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1. 发明申请

WO2007146767A3 BACTERIAL GLUTAMINE SYNTHETASES AND METHODS OF USE 审中-公开
标题翻译：细菌谷氨酰胺合成酶及其使用方法
公开(公告)号：WO2007146767A3
公开(公告)日：2008-04-17
申请号：PCT/US2007070690
申请日：2007-06-08
申请人： ATHENIX CORP , DUCK NICHOLAS B , HINSON TODD K , BEILINSON VADIM , SCHOUTEN LAURA COOPER , TOMSO DANIEL JOHN
发明人： DUCK NICHOLAS B , HINSON TODD K , BEILINSON VADIM , SCHOUTEN LAURA COOPER , TOMSO DANIEL JOHN
IPC分类号： A01H5/00 , C12N9/00 , C12N15/52 , C12N15/82
CPC分类号： C12N15/8277 , C12N9/93
摘要： Compositions and methods for conferring herbicide resistance to and improving nitrogen utilization of bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a polypeptide that confers resistance or tolerance to herbicidal glutamine synthetase inhibitors are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated polynucleotides corresponding to herbicidal glutamine synthetase inhibitor-resistant polynucleotides are provided. Additionally, polypeptides corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated polynucleotides comprising a variant of SEQ ID NO: 1, wherein the variant polynucleotide encodes a polypeptide that is resistant to inhibition by herbicidal glutamine synthetase inhibitor.
摘要翻译：提供了赋予除草剂抵抗和改善细菌，植物，植物细胞，组织和种子的氮利用的组合物和方法。提供了包含赋予除草谷氨酰胺合成酶抑制剂的抗性或耐受性的多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中用于在植物中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了对应于除草谷氨酰胺合成酶抑制剂抗性多核苷酸的分离的多核苷酸。另外，包括对应于多核苷酸的多肽。特别地，本发明提供了包含SEQ ID NO：1的变体的分离的多核苷酸，其中所述变体多核苷酸编码对除草谷氨酰胺合成酶抑制剂具有抑制作用的多肽。

2. 发明申请

WO2007146767A8 BACTERIAL GLUTAMINE SYNTHETASES AND METHODS OF USE 审中-公开
标题翻译：细菌谷氨酰胺合成酶及其使用方法
公开(公告)号：WO2007146767A8
公开(公告)日：2008-02-14
申请号：PCT/US2007070690
申请日：2007-06-08
申请人： ATHENIX CORP , DUCK NICHOLAS B , HINSON TODD K , BEILINSON VADIM , SCHOUTEN LAURA COOPER , TOMSO DANIEL JOHN
发明人： DUCK NICHOLAS B , HINSON TODD K , BEILINSON VADIM , SCHOUTEN LAURA COOPER , TOMSO DANIEL JOHN
IPC分类号： C12N9/00 , A01H5/00 , C12N15/52 , C12N15/82
CPC分类号： C12N15/8277 , C12N9/93
摘要： Compositions and methods for conferring herbicide resistance to and improving nitrogen utilization of bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a polypeptide that confers resistance or tolerance to herbicidal glutamine synthetase inhibitors are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated polynucleotides corresponding to herbicidal glutamine synthetase inhibitor-resistant polynucleotides are provided. Additionally, polypeptides corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated polynucleotides comprising a variant of SEQ ID NO: 1, wherein the variant polynucleotide encodes a polypeptide that is resistant to inhibition by herbicidal glutamine synthetase inhibitor.
摘要翻译：提供了赋予除草剂抗性并改善细菌，植物，植物细胞，组织和种子的氮利用的组合物和方法。提供了包含赋予对除草谷氨酰胺合成酶抑制剂的抗性或耐受性的多肽的编码序列的组合物。编码序列可以用于DNA构建体或表达盒中用于在植物中转化和表达。组合物还包含转化的细菌，植物，植物细胞，组织和种子。具体而言，提供了对应于除草谷氨酰胺合成酶抑制剂抗性多核苷酸的分离的多核苷酸。另外，包含对应于多核苷酸的多肽。具体而言，本发明提供了包含SEQ ID NO：1的变体的分离的多核苷酸，其中所述变体多核苷酸编码抗除草谷氨酰胺合成酶抑制剂抑制的多肽。

