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1. 发明申请

WO2012018767A2 ANTIBODIES DIRECTED AGAINST IL-17 审中-公开
标题翻译：针对IL-17的抗体
公开(公告)号：WO2012018767A2
公开(公告)日：2012-02-09
申请号：PCT/US2011046201
申请日：2011-08-02
申请人： ANAPTYSBIO INC , HORLICK ROBERT , KING DAVID , BOWERS PETER , DALTON JENNIFER , WU BETTY , ROBERTS TRACI , ZHANG XUE , ALTOBELL III LAURENCE
发明人： HORLICK ROBERT , KING DAVID , BOWERS PETER , DALTON JENNIFER , WU BETTY , ROBERTS TRACI , ZHANG XUE , ALTOBELL III LAURENCE
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要： The invention relates to an isolated IL-17-binding agent which comprises an immunoglobulin heavy chain polypeptide comprising SEQ ID NO: 1 and optionally an immunoglobulin light chain polypeptide comprising SEQ ID NO: 23, except that one or more specific of residues of SEQ ID NO: 1 and SEQ ID NO: 23 are replaced with a different residue. The invention also provides vectors, compositions, and methods of using the IL-17-binding agent to treat an IL-17-mediated disease.
摘要翻译：本发明涉及分离的IL-17结合剂，其包含包含SEQ ID NO：1的免疫球蛋白重链多肽和任选的包含SEQ ID NO：23的免疫球蛋白轻链多肽，不同之处在于SEQ ID NO：1的一个或多个特异性残基 NO：1和SEQ ID NO：23被不同的残基取代。本发明还提供了使用IL-17结合剂治疗IL-17介导的疾病的载体，组合物和方法。

2. 发明申请

WO2005108620A3 PROCESSING POLYNUCLEOTIDE-CONTAINING SAMPLES 审中-公开
标题翻译：加工含多核苷酸的样品
公开(公告)号：WO2005108620A3
公开(公告)日：2006-04-13
申请号：PCT/US2005015345
申请日：2005-05-03
申请人： HANDYLAB INC , WU BETTY , ALTHAUS JOHN S , BRAHMASANDRA SUNDARESH N , HANDIQUE KALYAN , PHADKE NIKHIL
发明人： WU BETTY , ALTHAUS JOHN S , BRAHMASANDRA SUNDARESH N , HANDIQUE KALYAN , PHADKE NIKHIL
IPC分类号： B01F5/06 , B01F13/00 , B01L3/00 , B01L3/14 , B01L7/00 , C12N15/10 , C12Q1/68 , F16K99/00 , C12M1/34 , C12P19/34
CPC分类号： C12Q1/686 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/5082 , B01L3/565 , B01L7/52 , B01L2200/10 , B01L2200/16 , B01L2300/0672 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0442 , B01L2400/0677 , B01L2400/0683 , B01L2400/0694 , C12N15/1006 , C12Q1/6806 , F16K99/0001 , F16K99/0019 , F16K99/0032 , F16K99/0036 , F16K99/0044 , F16K2099/0084 , C12Q2565/629
摘要： Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that regain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.
摘要翻译：公开了用于处理多核苷酸（例如DNA）的方法和系统。处理区域包括用在第一组条件（例如温度和pH）下重新获得多核苷酸的配体修饰的一个或多个表面（例如，颗粒表面），并在第二组条件（例如较高的温度和/ 或更多的碱性pH）。处理区域可用于例如浓缩样品的多核苷酸和/或来自多核苷酸的分离的扩增反应抑制剂。公开了具有处理区域的微流体装置。

