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1. 发明申请

WO2007027133A1 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS 审中-公开
标题翻译： 7-（2-氨基-1-羟基 - 乙基）-4-羟基苯并噻唑-2（3H） - 酮衍生物作为β2ADRENOCEPTOR AGONISTS
公开(公告)号：WO2007027133A1
公开(公告)日：2007-03-08
申请号：PCT/SE2006/000980
申请日：2006-08-28
申请人： ASTRAZENECA AB , BAILEY, Andrew , BONNERT, Roger , FLAHERTY, Alice , PAIRAUDEAU, Garry , STOCKS, Michael
发明人： BAILEY, Andrew , BONNERT, Roger , FLAHERTY, Alice , PAIRAUDEAU, Garry , STOCKS, Michael
IPC分类号： C07D277/68 , A61K31/428 , A61P11/00 , A61P11/06
CPC分类号： C07D277/68
摘要： The present invention provides compounds of formula (I) wherein e, R 1 , R 2 , R 3 , R 4 , R 5 , R 4' , R 5' , R6, R 7 , A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供式（I）化合物，其中e，R 1，R 2，R 3，R 4， R 5，R 5，R 4，R 5，R 6，R 7，A，D ，m和n如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

2. 发明申请

WO2007027134A1 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS 审中-公开
标题翻译： 7-（2-氨基-1-羟基 - 乙基）-4-羟基苯并噻唑-2（3H） - 酮衍生物作为β2ADRENOCEPTOR AGONISTS
公开(公告)号：WO2007027134A1
公开(公告)日：2007-03-08
申请号：PCT/SE2006/000981
申请日：2006-08-28
申请人： ASTRAZENECA AB , BAILEY, Andrew , BONNERT, Roger , CONNOLLY, Stephen , INGALL, Anthony , PAIRAUDEAU, Garry , STOCKS, Michael
发明人： BAILEY, Andrew , BONNERT, Roger , CONNOLLY, Stephen , INGALL, Anthony , PAIRAUDEAU, Garry , STOCKS, Michael
IPC分类号： C07D277/68 , A61K31/428 , A61P11/00 , A61P11/06
CPC分类号： C07D277/68
摘要： The present invention provides compounds of formula (I) wherein the variables are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供式（I）化合物，其中变量如本说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

3. 发明申请

WO2007123465A1 NEW ALKYL ESTERS OF CYCLIC AMINO ALCOHOLS WITH MUSCARINIC M3 RECEPTOR ANTAGONIST ACTIVITY, USEFUL FOR TREATING E.G. CHRONIC BRONCHIAL OBSTRUCTION, ASTHMA AND OVERACTIVE BLADDER 审中-公开
标题翻译：具有MUSCARINIC M3受体拮抗剂活性的循环氨基醇的新碱基，用于治疗E.G. 慢性BRONCHIAL OBGE，ASTHMA和OVERACTIVE BLADDER
公开(公告)号：WO2007123465A1
公开(公告)日：2007-11-01
申请号：PCT/SE2007/000389
申请日：2007-04-23
申请人： ASTRAZENECA AB , BAILEY, Andrew , METE, Antonio , PAIRAUDEAU, Garry , STOCKS, Michael , WENLOCK, Mark
发明人： BAILEY, Andrew , METE, Antonio , PAIRAUDEAU, Garry , STOCKS, Michael , WENLOCK, Mark
IPC分类号： C07D211/46 , A61K31/4409 , A61K31/4535 , A61K31/4545 , A61P11/00 , A61P13/10 , C07D401/12 , C07D409/12
CPC分类号： C07D211/48 , C07D409/12
摘要： The invention provides compounds of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions and their use in therapy (I).
摘要翻译：本发明提供式（I）化合物，其中R 1，R 2，R 3，R 4， R 5和X如说明书中所定义，其制备方法，含有它们的药物组合物，制备药物组合物的方法及其在治疗中的应用（I）。

