虑了制造多不饱和脂肪酸的方法以及通过这些方法获得的油。

2. 发明申请

WO2011006948A1 NOVEL FATTY ACID DESATURASES AND ELONGASES AND USES THEREOF 审中-公开
标题翻译：新型脂肪酸及其用途及其用途
公开(公告)号：WO2011006948A1
公开(公告)日：2011-01-20
申请号：PCT/EP2010/060178
申请日：2010-07-15
申请人： BASF PLANT SCIENCE COMPANY GMBH , BAUER, Jörg , NAPIER, Johnathan, A. , SAYANOVA, Olga
发明人： BAUER, Jörg , NAPIER, Johnathan, A. , SAYANOVA, Olga
IPC分类号： C07K14/435 , C12N15/82
CPC分类号： C12N15/8247 , C07K14/435 , C12N9/0071 , C12N9/93 , C12Y114/19 , C12Y114/19003 , C12Y114/19004 , C12Y114/19006 , C12Y602/01003
摘要： The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA).
摘要翻译：本发明提供了分离的核酸分子，其编码来自生物Emiliana huxleyi的新型脂肪酸去饱和酶和延伸酶。本发明还提供了含有去饱和酶或延伸酶核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及用于大规模生产长链多不饱和脂肪酸（LCPUFA）的方法。花生四烯酸（ARA），二十碳五烯酸（EPA）或二十二碳六烯酸（DHA）。

3. 发明申请

WO2010142522A2 NOVEL FATTY ACID ELONGATION COMPONENTS AND USES THEREOF 审中-公开
标题翻译：新型脂肪酸成分及其用途
公开(公告)号：WO2010142522A2
公开(公告)日：2010-12-16
申请号：PCT/EP2010/056936
申请日：2010-05-20
申请人： BASF PLANT SCIENCE COMPANY GMBH , ROTHAMSTED RESEARCH LTD. , NAPIER, Jonathan A. , SAYANOVA, Olga , BEAUDOIN, Frederic
发明人： NAPIER, Jonathan A. , SAYANOVA, Olga , BEAUDOIN, Frederic
IPC分类号： C12N15/82
CPC分类号： C12N15/8247 , C12N9/001 , C12N9/88 , C12P7/6427 , C12P7/6472
摘要： The invention provides isolated nucleic acid molecules which encodes a novel fatty acid nECR. The invention also provides recombinant expression vectors containing nECR nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA.
摘要翻译：本发明提供编码新型脂肪酸nECR的分离的核酸分子。本发明还提供了含有nECR核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及大规模生产长链多不饱和脂肪酸（LCPUFA）如ARA，EPA和DHA的方法。

4. 发明申请

WO2004057001A2 NOVEL METHOD FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS 审中-公开
标题翻译：用于生产聚氨酯脂肪酸的新方法
公开(公告)号：WO2004057001A2
公开(公告)日：2004-07-08
申请号：PCT/EP2003/014054
申请日：2003-12-11
申请人： UNIVERSITY OF BRISTOL , NAPIER, Johnathan, A. , SAYANOVA, Olga , LAZARUS, Colin, M. , QI, Baoxiu , HEINZ, Ernst , ZANK, Thorsten , ZÄHRINGER, Ulrich
发明人： NAPIER, Johnathan, A. , SAYANOVA, Olga , LAZARUS, Colin, M. , QI, Baoxiu , HEINZ, Ernst , ZANK, Thorsten , ZÄHRINGER, Ulrich
IPC分类号： C12N15/82
CPC分类号： C12N9/0083 , C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to an improved process for the specific production of poly-unsaturated omega-3 and omega-6 fatty acids and a process for the production of triglycerides having an increased content of unsaturated fatty acids, in particular omega-3 and omega-6 fatty acids having at least two double bonds and a 20 or 22 carbon atom chain length. The invention relates to the produc-tion of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, hav-ing an increased content of fatty acids, oils or lipids containing C20- or C22- fatty acids with a delta-5, 7, 8, 10 double bond, respectively due to the expression of a delta-8-desaturase and a delta-9- elon-gase from organisms such as plants preferably Algae like Isochrysis galbana or Euglena gracilis. In addition the invention relates to a process for the production of poly unsaturated fatty acids such as Eicosapentaenoic, Arachidonic, Docosapentaenoic or Docosahexaenoic acid through the co- expression of a delta -8-desaturase, a delta-9-elongase and a delta-5 desaturase in organisms such as microorganisms or plants.The invention additionally relates to the use of specific nucleic acid sequences encoding for the aforementioned proteins with delta-8-desaturase-, delta-9-elongase- or delta-5-desaturase-activity, nucleic acid constructs, vectors and organisms containing said nucleic acid sequences. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of at least 1 % by weight of unsaturated fatty acids and use thereof.
摘要翻译：本发明涉及一种用于特异性生产多不饱和ω-3和ω-6脂肪酸的改进方法，以及用于生产具有增加的不饱和脂肪酸含量，特别是ω-3和ω- 具有至少两个双键和20或22个碳原子链长度的6种脂肪酸。本发明涉及转基因生物体，优选转基因植物或转基因微生物的生产，其具有增加的脂肪酸含量，含有C20-或C22-脂肪酸的脂肪酸，含有δ-5,7 ，8,10双键，分别由于来自诸如植物优选藻类如等鞭毛藻或小球藻的生物体的δ-8-去饱和酶和δ-9-脱氢酶的表达。此外，本发明涉及通过共同表达δ-8-去饱和酶，δ-9-延伸酶和δ-5的多不饱和脂肪酸如二十碳五烯酸，花生四烯酸，多糖五烯酸或二十二碳六烯酸的生产方法除微生物或植物等生物体中的去饱和酶。本发明还涉及编码上述蛋白质的具有δ-8-去饱和酶，δ-9-延伸酶或δ-5-去饱和酶活性的特异性核酸序列的使用，核酸酸构建体，载体和含有所述核酸序列的生物体。本发明还涉及不饱和脂肪酸和甘油三酸酯，其具有增加的至少1重量％的不饱和脂肪酸的含量及其用途。