3. 发明申请

WO2007112114A2 INTEGRATED SYSTEM FOR PROCESSING MICROFLUIDIC SAMPLES, AND METHOD OF USING SAME 审中-公开
标题翻译：用于处理微流体样品的集成系统及其使用方法
公开(公告)号：WO2007112114A2
公开(公告)日：2007-10-04
申请号：PCT/US2007007513
申请日：2007-03-26
申请人： HANDYLAB INC , HANDIQUE KALYAN , BRAHMASANDRA SUNDARESH N , GANESAN KARTHIK , WU BETTY , PHADKE NIKHIL , PARUNAK GENE , WILLIAMS JEFF
发明人： HANDIQUE KALYAN , BRAHMASANDRA SUNDARESH N , GANESAN KARTHIK , WU BETTY , PHADKE NIKHIL , PARUNAK GENE , WILLIAMS JEFF
IPC分类号： C12M3/00
CPC分类号： B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2200/147 , B01L2200/148 , B01L2200/16 , B01L2300/021 , B01L2300/06 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/18 , B01L2300/1827 , B01L2300/1861 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B01L2400/0611 , B01L2400/0677 , B01L2400/0683 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N2035/00881
摘要： This patent application describes an integrated apparatus for processing polynucleotide-containing samples, and for providing a diagnostic result thereon. The apparatus is configured to receive a microfluidic cartridge that contains reagents and a network for processing a sample. Also described are methods of using the apparatus.
摘要翻译：该专利申请描述了用于处理含有多核苷酸的样品并用于在其上提供诊断结果的集成设备。该装置被配置为接收包含用于处理样品的试剂和网络的微流控盒。还描述了使用该装置的方法。

4. 发明申请

WO2005011867A3 PROCESSING PARTICLE-CONTAINING SAMPLES 审中-公开
标题翻译：处理含颗粒样品
公开(公告)号：WO2005011867A3
公开(公告)日：2005-04-21
申请号：PCT/US2004025181
申请日：2004-08-02
申请人： HANDYLAB INC , WU BETTY , HANDIQUE KALYAN , PARUNAK GENE , KEHRER AARON , GANESAN KARTHIK
发明人： WU BETTY , HANDIQUE KALYAN , PARUNAK GENE , KEHRER AARON , GANESAN KARTHIK
IPC分类号： B01L3/00 , B01L99/00 , B81B1/00
CPC分类号： C12Q1/6806 , B01L3/502707 , B01L3/502738 , B01L3/502753 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0677 , B33Y40/00 , B33Y80/00 , C12Q2523/109 , G01N1/40 , Y10T436/25 , Y10T436/25375
摘要： A microfluidic device includes an input port for inputting a particle-containing liquidic samples into the device, a retention member, and a pressure actuator. The retention member is in communication with the input port and is configured to spatially separate particles of the particle-containing liquidic sample from a first portion of the liquid of the particle containing fluidic sample. The pressure actuator recombines at least some of the separated particles with a subset of the first portion of the liquid separated from the particles. The device can also include a lysing chamber that receives the particles and liquid from the retention member. The lysing chamber thermally lyses the particles to release contents thereof.
摘要翻译：微流体装置包括用于将含颗粒液体样品输入装置的输入口，保持构件和压力致动器。保持构件与输入端口连通并且构造成将含颗粒液体样本的颗粒与含有流体样本的颗粒的液体的第一部分在空间上分离。压力致动器将至少一些分离的颗粒与从颗粒分离的液体的第一部分的子集重新结合。该装置还可以包括从保留部件接收颗粒和液体的裂解室。裂解室热溶解颗粒以释放其内容物。

