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1. 发明申请

WO0222681A3 NEURONALLY EXPRESSED PROTEIN AND USE THEREOF 审中-公开
标题翻译：神经元表达蛋白及其应用
公开(公告)号：WO0222681A3
公开(公告)日：2002-08-01
申请号：PCT/EP0110689
申请日：2001-09-15
申请人： BASF LYNX BIOSCIENCE AG , LANAHAN ANTHONY , WORLEY PAUL F , KAMMANDEL BIRGITTA , KUNER ROHINI , LORCH BEATE , NEWRZELLA DIETER , SCHEEK SIGRID , SCHNEIDER ARMIN
发明人： LANAHAN ANTHONY , WORLEY PAUL F , KAMMANDEL BIRGITTA , KUNER ROHINI , LORCH BEATE , NEWRZELLA DIETER , SCHEEK SIGRID , SCHNEIDER ARMIN
IPC分类号： C07K14/47 , C12N15/12 , C12Q1/68 , A01K67/027 , C07K16/18 , C12N15/70 , G01N33/53
CPC分类号： C07K14/47 , A01K2217/05 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The invention relates to novel, specifically expressed proteins, nucleic acid sequences, recombinant nucleic acid structures containing said nucleic acid sequences, and vectors containing the aforementioned nucleic acid sequences or recombinant nucleic acid structures, which code for the proteins. The invention also relates to transgenic organisms containing said nucleic acid sequences, said recombinant nucleic acid structures or said vectors, in addition to monoclonal or polyclonal antibodies, which are oriented against the isolated proteins. The invention further relates to a method for finding substances having a specific binding affinity with the inventive proteins, and a method for qualitatively or quantitatively detecting the inventive nucleic acid sequences or the inventive proteins. Also disclosed is the use of said nucleic acid sequences and proteins.
摘要翻译：本发明涉及新的特异表达的蛋白质，核酸序列，含有含核酸序列的核酸序列或载体的重组核酸构建体或编码蛋白质的重组核酸构建体。本发明还涉及含有核酸序列，重组核酸构建体或上述载体以及针对分离的蛋白质的单克隆或多克隆抗体的转基因生物体。此外，本发明涉及寻找与本发明蛋白质具有特异性结合亲和力的物质的方法，定性或定量检测根据本发明的核酸序列或根据本发明的蛋白质的方法。此外，本发明涉及核酸序列和蛋白质的用途。

2. 发明申请

WO0188108A8 NEURONAL SERINE-THREONINE PROTEIN KINASE 审中-公开
标题翻译：神经元丝氨酸蛋白激酶
公开(公告)号：WO0188108A8
公开(公告)日：2001-12-20
申请号：PCT/EP0105660
申请日：2001-05-17
申请人： BASF LYNX BIOSCIENCE AG , SCHNEIDER ARMIN , KLAUSSNER BETTINA , FISCHER ACHIM , NEWRZELLA DIETER , GOETZ BERNHARD , ROSSNER MORITZ , EISENHARDT GISELA , KUNER ROHINI , TRUTZEL ANNETTE , KAMMANDEL BIRGITTA , JOMANA NAIM STEPHANIE , SCHWANINGER MARKUS
发明人： SCHNEIDER ARMIN , KLAUSSNER BETTINA , FISCHER ACHIM , NEWRZELLA DIETER , GOETZ BERNHARD , ROSSNER MORITZ , EISENHARDT GISELA , KUNER ROHINI , TRUTZEL ANNETTE , KAMMANDEL BIRGITTA , JOMANA NAIM STEPHANIE , SCHWANINGER MARKUS
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/12 , A61K35/74 , A61K36/06 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61K51/04 , A61P1/04 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/47 , C07K16/40 , C12N1/19 , C12N1/21 , C12N5/08 , C12N5/10 , C12N9/12 , C12N9/99 , C12N15/09 , C12N15/12 , C12Q1/48 , G01N33/15 , G01N33/50 , C12N15/11 , A61K31/713 , A61K38/43 , C12N15/54 , C12Q1/68 , G01N33/577
CPC分类号： A61K51/0491 , A01K2217/05 , A61K38/00 , C12N9/1205
摘要： The invention relates to a gene and to the protein coded by said gene, which contributes to the appearance of the sequela of a local ischaemia. The novel protein is a serine-threonine protein kinase and provides a novel therapeutic approach to the prevention and treatment of apoplexy.
摘要翻译：本发明涉及基因和由其编码的蛋白质，其涉及局部缺血后遗症的发展。新蛋白是一种丝氨酸 - 苏氨酸蛋白激酶，为中风的预防和治疗提供了一种新的治疗方法。