3. 发明申请

WO2008002962A2 GRG32: A NOVEL EPSP SYNTHASE GENE CONFERRING HERBICIDE RESISTANCE 审中-公开
标题翻译： GRG32：一种新的EPSP合成酶基因，其抗除草剂抗性
公开(公告)号：WO2008002962A2
公开(公告)日：2008-01-03
申请号：PCT/US2007072203
申请日：2007-06-27
申请人： ATHENIX CORP , PETER CHERYL , VANDE BERG BRIAN , CARR BRIAN , TOMSO DANIEL JOHN
发明人： PETER CHERYL , VANDE BERG BRIAN , CARR BRIAN , TOMSO DANIEL JOHN
IPC分类号： C12N15/82
CPC分类号： C12N15/8275 , C12N9/1092
摘要： Compositions and methods for conferring herbicide resistance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include nucleic acid molecules encoding herbicide resistance or tolerance polypeptides, vectors comprising those nucleic acid molecules, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs or expression cassettes for transformation and expression in organisms, including microorganisms and plants. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, the present invention provides for isolated nucleic acid molecules comprising the nucleotide sequence set forth in SEQ ID NO: 1 or 14, a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:2, the herbicide resistance nucleotide sequence deposited in a bacterial host as Accession Nos. NRRL B-30931, as well as variants and fragments thereof.
摘要翻译：提供了赋予除草剂对细菌，植物，植物细胞，组织和种子的抗性的组合物和方法。组合物包括编码除草剂抗性或耐受性多肽的核酸分子，包含那些核酸分子的载体和包含载体的宿主细胞。本发明的核苷酸序列可用于DNA构建体或表达盒中用于在生物体（包括微生物和植物）中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，本发明提供了分离的核酸分子，其包含SEQ ID NO：1或14所示的核苷酸序列，编码SEQ ID NO：2所示的氨基酸序列的核苷酸序列，作为登录号NRRL B-30931的细菌宿主，以及其变体和片段。

4. 发明申请

WO2011103247A2 AXMI218, AXMI219, AXMI220, AXMI226, AXMI227, AXMI228, AXMI229, AXMI230, AND AXMI231 DELTA-ENDOTOXIN GENES AND METHODS FOR THEIR USE 审中-公开
标题翻译： AXMI218，AXMI219，AXMI220，AXMI226，AXMI227，AXMI228，AXMI229，AXMI230和AXMI231三角内毒素基因及其使用方法
公开(公告)号：WO2011103247A2
公开(公告)日：2011-08-25
申请号：PCT/US2011/025171
申请日：2011-02-17
申请人： ATHENIX CORP. , SAMPSON, Kimberly, S. , TOMSO, Daniel, John
发明人： SAMPSON, Kimberly, S. , TOMSO, Daniel, John
IPC分类号： A01H5/00 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , C07K14/00 , A01N37/18 , C12P21/00 , A01H1/00 , C12N15/82 , A01H5/10 , A01P7/04
CPC分类号： C07K14/325 , A01N37/46 , A01N63/02 , C12N15/8285 , C12N15/8286 , Y02A40/162 , Y02A40/164
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO: 13-30, or the nucleotide sequence set forth in SEQ ID NO: 1-12, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列，以及与这些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：13-30所示的氨基酸序列的核苷酸序列或SEQ ID NO：1-12所示的核苷酸序列，以及变体和片段。

5. 发明申请

WO2011014749A1 AXMI-192 FAMILY OF PESTICIDAL GENES AND METHODS FOR THEIR USE 审中-公开
标题翻译：农药的AXMI-192家族及其使用方法
公开(公告)号：WO2011014749A1
公开(公告)日：2011-02-03
申请号：PCT/US2010/043871
申请日：2010-07-30
申请人： ATHENIX CORP. , SAMPSON, Kimberly, S. , TOMSO, Daniel, John , GUO, Rong
发明人： SAMPSON, Kimberly, S. , TOMSO, Daniel, John , GUO, Rong
IPC分类号： C07K14/325 , C12N15/82
CPC分类号： C07K2/00 , C07K14/325 , C12N15/8285 , C12N15/8286 , Y02A40/162 , Y02A40/164
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:28-62, or the nucleotide sequence set forth in SEQ ID NO: 1-27, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列，以及与这些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：28-62所示氨基酸序列的核苷酸序列或SEQ ID NO：1-27所示的核苷酸序列，以及变体和片段。

