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1. 发明申请

WO0069504A9 AGENT DELIVERY SYSTEMS 审中-公开
标题翻译：代理交付系统
公开(公告)号：WO0069504A9
公开(公告)日：2002-02-21
申请号：PCT/US0013119
申请日：2000-05-12
申请人： BARD INC C R , GAMBALE RICHARD A , SHAH CHIRAG B , WEISER MICHAEL F , FORCUCCI STEPHEN J , FORDE SEAN
发明人： GAMBALE RICHARD A , SHAH CHIRAG B , WEISER MICHAEL F , FORCUCCI STEPHEN J , FORDE SEAN
IPC分类号： A61M36/04 , A61F2/00 , A61F2/02 , A61M31/00
CPC分类号： A61M37/0069 , A61F2/2493 , A61F2250/0067
摘要： The present invention provides a system for delivering a therapeutic agent into tissue in combination with an implant device (2). Preferably the therapeutic substance is contained within a pellet form (14) that is deliverable into the interior of the device (2) after it has been implanted. In a preferred embodiment the implant device (2) comprises a flexible coiled spring body, the coils (4) of which have a diameter and spacing to contain the pellet (14) within the interior of the device (2). A cavity (18) provided by the interior of the device (2) permits blood to pool around the pellet (14) and mix with the therapeutic agent. In treatment of ischemic tissue such as the of the myocardium of the heart, the mechanical irritation of the tissue caused by the implanted device (2) can help to provide an angiogenic effect. Several delivery systems have provided for delivering the implant and pellet (14) sequentially or simultaneously.
摘要翻译：本发明提供了一种用于将治疗剂与植入装置（2）组合递送到组织中的系统。优选地，治疗物质包含在颗粒形式（14）中，其在植入之后可输送到装置（2）的内部。在优选实施例中，植入装置（2）包括柔性螺旋弹簧体，其线圈（4）具有直径和间距以在装置（2）的内部内容纳颗粒（14）。由装置（2）的内部提供的空腔（18）允许血液围绕颗粒（14）聚集并与治疗剂混合。在治疗缺血组织如心脏的心肌时，由植入装置（2）引起的组织的机械刺激有助于提供血管生成作用。已经提供了几个递送系统来顺序地或同时地递送植入物和颗粒（14）。

2. 发明申请

WO0069504A8 AGENT DELIVERY SYSTEMS 审中-公开
标题翻译：代理交付系统
公开(公告)号：WO0069504A8
公开(公告)日：2001-11-08
申请号：PCT/US0013119
申请日：2000-05-12
申请人： BARD INC C R , GAMBALE RICHARD A , SHAH CHIRAG B , WEISER MICHAEL F , FORCUCCI STEPHEN J , FORDE SEAN
发明人： GAMBALE RICHARD A , SHAH CHIRAG B , WEISER MICHAEL F , FORCUCCI STEPHEN J , FORDE SEAN
IPC分类号： A61M36/04 , A61F2/00 , A61F2/02 , A61M31/00
CPC分类号： A61M37/0069 , A61F2/2493 , A61F2250/0067
摘要： The present invention provides a system for delivering a therapeutic agent into tissue in combination with an implant device (2). Preferably the therapeutic substance is contained within a pellet form (14) that is deliverable into the interior of the device (2) after it has been implanted. In a preferred embodiment the implant device (2) comprises a flexible coiled spring body, the coils (4) of which have a diameter and spacing to contain the pellet (14) within the interior of the device (2). A cavity (18) provided by the interior of the device (2) permits blood to pool around the pellet (14) and mix with the therapeutic agent. In treatment of ischemic tissue such as the of the myocardium of the heart, the mechanical irritation of the tissue caused by the implanted device (2) can help to provide an angiogenic effect. Several delivery systems have provided for delivering the implant and pellet (14) sequentially or simultaneously.
摘要翻译：本发明提供了一种用于将治疗剂与植入装置（2）组合递送到组织中的系统。优选地，治疗物质包含在颗粒形式（14）中，其在植入之后可输送到装置（2）的内部。在优选实施例中，植入装置（2）包括柔性螺旋弹簧体，其线圈（4）具有直径和间距以在装置（2）的内部内容纳颗粒（14）。由装置（2）的内部提供的空腔（18）允许血液围绕颗粒（14）聚集并与治疗剂混合。在治疗缺血组织如心脏的心肌时，由植入装置（2）引起的组织的机械刺激有助于提供血管生成作用。已经提供了几个递送系统来顺序地或同时地递送植入物和颗粒（14）。

