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1. 发明申请

WO02064776A3 SIGNAL TRANSDUCTION PROTEINS 15B3, 15B3-1 AND 15B3-2, AND RELATED DNA SEQUENCES 审中-公开
标题翻译：信号转导15B3，15B3-1和15B3-2和基础DNA序列
公开(公告)号：WO02064776A3
公开(公告)日：2003-08-21
申请号：PCT/EP0201562
申请日：2002-02-14
申请人： AXARON BIOSCIENCE AG , SCHNEIDER ARMIN , FISCHER ACHIM , KLAUSNER BETTINA , ROSSNER MORITZ , KAMMANDEL BIRGITTA , WIDENMEYER REBECCA , GOETZ BERNHARD , EISENHARDT GISELA , NAIM STEPHANIE JOMANA , NEWRZELLA DIETER
发明人： SCHNEIDER ARMIN , FISCHER ACHIM , KLAUSNER BETTINA , ROSSNER MORITZ , KAMMANDEL BIRGITTA , WIDENMEYER REBECCA , GOETZ BERNHARD , EISENHARDT GISELA , NAIM STEPHANIE JOMANA , NEWRZELLA DIETER
IPC分类号： A61K38/00 , A61K48/00 , A61P25/28 , A61P35/00 , C07K14/47 , C12N15/12 , A01K67/027 , C07K16/18 , C12N15/10 , C12N15/63
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： The invention relates to DNA sequences, expression vectors containing the inventive DNA sequences, host cells, gene products of the cited DNA sequences coding for signal transduction proteins, and other derivatives of the cited objects of the invention. Said DNA sequences and gene products either have a protective action, i.e. impart a certain resistance to apoplexy, or they cause an increase in ischaemic damage. The invention also relates to the use of the inventive DNA sequences or the signal transduction proteins expressed by said DNA sequences as pharmaceuticals, and to the non-therapeutic uses of the inventive DNA sequences or gene products.
摘要翻译：本发明涉及一种DNA序列，含有本发明的DNA序列，宿主细胞表达载体中，前述的DNA序列，其编码的信号转导，以及本发明的上述目的的其它衍生物的基因产物，wobie的DNA序列和基因产物有保护作用，即赋予该行程一定的阻力或要求的局部缺血损伤的扩大。此外，本发明公开了提供使用本发明的DNA序列的或由这些DNA序列Signaltrasduktionsprotein作为药物和根据本发明的DNA序列的非治疗用途BZM表达的蛋白质。基因产物。

2. 发明申请

WO0246457A2 METHOD FOR ENCODING HYBRIDIZATION PROBES 审中-公开
标题翻译：方法编码HYBRIDDISIERUNGSSONDEN
公开(公告)号：WO0246457A2
公开(公告)日：2002-06-13
申请号：PCT/EP0114391
申请日：2001-12-07
申请人： AXARON BIOSCIENCE AG , FISCHER ACHIM , NEWRZELLA DIETER
发明人： FISCHER ACHIM , NEWRZELLA DIETER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6855 , C12Q2565/501 , C12Q2525/191
摘要： The invention relates to a method for identifying nucleic acids which is characterized by the following steps: (a) providing at least one DNA fragment with one overhang having a known length and an unknown sequence, (b) attaching a determined encoder from a mixture of encoders that also has an overhang to the DNA fragment's overhang having an unknown sequence, the overhang of the attached encoder and the DNA fragment's overhang having an unknown sequence being completely complementary to each other, (c) optionally removing those encoders that were not attached to a DNA fragment in step (b), (d) labeling the attached product from step (b) unless already labeled encoders were used for attachment, (e) hybridizing the labeled attached product to an array of oligonucleotides which are substantially complementary to one of the strands of any encoder from the mixture of encoders or from a selection thereof.
摘要翻译：本发明涉及用于核酸识别的方法，其特征在于下列步骤：a）提供具有已知长度和未知序列的悬垂端的至少一个DNA片段; b）由编码器的混合物中，也与悬垂的DNA片段，其特征在于，所述固定编码器的突出端部和DNA片段的突出末端未知序列是彼此完全互补的突出末端未知序列的端部的特定编码器的紧固; c）中任选除去其中）已经被连接到任何DNA片段（在步骤b中这些编码器; D）标记从步骤（b紧固件产品），如果尚未标记的编码器已被用于附接; E）的寡核苷酸具有从编码器的混合物或选择所有可能的编码器的链之一是其基本上互补的阵列标记紧固件产品的杂交。