4. 发明申请

WO2007102771A1 PHENETHANOLAMINE DERIVATIVES AS BETA2 ADRENORECEPTOR AGONISTS 审中-公开
标题翻译：苯乙醇胺衍生物作为BETA2 ADRENORECEPTOR AGONISTS
公开(公告)号：WO2007102771A1
公开(公告)日：2007-09-13
申请号：PCT/SE2007/000217
申请日：2007-03-06
申请人： ASTRAZENECA AB , ALCARAZ, Lilian , BAILEY, Andrew , COX, Rhona , MEGHANI, Premji , PAIRAUDEAU, Garry , STOCKS, Michael
发明人： ALCARAZ, Lilian , BAILEY, Andrew , COX, Rhona , MEGHANI, Premji , PAIRAUDEAU, Garry , STOCKS, Michael
IPC分类号： C07D401/12 , A61K31/137 , A61K31/428 , A61K31/445 , A61K31/454 , A61K31/4704 , A61K31/4709 , A61P11/00 , A61P11/06 , A61P11/08 , C07C211/36 , C07D211/26 , C07D215/26 , C07D417/12
CPC分类号： C07D215/26 , C07D401/12 , C07D417/12
摘要： The present invention relates to compounds according to formula (I), a process for preparing them, the intermediate compounds of the process and the use of the compounds in the manufacture of a medicament for use in treating diseases such as ARDS, pulmonary emphysema, bronchitis, bronchiectasis, COPD, asthma and rhinitis. The compounds are beta2 adrenoreceptor agonists.
摘要翻译：本发明涉及式（I）化合物，其制备方法，该方法的中间体化合物和该化合物在制备用于治疗疾病如ARDS，肺气肿，支气管炎的药物中的用途，支气管扩张，COPD，哮喘和鼻炎。这些化合物是β2肾上腺素受体激动剂。

5. 发明申请

WO2004000819A1 NEW USE OF PYRIMIDINE - OR TRIAZINE- 2-CARBONITILES FOR TREATING DISEASES ASSOCIATED WITH CYSTEINE PROTEASE ACTIVITY AND NOVEL PYRIMIDINE-2-CARBONITILE DERIVATIVES 审中-公开
标题翻译：新亚利辛 - 或二噻二碳二烯的新用途，用于治疗与CYSTEINE PROTEASE活性相关的疾病和新型的嘧啶-2-羰基衍生物
公开(公告)号：WO2004000819A1
公开(公告)日：2003-12-31
申请号：PCT/SE2003/001078
申请日：2003-06-23
申请人： ASTRAZENECA AB , BAILEY, Andrew , PAIRAUDEAU, Garry , PATEL, Anil , THOM, Stephen
发明人： BAILEY, Andrew , PAIRAUDEAU, Garry , PATEL, Anil , THOM, Stephen
IPC分类号： C07D239/24
CPC分类号： C07D239/47 , A61K31/506 , A61K31/53 , C07D239/48 , C07D239/50 , C07D251/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/14 , C07D487/08
摘要： The present invention therefore provides use of a compound of formula (I) and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition, this invention also discloses processes for the preparation of such inhibitors.
摘要翻译：因此，本发明提供式（I）化合物和组合物用于治疗与半胱氨酸蛋白酶活性相关的疾病的用途。这些化合物是半胱氨酸蛋白酶S，K，F，L和B的可逆抑制剂。特别关注的是与组织蛋白酶S相关的疾病。此外，本发明还公开了制备这种抑制剂的方法。

6. 发明申请

WO2004000825A1 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO2004000825A1
公开(公告)日：2003-12-31
申请号：PCT/SE2003/001080
申请日：2003-06-23
申请人： ASTRAZENECA AB , BAILEY, Andrew , PAIRAUDEAU, Garry , PATEL, Anil , THOM, Stephen
发明人： BAILEY, Andrew , PAIRAUDEAU, Garry , PATEL, Anil , THOM, Stephen
IPC分类号： C07D295/182
CPC分类号： C07D295/185 , A61K31/472 , A61K31/495 , A61K31/5375 , C07D211/66 , C07D217/06 , C07D309/14
摘要： The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition this invention also discloses processes for the preparation of such inhibitors. (I) in which: A is a 6-membered ring optionally containing a double bond and optionally containing an oxygen atom or NR group in the ring;
摘要翻译：本发明涉及用于治疗与半胱氨酸蛋白酶活性相关的疾病的化合物和组合物。这些化合物是半胱氨酸蛋白酶S，K，F，L和B的可逆抑制剂。特别有意义的是与组织蛋白酶S相关的疾病。此外，本发明还公开了制备这种抑制剂的方法。（I）其中：A是任选地含有双键并任选地在环中含有氧原子或NR基团的6元环;

