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1. 发明申请

WO2002064777A2 PROTEIN 7B6 UND 11B4 UND ZUGRUNDELIEGENDE DNA-SEQUENZEN 审中-公开
标题翻译：蛋白和7B6 11B4和基础DNA序列
公开(公告)号：WO2002064777A2
公开(公告)日：2002-08-22
申请号：PCT/EP2002/001564
申请日：2002-02-14
申请人： BASF-LYNX BIOSCIENCE AG , SCHNEIDER, Armin , FISCHER, Achim , KLAUSNER, Bettina , ROSSNER, Moritz , KAMMANDEL, Birgitta , WIDENMEYER, Rebecca , GÖTZ, Bernhard , EISENHARDT, Gisela , STEPHANIE, Jomana, Naim
发明人： SCHNEIDER, Armin , FISCHER, Achim , KLAUSNER, Bettina , ROSSNER, Moritz , KAMMANDEL, Birgitta , WIDENMEYER, Rebecca , GÖTZ, Bernhard , EISENHARDT, Gisela , STEPHANIE, Jomana, Naim
IPC分类号： C12N15/11
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505
摘要： Die vorliegende Erfindung betrifft DNA-Sequenzen, Expressions- vektoren, die die erfindungsgema?en DNA-Sequenzen enthalten, Wirtszellen, die die erfindungsgema?en Expressionsvektoren aufweisen und die Genprodukte 7B6 oder 11B4, die durch die erfindungsgema?en Sequenzen kodiert werden. Zudem betrifft die vorliegende Erfindung gegen erfindungsgemä?e Genprodukte gerichtete Antikörper, Verfahren zur Expression bzw. Isolierung von erfindungsgemä?en Genprodukten, die Verwendung von erfin-dungsgemä?en DNA-Sequenzen bzw. Genprodukten als Arzneimittel, pharmazeutisch wirksame Verbindungen und Verfahren zu deren Herstellung sowie Verwendung derartiger erfindungsgemä?er Verbindungen.
摘要翻译：本发明涉及DNA序列，包含erfindungsgema <烯的DNA序列，即具有erfindungsgema宿主细胞的表达载体？s的表达载体和基因产物7B6或11B4，其由erfindungsgema？恩序列编码。此外，本发明涉及本发明的ΔE基因导向的抗体，表达和创造性？恩基因产物分离的方法，利用本发明的？恩的DNA序列和基因产物作为药物的，药用活性化合物和它们的制备方法他的连接和使用这些发明的？

2. 发明申请

WO02064776A3 SIGNAL TRANSDUCTION PROTEINS 15B3, 15B3-1 AND 15B3-2, AND RELATED DNA SEQUENCES 审中-公开
标题翻译：信号转导15B3，15B3-1和15B3-2和基础DNA序列
公开(公告)号：WO02064776A3
公开(公告)日：2003-08-21
申请号：PCT/EP0201562
申请日：2002-02-14
申请人： AXARON BIOSCIENCE AG , SCHNEIDER ARMIN , FISCHER ACHIM , KLAUSNER BETTINA , ROSSNER MORITZ , KAMMANDEL BIRGITTA , WIDENMEYER REBECCA , GOETZ BERNHARD , EISENHARDT GISELA , NAIM STEPHANIE JOMANA , NEWRZELLA DIETER
发明人： SCHNEIDER ARMIN , FISCHER ACHIM , KLAUSNER BETTINA , ROSSNER MORITZ , KAMMANDEL BIRGITTA , WIDENMEYER REBECCA , GOETZ BERNHARD , EISENHARDT GISELA , NAIM STEPHANIE JOMANA , NEWRZELLA DIETER
IPC分类号： A61K38/00 , A61K48/00 , A61P25/28 , A61P35/00 , C07K14/47 , C12N15/12 , A01K67/027 , C07K16/18 , C12N15/10 , C12N15/63
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： The invention relates to DNA sequences, expression vectors containing the inventive DNA sequences, host cells, gene products of the cited DNA sequences coding for signal transduction proteins, and other derivatives of the cited objects of the invention. Said DNA sequences and gene products either have a protective action, i.e. impart a certain resistance to apoplexy, or they cause an increase in ischaemic damage. The invention also relates to the use of the inventive DNA sequences or the signal transduction proteins expressed by said DNA sequences as pharmaceuticals, and to the non-therapeutic uses of the inventive DNA sequences or gene products.
摘要翻译：本发明涉及一种DNA序列，含有本发明的DNA序列，宿主细胞表达载体中，前述的DNA序列，其编码的信号转导，以及本发明的上述目的的其它衍生物的基因产物，wobie的DNA序列和基因产物有保护作用，即赋予该行程一定的阻力或要求的局部缺血损伤的扩大。此外，本发明公开了提供使用本发明的DNA序列的或由这些DNA序列Signaltrasduktionsprotein作为药物和根据本发明的DNA序列的非治疗用途BZM表达的蛋白质。基因产物。

