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1. 发明申请

WO2006083891A3 AXMI-018, AXMI-020, AND AXMI-021, A FAMILY OF DELTA-ENDOTOXIN GENES AND METHODS FOR THEIR USE 审中-公开
标题翻译： AXMI-018，AXMI-020和AXMI-021，三肽内毒素基因家族及其使用方法
公开(公告)号：WO2006083891A3
公开(公告)日：2006-11-30
申请号：PCT/US2006003434
申请日：2006-01-31
申请人： ATHENIX CORP , CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B
发明人： CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B
IPC分类号： C07K14/325 , A01N63/02 , C12N15/00
CPC分类号： C07K14/325 , A01N63/02 , C12N15/8281 , C12N15/8285 , C12N15/8286 , Y02A40/162 , Y02A40/164
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID N0: 2, 4, or 6, or the nucleotide sequence set forth in SEQ ID NO: 1, 3, or 5, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含δ-内毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的δ-内毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：2,4或6所示氨基酸序列的核苷酸序列或SEQ ID NO：1,3或5所示的核苷酸序列，以及其变体和片段。

2. 发明申请

WO2004074462A2 DELTA-ENDOTOXIN GENES AND METHODS FOR THEIR USE 审中-公开
标题翻译： DELTA-内毒素基因及其使用方法
公开(公告)号：WO2004074462A2
公开(公告)日：2004-09-02
申请号：PCT/US2004005829
申请日：2004-02-20
申请人： ATHENIX CORP , CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B , CARR BRIAN
发明人： CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B , CARR BRIAN
IPC分类号： C07K14/325 , C12N15/82 , C12N
CPC分类号： C12N15/8286 , C07K14/325 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin and delta-endotoxin-associated polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin and delta-endotoxin-associated nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequences shown in in SEQ ID NOS:3, 5, 7, 9, 11, 14, 16, 18, 20, 22, 24, 27, and 29, and the nucleotide sequences set forth in SEQ ID NOS:1, 2, 4, 6, 8, 10, 12, 13, 15, 17, 19, 21, 23, 25, 26, and 28, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含δ-内毒素和δ-内毒素相关多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的δ-内毒素和δ-内毒素相关的核酸分子。另外，包括对应于多核苷酸的氨基酸序列。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：3,5,7,9,11,14,16,18,20,22,24,27中所示的氨基酸序列的核苷酸序列和29，以及SEQ ID NO：1,2,4,6,8,10,12,13,15,17,19,21,23,25,26和28所示的核苷酸序列，以及作为其变体和片段。

3. 发明申请

WO2010141141A3 AXMI-001, AXMI-002, AXMI-030, AXMI-035, AND AXMI-045: INSECTICIDAL PROTEINS FROM BACILLUS THURINGIENSIS AND METHODS FOR THEIR USE 审中-公开
标题翻译： AXMI-001，AXMI-002，AXMI-030，AXMI-035和AXMI-045：来自BACILLUS THURINGIENSIS的杀虫蛋白及其使用方法
公开(公告)号：WO2010141141A3
公开(公告)日：2011-05-05
申请号：PCT/US2010026914
申请日：2010-03-11
申请人： ATHENIX CORP , CAROZZI NADINE , DUCK NICHOLAS B , KOZIEL MICHAEL G , HARGISS TRACY , DETER REBEKAH , PETERS CHERYL L , VOLRATH SANDRA L , TOMSO DANIEL J
发明人： CAROZZI NADINE , DUCK NICHOLAS B , KOZIEL MICHAEL G , HARGISS TRACY , DETER REBEKAH , PETERS CHERYL L , VOLRATH SANDRA L , TOMSO DANIEL J
IPC分类号： C07K14/325 , A01H5/00 , C12N15/82
CPC分类号： C12N15/8286 , A01N63/02 , C07K14/325 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO: 6-11, or the nucleotide sequence set forth in SEQ ID NO: 1-5, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含δ-内毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的δ-内毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列，以及与这些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：6-11所示的氨基酸序列的核苷酸序列，或SEQ ID NO：1-5所示的核苷酸序列，以及变体和片段。