7. 发明申请

WO2004000843A1 NOVEL PURINE- OR PYRROLOL[2,3-d]PYRIMIDINE-2-CARBONITILES FOR TREATING DISEASES ASSOCIATED WITH CYSTEINE PROTEASE ACTIVITY 审中-公开
标题翻译：新型嘌呤或吡咯烷[2,3-d]嘧啶-2-羰基化合物用于治疗与CYSTEINE蛋白酶活性相关的疾病
公开(公告)号：WO2004000843A1
公开(公告)日：2003-12-31
申请号：PCT/SE2003/001079
申请日：2003-06-23
申请人： ASTRAZENECA AB , BAILEY, Andrew , PAIRAUDEAU, Garry , PATEL, Anil , THOM, Stephen
发明人： BAILEY, Andrew , PAIRAUDEAU, Garry , PATEL, Anil , THOM, Stephen
IPC分类号： C07D473/00
CPC分类号： C07D473/00 , C07D473/34 , C07D487/04
摘要： The present invention therefore provides a compound of formula (I) and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition this invention also discloses processes for the preparation of such inhibitors.
摘要翻译：因此，本发明提供式（I）化合物和用于治疗与半胱氨酸蛋白酶活性相关的疾病的组合物。这些化合物是半胱氨酸蛋白酶S，K，F，L和B的可逆抑制剂。特别有意义的是与组织蛋白酶S相关的疾病。此外，本发明还公开了制备这种抑制剂的方法。

8. 发明申请

WO2009098448A1 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2009098448A1
公开(公告)日：2009-08-13
申请号：PCT/GB2009/000298
申请日：2009-02-04
申请人： ASTRAZENECA AB , ARGENTA DISCOVERY LIMITED , ALCARAZ, Lilian , BAILEY, Andrew , BULL, Richard, James , JOHNSON, Timoty , KINDON, Nicholas, David , LISTER, Andrew, Stuart , ROBBINS, Andrew, James , STOCKS, Michael, John , TOBALD, Barry, John
发明人： ALCARAZ, Lilian , BAILEY, Andrew , BULL, Richard, James , JOHNSON, Timoty , KINDON, Nicholas, David , LISTER, Andrew, Stuart , ROBBINS, Andrew, James , STOCKS, Michael, John , TOBALD, Barry, John
IPC分类号： C07D498/10 , A61K31/357 , A61P11/06 , A61P11/08
CPC分类号： C07D498/10
摘要： Diazaspiro [5.5] undecane derivatives and related compounds as muscarinic-receptor antagonists and beta-adrenoceptor agonists for the treatment of pulmonary disorders.
摘要翻译：二氮杂螺[5.5]十一烷衍生物和相关化合物作为毒蕈碱受体拮抗剂和β-肾上腺素受体激动剂治疗肺功能障碍。