3. 发明申请

WO0222681A3 NEURONALLY EXPRESSED PROTEIN AND USE THEREOF 审中-公开
标题翻译：神经元表达蛋白及其应用
公开(公告)号：WO0222681A3
公开(公告)日：2002-08-01
申请号：PCT/EP0110689
申请日：2001-09-15
申请人： BASF LYNX BIOSCIENCE AG , LANAHAN ANTHONY , WORLEY PAUL F , KAMMANDEL BIRGITTA , KUNER ROHINI , LORCH BEATE , NEWRZELLA DIETER , SCHEEK SIGRID , SCHNEIDER ARMIN
发明人： LANAHAN ANTHONY , WORLEY PAUL F , KAMMANDEL BIRGITTA , KUNER ROHINI , LORCH BEATE , NEWRZELLA DIETER , SCHEEK SIGRID , SCHNEIDER ARMIN
IPC分类号： C07K14/47 , C12N15/12 , C12Q1/68 , A01K67/027 , C07K16/18 , C12N15/70 , G01N33/53
CPC分类号： C07K14/47 , A01K2217/05 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The invention relates to novel, specifically expressed proteins, nucleic acid sequences, recombinant nucleic acid structures containing said nucleic acid sequences, and vectors containing the aforementioned nucleic acid sequences or recombinant nucleic acid structures, which code for the proteins. The invention also relates to transgenic organisms containing said nucleic acid sequences, said recombinant nucleic acid structures or said vectors, in addition to monoclonal or polyclonal antibodies, which are oriented against the isolated proteins. The invention further relates to a method for finding substances having a specific binding affinity with the inventive proteins, and a method for qualitatively or quantitatively detecting the inventive nucleic acid sequences or the inventive proteins. Also disclosed is the use of said nucleic acid sequences and proteins.
摘要翻译：本发明涉及新的特异表达的蛋白质，核酸序列，含有含核酸序列的核酸序列或载体的重组核酸构建体或编码蛋白质的重组核酸构建体。本发明还涉及含有核酸序列，重组核酸构建体或上述载体以及针对分离的蛋白质的单克隆或多克隆抗体的转基因生物体。此外，本发明涉及寻找与本发明蛋白质具有特异性结合亲和力的物质的方法，定性或定量检测根据本发明的核酸序列或根据本发明的蛋白质的方法。此外，本发明涉及核酸序列和蛋白质的用途。