4. 发明申请

WO2005021585B1 AXMI-003, A DELTA-ENDOTOXIN GENE AND METHODS FOR ITS USE 审中-公开
公开(公告)号：WO2005021585B1
公开(公告)日：2005-08-25
申请号：PCT/US2004028024
申请日：2004-08-27
申请人： ATHENIX CORP , CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B , CARR BRIAN
发明人： CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B , CARR BRIAN
IPC分类号： A01N63/02 , C07H21/04 , C07K14/325 , C12N15/82
CPC分类号： C07H21/04 , C07K14/325
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2 or 4, or the nucleotide sequence set forth in SEQ ID NO:1 or 3, as well as variants thereof.

5. 发明申请

WO2010003065A3 AXMI-IL 5, AXMI-113, AXMI-005, AXMI-163 AND AXMI-184 : VIP3A INSECTICIDAL PROTEINS FROM BACILLUS THURINGIENSIS AND METHODS FOR THEIR USE 审中-公开
标题翻译： AXMI-IL 5，AXMI-113，AXMI-005，AXMI-163和AXMI-184：来自BACILLUS THURINGIENSIS的VIP3A杀虫蛋白及其使用方法
公开(公告)号：WO2010003065A3
公开(公告)日：2010-05-20
申请号：PCT/US2009049527
申请日：2009-07-02
申请人： ATHENIX CORP , SAMPSON KIMBERLY S , AGARWAL SHRUTI , CAMPBELL CHRIS , MCNULTY BRIAN , TOMSO DANIEL J , CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B , HEINRICHS VOLKER
发明人： SAMPSON KIMBERLY S , AGARWAL SHRUTI , CAMPBELL CHRIS , MCNULTY BRIAN , TOMSO DANIEL J , CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B , HEINRICHS VOLKER
IPC分类号： C07K14/325 , A01H5/00 , C12N15/82
CPC分类号： C07K14/325 , A01N37/18 , C07K14/32 , C07K16/1278 , C12N15/8286 , Y02A40/162
摘要： Compositions and methods for conferring insecticidal activity to host cells are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in host cells. Compositions also comprise transformed host cells. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:4, 5, 6, 13, or 14, or the nucleotide sequence set forth in SEQ ID NO: 1, 2, 3, 11, or 12, as well as variants and fragments thereof.
摘要翻译：提供了赋予宿主细胞杀虫活性的组合物和方法。提供了包含δ-内毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中用于在宿主细胞中转化和表达。组合物还包含转化的宿主细胞。特别地，提供了分离的δ-内毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列，以及与这些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：4,5,6,13或14所示氨基酸序列的核苷酸序列或SEQ ID NO：1所示的核苷酸序列， 2,3,11或12，以及其变体和片段。

6. 发明申请

WO2005021585A3 AXMI-003, A DELTA-ENDOTOXIN GENE AND METHODS FOR ITS USE 审中-公开
标题翻译： AXMI-003，Δ-内毒素基因及其使用方法
公开(公告)号：WO2005021585A3
公开(公告)日：2005-06-16
申请号：PCT/US2004028024
申请日：2004-08-27
申请人： ATHENIX CORP , CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B , CARR BRIAN
发明人： CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B , CARR BRIAN
IPC分类号： A01N63/02 , C07H21/04 , C07K14/325 , C12N15/82
CPC分类号： C07H21/04 , C07K14/325
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2 or 4, or the nucleotide sequence set forth in SEQ ID NO:1 or 3, as well as variants thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子杀虫活性的组合物和方法。提供了包含δ-内毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中用于在植物和细菌中转化和表达。组合物还包含转化的细菌，植物，植物细胞，组织和种子。具体而言，提供了分离的δ-内毒素核酸分子。另外，包含对应于多核苷酸的氨基酸序列。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：2或4所示的氨基酸序列或SEQ ID NO：1或3所示的核苷酸序列的核苷酸序列及其变体。