5. 发明申请

WO2009133145A1 DESATURASE AND METHOD FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS 审中-公开
标题翻译：在转基因生物中生产聚氨酯脂肪酸的脱脂和方法
公开(公告)号：WO2009133145A1
公开(公告)日：2009-11-05
申请号：PCT/EP2009/055210
申请日：2009-04-29
申请人： BASF PLANT SCIENCE GMBH , BAUER, Joerg , NAPIER, Johnathan A. , SAYANOVA, Olga
发明人： BAUER, Joerg , NAPIER, Johnathan A. , SAYANOVA, Olga
IPC分类号： C12N15/82 , C12N9/02 , C12N15/53 , C12P7/64 , A01H5/00
CPC分类号： C12N15/8247 , C12N9/0083 , C12P7/6427 , C12P7/6436 , C12P7/6472 , C12P7/6481
摘要： The present invention relates to a polynucleotide from Emiliana huxleyi which codes for a desaturase and which can be employed for the recombinant production of polyun- saturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotide according to the invention, and to the polypeptides encoded by the polynucleotide. The invention furthermore relates to antibodies against the polypeptide according to the invention. Finally, the invention also relates to production methods for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
摘要翻译：本发明涉及编码去饱和酶的Emiliana huxleyi的多核苷酸，其可用于重组生产多聚饱和脂肪酸。本发明还涉及包含根据本发明的多核苷酸的载体，宿主细胞和转基因非人生物以及由多核苷酸编码的多肽。本发明还涉及针对根据本发明的多肽的抗体。最后，本发明还涉及多不饱和脂肪酸和油，脂肪和脂肪酸组合物的制备方法以及它们作为药物，化妆品，食品，饲料，优选鱼食或食品补充剂的用途。

6. 发明申请

WO2007042510A3 PROCESS FOR THE PRODUCTION OF ARACHIDONIC ACID AND/OR EICOSAPENTAENOIC ACID 审中-公开
公开(公告)号：WO2007042510A3
公开(公告)日：2007-04-19
申请号：PCT/EP2006/067223
申请日：2006-10-10
申请人： BASF PLANT SCIENCE GMBH , NAPIER, Johnathan A. , SAYANOVA, Olga
发明人： NAPIER, Johnathan A. , SAYANOVA, Olga
IPC分类号： C12N9/02 , C12N9/10 , C12N15/82
摘要： vectors and transgenic plants containing said nucleic acid sequences.