6. 发明申请

WO2007146765A2 NOVEL EPSP SYNTHASE GENES CONFERRING HERBICIDE RESISTANCE 审中-公开
标题翻译：新的EPSP合成基因决定抗药性
公开(公告)号：WO2007146765A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/070683
申请日：2007-06-08
申请人： ATHENIX CORPORATION , CARR, Brian , VANDE BERG, Brian , TOMSO, Daniel, John , PETERS, Cheryl
发明人： CARR, Brian , VANDE BERG, Brian , TOMSO, Daniel, John , PETERS, Cheryl
IPC分类号： C12N15/82
CPC分类号： C12N15/8275 , C12N9/1092
摘要： Compositions and methods for conferring herbicide resistance or tolerance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a polypeptide that confers resistance or tolerance to glyphosate herbicides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated nucleic acid molecules corresponding to glyphosate resistant nucleic acid sequences are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NOS:2, 4, 6, 8, 10, 12, or 14 or the nucleotide sequence set forth in SEQ ID NOS: 1, 3, 5, 7, 9, 11, 13, 28, 29, 30, 31, 32, 33, or 34.
摘要翻译：提供了赋予除草剂抗性或对细菌，植物，植物细胞，组织和种子的耐受性的组合物和方法。提供了包含赋予对草甘膦除草剂的抗性或耐受性的多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中用于在植物中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了对应于草甘膦抗性核酸序列的分离的核酸分子。另外，包括对应于多核苷酸的氨基酸序列。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：2,4,6,8,10,12或14所示氨基酸序列的核苷酸序列或SEQ ID NOS ：1，3，5，7，9，11，13，28，29，30，31，32，33或34。

7. 发明申请

WO2011103248A2 AXMI221z, AXMI222z, AXMI223z, AXMI224z, AND AXMI225z DELTA-ENDOTOXIN GENES AND METHODS FOR THEIR USE 审中-公开
标题翻译： AXMI221z，AXMI222z，AXMI223z，AXMI224z和AXMI225Z DELTA-ENDOTOXIN基因及其使用方法
公开(公告)号：WO2011103248A2
公开(公告)日：2011-08-25
申请号：PCT/US2011/025172
申请日：2011-02-17
申请人： ATHENIX CORP. , SAMPSON, Kimberly, S. , TOMSO, Daniel, John
发明人： SAMPSON, Kimberly, S. , TOMSO, Daniel, John
IPC分类号： A01H5/00 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , C07K14/00 , A01N37/18 , C12P21/00 , A01H1/00 , C12N15/82 , A01H5/10 , A01P7/04
CPC分类号： C12N15/8286 , A01N37/46 , A01N63/02 , C07K14/325 , C07K16/1278 , C12N15/8279 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO :21-32, or the nucleotide sequence set forth in SEQ ID NO: 1-20, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列，以及与这些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：21-32所示的氨基酸序列的核苷酸序列或SEQ ID NO：1-20所示的核苷酸序列，以及变体和片段。

8. 发明申请

WO2008002962A3 GRG32: A NOVEL EPSP SYNTHASE GENE CONFERRING HERBICIDE RESISTANCE 审中-公开
公开(公告)号：WO2008002962A3
公开(公告)日：2008-01-03
申请号：PCT/US2007/072203
申请日：2007-06-27
申请人： ATHENIX CORPORATION , PETER, Cheryl , VANDE BERG, Brian , CARR, Brian , TOMSO, Daniel, John
发明人： PETER, Cheryl , VANDE BERG, Brian , CARR, Brian , TOMSO, Daniel, John
IPC分类号： C12N9/10 , C12N15/54 , C12N15/82 , A01H5/00
摘要： Compositions and methods for conferring herbicide resistance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include nucleic acid molecules encoding herbicide resistance or tolerance polypeptides, vectors comprising those nucleic acid molecules, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs or expression cassettes for transformation and expression in organisms, including microorganisms and plants. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, the present invention provides for isolated nucleic acid molecules comprising the nucleotide sequence set forth in SEQ ID NO: 1 or 14, a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:2, the herbicide resistance nucleotide sequence deposited in a bacterial host as Accession Nos. NRRL B-30931, as well as variants and fragments thereof.