3. 发明申请

WO02072879A3 PRODUCTION AND USE OF RANDOM ARRANGEMENTS OF CLONAL NUCLEAR ACID ISLANDS ON A SURFACE 审中-公开
标题翻译：生产和随机排列的使用克隆NUCLEIC群岛上的表面
公开(公告)号：WO02072879A3
公开(公告)日：2003-10-02
申请号：PCT/EP0201406
申请日：2002-02-11
申请人： AXARON BIOSCIENCE AG , FISCHER ACHIM
发明人： FISCHER ACHIM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , B01J2219/00274 , C12Q2565/537 , C12Q2525/191
摘要： The invention relates to a method for producing a random arrangement of clonal islands on a surface, comprising the following steps a1) preparing a surface having at least one priming type whose primer molecules are immobilised in an at least partially reversible manner on the surface; b1) hybridising the nucleic acids which need to amplified with the primers from step a1); c1) amplification of the nucleic acids from step b1) which need to be amplified, at least one counter primer type is being used for amplification, the primer molecules thereof being at least partially non immobilised and whose primer molecules containing the primer from step a1) form at least one PCR- primer pair with respect to the nucleic acids which are to be amplified. The reaction area of the amplification is formed by the area which is defined by the surface and by a micro-compartmenting matrix adjacent to the surface.
摘要翻译：本发明涉及一种方法，用于产生在表面上克隆岛的随机布置中，其包括a1的步骤：a）提供包含至少一种引物类型，其引物分子至少被固定在不可逆的表面部分的表面; b1）中的核酸杂交与步骤a1）的引物进行扩增; C1）的从步骤b1扩增的核酸）的扩增中，所述至少一种反向引物类型用于扩增，引物分子不固定至少部分及其与步骤a1的相对于所述的引物）引物分子扩增的核酸形式的至少一个PCR引物对，并且其中所述扩增的反应空间由由所述表面，并通过一个表面邻接mikrokompartimentierende矩阵限定的空间形成。

4. 发明申请

WO0148184A3 METHOD FOR CARRYING OUT THE PARALLEL SEQUENCING OF A NUCLEIC ACID MIXTURE ON A SURFACE 审中-公开
标题翻译：方法的在表面上NUCLEIC合剂的平行测序
公开(公告)号：WO0148184A3
公开(公告)日：2002-05-16
申请号：PCT/EP0013157
申请日：2000-12-22
申请人： AXARON BIOSCIENCE AG , FISCHER ACHIM
发明人： FISCHER ACHIM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2565/543 , C12Q2525/191 , C12Q2521/313 , C12Q2525/301
摘要： The invention relates to a method for carrying out the parallel sequencing of at least two different nucleic acids contained in a nucleic acid mixture, whereby: (a) a surface is prepared which comprises islands of nucleic acids of the same type of tertiary nucleic acids; (b) opposite strands of the tertiary nucleic acids GTN are prepared; (c) the GTN are lengthened by one nucleotide, whereby the nucleotide, on the 2'-OH position or on the 3'-OH position, carries a protective group, which prevents an additional lengthening, and the nucleotide carries a molecular group, which enables the identification of the nucleotide; (d) the incorporated nucleotide is identified; (e) the protective group is removed and said molecular group of the incorporated nucleotide is removed or modified, and; (f) step (c) and the following steps are repeated until the desired sequence information has been obtained.
摘要翻译：本发明涉及一种包含在一个Nuckleisäuregemisch，至少两种不同的核酸并行测序的方法，其中（a）是提供一种表面，其包括核酸各品种，叔核酸岛; （B）是第三核酸，GTN提供相反链; （C）在GTN一个核苷酸，其中所述核苷酸在2'-OH位置或3'-OH位置，其防止进一步延伸带有一个保护基进行扩展，所述核苷酸带有一个分子基团，识别，所述的核苷酸允许; （D）识别所述掺入的核苷酸; （E）的Schuztgruppe被去除，并去除用于掺入的核苷酸或经修饰的，和（f）步骤（c）和随后的步骤的识别分子组被重复，直到已经获得所需的序列信息。