3. 发明申请

WO2011093941A2 DEVICES AND SYSTEMS FOR TREATING HEART FAILURE 审中-公开
标题翻译：用于治疗心脏衰竭的装置和系统
公开(公告)号：WO2011093941A2
公开(公告)日：2011-08-04
申请号：PCT/US2010058110
申请日：2010-11-24
申请人： DC DEVICES INC , FINCH MATTHEW J , MCNAMARA EDWARD , FORCUCCI STEPHEN J , SUGIMOTO HIROATSU
发明人： FINCH MATTHEW J , MCNAMARA EDWARD , FORCUCCI STEPHEN J , SUGIMOTO HIROATSU
IPC分类号： A61M25/01 , A61B17/34 , A61F2/24 , A61F2/84 , A61L31/04
CPC分类号： A61B17/0057 , A61B6/12 , A61B6/4423 , A61B8/0841 , A61B2017/00252 , A61B2017/00526 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/00867 , A61B2560/063 , A61F2/2412 , Y10T29/49002 , Y10T29/49005 , Y10T29/53843 , Y10T29/53909 , Y10T29/53913
摘要： The present disclosure relates to devices and methods for implanting a prosthesis into a heart of a mammal, such as a person. The disclosure includes a prosthesis that acts as a pressure vent between the left and right atria of the heart. The disclosure also includes a mounting tool for mounting the prosthesis onto a loading tool, the loading tool useful for loading the prosthesis onto a device for delivering the prosthesis into the patient's heart. Control devices and methods for using these devices are also disclosed. The intracardiac pressure vents disclosed allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms. The devices also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombi or other embolic material from entering arterial circulation.
摘要翻译：本公开涉及用于将假体植入哺乳动物（例如人）的心脏中的装置和方法。该公开内容包括用作心脏左心房和右心房之间的压力通气口的假体。本公开还包括用于将假体安装到装载工具上的安装工具，所述装载工具可用于将假体装载到用于将假体递送到患者心脏的装置上。还公开了用于使用这些装置的控制装置和方法。所公开的心内压力通风口允许从左心房到右心房的足够的流动，以缓解升高的左心房压力和导致的患者症状。这些装置还限制从右心房到左心房的流量，以最小化血栓或其他栓塞物质进入动脉循环的可能性。

4. 发明申请

WO2011093941A3 DEVICES AND SYSTEMS FOR TREATING HEART FAILURE 审中-公开
标题翻译：用于治疗心脏病的装置和系统
公开(公告)号：WO2011093941A3
公开(公告)日：2011-10-20
申请号：PCT/US2010058110
申请日：2010-11-24
申请人： DC DEVICES INC , FINCH MATTHEW J , MCNAMARA EDWARD , FORCUCCI STEPHEN J , SUGIMOTO HIROATSU
发明人： FINCH MATTHEW J , MCNAMARA EDWARD , FORCUCCI STEPHEN J , SUGIMOTO HIROATSU
IPC分类号： A61M25/01 , A61B17/34 , A61F2/24 , A61F2/84 , A61L31/04
CPC分类号： A61B17/0057 , A61B6/12 , A61B6/4423 , A61B8/0841 , A61B2017/00252 , A61B2017/00526 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/00867 , A61B2560/063 , A61F2/2412 , Y10T29/49002 , Y10T29/49005 , Y10T29/53843 , Y10T29/53909 , Y10T29/53913
摘要： The present disclosure relates to devices and methods for implanting a prosthesis into a heart of a mammal, such as a person. The disclosure includes a prosthesis that acts as a pressure vent between the left and right atria of the heart. The disclosure also includes a mounting tool for mounting the prosthesis onto a loading tool, the loading tool useful for loading the prosthesis onto a device for delivering the prosthesis into the patient's heart. Control devices and methods for using these devices are also disclosed. The intracardiac pressure vents disclosed allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms. The devices also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombi or other embolic material from entering arterial circulation.
摘要翻译：本公开涉及用于将假体植入哺乳动物（例如人）的心脏中的装置和方法。本公开内容包括充当心脏左心房和右心房之间的压力通气孔的假体。本公开还包括用于将假体安装到加载工具上的安装工具，加载工具用于将假体装载到用于将假体输送到患者心脏中的装置上。还公开了使用这些设备的控制设备和方法。所公开的心内压力通风口允许从左心房到右心房的足够流量以缓解升高的左心房压力并导致患者症状。这些装置还限制从右心房流到左心房的流量，以使血栓或其他栓塞材料进入动脉循环的可能性最小化。

