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1. 发明申请

WO2010064150A2 SYSTEMS AND METHODS FOR DETERMING INTRAOCULAR LENS POWER 审中-公开
标题翻译：确定眼内镜片能量的系统和方法
公开(公告)号：WO2010064150A2
公开(公告)日：2010-06-10
申请号：PCT/IB2009/008074
申请日：2009-04-06
申请人： AMO REGIONAL HOLDINGS , NORRBY, Sverker , BERGMAN, Rolf
发明人： NORRBY, Sverker , BERGMAN, Rolf
IPC分类号： A61F2/16 , A61B3/10
CPC分类号： A61F2/1613 , A61B3/0025 , A61B3/103 , A61B3/107
摘要： A system for providing an intraocular lens includes a processor and a computer readable memory. The computer readable memory is configured to communicate with the processor, the memory having stored therein at least one of: one or more ocular dimensions, and at least one predetermined refractive outcome. The memory further includes a sequence of instructions which, when executed by the processor, cause the processor to select an intraocular lens, select a power of an intraocular lens, or provide an intraocular lens. The sequence of instructions includes determining one or more dimensions of an eye. The instructions also include calculating, based on a mathematical relationship, a distance from an apex of a cornea of the eye to an apex or plane of the intraocular lens after insertion into the eye. The instructions further calculating an optical power of the intraocular lens suitable for providing a predetermined refractive outcome. The mathematical relationship includes an axial length of the eye, an anterior chamber depth of the natural crystalline lens, and a corneal radius of the eye, but is independent of a thickness of the natural crystalline lens.
摘要翻译：用于提供人工晶状体的系统包括处理器和计算机可读存储器。计算机可读存储器被配置为与处理器通信，存储器中存储有以下中的至少一个：一个或多个眼部尺寸以及至少一个预定的屈光结果。存储器还包括一系列指令，所述指令序列在由处理器执行时使处理器选择眼内透镜，选择眼内透镜的光焦度或提供眼内透镜。指令序列包括确定眼睛的一个或多个维度。该说明书还包括基于数学关系计算在插入眼中之后从眼角膜的顶点到眼内晶状体的顶点或平面的距离。该指令进一步计算适合于提供预定屈光结果的眼内透镜的光焦度。数学关系包括眼睛的轴向长度，自然晶状体的前房深度和眼睛的角膜半径，但与天然晶状体的厚度无关。

2. 发明申请

WO2003096875A3 KIT AND METHOD IN EYE SURGERY 审中-公开
公开(公告)号：WO2003096875A3
公开(公告)日：2003-11-27
申请号：PCT/SE2003/000794
申请日：2003-05-16
申请人： PHARMACIA GRONINGEN BV , NORRBY, Sverker , BERGMAN, Rolf , HILLBORN, Jöns
发明人： NORRBY, Sverker , BERGMAN, Rolf , HILLBORN, Jöns
IPC分类号： A61L27/24
摘要： A kit is provided, which comprises a) a collagen patch and b) an adhesive composition comprising (i) fibrin, fibrinogen or a combination thereof, and (ii) a biocompatible polymer capable of forming a viscous aqueous solution. Also provided is use of the kit for the preparation of a sealing device for use in ophthalmic surgery to replace a natural lens which has been removed, in which sealing device the collagen patch of the kit is adapted to seal an opening in a capsular bag of an eye while admitting the entrance of an injection device through the opening for injection of a lens-forming material into the capsule; and in which sealing device the adhesive composition of the kit is adapted to be applied to the collagen patch so as to enable adhesion of the collagen patch to the capsular bag. Also provided are methods for sealing an opening in a capsular bag of an eye, in which methods the kit is employed.