5. 发明申请

WO0192568A3 METHOD FOR PRODUCING DNA-ARRAYS 审中-公开
标题翻译：用于生产DNA芯片
公开(公告)号：WO0192568A3
公开(公告)日：2003-06-05
申请号：PCT/EP0106248
申请日：2001-06-01
申请人： AXARON BIOSCIENCE AG , FISCHER ACHIM
发明人： FISCHER ACHIM
IPC分类号： C12Q1/68 , B01J19/00 , B01L7/00
CPC分类号： C12Q1/6837 , C12Q2565/543
摘要： The invention relates to a method for analyzing nucleic acids. A surface is provided with islands of DNA of the same variety, i.e. tertiary nucleic acids; the tertiary nucleic acids are brought into contact with a probe or a mixture of several probes to enable hybridization to occur between the tertiary nucleic acids and the probe or probes; the tertiary nucleic acids and/or probes which are localized at points where a differential hybridization event occurs are separated from other nucleic acids and/or probes where no differential hybridization event is localized.
摘要翻译：本发明涉及一种用于Nuleinsäureanalytik，其中一个表面，提供了一种方法，其包括每一个品种，叔核酸的核酸岛; 第三核酸与探针或多个探针的接触的混合物接触，使得杂交可以采取第三核酸和所述探针或探针之间的地方; 第三核酸和/或探针，位于其中一个差动杂交事件位于的地方，将被从所述其它的核酸和/或探针，它们位于在其中不存在差异杂交事件位于的地方分离。

6. 发明申请

WO0175154A3 NOVEL METHOD FOR THE PARALLEL SEQUENCING OF A NUCLEIC ACID MIXTURE ON A SURFACE 审中-公开
标题翻译：新方法的表面NUCLEIC合剂的平行测序
公开(公告)号：WO0175154A3
公开(公告)日：2003-01-03
申请号：PCT/EP0103777
申请日：2001-04-03
申请人： AXARON BIOSCIENCE AG , FISCHER ACHIM
发明人： FISCHER ACHIM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2565/543 , C12Q2525/191 , C12Q2521/313 , C12Q2525/301
摘要： The invention relates to a method for the parallel sequencing of at least two nucleic acids that are contained in a nucleic acid mixture. According to said method, a surface is provided which has islands of nucleic acids, each of the same type, i.e. tertiary nucleic acids; - the tertiary nucleic acids are treated in such a way that the products are only connected to the surface by the 5' end of one strand of a double-strand; - the tertiary nucleic acids are cleaved by restriction endonucleases of the IIS type, in such a way that 3' overhanging ends or 5' overhanging ends are created; - one or more bases of the tertiary nucleic acids are determined; - linker molecules are connected by ligation to the free ends of the tertiary nucleic acid molecules, whereby the linker molecules have one or more recognition sites for restriction endonucleases of the IIS type; - the tertiary nucleic acids are cleaved once again by one or more restriction endonucleases of the IIS type, which recognize the sequence parts that have been introduced into the tertiary nucleic acids by the linker molecules in step (e); and - steps (d), (e) and (f) are repeated until the desired sequence information is obtained.
摘要翻译：本发明涉及一种包含一个核酸混合物中的至少两个不同的核酸平行测序，其中提供了一种表面，每个品种的核酸，其包含岛屿，叔核酸的方法; 第三核酸处理，使得产品仅连接到与表面双链的一条链的5“端; 第三核酸通过限制性内切酶IIS型，从而生成3'突出端或5'突出端; 待确定的三级核酸的一个或多个碱基; 接头分子是通过连接接合到第三核酸分子的自由端，其中所述接头分子具有IIS型的一个或多个限制性内切酶识别位点; 第三核酸再次被一个或多个限制性内切酶类型IIS被切割通过引入第三核酸接头分子识别哪些已经在步骤（e）的序列部分; 和步骤（D），（E）和（f），直到已经获得所需的序列信息被重复许多次。