7. 发明申请

WO03078582B1 INTEGRATED SYSTEM FOR HIGH THROUGHPUT CAPTURE OF GENETIC DIVERSITY 审中-公开
标题翻译：用于遗传多样性的高通量捕获的综合系统
公开(公告)号：WO03078582B1
公开(公告)日：2004-04-15
申请号：PCT/US0307594
申请日：2003-03-11
申请人： ATHENIX CORP , DUCK NICHOLAS B , KOZIEL MICHAEL G , CAROZZI NADINE , CARR BRIAN , HARGISS TRACY
发明人： DUCK NICHOLAS B , KOZIEL MICHAEL G , CAROZZI NADINE , CARR BRIAN , HARGISS TRACY
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/22 , G06F19/00 , G06F17/30
CPC分类号： G06F19/22 , C12Q1/6888 , C12Q1/689
摘要： Compositions and methods for rapid and highly efficient characterization of genetic diversity in organisms are provided. The methods involve rapid sequencing and characterization of extrachromosomal DNA, particularly plasmids, to identify and isolate useful nucleotide sequences. The method targets plasmid DNA and avoids repeated cloning and sequencing of the host chromosome, thus allowing one to focus on the genetic elements carrying maximum genetic diversity. The method involves generating a library of extrachromosomal DNA clones, sequencing a portion of the clones, comparing the sequences against a database of existing DNA sequences, using an algorithm to select said novel nucleotide sequence based on the presence or absence of said portion in a database, and identification of at least one novel nucleotide sequence. The DNA sequence can also be translated in all six frames and the resulting amino acid sequences can be compared against a database of protein sequences. The integrated approach provides a rapid and efficient method to identify and isolate useful genes. Organisms of particular interest include, but are not limited to bacteria, fungi, algae, and the like. Compositions comprise a mini-cosmid vector comprising a stuffer fragment and at least one cos site.
摘要翻译：提供了生物体遗传多样性快速高效表征的组成和方法。该方法涉及染色体外DNA特别是质粒的快速测序和表征，以鉴定和分离有用的核苷酸序列。该方法针对质粒DNA，避免宿主染色体的重复克隆和测序，从而允许人们集中在携带最大遗传多样性的遗传因素上。该方法包括产生染色体外DNA序列文库，测序一部分克隆，比较序列与现有DNA序列的数据库，使用算法根据数据库中所述部分的存在或不存在来选择所述新的核苷酸序列，以及鉴定至少一个新的核苷酸序列。 DNA序列也可以在所有六个帧中翻译，并将得到的氨基酸序列与蛋白质序列的数据库进行比较。综合方法提供了一种快速有效的方法来鉴定和分离有用的基因。特别感兴趣的生物体包括但不限于细菌，真菌，藻类等。组合物包含迷你粘粒载体，其包含填充片段和至少一个cos位点。

8. 发明申请

WO2007147096A3 A FAMILY OF PESTICIDAL PROTEINS AND METHODS FOR THEIR USE 审中-公开
标题翻译：一种农药蛋白质及其使用方法
公开(公告)号：WO2007147096A3
公开(公告)日：2008-07-24
申请号：PCT/US2007071298
申请日：2007-06-15
申请人： ATHENIX CORP , KOZIEL MICHAEL G , DESAI NALINI , DETER REBEKAH , TOMSO DANIEL JOHN , HARGISS TRACY , DUCK NICHOLAS B , CAROZZI NADINE , GUO RONG
发明人： KOZIEL MICHAEL G , DESAI NALINI , DETER REBEKAH , TOMSO DANIEL JOHN , HARGISS TRACY , DUCK NICHOLAS B , CAROZZI NADINE , GUO RONG
IPC分类号： C07K14/195 , C07K14/32 , C12N15/82
CPC分类号： C12N15/8286 , A01N37/44 , C07K14/325 , C12P21/02 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 4, 6, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37 or 61, the nucleotide sequence set forth in SEQ ID NO: 1, 3, 5, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or 60, or the nucleotide sequence deposited in a bacterial host as Accession No. NRRL B-30961, B-30955, B-30956, B-30957, B-30958, B-30942, B-30939, B-30941, B-50047, B-50047, B-30959, B-30960, B-30943, B-50048, or B-50048, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含杀虫多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的杀虫核酸分子。另外，包括对应于多核苷酸的氨基酸序列。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO： 25，27，29，31，33，35，37或61所述的核苷酸序列，所述核苷酸序列如SEQ ID NO：1,3,5,8,10,12,14,16,18,20,22,24， 26,28,30,32,34,36或60个核苷酸序列，或作为保藏号NRRL B-30961，B-30955，B-30956，B-30957，B-30958，B -30942，B-30939，B-30941，B-50047，B-50047，B-30959，B-30960，B-30943，B-50048或B-50048，以及它们的变体和片段。

