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1. 发明申请

WO2005089437A2 SYSTEM AND METHOD FOR MANIPULATING AND PROCESSING MATERIALS USING HOLOGRAPHIC OPTICAL TRAPPING 审中-公开
标题翻译：使用全息光学跟踪处理和处理材料的系统和方法
公开(公告)号：WO2005089437A2
公开(公告)日：2005-09-29
申请号：PCT/US2005/008934
申请日：2005-03-17
申请人： ARRYX, INC. , PLEWA, Joseph , TANNER, Evan , MUETH, Dan , GRUBER, Lewis , BRADLEY, Kenneth
发明人： PLEWA, Joseph , TANNER, Evan , MUETH, Dan , GRUBER, Lewis , BRADLEY, Kenneth
IPC分类号： G21K1/00 , H05H3/04
CPC分类号： B82Y20/00 , B82Y10/00 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： A method and apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
摘要翻译：一种用于通过用衍射光学元件（DOE）调制激光束而形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的方法和装置。选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。根据材料的至少一个选定特征计算DOE的值。光束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱; 陷阱聚焦到光束焦点或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。

2. 发明申请

WO2005060431A2 SYSTEM AND METHOD FOR MANIPULATING AND PROCESSING MATERIALS USING HOLOGRAPHIC OPTICAL TRAPPING 审中-公开
标题翻译：使用全息光学跟踪处理和处理材料的系统和方法
公开(公告)号：WO2005060431A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/035538
申请日：2004-10-28
申请人： ARRYX, INC. , PLEWA, Joseph , TANNER, Evan , MUETH, Dan , GRUBER, Lewis , BRADLEY, Kenneth
发明人： PLEWA, Joseph , TANNER, Evan , MUETH, Dan , GRUBER, Lewis , BRADLEY, Kenneth
IPC分类号： G02B5/32 , G03H1/08 , G03H1/22
CPC分类号： G03H1/22 , G02B5/32 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/2284
摘要： A method for manipulating one or more particles having one or more characteristics with an optical trap formed by modulating a laser beam with a Dynamic Optical Element (DOE). The method includes the steps of selecting at least one characteristic of the particle, generating a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the particle, and selecting calculated values of the DOE, the calculated values corresponding to the at least one selected characteristic of the particles. The method further includes the steps of modulating the beam and the DOE to produce at least one holographic optical trap having properties corresponding to the at least one selected characteristic to, focusing the trap to a beam focus or spot size having a selected size, and locating the beam focus near a particle location for trapping the particle therein.
摘要翻译：一种通过用动态光学元件（DOE）调制激光束形成的光阱来操纵具有一个或多个特性的一个或多个特征的方法。该方法包括以下步骤：选择粒子的至少一个特征，产生具有与粒子的至少一个选定特征相对应的选定波长的激光束，并选择DOE的计算值，计算出的值对应于at 至少一个选定的颗粒特征。该方法还包括以下步骤：调制光束和DOE以产生具有对应于至少一个所选特征的特性的至少一个全息光学陷阱，以将陷阱聚焦到具有所选尺寸的光束聚焦或光斑尺寸，以及定位光束聚焦在颗粒位置附近，用于将颗粒捕获在其中。

3. 发明申请

WO2005023391A2 MULTIPLE LAMINAR FLOW-BASED PARTICLE AND CELLULAR SEPARATION WITH LASER STEERING 审中-公开
标题翻译：多层次流动粒子和细胞分离与激光转向
公开(公告)号：WO2005023391A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/029053
申请日：2004-09-03
申请人： ARRYX, INC. , ROSENBAUM, Neil, Harris , ANDERSON, Amy , GRUBER, Lewis , MUETH, Dan , PLEWA, Joseph , SHIREMAN, Jessica
发明人： ROSENBAUM, Neil, Harris , ANDERSON, Amy , GRUBER, Lewis , MUETH, Dan , PLEWA, Joseph , SHIREMAN, Jessica
IPC分类号： B01D
CPC分类号： A61M1/36 , A61M1/38 , B03C1/28 , B03C5/005 , B03C2201/02 , B03C2201/18 , G01N30/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , H05H3/04
摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
摘要翻译：本发明提供了一种用于分离血液和其他类型的细胞组分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