7. 发明申请

WO0188108A8 NEURONAL SERINE-THREONINE PROTEIN KINASE 审中-公开
标题翻译：神经元丝氨酸蛋白激酶
公开(公告)号：WO0188108A8
公开(公告)日：2001-12-20
申请号：PCT/EP0105660
申请日：2001-05-17
申请人： BASF LYNX BIOSCIENCE AG , SCHNEIDER ARMIN , KLAUSSNER BETTINA , FISCHER ACHIM , NEWRZELLA DIETER , GOETZ BERNHARD , ROSSNER MORITZ , EISENHARDT GISELA , KUNER ROHINI , TRUTZEL ANNETTE , KAMMANDEL BIRGITTA , JOMANA NAIM STEPHANIE , SCHWANINGER MARKUS
发明人： SCHNEIDER ARMIN , KLAUSSNER BETTINA , FISCHER ACHIM , NEWRZELLA DIETER , GOETZ BERNHARD , ROSSNER MORITZ , EISENHARDT GISELA , KUNER ROHINI , TRUTZEL ANNETTE , KAMMANDEL BIRGITTA , JOMANA NAIM STEPHANIE , SCHWANINGER MARKUS
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/12 , A61K35/74 , A61K36/06 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61K51/04 , A61P1/04 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/47 , C07K16/40 , C12N1/19 , C12N1/21 , C12N5/08 , C12N5/10 , C12N9/12 , C12N9/99 , C12N15/09 , C12N15/12 , C12Q1/48 , G01N33/15 , G01N33/50 , C12N15/11 , A61K31/713 , A61K38/43 , C12N15/54 , C12Q1/68 , G01N33/577
CPC分类号： A61K51/0491 , A01K2217/05 , A61K38/00 , C12N9/1205
摘要： The invention relates to a gene and to the protein coded by said gene, which contributes to the appearance of the sequela of a local ischaemia. The novel protein is a serine-threonine protein kinase and provides a novel therapeutic approach to the prevention and treatment of apoplexy.
摘要翻译：本发明涉及基因和由其编码的蛋白质，其涉及局部缺血后遗症的发展。新蛋白是一种丝氨酸 - 苏氨酸蛋白激酶，为中风的预防和治疗提供了一种新的治疗方法。

8. 发明申请

WO2005016505A3 METHOD FOR THE MANUFACTURE OF CYANOPYRIDINES AND CATALYSTS SUITABLE THEREFOR 审中-公开
标题翻译：氰基吡啶的制备方法及其适用的催化剂
公开(公告)号：WO2005016505A3
公开(公告)日：2005-06-09
申请号：PCT/US2004024939
申请日：2004-07-30
申请人： REILLY IND INC , FISCHER ACHIM , MARTIN ANDREAS , LUCKE BERNHARD , KALEVARU VENKATA , WECKBECKER CHRISTOPH , HUTHMACHER KLAUS
发明人： FISCHER ACHIM , MARTIN ANDREAS , LUCKE BERNHARD , KALEVARU VENKATA , WECKBECKER CHRISTOPH , HUTHMACHER KLAUS
IPC分类号： B01J20060101 , B01J21/06 , B01J27/198 , B01J37/00 , C07D213/57 , C07D213/85
CPC分类号： C07D213/84 , B01J21/06 , B01J21/063 , B01J23/002 , B01J27/198 , B01J37/0009 , B01J37/0036 , B01J2523/00 , B01J2523/31 , B01J2523/51 , B01J2523/55
摘要： The invention relates to a method for the manufacture of cyanopyridines from methylpyridines by their conversion with ammonia and oxygen and catalysts suitable therefor which contain further transition metals in addition to vanadium and phosphorus.
摘要翻译：本发明涉及一种由甲基吡啶通过氨和氧转化而制备氰基吡啶的方法及其适用的催化剂，其中还含有除钒和磷之外的其它过渡金属。