9. 发明申请

WO2007146767A2 BACTERIAL GLUTAMINE SYNTHETASES AND METHODS OF USE 审中-公开
标题翻译：细菌谷氨酰胺合成酶及其使用方法
公开(公告)号：WO2007146767A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/070690
申请日：2007-06-08
申请人： ATHENIX CORPORATION , DUCK, Nicholas, B. , HINSON, Todd, K. , BEILINSON, Vadim , SCHOUTEN, Laura, Cooper , TOMSO, Daniel, John
发明人： DUCK, Nicholas, B. , HINSON, Todd, K. , BEILINSON, Vadim , SCHOUTEN, Laura, Cooper , TOMSO, Daniel, John
IPC分类号： C12N9/00 , C12N15/52 , C12N15/82 , A01H5/00
CPC分类号： C12N15/8277 , C12N9/93
摘要： Compositions and methods for conferring herbicide resistance to and improving nitrogen utilization of bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a polypeptide that confers resistance or tolerance to herbicidal glutamine synthetase inhibitors are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated polynucleotides corresponding to herbicidal glutamine synthetase inhibitor-resistant polynucleotides are provided. Additionally, polypeptides corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated polynucleotides comprising a variant of SEQ ID NO: 1, wherein the variant polynucleotide encodes a polypeptide that is resistant to inhibition by herbicidal glutamine synthetase inhibitor.
摘要翻译：提供了赋予除草剂对细菌，植物，植物细胞，组织和种子的氮利用的抗性和改善的组合物和方法。提供了包含赋予除草谷氨酰胺合成酶抑制剂的抗性或耐受性的多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中用于在植物中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了对应于除草谷氨酰胺合成酶抑制剂抗性多核苷酸的分离的多核苷酸。另外，包括对应于多核苷酸的多肽。特别地，本发明提供了包含SEQ ID NO：1的变体的分离的多核苷酸，其中所述变体多核苷酸编码对除草谷氨酰胺合成酶抑制剂具有抑制作用的多肽。

10. 发明申请

WO2011103247A3 AXMI218, AXMI219, AXMI220, AXMI226, AXMI227, AXMI228, AXMI229, AXMI230, AND AXMI231 DELTA-ENDOTOXIN GENES AND METHODS FOR THEIR USE 审中-公开
标题翻译： AXMI218，AXMI219，AXMI220，AXMI226，AXMI227，AXMI228，AXMI229，AXMI230和AXMI231Δ-内毒素基因及其使用方法
公开(公告)号：WO2011103247A3
公开(公告)日：2011-12-01
申请号：PCT/US2011025171
申请日：2011-02-17
申请人： ATHENIX CORP , SAMPSON KIMBERLY S , TOMSO DANIEL JOHN
发明人： SAMPSON KIMBERLY S , TOMSO DANIEL JOHN
IPC分类号： A01H5/00 , C07K14/325 , C12N1/20 , C12N5/14 , C12N15/32
CPC分类号： C07K14/325 , A01N37/46 , A01N63/02 , C12N15/8285 , C12N15/8286 , Y02A40/162 , Y02A40/164
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO: 13-30, or the nucleotide sequence set forth in SEQ ID NO: 1-12, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子杀虫活性的组合物和方法。提供了包含毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中用于在植物和细菌中转化和表达。组合物还包含转化的细菌，植物，植物细胞，组织和种子。具体而言，提供了分离的毒素核酸分子。此外，还包括对应于多核苷酸的氨基酸序列，以及与那些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：13-30所示氨基酸序列或SEQ ID NO：1-12所示核苷酸序列的核苷酸序列，以及变体和其片段。

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