3. 发明申请

WO2003096875A2 KIT AND METHOD IN EYE SURGERY 审中-公开
标题翻译：眼科手术中的包装和方法
公开(公告)号：WO2003096875A2
公开(公告)日：2003-11-27
申请号：PCT/SE2003/000794
申请日：2003-05-16
申请人： PHARMACIA GRONINGEN BV , NORRBY, Sverker , BERGMAN, Rolf , HILLBORN, Jöns
发明人： NORRBY, Sverker , BERGMAN, Rolf , HILLBORN, Jöns
IPC分类号： A61B
CPC分类号： A61F2/1616 , A61F9/00736 , A61L31/044 , A61L31/046 , C09J189/00
摘要： A kit is provided, which comprises a) a collagen patch and b) an adhesive composition comprising (i) fibrin, fibrinogen or a combination thereof, and (ii) a biocompatible polymer capable of forming a viscous aqueous solution. Also provided is use of the kit for the preparation of a sealing device for use in ophthalmic surgery to replace a natural lens which has been removed, in which sealing device the collagen patch of the kit is adapted to seal an opening in a capsular bag of an eye while admitting the entrance of an injection device through the opening for injection of a lens-forming material into the capsule; and in which sealing device the adhesive composition of the kit is adapted to be applied to the collagen patch so as to enable adhesion of the collagen patch to the capsular bag. Also provided are methods for sealing an opening in a capsular bag of an eye, in which methods the kit is employed.
摘要翻译：提供了一种试剂盒，其包括a）胶原蛋白片和b）包含（i）纤维蛋白，纤维蛋白原或其组合的粘合剂组合物，和（ii）能够形成粘性水溶液的生物相容性聚合物。还提供了该套件的用途，用于制备用于眼科手术中的密封装置，以取代已经去除的天然晶状体，其中，所述套件的胶原贴片适合于密封胶囊袋中的开口的密封装置眼睛同时通过用于将透镜形成材料注射到胶囊中的开口进入注射装置; 并且其中将所述试剂盒的粘合剂组合物适用于所述胶原蛋白贴片的密封装置，以便能够将所述胶原蛋白贴片粘附到所述胶囊袋上。还提供了用于密封眼睛囊袋中的开口的方法，其中采用该试剂盒的方法。

4. 发明申请

WO2006034383A1 VISCOELASTIC SOLUTION OR GEL FORMULATION, AND METHODS OF TREATING A BODY SITE WITH THE SAME 审中-公开
标题翻译：粘弹性溶液或凝胶配方，以及与其相同处理体系的方法
公开(公告)号：WO2006034383A1
公开(公告)日：2006-03-30
申请号：PCT/US2005/033932
申请日：2005-09-21
申请人： ADVANCED MEDICAL OPTICS, INC. , TERWEE, Thom , NORRBY, Sverker , SHIMIZU, Robert , BERGMAN, Rolf
发明人： TERWEE, Thom , NORRBY, Sverker , SHIMIZU, Robert , BERGMAN, Rolf
IPC分类号： A61K9/08
CPC分类号： A61K9/0048
摘要： The invention relates to method of preparing a viscoelastic therapeutic liquid comprising a viscoelastic agent and a homogenously distributed therapeutically active agent, wherein the therapeutically active agent is distributed throughout the viscoelastic compound when the viscoelastic compound is in dry form. In one embodiment of the invention, the viscoelastic compound in dry form is mixed with an aqueous solution of the therapeutically active agent. The invention further relates to utilities of homogenous viscoelastic compositions in therapeutic applications including ophthalmic surgery.
摘要翻译：本发明涉及制备包含粘弹性剂和均匀分布的治疗活性剂的粘弹性治疗液的方法，其中当粘弹性化合物为干燥形式时，治疗活性剂分布在整个粘弹性化合物中。在本发明的一个实施方案中，将干燥形式的粘弹性化合物与治疗活性剂的水溶液混合。本发明还涉及均匀粘弹性组合物在治疗应用中的用途，包括眼科手术。

5. 发明申请

WO2006067638A2 AMPHIPHILIC BLOCK COPOLYMERS AND THEIR USE 审中-公开
标题翻译：丙烯酸嵌段共聚物及其用途
公开(公告)号：WO2006067638A2
公开(公告)日：2006-06-29
申请号：PCT/IB2005/004116
申请日：2005-12-20
申请人： AMO GRONINGEN B.V. , LIU, Yan , HILBORN, Jons, Gunnar , HAITJEMA, Hendrick, Jan , NORRBY, Sverker , TERWEE, Thom
发明人： LIU, Yan , HILBORN, Jons, Gunnar , HAITJEMA, Hendrick, Jan , NORRBY, Sverker , TERWEE, Thom
CPC分类号： C08G18/61 , A61L24/046 , A61L27/34 , C08G18/72 , C08G71/04 , C08G77/452 , C08G77/458 , C08G77/46 , C09J183/12 , G02B1/043 , C08L83/04
摘要： The present invention relates to amphiphilic block copolymers comprising at least one block of hydrophilic units and at least one block of hydrophobic units, wherein at least one hydrophobic block contains siloxane units. The present invention may be particularly useful as a tissue adhesive or as a coating for an intraocular lens (IOL). As an IOL coating, copolymers according to the invention may be used, for example, to promote tissue adhesion for the prevention of posterior capsule opacification.
摘要翻译：本发明涉及包含至少一个亲水单元嵌段和至少一个疏水单元嵌段的两亲嵌段共聚物，其中至少一个疏水嵌段含有硅氧烷单元。本发明可以特别用作组织粘合剂或用作眼内透镜（IOL）的涂层。作为IOL涂层，根据本发明的共聚物可用于例如促进组织粘连以防止后囊混浊。

