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    • 1. 发明申请
    • STORING LOG DATA EFFICIENTLY WHILE SUPPORTING QUERYING
    • 在支持查询时有效地存储日志数据
    • WO2010028279A1
    • 2010-03-11
    • PCT/US2009/056090
    • 2009-09-04
    • ARCSIGHT, INC.HUANG, WeiZHOU, YizhengYU, BinTANG, WentingBEEDGEN, Christian, F.
    • HUANG, WeiZHOU, YizhengYU, BinTANG, WentingBEEDGEN, Christian, F.
    • G06F7/00
    • H04L63/1425G06F11/3476G06F17/30595G06F21/552G06F2201/86G06F2221/034H04L63/1408
    • A logging system includes an event receiver and a storage manager. The receiver receives log data, processes it, and outputs a column-based data "chunk." The manager receives and stores chunks. The receiver includes buffers that store events and a metadata structure that stores metadata about the contents of the buffers. Each buffer is associated with a particular event field and includes values from that field from one or more events. The metadata includes, for each "field of interest," a minimum value and a maximum value that reflect the range of values of that field over all of the events in the buffers. A chunk is generated for each buffer and includes the metadata structure and a compressed version of the buffer contents. The metadata structure acts as a search index when querying event data. The logging system can be used in conjunction with a security information/event management (SIEM) system.
    • 记录系统包括事件接收器和存储管理器。 接收器接收日志数据,处理它,并输出基于列的数据“块”。 经理收到并存储块。 接收器包括存储事件的缓冲器和存储关于缓冲器的内容的元数据的元数据结构。 每个缓冲区与一个特定事件字段相关联,并包含一个或多个事件的该字段的值。 对于每个“感兴趣的领域”,元数据包括反映缓冲器中的所有事件的该字段的值的范围的最小值和最大值。 为每个缓冲区生成一个块,并包括元数据结构和缓冲区内容的压缩版本。 元数据结构在查询事件数据时用作搜索索引。 记录系统可以与安全信息/事件管理(SIEM)系统结合使用。
    • 10. 发明申请
    • METHODS AND COMPOSITIONS FOR DETERMINING VIRUS SUSCEPTIBILITY TO INTEGRASE INHIBITORS
    • 用于确定集成抑制剂病毒易感性的方法和组合物
    • WO2012116371A1
    • 2012-08-30
    • PCT/US2012/026794
    • 2012-02-27
    • LABORATORY CORPORATION OF AMERICA HOLDINGSHUANG, WeiPETROPOULOS, Christos John
    • HUANG, WeiPETROPOULOS, Christos John
    • C12Q1/70
    • C12Q1/703C12Q2600/106C12Q2600/156
    • Methods and compositions for the efficient and accurate determination of HIV susceptibility to an integrase inhibitor and/or HIV replication capacity are provided. In certain aspects, the methods involve detecting in a biological sample a nucleic acid encoding an HIV integrase that comprises a primary mutation at codon 143, wherein the mutation at codon 143 does not encode arginine (R) or cysteine (C), and wherein the presence of the integrase-encoding nucleic acid in the biological sample indicates that the HIV has a decreased susceptibility to an integrase inhibitor or altered replication capacity relative to a reference HIV. In certain embodiments, the HIV also contains one or more secondary mutations in integrase. Also provided are methods for determining the selective advantage of a mutation or mutation profile based on the difficulty to create the mutation, and its effect on susceptibility to an integrase inhibitor or replication capacity.
    • 提供了有效和准确地确定对整合酶抑制剂和/或HIV复制能力的HIV敏感性的方法和组合物。 在某些方面,所述方法包括在生物样品中检测编码HIV整合酶的核酸,所述核酸编码包含143位密码子的初级突变,其中143位密码子的突变不编码精氨酸(R)或半胱氨酸(C),其中 生物样品中整合酶编码核酸的存在表明HIV相对于参考HIV具有降低的对整合酶抑制剂的易感性或改变的复制能力。 在某些实施方案中,HIV还含有整合酶中的一个或多个次要突变。 还提供了基于产生突变的难度确定突变或突变特征的选择性优势的方法及其对整合酶抑制剂或复制能力的易感性的影响。