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1. 发明申请

WO2010066703A2 DESATURASES AND PROCESS FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS 审中-公开
标题翻译：在转基因生物体中生产多不饱和脂肪酸的脱盐和方法
公开(公告)号：WO2010066703A2
公开(公告)日：2010-06-17
申请号：PCT/EP2009/066569
申请日：2009-12-08
申请人： BASF PLANT SCIENCE GMBH , SENGER, Toralf , BAUER, Jörg , NAPIER, Johnathan A.
发明人： NAPIER, Johnathan A.
IPC分类号： C12N15/82 , C12N9/02 , C12N15/53 , C12P7/64 , A01H5/00
CPC分类号： C12P7/6409 , C12N9/0071 , C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12P7/6481 , C12Y114/19001
摘要： The present invention relates to polynucleotides from Cochliobolus heterostrophus C5, Cyanothece sp. CCY0110, Mycocentrospora acerina and Hyaloperonospora parasitica, which code for desaturases and which can be employed for the recom bi nant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides according to the invention, and to the polypeptides encoded by the polynucleotides. The invention furthermore relates to antibodies against the polypeptides according to the invention. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
摘要翻译：本发明涉及来自旋毛虫异旋藻C5，Cyanothece sp。的多核苷酸。 CCY0110，Mycocentrospora acerina和寄生透明单胞菌，其编码去饱和酶并可用于多不饱和脂肪酸的重组生产。本发明还涉及包含根据本发明的多核苷酸的载体，宿主细胞和转基因非人生物体，并涉及由多核苷酸编码的多肽。本发明还涉及针对根据本发明的多肽的抗体。最后，本发明还涉及用于多不饱和脂肪酸和油，脂质和脂肪酸组合物的生产方法以及它们作为药物，化妆品，食品，饲料，优选鱼食或食品补充剂的用途。

2. 发明申请

WO2004057001A3 METHOD FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS 审中-公开
标题翻译：生产聚氨酯脂肪酸的方法
公开(公告)号：WO2004057001A3
公开(公告)日：2004-11-04
申请号：PCT/EP0314054
申请日：2003-12-11
申请人： UNIV BRISTOL , NAPIER JOHNATHAN A , SAYANOVA OLGA , LAZARUS COLIN M , QI BAOXIU , HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH
发明人： NAPIER JOHNATHAN A , SAYANOVA OLGA , LAZARUS COLIN M , QI BAOXIU , HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH
IPC分类号： C12N9/02 , C12N9/10 , C12N15/82 , C12P7/64
CPC分类号： C12N9/0083 , C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to an improved process for the specific production of poly-unsaturated omega-3 and omega-6 fatty acids and a process for the production of triglycerides having an increased content of unsaturated fatty acids, in particular omega-3 and omega-6 fatty acids having at least two double bonds and a 20 or 22 carbon atom chain length. The invention relates to the produc-tion of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, hav-ing an increased content of fatty acids, oils or lipids containing C20- or C22- fatty acids with a delta-5, 7, 8, 10 double bond, respectively due to the expression of a delta-8-desaturase and a delta-9- elon-gase from organisms such as plants preferably Algae like Isochrysis galbana or Euglena gracilis. In addition the invention relates to a process for the production of poly unsaturated fatty acids such as Eicosapentaenoic, Arachidonic, Docosapentaenoic or Docosahexaenoic acid through the co- expression of a delta -8-desaturase, a delta-9-elongase and a delta-5 desaturase in organisms such as microorganisms or plants.The invention additionally relates to the use of specific nucleic acid sequences encoding for the aforementioned proteins with delta-8-desaturase-, delta-9-elongase- or delta-5-desaturase-activity, nucleic acid constructs, vectors and organisms containing said nucleic acid sequences. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of at least 1 % by weight of unsaturated fatty acids and use thereof.

3. 发明申请

WO0055330A9 POLYSATURATED FATTY ACID (PUFA) ELONGASE FROM CAENORHABDITIS ELEGANS 审中-公开
标题翻译：来自CAENORHABDITIS ELEGANS的多糖脂肪酸（PUFA）ELONGASE
公开(公告)号：WO0055330A9
公开(公告)日：2002-08-29
申请号：PCT/GB0001035
申请日：2000-03-20
申请人： UNIV BRISTOL , NAPIER JOHNATHAN A
发明人： NAPIER JOHNATHAN A
IPC分类号： A01K67/033 , A23L1/30 , A61K31/201 , A61K31/202 , A61K38/00 , A61P43/00 , C12N1/19 , C12N1/21 , C12N9/00 , C12N9/10 , C12N15/09 , C12N15/54 , C12P7/64 , A01H5/00 , A61K38/45 , C07C57/03 , C07C57/12
CPC分类号： C12N9/1029 , A01K2217/05 , A61K38/00
摘要： A isolated polypeptide comprising a functional long chain polyunsaturated fatty acid (PUFA) elongase.
摘要翻译：包含功能性长链多不饱和脂肪酸（PUFA）延伸酶的分离的多肽。