5. 发明申请

WO2011081869A3 METHOD AND MATERIALS FOR SEPARATING NUCLEIC ACID MATERIALS 审中-公开
标题翻译：分离核酸材料的方法和材料
公开(公告)号：WO2011081869A3
公开(公告)日：2011-10-13
申请号：PCT/US2010060025
申请日：2010-12-13
申请人： WU BETTY
发明人： WU BETTY
IPC分类号： C12Q1/68 , C12N15/10 , C12S3/20
CPC分类号： C08L79/02 , C08G73/0206 , C12N15/1006
摘要： Nucleic acid material can be effectively separated from a fluid by first contacting the fluid with a positively charged polymer which binds the nucleic acid material. Thereafter, the polymer, having the nucleic acid material bonded thereto, is contacted with a releasing agent which comprises a solution of an alkaline material and a glycol. The solution has a pH of no more than 12 and operates to release the nucleic acid material from the polymer under relatively low temperature conditions, typically no more than 5O0C, and in particular instances, no more than 4O0C. The glycol material may comprise a monomeric glycol such as ethylene glycol, propylene glycol, or the like, or it may comprise a polymeric glycol such as polyethylene glycol. Also disclosed is a novel positively charged polymer which may be employed in the separation process. This polymer comprises an acidified polyamine, such as polyethyleneimine which has been reacted with a nonacidified polyethyleneimine in a coupling reaction. The acidified polyethyleneimine may be a coarboxylated and/or sulfonated polyethyleneimine.
摘要翻译：首先使流体与结合核酸材料的带正电荷的聚合物接触，使核酸材料与流体有效分离。然后，将与其结合的核酸材料的聚合物与包含碱性物质和二醇的溶液的脱模剂接触。该溶液具有不超过12的pH，并且用于在相对低的温度条件（通常不超过50℃），特别是不超过40℃的温度条件下从聚合物中释放核酸材料。乙二醇物质可以包含单体二醇如乙二醇，丙二醇等，或者它可以包含聚乙二醇如聚乙二醇。还公开了可用于分离过程中的新型带正电聚合物。该聚合物包含酸化的多胺，例如在偶联反应中已与未酸化的聚乙烯亚胺反应的聚乙烯亚胺。酸化的聚乙烯亚胺可以是共羧化和/或磺化聚乙烯亚胺。

6. 发明申请

WO2007044917A3 POLYNUCLEOTIDE SAMPLE PREPARATION DEVICE 审中-公开
标题翻译：多核苷酸样品制备装置
公开(公告)号：WO2007044917A3
公开(公告)日：2007-07-26
申请号：PCT/US2006040171
申请日：2006-10-11
申请人： HANDYLAB INC , HANDIQUE KALYAN , WILLIAMS JEFF , BRAHMASANDRA SUNDARESH N , PHADKE NIKHIL , WU BETTY
发明人： HANDIQUE KALYAN , WILLIAMS JEFF , BRAHMASANDRA SUNDARESH N , PHADKE NIKHIL , WU BETTY
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： B01L3/502715 , B01L3/5025 , B01L3/5027 , B01L3/502738 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2200/147 , B01L2300/0636 , B01L2300/0681 , B01L2300/0809 , B01L2300/0867 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2400/0487 , B01L2400/0677 , F16K99/0001 , F16K99/0019 , F16K99/0032 , F16K99/0034 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N1/34 , G01N2035/00158
摘要： Methods and systems for preparing polynucleotide samples are disclosed. The invention includes a microfluidic system for converting a sample containing one or more polynucleotides into a form suitable for analyzing the polynucleotides, comprising: a cartridge receiving element, an insertable and removable cartridge, a heating element configured to heat one or more regions of the cartridge, and control circuitry, wherein the insertable cartridge comprises: a microfluidic component that is configured to accept the sample and one or more reagents, and to react the sample and the reagents, in order to produce a prepared sample suitable for analyzing the one or more polynucleotides. The invention further comprises a multi-sample cartridge for converting a number of samples, each containing one or more polynucleotides, into respective forms suitable for analyzing the polynucleotides, comprising: at least a first microfluidic component and a second microfluidic component.
摘要翻译：公开了制备多核苷酸样品的方法和系统。本发明包括用于将含有一种或多种多核苷酸的样品转化成适于分析多核苷酸的形式的微流体系统，包括：盒接收元件，可插入和可移除的盒，加热元件，其配置成加热盒的一个或多个区域以及控制电路，其中所述可插入筒包括：微流体组分，其被配置为接受所述样品和一种或多种试剂，并使所述样品和所述试剂反应，以便产生适于分析所述一种或多种多核苷酸。本发明还包括用于将多个样品（各自含有一个或多个多核苷酸）转化成适于分析多核苷酸的各自形式的多样品盒，包括：至少第一微流体组分和第二微流体组分。

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