4. 发明申请

WO9931260A2 REGULATORY SEQUENCES INVOLVED IN PANCREAS-SPECIFIC GENE EXPRESSION 审中-公开
标题翻译：参与胰腺特异基因表达的调节序列
公开(公告)号：WO9931260A2
公开(公告)日：1999-06-24
申请号：PCT/EP9808215
申请日：1998-12-15
申请人： MAX PLANCK GESELLSCHAFT , GRUSS PETER , KAMMANDEL BIRGITTA
发明人： GRUSS PETER , KAMMANDEL BIRGITTA
IPC分类号： A61K48/00 , A61P5/48 , C12N15/12 , C12N15/85 , A01K67/027 , C07K16/44 , C12Q1/68 , G01N33/53
CPC分类号： C12N15/85 , A01K2217/05 , A61K48/00 , C12N2830/008 , C12N2830/15 , C12N2830/60 , C12N2830/85 , C12N2840/203
摘要： Described are regulatory sequences of the promoter of the Pax6 gene or a gene homologous to the Pax6 gene, being capable of conferring expression in pancreatic cells. Recombinant DNA molecules and vectors comprising said regulatory sequences as well as to host cells transformed therewith. Described are also pharmaceutical and diagnostic compositions comprising such regulatory sequences, recombinant DNA molecules and vectors. Furthermore, transgenic non-human animals, comprising the afore-mentioned recombinant DNA molecules or vectors stably integrated into their genome. Also provided are uses of the before described recombinant DNA molecules and vectors for the preparation of pharmaceutical compositions for treating, preventing and/or delaying a disease related to the pancreas in a subject. Furthermore, uses of the regulatory sequences, the recombinant DNA molecules and vectors of the invention for the preparation of pharmaceutical compositions for inducing a pancreatic disease in a non-human animal are provided. Additionally a method for identifying agonists/activators or antagonists/inhibitors of genes or gene products involved in pancreatic diseases employing the above mentioned regulatory sequences, recombinant DNA molecules, vectors, cells and non-human transgenic animals, to compounds identifyable by said method, to antibodies directed to said compounds as well as to pharmaceutical and diagnostic compositions comprising said agonists/activators, antagonists/inhibitors and/or antibodies.
摘要翻译：描述了Pax6基因的启动子或与Pax6基因同源的基因的调节序列，能够赋予胰腺细胞中的表达。包含所述调节序列的重组DNA分子和载体以及用其转化的宿主细胞。还描述了包含这种调节序列，重组DNA分子和载体的药物和诊断组合物。此外，包含上述重组DNA分子或稳定整合到其基因组中的载体的转基因非人动物。还提供了前述重组DNA分子和载体用于制备用于治疗，预防和/或延缓与受试者中的胰腺相关的疾病的药物组合物的用途。此外，提供了本发明的调节序列，重组DNA分子和载体用于制备用于在非人动物中诱导胰腺疾病的药物组合物的用途。另外，使用上述调节序列，重组DNA分子，载体，细胞和非人转基因动物鉴定涉及胰腺疾病的基因或基因产物的激动剂/激活剂或拮抗剂/抑制剂的方法可用于通过所述方法鉴定的化合物，针对所述化合物的抗体以及包含所述激动剂/激活剂，拮抗剂/抑制剂和/或抗体的药物和诊断组合物。