9. 发明申请

WO2012085583A1 NEW COMPOUND 审中-公开
标题翻译：新化合物
公开(公告)号：WO2012085583A1
公开(公告)日：2012-06-28
申请号：PCT/GB2011/052560
申请日：2011-12-22
申请人： ASTRAZENECA AB , PULMAGEN THERAPEUTICS (SYNERGY) LIMITED , ALCARAZ, Lilian , BAILEY, Andrew , KINDON, Nicholas
发明人： ALCARAZ, Lilian , BAILEY, Andrew , KINDON, Nicholas
IPC分类号： A61K31/425 , A61K31/535
CPC分类号： A61K31/425 , A61K31/535 , A61K45/06 , A61K2300/00
摘要： The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is N-Butyl-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H- benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)-3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-5 oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanamide or a salt thereof, and a second active ingredient selected from: a non-steroidal Glucocorticoid Receptor (GR Receptor) Agonist; an antioxidant; a CCR1 antagonist; a chemokine antagonist (not CCR1); a corticosteroid; a CRTh2 antagonist; a DP1 antagonist; an Histone Deacetylase activator; an IKK2 kinase inhibitor; a COX inhibitor; a lipoxygenase inhibitor; a leukotriene receptor antagonist; an MPO inhibitor; a PDE4 inhibitor; a PPAR ϒ agonist; a protease inhibitor; a p38 inhibitor, a selective glucocorticoid receptor agonist (SEGRA), a Statin; a thromboxane antagonist; a vasodilator; or, an ENAC blocker (Epithelial Sodium-channel blocker); and its use in the treatment of respiratory disease.
摘要翻译：本发明提供了包含N-丁基-N-（2-（2-（5-羟基-3-氧代-3,4-二氢-2H-苯并[b] 乙基氨基）乙基）-3-（3-（2-（4-（2-异丙基噻唑-4-羰基）-1-氧代-4,9-二氮杂螺[5.5] 十一烷-9-基）乙基）苯乙氧基）丙酰胺或其盐，和第二活性成分，选自：非甾体糖皮质激素受体（GR受体）激动剂; 抗氧化剂 CCR1拮抗剂; 趋化因子拮抗剂（不是CCR1）; 皮质类固醇 CRTh2拮抗剂; DP1拮抗剂; 组蛋白脱乙酰酶激活剂; IKK2激酶抑制剂; COX抑制剂; 脂氧合酶抑制剂; 白细胞三烯受体拮抗剂; MPO抑制剂; PDE4抑制剂; 一个PPAR？激动剂; 蛋白酶抑制剂; p38抑制剂，选择性糖皮质激素受体激动剂（SEGRA），他汀类药物; 血栓素拮抗剂; 血管扩张剂或ENAC阻断剂（上皮钠通道阻断剂）; 并用于治疗呼吸系统疾病。

10. 发明申请

WO2012085582A1 COMPOUND 审中-公开
标题翻译：复合
公开(公告)号：WO2012085582A1
公开(公告)日：2012-06-28
申请号：PCT/GB2011/052559
申请日：2011-12-22
申请人： ASTRAZENECA AB , PULMAGEN THERAPEUTICS (SYNERGY) LIMITED , ALCARAZ, Lilian , BAILEY, Andrew , KINDON, Nicholas
发明人： ALCARAZ, Lilian , BAILEY, Andrew , KINDON, Nicholas
IPC分类号： A61K31/535 , A61K31/425
CPC分类号： A61K31/425 , A61K31/535 , A61K45/06 , A61K2300/00
摘要： The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is 3-(2-Chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl(ethylamino)ethyl)propanamide or a salt thereof, and a second active ingredient selected from: a non-steroidal Glucocorticoid Receptor (GR Receptor) Agonist; an antioxidant; a CCR1 antagonist; a chemokine antagonist (not CCR1); a corticosteroid; a CRTh2 antagonist; a DP1 antagonist; an Histone Deacetylase activator; an IKK2 kinase inhibitor; a COX inhibitor; a lipoxygenase inhibitor; a leukotriene receptor antagonist; an MPO inhibitor; a PDE4 inhibitor; a PPARϒ agonist; a protease inhibitor; a p38 inhibitor, a selective glucocorticoid receptor agonist (SEGRA), a Statin; a thromboxane antagonist; a vasodilator; or, an ENAC blocker (Epithelial Sodium-channel blocker); and its use in the treatment of respiratory disease.
摘要翻译：本发明提供包含第一活性成分的药物产品，试剂盒或组合物，其为3-（2-氯-3 - （（4-（2-乙基噻唑-4-羰基）-1-氧杂-4,9-二氮杂螺[ 5.5]十一碳-9-基）甲基）苯乙氧基）-N-环戊基-N-（2-（2-（5-羟基-3-氧代-3,4-二氢-2H-苯并[b] [1,4 （乙基氨基）乙基）丙酰胺或其盐和选自以下的第二活性成分：非甾体糖皮质激素受体（GR受体）激动剂;抗氧化剂; CCR1拮抗剂;趋化因子拮抗剂（不是CCR1 ）;皮质类固醇; CRTh2拮抗剂; DP1拮抗剂;组蛋白脱乙酰酶激活剂; IKK2激酶抑制剂; COX抑制剂;脂氧合酶抑制剂;白三烯受体拮抗剂; MPO抑制剂; PDE4抑制剂;PPARα激动剂; 蛋白酶抑制剂; p38抑制剂，选择性糖皮质激素受体激动剂（SEGRA），他汀类药物;血栓烷拮抗剂;血管扩张剂;或ENAC阻滞剂（上皮钠通道阻滞剂）;及其在治疗中的用途的呼吸系统疾病。

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