4. 发明申请

WO2011161093A1 ACYLTRANSFERASES AND USES THEROF IN FATTY ACID PRODUCTION 审中-公开
标题翻译： ACYLTRANSFERASES及其在脂肪酸生产中的应用
公开(公告)号：WO2011161093A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060315
申请日：2011-06-21
申请人： BASF PLANT SCIENCE COMPANY GMBH , SENGER, Toralf , MARTY, Laurent , STYMNE, Sten , LINDBERG YILMAZ, Jenny , NAPIER, Johnathan A. , SAYANOVA, Olga , HASLAM, Richard , NOEMI, Ruiz Lopez
发明人： SENGER, Toralf , MARTY, Laurent , STYMNE, Sten , LINDBERG YILMAZ, Jenny , NAPIER, Johnathan A. , SAYANOVA, Olga , HASLAM, Richard , NOEMI, Ruiz Lopez
IPC分类号： C12N15/82 , C12P7/64
CPC分类号： C12N9/1029 , A23D9/02 , A23K20/158 , A23L33/105 , A23L33/115 , A23L33/12 , A23V2002/00 , A23V2250/1862 , A23V2250/1868 , A23V2250/187 , A23V2250/1882 , C11C1/045 , C12N15/8247 , C12P7/6427 , C12Y203/0102 , Y02P20/52
摘要： The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucletides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
摘要翻译：本发明涉及多不饱和脂肪酸的重组制造。具体地说，它涉及酰基转移酶多肽，编码所述酰基转移酶的多核苷酸以及载体，宿主细胞，含有所述多核苷酸的非人转基因生物。此外，本发明考虑了制造多不饱和脂肪酸的方法以及通过这些方法获得的油。

5. 发明申请

WO2010066703A3 DESATURASES AND PROCESS FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS 审中-公开
标题翻译：在转基因生物中生产聚氨酯脂肪酸的苦味和过程
公开(公告)号：WO2010066703A3
公开(公告)日：2010-09-23
申请号：PCT/EP2009066569
申请日：2009-12-08
申请人： BASF PLANT SCIENCE GMBH , SENGER TORALF , BAUER JOERG , NAPIER JOHNATHAN A
发明人： SENGER TORALF , BAUER JOERG , NAPIER JOHNATHAN A
IPC分类号： C12N15/82 , A01H5/00 , C12N9/02 , C12N15/53 , C12P7/64
CPC分类号： C12P7/6409 , C12N9/0071 , C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12P7/6481 , C12Y114/19001
摘要： The present invention relates to polynucleotides from Cochliobolus heterostrophus C5, Cyanothece sp. CCY0110, Mycocentrospora acerina and Hyaloperonospora parasitica, which code for desaturases and which can be employed for the recom bi nant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides according to the invention, and to the polypeptides encoded by the polynucleotides. The invention furthermore relates to antibodies against the polypeptides according to the invention. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
摘要翻译：本发明涉及来自嗜球菌（Cocchioiobolus heterostrophus）C5，蓝藻（Cyanothece sp。）的多核苷酸 CCY0110，Acycina霉菌和Hyaloperonospora parasitica，其代码为去饱和酶，可用于多不饱和脂肪酸的重复生产。本发明还涉及包含根据本发明的多核苷酸的载体，宿主细胞和转基因非人生物以及由多核苷酸编码的多肽。本发明还涉及针对根据本发明的多肽的抗体。最后，本发明还涉及多不饱和脂肪酸和油，脂和脂肪酸组合物的生产方法以及它们作为药物，化妆品，食品，饲料，优选鱼食或食品添加剂的用途。