9. 发明申请

WO2006107761A2 AXMI-027, AXMI-036 AND AXMI-038, A FAMILY OF DELTA-ENDOTOXIN GENES AND METHODS FOR THEIR USE 审中-公开
标题翻译： AXMI-027，AXMI-036和AXMI-038，三内酰胺基因家族及其使用方法
公开(公告)号：WO2006107761A2
公开(公告)日：2006-10-12
申请号：PCT/US2006011983
申请日：2006-04-03
申请人： ATHENIX CORP , CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL , DUCK NICHOLAS B , KAHN THEODORE W
发明人： CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL , DUCK NICHOLAS B , KAHN THEODORE W
IPC分类号： C07K14/325 , A01N63/02 , C12N15/82
CPC分类号： C07K14/325 , A01N63/02 , C12N15/8286 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NOS: 2, 11 and 13, or the nucleotide sequences set forth in SEQ ID NOS: 1, 10 and 12, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含δ-内毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的δ-内毒素核酸分子。另外，包含对应于多核苷酸的氨基酸序列。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：2,11和13所示的氨基酸序列的核苷酸序列或SEQ ID NO：1,10和12所示的核苷酸序列，作为以及其变体和片段。

10. 发明申请

WO2004081185B1 METHODS TO ENHANCE THE ACTIVITY OF LIGNOCELLULOSE-DEGRADING ENZYMES 审中-公开
标题翻译：提高木糖醇降解酶活性的方法
公开(公告)号：WO2004081185B1
公开(公告)日：2004-12-23
申请号：PCT/US2004007086
申请日：2004-03-08
申请人： ATHENIX CORP , BURDETTE JILL , VANDE BERG BRIAN , CARR BRIAN , DUCK NICHOLAS B , CAROZZI NADINE , KOZIEL MICHAEL G , PATEL PARESMA R
发明人： BURDETTE JILL , VANDE BERG BRIAN , CARR BRIAN , DUCK NICHOLAS B , CAROZZI NADINE , KOZIEL MICHAEL G , PATEL PARESMA R
IPC分类号： C12N20060101 , C12N9/04 , C12N9/18 , C12N9/20 , C12P7/10 , C12P19/02 , C12S3/00 , C13K1/02 , D06M10/00
CPC分类号： C12P7/10 , C08H8/00 , C12N9/0006 , C12N9/18 , C12N9/20 , D21C5/005 , D21C9/16 , D21C11/0007 , Y02E50/16
摘要： Methods for hydrolyzing lignocellulose are provided, comprising contacting the lignocellulose with at least one chemical treatment. Methods for pretreating a lignocellulosic material comprising contacting the material with at least one chemical are also provided. Methods for liberating a substance such as an enzyme, a pharmaceutical, or a nutraceutical from plant material are also provided. These methods are more efficient, more economical, and less toxic than current methods.
摘要翻译：提供水解木质纤维素的方法，包括使木质纤维素与至少一种化学处理接触。还提供了用于预处理木质纤维素材料的方法，包括使材料与至少一种化学品接触。还提供了用于从植物材料释放诸如酶，药物或营养品的物质的方法。这些方法比目前的方法更有效，更经济，毒性更低。

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