7. 发明申请

WO2007051577A3 VERFAHREN ZUR HERSTELLUNG VON γ-LINOLENSÄURE UND/ ODER STEARIDONSÄURE IN TRANSGENEN BRASSICACEAE UND LINACEAE 审中-公开
公开(公告)号：WO2007051577A3
公开(公告)日：2007-05-10
申请号：PCT/EP2006/010408
申请日：2006-10-30
申请人： BASF PLANT SCIENCE GMBH , NAPIER, Johnathan, A. , SAYANOVA, Olga , VENEGAS CALERON, Monica
发明人： NAPIER, Johnathan, A. , SAYANOVA, Olga , VENEGAS CALERON, Monica
IPC分类号： C12N15/82 , C07K14/415
摘要： Die vorliegende Erfindung betrifft die Herstellung von γ-Linolensäure (18:3 Δ6,9,12 ) oder Stearidonsäure (18:4 Δ6,9,12,15 ) oder γ-Linolensäure (18:3 Δ6,9,12 ) und Stearidonsäure (18:4 Δ6,9,12,15 ) in transgenen Pflanzen der Familie Brassicaceae, wobei die transgenen Pflanzen mindestens 10 Gew-% Ölsäure bezogen auf den Gesamtfettsäuregehalt enthalten und durch die Aktivität der im Verfahren verwendeten Δ-6-Desaturasen einen erhöhten Gehalt an Δ-6-C 18 -Fettsäuren aufweisen. Außerdem betrifft die Erfindung neue Nukleinsäuresequenzen, die für die im Verfahren verwendeten Δ-6-Desatu rasen codieren, Genkonstrukte enthaltend diese Nukleinsäuresequenzen, einen Vektor und transgene Pflanzen enthaltend mindestens eine Nukleinsäuresequenz bzw. ein Genkonstrukt.

8. 发明申请

WO2003072784A1 DELTA 6-DESATURASES FROM PRIMULACEAE, EXPRESSING PLANTS AND PUFA-CONTAINING OILS 审中-公开
标题翻译：来自PRIMULACEAE的DELTA 6-脱氧核糖核酸，表达植物和含PUFA的油
公开(公告)号：WO2003072784A1
公开(公告)日：2003-09-04
申请号：PCT/EP2003/001161
申请日：2003-02-06
申请人： ROTHAMSTED EXPERIMENTAL STATION , NAPIER, Johnathan, A. , SAYANOVA, Olga
发明人： NAPIER, Johnathan, A. , SAYANOVA, Olga
IPC分类号： C12N15/53
CPC分类号： C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to an improved method for the specific production of unsaturated ω-3 fatty acids and a method for the production of triglycerides having an increased content of unsaturated fatty acids, in particular ω-3 fatty acids having more than three double bonds. The invention relates to the production of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, having an increased content of fatty acids, oils or lipids having Δ 6 double bonds due to the expression of a Δ 6-desaturase from Primulaceae. The invention additionally relates to expression cassettes containing a nucleic acid sequence, a vector and organisms containing at least one nucleic acid sequence or an expression cassette. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of unsaturated fatty acids and use thereof.
摘要翻译：本发明涉及用于特异性生产不饱和ω-3脂肪酸的改进方法以及生产具有增加的不饱和脂肪酸含量，特别是具有多于三个双键的ω-3脂肪酸的甘油三酸酯的方法。本发明涉及转基因生物，优选转基因植物或转基因微生物的生产，其具有增加的具有DELTA 6双键的脂肪酸，油或脂质含量，这是由于来自菜ace科的DELTA6-去饱和酶的表达。本发明还涉及含有核酸序列，载体和含有至少一个核酸序列或表达盒的生物体的表达盒。本发明还涉及具有增加的不饱和脂肪酸含量的不饱和脂肪酸和甘油三酸酯及其用途。

9. 发明申请

WO2007093776A2 NUCLEIC ACID 审中-公开
标题翻译：核酸
公开(公告)号：WO2007093776A2
公开(公告)日：2007-08-23
申请号：PCT/GB2007/000491
申请日：2007-02-13
申请人： BASF PLANT SCIENCE GMBH , NAPIER, Johnathan , SAYANOVA, Olga , VENEGAS CALERON, Monica
发明人： NAPIER, Johnathan , SAYANOVA, Olga , VENEGAS CALERON, Monica
IPC分类号： C12N15/54 , C12N15/53 , C12P7/64 , A01H5/00
CPC分类号： C12N15/8247 , C12N9/0083 , C12N9/1029 , C12P7/6427 , C12P7/6472
摘要： The invention relates to nucleic acid derived from Perkinsus marinus which encodes a 9-elongase, a Δ8-desaturase and a Δ5-desaturase enzyme. All of the coding sequences can be transcribed as a single transcript.
摘要翻译：本发明涉及编码9-延伸酶，Δ8-去饱和酶和Δ5-去饱和酶的源自Perkinsus marinus的核酸。所有的编码序列都可以被转录成单个转录本。

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