6. 发明申请

WO2009156469A1 RECOMBINANT CELLS AND PLANTS FOR SYNTHESIS OF VERY LONG CHAINS FATTY ACID (VLCFA) 审中-公开
标题翻译：用于合成非常长链脂肪酸（VLCFA）的重组细胞和植物
公开(公告)号：WO2009156469A1
公开(公告)日：2009-12-30
申请号：PCT/EP2009/057964
申请日：2009-06-25
申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ROTHAMSTED RESEARCH LTD , FAURE, Jean-Denis , BACH, Liên , MIQUEL, Martine , NAPIER, Johnathan
发明人： FAURE, Jean-Denis , BACH, Liên , MIQUEL, Martine , NAPIER, Johnathan
IPC分类号： C12N15/82
CPC分类号： C12N15/8247 , A23D9/00 , C12N9/88 , C12N15/8261 , C12N15/827 , C12P7/6409 , C12P7/6463 , Y02A40/146
摘要： The present invention is relative to a method for the production of Very-Long-Chain Fatty Acids (VLCFA) into a plant cell, comprising culturing a recombinant plant cell in an appropriate medium, wherein said plant cell is transformed with an heterologous gene encoding for an hydroxyacyl-CoA dehydratase. The invention is also relative to a method for producing vegetable oil comprising high levels of VLCFA.
摘要翻译：本发明涉及用于生产非常长链脂肪酸（VLCFA）到植物细胞中的方法，包括在合适的培养基中培养重组植物细胞，其中所述植物细胞用编码羟基酰辅酶A脱水酶。本发明还涉及一种生产包含高含量VLCFA的植物油的方法。

7. 发明申请

WO2007093776A3 NUCLEIC ACID 审中-公开
标题翻译：核酸
公开(公告)号：WO2007093776A3
公开(公告)日：2007-12-06
申请号：PCT/GB2007000491
申请日：2007-02-13
申请人： BASF PLANT SCIENCE GMBH , NAPIER JOHNATHAN , SAYANOVA OLGA , VENEGAS CALERON MONICA
发明人： NAPIER JOHNATHAN , SAYANOVA OLGA , VENEGAS CALERON MONICA
IPC分类号： C12N15/54 , A01H5/00 , C12N15/53 , C12P7/64
CPC分类号： C12N15/8247 , C12N9/0083 , C12N9/1029 , C12P7/6427 , C12P7/6472
摘要： The invention relates to nucleic acid derived from Perkinsus marinus which encodes a 9-elongase, a ?8-desaturase and a ?5-desaturase enzyme. All of the coding sequences can be transcribed as a single transcript.
摘要翻译：本发明涉及来源于编码9-延伸酶，α8-去饱和酶和α5-去饱和酶的Perkinsus marinus的核酸。所有编码序列都可以转录为单个转录本。

8. 发明申请

WO2007051577A2 METHOD FOR THE PRODUCTION OF ?-LINOLENIC ACID AND/OR STEARIDONIC ACID IN TRANSGENIC BRASSICACEAE AND LINACEAE 审中-公开
标题翻译：用于生产？亚麻酸和/或在转基因亚麻十字花科和亚麻科
公开(公告)号：WO2007051577A2
公开(公告)日：2007-05-10
申请号：PCT/EP2006010408
申请日：2006-10-30
申请人： ROTHAMSTED RES , NAPIER JOHNATHAN A , SAYANOVA OLGA , VENEGAS CALERON MONICA
发明人： NAPIER JOHNATHAN A , SAYANOVA OLGA , VENEGAS CALERON MONICA
IPC分类号： C12N15/82 , C07K14/415
CPC分类号： C12N15/8247 , C12N9/0071
摘要： The invention relates to the production of ?-linolenic acid (18:3 ?6,9,12 ) or stearidonic acid (18:4 ?6,9,12,15 ) or ?-linolenic acid (18:3 ?6,9,12 ) and stearidonic acid (18:4 ?6,9,12,15 ) in transgenic plants of the brassicaceae family, said transgenic plants containing at least 10 percent by weight of oleic acid relative to the total fatty acid concentration and being provided with an increased ?-6-C 18 fatty acid concentration as a result of the activity of the ?-6 desaturases used in the method. The invention also relates to novel nucleic acid sequences coding for the ?-6 desaturases used in the method, gene constructs containing said nucleic acid sequences, a vector and transgenic plants containing at least one nucleic acid sequence or a gene construct.
摘要翻译：本发明涉及生产亚麻酸（18：3 ^{6,9,12 ？）或者十八碳四烯酸（18：4 ^{6,9,12,15- ）？？或亚麻酸（18：3 ^{6,9,12 α）和十八碳四烯酸：在十字花科的转基因植物（18 4 ^{6,9,12,15- ）其中至少10重量％，基于油酸以总脂肪酸含量和所用的方法的类型的转基因植物的？-6-去饱和酶的？-6-C _{18 包括脂肪酸的含量增加。此外，本发明涉及编码用于在方法中使用的新颖的草坪核酸序列？-6-去饱和酶，含有包含至少一种核酸序列或基因构建这些核酸序列，载体和转基因植物的基因构建体。}}}}}