4. 发明申请

WO2004012133A2 SYSTEM AND METHOD OF SORTING MATERIALS USING HOLOGRAPHIC LASER STEERING 审中-公开
标题翻译：使用全息激光转向分选材料的系统和方法
公开(公告)号：WO2004012133A2
公开(公告)日：2004-02-05
申请号：PCT/US2003/023822
申请日：2003-07-31
申请人： ARRYX, INC. , GRUBER, Lewis , BRADLEY, Kenneth , LOPES, Ward , LANCELOT, Robert, W. , PLEWA, Joseph, S. , GRIER, David
发明人： GRUBER, Lewis , BRADLEY, Kenneth , LOPES, Ward , LANCELOT, Robert, W. , PLEWA, Joseph, S. , GRIER, David
IPC分类号： G06K
CPC分类号： G01N15/1459 , B01L3/5027 , G01N2015/149 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , H05H3/04
摘要： The present invention employs a beam steering apparatus to isolate valuable cells from others cells, tissues, and contaminants. In one embodiment, the system balances optical trapping agains flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation.
摘要翻译：本发明采用波束控制装置将有价值的细胞与其他细胞，组织和污染物分离。在一个实施方案中，系统平衡光捕获再次流动以在计算机程序指导的捕获器的灵活控制下并行化细胞分选，所述计算机程序指导的捕获器基于它们的组合物或标签差异地操纵细胞以直接分离。

5. 发明申请

WO2003044483A3 SAMPLE CHIP 审中-公开
公开(公告)号：WO2003044483A3
公开(公告)日：2003-05-30
申请号：PCT/US2002/036804
申请日：2002-11-15
申请人： ARRYX, INC. , GRUBER, Lewis , MUETH, Dan
发明人： GRUBER, Lewis , MUETH, Dan
IPC分类号： C12N13/00
摘要： A sample chip (10) includes a body portion (16); and a cover portion (14) disposed on the body portion (16); wherein an upper surface (20) of the body portion (16) includes a plurality of microchannels (12) in which objects are introduced for examination and manipulation by optical traps. In one embodiment, at least one of the microchannels (12) includes a barrier (62) which holds the objects so that they can be held and manipulated by the optical traps. In another embodiment, at least one of the microchannels (12) includes a sample chamber (50) at which the barrier (62) is disposed. The number of microchannels (12) and their configuration can vary, and the microchannels (12) may intersect, the sample chamber (50) being disposed at the intersection. The barrier (93) includes at least one of a plurality of barrier structures (101) which are integrally formed or removably disposed in the sample chamber (50). The barrier structures (101) can take different shapes and can be in any combination of shapes.

6. 发明申请

WO2003044483A2 SAMPLE CHIP 审中-公开
标题翻译：样片
公开(公告)号：WO2003044483A2
公开(公告)日：2003-05-30
申请号：PCT/US2002/036804
申请日：2002-11-15
申请人： ARRYX, INC. , GRUBER, Lewis , MUETH, Dan
发明人： GRUBER, Lewis , MUETH, Dan
IPC分类号： G01N
CPC分类号： B01L3/502761 , B01L3/502746 , B01L2200/0647 , B01L2200/0668 , B01L2300/0681 , B01L2300/0816 , B01L2400/0418 , B01L2400/0454 , B01L2400/0478 , B01L2400/0487 , B01L2400/086
摘要： A sample chip includes a body portion; and a cover portion disposed on the body portion; wherein an upper surface of the body portion includes a plurality of microchannels in which objects are introduced for examination and manipulation by optical traps. In one embodiment, at least one of the microchannels includes a barrier which holds the objects so that they can be held and manipulated by the optical traps. In another embodiment, at least one of the microchannels includes a sample chamber at which the barrier is disposed. The number of microchannels and their configuration can vary, and the microchannels may intersect, the sample chamber being disposed at the intersection. The barrier includes at least one of a plurality of barrier structures which are integrally formed or removably disposed in the sample chamber. The barrier structures can take different shapes and can be in any combination of shapes.
摘要翻译：样品芯片包括主体部分; 以及设置在主体部分上的盖部分; 其中所述主体部分的上表面包括多个微通道，在所述微通道中引入物体用于通过光阱进行检查和操作。在一个实施例中，微通道中的至少一个包括阻挡物，该阻挡物保持物体使得它们可以被光阱保持和操纵。在另一个实施例中，微通道中的至少一个包括样品室，在该样品室中设置有屏障。微通道的数量及其构造可以变化，并且微通道可以相交，样品室被布置在交叉点处。屏障包括多个屏障结构中的至少一个，屏障结构整体形成或可移除地设置在样品室中。屏障结构可以采取不同的形状并且可以是任何形状的组合。