6. 发明申请

WO2014140812A2 MICRO-INCISION IOL AND POSITIONING OF THE IOL IN THE EYE 审中-公开
标题翻译：微血管内窥镜和眼睛中IOL的定位
公开(公告)号：WO2014140812A2
公开(公告)日：2014-09-18
申请号：PCT/IB2014/000831
申请日：2014-03-04
申请人： AMO GRONINGEN B.V. , WEEBER, Hendrik, A. , NORRBY, Sverker , VAN DER MOOREN, Marrie, H. , FRANSSEN, Luuk
发明人： WEEBER, Hendrik, A. , NORRBY, Sverker , VAN DER MOOREN, Marrie, H. , FRANSSEN, Luuk
CPC分类号： A61F2/1656 , A61F2/161 , A61F2/1648 , A61F2/1654 , A61F9/007 , A61F2002/1681 , A61F2002/16905 , A61F2220/0016
摘要： An intraocular lens that is capable of being inserted through a micro-incision includes an optic having an anterior and a posterior surface and a plurality of projections extending from the anterior and posterior surfaces. The anterior and posterior surfaces include a recess. The optic is implanted such that a rim of the capsulorhexis is disposed in the recess such that the plurality of projections grip the capsular bag.
摘要翻译：能够通过微切口插入的眼内透镜包括具有前表面和后表面的光学元件和从前表面和后表面延伸的多个突起。前表面和后表面包括凹部。植入光学元件使得将撕囊的边缘设置在凹部中，使得多个突起夹持囊袋。

7. 发明申请

WO2007127873A2 ENHANCEMENT OF LENS REGENERATION USING MATERIALS COMPRISING POLYSILOXANE POLYMERS 审中-公开
标题翻译：使用含有聚硅氧烷聚合物的材料增强透镜再生
公开(公告)号：WO2007127873A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/067551
申请日：2007-04-26
申请人： ADVANCED MEDICAL OPTICS, INC. , GWON, Arlene , NORRBY, Sverker , TERWEE, Thomas , KOOPMANS, Steven
发明人： GWON, Arlene , NORRBY, Sverker , TERWEE, Thomas , KOOPMANS, Steven
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61L27/18 , A61L2430/16 , C08L83/04
摘要： The present invention addresses the treatment of ocular conditions by the enhancement of lens regeneration. Enhancement of lens regeneration is accomplished by the administration of a composition comprising a polysiloxane polymer having functional acryl groups useful in the preparation of intraocular lenses (10Ls).
摘要翻译：本发明致力于通过增强晶状体再生来治疗眼部疾病。透镜再生的增强通过施用包含用于制备眼内透镜（10Ls）的具有功能性丙烯酰基的聚硅氧烷聚合物的组合物来实现。

8. 发明申请

WO2006053216A2 DEVICES AND METHODS FOR SELECTING INTRAOCULAR LENSES 审中-公开
标题翻译：用于选择眼内镜片的装置和方法
公开(公告)号：WO2006053216A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040930
申请日：2005-11-11
申请人： ADVANCED MEDICAL OPTICS, INC. , NORRBY, Sverker
发明人： NORRBY, Sverker
IPC分类号： A61F20060101 , A61F2/16
CPC分类号： A61F2/1613 , A61B3/0025 , A61F2240/002
摘要： The invention relates to devices and methods for selecting IOLs for implantation and eye models useful with the methods. One method comprises the steps of determining the axial eye length, the pupil size at a desired light level; the desired postoperative refraction; determining an aspheric representation of the corneal curvature and determining the location of the plane of fixation of the IOL following implantation.
摘要翻译：本发明涉及用于选择用于植入的IOL和用于该方法的眼模型的装置和方法。一种方法包括以下步骤：确定轴向眼睛长度，在期望的光水平下的瞳孔尺寸; 所需的术后折射; 确定角膜曲率的非球面表示并确定植入后IOL的固定平面的位置。