9. 发明申请

WO2004057001A2 NOVEL METHOD FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS 审中-公开
标题翻译：用于生产聚氨酯脂肪酸的新方法
公开(公告)号：WO2004057001A2
公开(公告)日：2004-07-08
申请号：PCT/EP2003/014054
申请日：2003-12-11
申请人： UNIVERSITY OF BRISTOL , NAPIER, Johnathan, A. , SAYANOVA, Olga , LAZARUS, Colin, M. , QI, Baoxiu , HEINZ, Ernst , ZANK, Thorsten , ZÄHRINGER, Ulrich
发明人： NAPIER, Johnathan, A. , SAYANOVA, Olga , LAZARUS, Colin, M. , QI, Baoxiu , HEINZ, Ernst , ZANK, Thorsten , ZÄHRINGER, Ulrich
IPC分类号： C12N15/82
CPC分类号： C12N9/0083 , C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to an improved process for the specific production of poly-unsaturated omega-3 and omega-6 fatty acids and a process for the production of triglycerides having an increased content of unsaturated fatty acids, in particular omega-3 and omega-6 fatty acids having at least two double bonds and a 20 or 22 carbon atom chain length. The invention relates to the produc-tion of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, hav-ing an increased content of fatty acids, oils or lipids containing C20- or C22- fatty acids with a delta-5, 7, 8, 10 double bond, respectively due to the expression of a delta-8-desaturase and a delta-9- elon-gase from organisms such as plants preferably Algae like Isochrysis galbana or Euglena gracilis. In addition the invention relates to a process for the production of poly unsaturated fatty acids such as Eicosapentaenoic, Arachidonic, Docosapentaenoic or Docosahexaenoic acid through the co- expression of a delta -8-desaturase, a delta-9-elongase and a delta-5 desaturase in organisms such as microorganisms or plants.The invention additionally relates to the use of specific nucleic acid sequences encoding for the aforementioned proteins with delta-8-desaturase-, delta-9-elongase- or delta-5-desaturase-activity, nucleic acid constructs, vectors and organisms containing said nucleic acid sequences. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of at least 1 % by weight of unsaturated fatty acids and use thereof.
摘要翻译：本发明涉及一种用于特异性生产多不饱和ω-3和ω-6脂肪酸的改进方法，以及用于生产具有增加的不饱和脂肪酸含量，特别是ω-3和ω- 具有至少两个双键和20或22个碳原子链长度的6种脂肪酸。本发明涉及转基因生物体，优选转基因植物或转基因微生物的生产，其具有增加的脂肪酸含量，含有C20-或C22-脂肪酸的脂肪酸，含有δ-5,7 ，8,10双键，分别由于来自诸如植物优选藻类如等鞭毛藻或小球藻的生物体的δ-8-去饱和酶和δ-9-脱氢酶的表达。此外，本发明涉及通过共同表达δ-8-去饱和酶，δ-9-延伸酶和δ-5的多不饱和脂肪酸如二十碳五烯酸，花生四烯酸，多糖五烯酸或二十二碳六烯酸的生产方法除微生物或植物等生物体中的去饱和酶。本发明还涉及编码上述蛋白质的具有δ-8-去饱和酶，δ-9-延伸酶或δ-5-去饱和酶活性的特异性核酸序列的使用，核酸酸构建体，载体和含有所述核酸序列的生物体。本发明还涉及不饱和脂肪酸和甘油三酸酯，其具有增加的至少1重量％的不饱和脂肪酸的含量及其用途。

10. 发明申请

WO9933958A3 DESATURASE 审中-公开
标题翻译：去饱和酶
公开(公告)号：WO9933958A3
公开(公告)日：1999-09-02
申请号：PCT/GB9803895
申请日：1998-12-23
申请人： UNIV BRISTOL , NAPIER JOHNATHAN A , MICHAELSON LOUISE , STOBART KEITH
发明人： NAPIER JOHNATHAN A , MICHAELSON LOUISE , STOBART KEITH
IPC分类号： A01H5/00 , A01K67/027 , A23L1/00 , A61K31/202 , A61K38/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/09 , C12N15/82 , C12P7/64 , C12Q1/68 , C12N15/53 , A61K31/20 , C12N15/11 , C12N15/81
CPC分类号： C12N9/0083 , A01K2217/05 , A61K38/00 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： This invention relates to cDNA sequences encoding DELTA 5-fatty acid desaturases comprising the sequences shown in SEQ.1 and SEQ.2.
摘要翻译：本发明涉及编码包含SEQ.1和SEQ.2所示序列的Δ5-脂肪酸去饱和酶的cDNA序列。

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