5. 发明申请

WO0181623A3 NEURONALLY EXPRESSED PROTEIN HAVING APOPTOTIC ACTIVITY, AND USE THEREOF 审中-公开
标题翻译：神经元表达蛋白凋亡活性的多肽和需求
公开(公告)号：WO0181623A3
公开(公告)日：2002-11-28
申请号：PCT/EP0104311
申请日：2001-04-17
申请人： BASF LYNX BIOSCIENCE AG , GOETZ BERNHARD , KAMMANDEL BIRGITTA , KUNER ROHINI , SCHEEK SIGRID , HIEMISCH HOLGER
发明人： GOETZ BERNHARD , KAMMANDEL BIRGITTA , KUNER ROHINI , SCHEEK SIGRID , HIEMISCH HOLGER
IPC分类号： C12N1/21 , C12N15/12 , C12Q1/68 , A61K38/00 , A61K39/00 , C07K14/47 , G01N33/53 , G01N33/68
CPC分类号： C12Q1/6883 , A01K2217/075 , C12Q2600/158
摘要： The invention relates to novel specifically expressed proteins, and to nucleic acid sequences or recombinant nucleic acid constructs encoding said proteins. The invention further relates to host organisms or transgenic animals containing said nucleic acid sequences or recombinant nucleic acid constructs, and to monoclonal or polyclonal antibodies directed to the isolated proteins. The invention also relates to a method for finding substances having a specific binding affinity to the inventive proteins, and to a method for the qualitative or quantitative analysis of the inventive nucleic acid sequences or inventive proteins. The invention further relates to the use of the nucleic acid sequences and proteins.
摘要翻译：本发明涉及新的特异性表达的蛋白和核酸序列或重组的核酸构建体编码的蛋白质。本发明还涉及宿主含有的核酸序列或重组的核酸构建体的生物体或转基因动物，以及单 - 或针对分离的蛋白质的多克隆抗体。此外，本发明涉及一种用于寻找具有根据本发明，用于本发明核酸序列或本发明的蛋白质的定性或定量检测的方法中的蛋白质特异性结合亲和力的物质的方法。此外，本发明涉及使用核酸序列和蛋白质的。

6. 发明申请

WO2002064777A3 PROTEIN 7B6 UND 11B4 UND ZUGRUNDELIEGENDE DNA-SEQUENZEN 审中-公开
公开(公告)号：WO2002064777A3
公开(公告)日：2002-08-22
申请号：PCT/EP2002/001564
申请日：2002-02-14
申请人： AXARON BIOSCIENCE AG , SCHNEIDER, Armin , FISCHER, Achim , KLAUSNER, Bettina , ROSSNER, Moritz , KAMMANDEL, Birgitta , WIDENMEYER, Rebecca , GÖTZ, Bernhard , EISENHARDT, Gisela , STEPHANIE, Jomana, Naim
发明人： SCHNEIDER, Armin , FISCHER, Achim , KLAUSNER, Bettina , ROSSNER, Moritz , KAMMANDEL, Birgitta , WIDENMEYER, Rebecca , GÖTZ, Bernhard , EISENHARDT, Gisela , STEPHANIE, Jomana, Naim
IPC分类号： C12N15/11
摘要： Die vorliegende Erfindung betrifft DNA-Sequenzen, Expressions- vektoren, die die erfindungsgemässen DNA-Sequenzen enthalten, Wirtszellen, die die erfindungsgemässen Expressionsvektoren aufweisen und die Genprodukte 7B6 oder 11B4, die durch die erfindungsgemässen Sequenzen kodiert werden. Zudem betrifft die vorliegende Erfindung gegen erfindungsgemässe Genprodukte gerichtete Antikörper, Verfahren zur Expression bzw. Isolierung von erfindungsgemässen Genprodukten, die Verwendung von erfin-dungsgemässen DNA-Sequenzen bzw. Genprodukten als Arzneimittel, pharmazeutisch wirksame Verbindungen und Verfahren zu deren Herstellung sowie Verwendung derartiger erfindungsgemässer Verbindungen.