9. 发明申请

WO2006040104A3 SEQUENCING OF NUCLEIC ACIDS WITH STRAND DISPLACEMENT 审中-公开
标题翻译：核酸测序下BEACH位移的
公开(公告)号：WO2006040104A3
公开(公告)日：2006-07-20
申请号：PCT/EP2005010869
申请日：2005-10-08
申请人： FISCHER ACHIM
发明人： FISCHER ACHIM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2537/137 , C12Q2535/119
摘要： The invention relates to a method for nucleic acid sequencing, comprising the steps: (a) preparation of a nucleic acid for sequencing in immobilised and at least partly double-stranded form, (b) hybridisation of a sequencing primer on one of the strands of the nucleic acid, (c) sequencing of at least a section of the nucleic acid with extension of the sequencing primer and strand displacement of that nucleic acid strand which was present in hybridised form on the primer binding strand.
摘要翻译：本发明涉及一种用于包括以下步骤的核酸测序方法，包括：（a）提供至少一个待测序的核酸固定化和至少部分双链的形式，（b）一种测序引物与所述核酸的两条链中的一个杂交，（c）中的测序至少一个通过核酸的该链杂交的引物结合链存在的测序引物和海滩位移的扩展的核酸的一部分。

10. 发明申请

WO2004033721A3 HYBRIDIZATION SAMPLES HAVING A REDUCED COMPLEXITY 审中-公开
标题翻译：杂交样品降低了复杂性
公开(公告)号：WO2004033721A3
公开(公告)日：2004-11-11
申请号：PCT/EP0311117
申请日：2003-10-08
申请人： FISCHER ACHIM
发明人： FISCHER ACHIM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2539/107 , C12Q2521/313
摘要： Disclosed is a method for analyzing a nucleic acid mixture by hybridizing a DNA array comprising a complexity-reduced version of said nucleic acid mixture. According to said method, the nucleic acid mixture that is to be analyzed is split by means of at least one BcgI-similar restriction endonuclease, marked, and optionally isolated. A hybridization sample comprising a marked nucleic acid fragment mixture with improved hybridization specificity and fragments that are essentially of the same length can be obtained by means of several methods. A marked nucleic acid fragment mixture which comprises fragments of substantially identical length and is obtained by means of the inventive method is used for hybridization with immobilized nucleic acids, particularly DNA arrays. The invention also relates to a DNA array comprising immobilized oligonucleotides, the sequence of which is at least largely identical with the sequence of nucleic acid fragments that can be liberated from a nucleic acid mixture by means of one or several BcgI-similar restriction endonucleases.
摘要翻译：在通过杂交与所述核酸混合物的复杂性得以降低的版本的DNA阵列分析的核酸混合物的方法中，被切割的分析物核酸混合物与至少一种类似BCGI限制性内切酶，标记的和，如果合适的话，分离的。包括用具有改进的杂交特异性基本上相同，并且长的片段的标记的核酸片段混合物杂交探针根据各种方法是可获得的。具有基本上相同的长片段的标记的核酸片段的混合物，其是通过该方法获得，被用于具有固定化核酸的杂交，特别是与DNA阵列。本发明的另一个目的涉及固定的寡核苷酸的DNA阵列，其序列至少基本上相同于与一个或多个限制性内切酶可释放BCGI相似的核酸片段的核酸混合物的序列。

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