3. 发明申请

WO02064776A3 SIGNAL TRANSDUCTION PROTEINS 15B3, 15B3-1 AND 15B3-2, AND RELATED DNA SEQUENCES 审中-公开
标题翻译：信号转导15B3，15B3-1和15B3-2和基础DNA序列
公开(公告)号：WO02064776A3
公开(公告)日：2003-08-21
申请号：PCT/EP0201562
申请日：2002-02-14
申请人： AXARON BIOSCIENCE AG , SCHNEIDER ARMIN , FISCHER ACHIM , KLAUSNER BETTINA , ROSSNER MORITZ , KAMMANDEL BIRGITTA , WIDENMEYER REBECCA , GOETZ BERNHARD , EISENHARDT GISELA , NAIM STEPHANIE JOMANA , NEWRZELLA DIETER
发明人： SCHNEIDER ARMIN , FISCHER ACHIM , KLAUSNER BETTINA , ROSSNER MORITZ , KAMMANDEL BIRGITTA , WIDENMEYER REBECCA , GOETZ BERNHARD , EISENHARDT GISELA , NAIM STEPHANIE JOMANA , NEWRZELLA DIETER
IPC分类号： A61K38/00 , A61K48/00 , A61P25/28 , A61P35/00 , C07K14/47 , C12N15/12 , A01K67/027 , C07K16/18 , C12N15/10 , C12N15/63
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： The invention relates to DNA sequences, expression vectors containing the inventive DNA sequences, host cells, gene products of the cited DNA sequences coding for signal transduction proteins, and other derivatives of the cited objects of the invention. Said DNA sequences and gene products either have a protective action, i.e. impart a certain resistance to apoplexy, or they cause an increase in ischaemic damage. The invention also relates to the use of the inventive DNA sequences or the signal transduction proteins expressed by said DNA sequences as pharmaceuticals, and to the non-therapeutic uses of the inventive DNA sequences or gene products.
摘要翻译：本发明涉及一种DNA序列，含有本发明的DNA序列，宿主细胞表达载体中，前述的DNA序列，其编码的信号转导，以及本发明的上述目的的其它衍生物的基因产物，wobie的DNA序列和基因产物有保护作用，即赋予该行程一定的阻力或要求的局部缺血损伤的扩大。此外，本发明公开了提供使用本发明的DNA序列的或由这些DNA序列Signaltrasduktionsprotein作为药物和根据本发明的DNA序列的非治疗用途BZM表达的蛋白质。基因产物。

4. 发明申请

WO0246457A2 METHOD FOR ENCODING HYBRIDIZATION PROBES 审中-公开
标题翻译：方法编码HYBRIDDISIERUNGSSONDEN
公开(公告)号：WO0246457A2
公开(公告)日：2002-06-13
申请号：PCT/EP0114391
申请日：2001-12-07
申请人： AXARON BIOSCIENCE AG , FISCHER ACHIM , NEWRZELLA DIETER
发明人： FISCHER ACHIM , NEWRZELLA DIETER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6855 , C12Q2565/501 , C12Q2525/191
摘要： The invention relates to a method for identifying nucleic acids which is characterized by the following steps: (a) providing at least one DNA fragment with one overhang having a known length and an unknown sequence, (b) attaching a determined encoder from a mixture of encoders that also has an overhang to the DNA fragment's overhang having an unknown sequence, the overhang of the attached encoder and the DNA fragment's overhang having an unknown sequence being completely complementary to each other, (c) optionally removing those encoders that were not attached to a DNA fragment in step (b), (d) labeling the attached product from step (b) unless already labeled encoders were used for attachment, (e) hybridizing the labeled attached product to an array of oligonucleotides which are substantially complementary to one of the strands of any encoder from the mixture of encoders or from a selection thereof.
摘要翻译：本发明涉及用于核酸识别的方法，其特征在于下列步骤：a）提供具有已知长度和未知序列的悬垂端的至少一个DNA片段; b）由编码器的混合物中，也与悬垂的DNA片段，其特征在于，所述固定编码器的突出端部和DNA片段的突出末端未知序列是彼此完全互补的突出末端未知序列的端部的特定编码器的紧固; c）中任选除去其中）已经被连接到任何DNA片段（在步骤b中这些编码器; D）标记从步骤（b紧固件产品），如果尚未标记的编码器已被用于附接; E）的寡核苷酸具有从编码器的混合物或选择所有可能的编码器的链之一是其基本上互补的阵列标记紧固件产品的杂交。

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