5. 发明申请

WO2005057062A3 VALVE FOR USE WITH CHEST DRAINAGE SYSTEM 审中-公开
标题翻译：阀门用于排风系统
公开(公告)号：WO2005057062A3
公开(公告)日：2005-11-10
申请号：PCT/US2004040903
申请日：2004-12-08
申请人： ATRIUM MEDICAL CORP , CORBEIL SCOTT E , KARWOSKI THEODORE , WANT NICHOLAS , FORCUCCI STEPHEN J
发明人： CORBEIL SCOTT E , KARWOSKI THEODORE , WANT NICHOLAS , FORCUCCI STEPHEN J
IPC分类号： A61M1/00 , A61M39/24 , F16K17/18 , F16K17/26 , F16K15/14
CPC分类号： F16K17/18 , A61M1/0013 , A61M39/24 , Y10T137/7771 , Y10T137/778 , Y10T137/7882
摘要： A valve for use in a chest drainage device is disclosed, the chest drainage device is adapted to receive liquid and air a patient's chest cavity via an inlet and to permit air to escape through an outlet for air to leave the chest drain, the inlet and outlet define a flow path and the valve is disposed along the flow path. The valve has a valve element that separates an upstream chamber from a downstream chamber and has a first and second sealing surface that are opposed so that when the first and second sealing surfaces that are opposed so that when the first and second sealing surfaces are in contact, air pressure below a predetermined value will be prevented from moving from the downstream location to the upstream location.
摘要翻译：公开了一种用于胸部引流装置的阀，胸部引流装置适于接收液体并经由入口将患者的胸腔空气排出，并允许空气通过出口逸出以使空气离开胸腔排泄物，入口和出口限定了流动路径，并且阀沿着流动路径设置。该阀具有将上游室与下游室隔开的阀元件，并具有相对的第一和第二密封表面，使得当第一和第二密封表面相对时，使得当第一和第二密封表面接触时将防止低于预定值的空气压力从下游位置移动到上游位置。