7. 发明申请

WO2003018299A1 OPTICAL TOOLS MANIPULATED BY OPTICAL TRAPS 审中-公开
标题翻译：光学工具制作的光学工具
公开(公告)号：WO2003018299A1
公开(公告)日：2003-03-06
申请号：PCT/US2002/027944
申请日：2002-09-03
申请人： ARRYX, INC. , GRUBER, Lewis , BRADLEY, Kenneth
发明人： GRUBER, Lewis , BRADLEY, Kenneth
IPC分类号： B29D11/00
CPC分类号： B82Y20/00 , B82Y10/00 , B82Y30/00 , G02B21/32
摘要： Micrometer and nanometer-sized tools (69), refered to as MOTS an d NOTS, respectively, are manipulated in the illumination (71) of an optical trap (70) and are able to alter the physical, chemical or electronic structure or orientation of a workpiece (68).
摘要翻译：在光阱（70）的照明（71）中分别称为千分尺和纳米级工具（69），分别称为MOTS和NO NO，并且能够改变光阱（70）的物理，化学或电子结构或取向工件（68）。

8. 发明申请

WO2003001178A2 CONFIGURABLE DYNAMIC THREE DIMENSIONAL ARRAY 审中-公开
标题翻译：可配置的动态三维阵列
公开(公告)号：WO2003001178A2
公开(公告)日：2003-01-03
申请号：PCT/US2002/011586
申请日：2002-04-12
申请人： ARRYX, INC. , GRUBER, Lewis
发明人： GRUBER, Lewis , GRIER, David , LOPES, Ward
IPC分类号： G01N
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00441 , B01J2219/00576 , B01J2219/00596 , B01J2219/00599 , B01J2219/00664 , B01J2219/00711 , B01L3/5027 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0819 , B01L2300/0877 , B01L2400/0454 , C40B50/08 , C40B60/14 , G01N21/253
摘要： The present invention relates generally to a configurable array of probes for assaying targets within a fluid. The probes are contained within optical traps which allows for alterations in the selection and re-configuration of the quantity or quality of probes in the array. Moreover, the array is dynamic in that once configured the optical traps may allow for independent repositioning of a given optical trap and contained probe.
摘要翻译：本发明一般涉及用于测定流体内的靶的可配置的探针阵列。探针包含在光阱内，可以改变阵列中探针数量或质量的选择和重新配置。此外，该阵列是动态的，因为一旦配置了光阱可以允许独立重定位给定的光阱和包含的探针。

9. 发明申请

WO2012071269A2 SELECTIVE REMOVAL OF CELLS HAVING ACCUMULATED AGENTS 审中-公开
标题翻译：选择性去除具有累积剂的细胞
公开(公告)号：WO2012071269A2
公开(公告)日：2012-05-31
申请号：PCT/US2011/061387
申请日：2011-11-18
申请人： SIWA CORPORATION , GRUBER, Lewis
发明人： GRUBER, Lewis
IPC分类号： A61B18/00 , A61N7/00 , A61K45/00 , A61P35/00
CPC分类号： A61N7/00 , A61B8/00 , A61B17/320068 , C12N5/0093 , C12N13/00
摘要： A method of treating a condition associate with accumulation of an agent in cells in a patient includes exposing the cells to ultrasound, to selectively kill or induce apoptosis in the cells. The cells include the accumulated agent.
摘要翻译：治疗与患者细胞中的药物累积相关联的病症的方法包括将细胞暴露于超声波，以选择性地杀死或诱导细胞凋亡。细胞包括累积剂。

10. 发明申请

WO2012135616A1 VACCINATION AGAINST ADVANCED GLYCATION END-PRODUCTS 审中-公开
标题翻译：对高级糖果终产品进行疫苗接种
公开(公告)号：WO2012135616A1
公开(公告)日：2012-10-04
申请号：PCT/US2012/031446
申请日：2012-03-30
申请人： SIWA CORPORATION , GRUBER, Lewis
发明人： GRUBER, Lewis
IPC分类号： A61K39/00 , A61K39/38
CPC分类号： A61K39/0005 , A61K2039/55505
摘要： A vaccine composition, for immunizing a human patient, comprises an AGE antigen, an adjuvant, a preservative, and optionally an excipient. A method of immunizing a human patient against AGE-modified proteins comprises administering the vaccine composition, in an amount effective to cause immunization against AGE- modified proteins. Immunizing a human patient against AGE-modified proteins may be used to treat atherosclerosis.
摘要翻译：用于免疫人类患者的疫苗组合物包含AGE抗原，佐剂，防腐剂和任选的赋形剂。免疫人类患者抗AGE修饰的蛋白质的方法包括以有效引起针对AGE修饰的蛋白质免疫的量施用疫苗组合物。免疫人类患者抗AGE修饰的蛋白质可用于治疗动脉粥样硬化。

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