7. 发明申请

WO2002064776A2 SIGNALTRANSDUKTIONSPROTEINE 15B3, 15B3-1 UND 15B3-2 UND ZUGRUNDELIEGENDE DNA-SEQUENZEN 审中-公开
标题翻译：信号转导15B3，15B3-1和15B3-2和基础DNA序列
公开(公告)号：WO2002064776A2
公开(公告)日：2002-08-22
申请号：PCT/EP2002/001562
申请日：2002-02-14
申请人： BASF-LYNX BIOSCIENCE AG , SCHNEIDER, Armin , FISCHER, Achim , KLAUSNER, Bettina , ROSSNER, Moritz , KAMMANDEL, Birgitta , WIDENMEYER, Rebecca , GÖTZ, Bernhard , EISENHARDT, Gisela , NAIM, Stephanie, Jomana , NEWRZELLA, Dieter
发明人： SCHNEIDER, Armin , FISCHER, Achim , KLAUSNER, Bettina , ROSSNER, Moritz , KAMMANDEL, Birgitta , WIDENMEYER, Rebecca , GÖTZ, Bernhard , EISENHARDT, Gisela , NAIM, Stephanie, Jomana , NEWRZELLA, Dieter
IPC分类号： C12N15/11
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： Die vorliegende Erfindung betrifft DNA-Sequenzen, Expressionsvektoren, die erfindungsgemässe DNA-Sequenzen enthalten, Wirtszellen, Genprodukte der vorgenannten DNA-Sequenzen, die für Signaltransduktionsproteine codieren, sowie weitere Derivate der vorgenannten Erfindungsgegenstände. Weiterhin offenbart die vorliegende Erfindung die Verwendung von erfindungsgemässen DNA-Sequenzen bzw. den von diesen DNA-Sequenzen exprimierten Signaltransduktionsprotein als Arzneimittel und nicht therapeutische Verwendungen erfindungsgemässer DNA-Sequenzen bzw. Genprodukte.
摘要翻译：本发明涉及DNA序列，表达载体，根据本发明的含有DNA序列的宿主细胞，上述DNA序列，其编码的信号转导的基因产物，以及本发明的上述目的的其它衍生物。此外，本发明公开了一种使用本发明的DNA序列或由这些DNA序列Signaltransduktionsprotein作为根据本发明的DNA序列或基因产物的药物和非治疗用途所表达的蛋白质。

8. 发明申请

WO0188108A8 NEURONAL SERINE-THREONINE PROTEIN KINASE 审中-公开
标题翻译：神经元丝氨酸蛋白激酶
公开(公告)号：WO0188108A8
公开(公告)日：2001-12-20
申请号：PCT/EP0105660
申请日：2001-05-17
申请人： BASF LYNX BIOSCIENCE AG , SCHNEIDER ARMIN , KLAUSSNER BETTINA , FISCHER ACHIM , NEWRZELLA DIETER , GOETZ BERNHARD , ROSSNER MORITZ , EISENHARDT GISELA , KUNER ROHINI , TRUTZEL ANNETTE , KAMMANDEL BIRGITTA , JOMANA NAIM STEPHANIE , SCHWANINGER MARKUS
发明人： SCHNEIDER ARMIN , KLAUSSNER BETTINA , FISCHER ACHIM , NEWRZELLA DIETER , GOETZ BERNHARD , ROSSNER MORITZ , EISENHARDT GISELA , KUNER ROHINI , TRUTZEL ANNETTE , KAMMANDEL BIRGITTA , JOMANA NAIM STEPHANIE , SCHWANINGER MARKUS
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/12 , A61K35/74 , A61K36/06 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61K51/04 , A61P1/04 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/47 , C07K16/40 , C12N1/19 , C12N1/21 , C12N5/08 , C12N5/10 , C12N9/12 , C12N9/99 , C12N15/09 , C12N15/12 , C12Q1/48 , G01N33/15 , G01N33/50 , C12N15/11 , A61K31/713 , A61K38/43 , C12N15/54 , C12Q1/68 , G01N33/577
CPC分类号： A61K51/0491 , A01K2217/05 , A61K38/00 , C12N9/1205
摘要： The invention relates to a gene and to the protein coded by said gene, which contributes to the appearance of the sequela of a local ischaemia. The novel protein is a serine-threonine protein kinase and provides a novel therapeutic approach to the prevention and treatment of apoplexy.
摘要翻译：本发明涉及基因和由其编码的蛋白质，其涉及局部缺血后遗症的发展。新蛋白是一种丝氨酸 - 苏氨酸蛋白激酶，为中风的预防和治疗提供了一种新的治疗方法。

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