6. 发明申请

WO0108741A9 CATHETER POSITIONING SYSTEMS 审中-公开
标题翻译：导管定位系统
公开(公告)号：WO0108741A9
公开(公告)日：2002-09-12
申请号：PCT/US0020575
申请日：2000-07-28
申请人： BARD INC C R
发明人： GAMBALE RICHARD A , FORCUCCI STEPHEN J , SHAH CHIRAG B , WEISER MICHAEL F , FORDE SEAN
IPC分类号： A61M25/00 , A61M25/01 , A61M25/04 , A61M29/00
CPC分类号： A61M25/04 , A61B2017/3488 , A61M25/0084 , A61M2025/0087
摘要： The present invention provides a catheter positioning system which serves to control and stabilize a distal end (12) of a catheter (10) at a treatment site within a patient so that a medical procedure can be performed with accuracy. Generally, the positioning system operates by providing deformable mechanical members at the distal end of the catheter which can be operated from the proximal end of the catheter (10) to extend radially outward to engage surrounding tissue adjacent to treatment site. In one embodiment of the invention a flexible superstructure comprising the plurality of flexible veins (16) extending longitudinally along the distal end of the catheter can be deformed to bow radially outward to engage surrounding tissue. The distal tip of the catheter joined to one of the veins was correspondingly displaced or rotated angularly as the veins bow outward. In another embodiment radially projecting fingers (50) are joined to the distal end of the catheter.
摘要翻译：本发明提供了一种导管定位系统，其用于控制和稳定患者内的治疗部位处的导管（10）的远端（12），使得可以精确地执行医疗程序。通常，定位系统通过在导管的远端处提供可变形的机械构件来操作，其可以从导管（10）的近端操作以径向向外延伸以接合邻近治疗部位的周围组织。在本发明的一个实施例中，包括沿着导管的远端纵向延伸的多个柔性静脉（16）的柔性上部结构可以变形以径向向外弯曲以接合周围的组织。当静脉向外弯曲时，连接到静脉中的一个静脉的导管的远端相应地位移或旋转。在另一个实施例中，径向突出的指状物（50）连接到导管的远端。

7. 发明申请

WO0018462A3 TRANSTHORACIC DRUG DELIVERY DEVICE 审中-公开
标题翻译： TRANSTHORACIC药物递送装置
公开(公告)号：WO0018462A3
公开(公告)日：2000-08-17
申请号：PCT/US9922541
申请日：1999-09-30
申请人： BARD INC C R
发明人： GAMBALE RICHARD A , FORCUCCI STEPHEN J , CHOH RICHARD T , CAFFERATA ROBERT
IPC分类号： A61M5/14 , A61B17/00 , A61M25/00
CPC分类号： A61M25/0068 , A61B2017/00247 , A61B2018/00392 , A61M25/008 , A61M25/0084 , A61M25/0133 , A61M25/0147 , A61M2025/0002 , A61M2025/0003 , A61M2025/0034 , A61M2025/0036 , A61M2025/0086 , A61M2210/10 , A61M2230/005
摘要： The present invention provides a transthoracic drug delivery device (10) that utilizes pressure to determine the precise location of the distal tip (18) of the delivery tube (14) of the device to insure that therapeutic substances are ejected into the myocardium (4) and not dissipated in unintended tissue locations. In one embodiment the drug delivery device (10) comprises a pressure sensing tube (12) mounted in parallel to a drug delivery tube (14) wherein the tubes are staggered so that the pressure tube (12) extends beyond the delivery tube (14). In another embodiment, a steerable syringe is provided so that multiple sites in the myocardium can be treated with a therapeutic substance with only one penetration into the heart. Once the delivery tube (28) of the syringe penetrates the left ventricle, its distal tip (32) can be deflected back toward the endocardial surface (6) and the tube (28) withdrawn proximally to cause penetration of the tip (32) into the myocardium (4). The deflectable tip (32) can be adjusted to a different deflection angle and the delivery tube (28) rotated to make available a circular array of points that may be accessed by the syringe.
摘要翻译：本发明提供了经胸廓药物输送装置（10），其利用压力来确定装置的输送管（14）的远端尖端（18）的精确位置，以确保将治疗物质喷射到心肌（4）中，并且不会在非预期的组织位置消散。在一个实施方案中，药物输送装置（10）包括平行于药物输送管（14）安装的压力感测管（12），其中管交错，使得压力管（12）延伸超出输送管（14）。在另一个实施例中，提供可转向注射器，使得心肌中的多个部位可以用仅具有一次穿透入心脏的治疗物质来治疗。一旦注射器的输送管（28）穿过左心室，其远端尖端（32）可被偏转回到心内膜表面（6），并且管（28）向近端撤回以引起尖端（32）的穿透心肌（4）。可偏转尖端（32）可以被调节到不同的偏转角度，并且输送管（28）旋转以提供可由注射器访问的点的圆形阵列。

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