9. 发明申请

WO2004049979A1 MULTIFOCAL OPHTHALMIC LENS 审中-公开
标题翻译：多功能眼镜
公开(公告)号：WO2004049979A1
公开(公告)日：2004-06-17
申请号：PCT/EP2003/013683
申请日：2003-11-27
申请人： PHARMACIA GRONINGEN BV , PIERS, Patricia, Ann , WEEBER, Hendrik, Albert , NORRBY, Sverker
发明人： PIERS, Patricia, Ann , WEEBER, Hendrik, Albert , NORRBY, Sverker
IPC分类号： A61F2/16
CPC分类号： A61F2/1618 , A61B3/0025 , A61F2/1613 , A61F2/1637 , A61F2/164 , A61F2/1654 , A61F2002/1696 , A61F2240/002 , G01J9/00 , G02C7/027 , G02C7/028 , G02C7/041 , G02C7/06 , G02C2202/20 , G02C2202/22
摘要： A method of designing a multifocal ophthalmic lens with one base focus and at least one additional focus, capable of reducing aberrations of the eye for at least one of the foci after its implantation, comprising the steps of: (i) characterizing at least one corneal surface as a mathematical model; (ii) calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model; (iii) modelling the multifocal ophthalmic lens such that a wavefront arriving from an optical system comprising said lens and said at least one corneal surface obtains reduced aberrations for at least one of the foci. There is also disclosed a method of selecting a multifocal intraocular lens, a method of designing a multifocal ophthalmic lens based on corneal data from a group of patients, and a multifocal ophthalmic lens.
摘要翻译：一种设计具有一个基底焦点和至少一个附加焦点的多焦点眼科镜片的方法，其能够在其植入之后减少至少一个焦点的眼睛的像差，包括以下步骤：（i）表征至少一个角膜表面作为数学模型; （ii）通过使用所述数学模型来计算所得到的所述角膜表面的像差; （iii）对多焦点眼科镜片进行建模，使得从包括所述透镜和所述至少一个角膜表面的光学系统到达的波前获得至少一个焦点的减少的像差。还公开了一种选择多焦点眼内透镜的方法，基于来自一组患者的角膜数据设计多焦点眼科镜片的方法和多焦点眼科镜片。

10. 发明申请

WO2004030653A1 COMPOSITIONS FOR PREVENTING POSTERIOR CAPSULAR OPACIFICATION AND THE USE THEREOF 审中-公开
标题翻译：用于预防前列腺囊肿的组合物及其用途
公开(公告)号：WO2004030653A1
公开(公告)日：2004-04-15
申请号：PCT/SE2003/001504
申请日：2003-09-29
申请人： PHARMACIA GRONINGEN BV , NORRBY, Sverker
发明人： NORRBY, Sverker
IPC分类号： A61K9/08
CPC分类号： A61K31/00 , A61K9/0048 , A61L27/54 , A61L2300/252 , A61L2300/258 , A61L2300/416 , A61L2300/432
摘要： The present invention relates to a composition comprising a sterile ophthalmic composition, which comprises one or more agents capable of inhibiting lens epithelial proliferation (e.g. fluorouracil, saporin, mitomycin or doxorubicin), dissolved in a physiologically isotonic solution. The present invention also relates to a method of preventing capsular opacification by using said composition. The method comprises the steps of : creating an incision within an eye and a capsulorhexis in a capsular bag of said eye; inserting at least a portion of cannula in said capsulorhexis; separating the natural crystalline lens from the capsular bag by injecting through a cannula the composition in a manner that generates a space between the capsular bag and the natural crystalline lens; retaining the composition in said space between the capsule and the natural crystalline lens for a sufficient time for said composition to effectively kill or render non-proliferative lens epithelial cells in or adjacent to said space; removing the lens and said composition; inserting an implant into the capsular bag.
摘要翻译：本发明涉及包含无菌眼用组合物的组合物，其包含一种或多种溶解于生理学等渗溶液中的能够抑制晶状体上皮增生的试剂（例如氟尿嘧啶，皂体蛋白，丝裂霉素或多柔比星）。本发明还涉及通过使用所述组合物来防止荚膜混浊的方法。该方法包括以下步骤：在眼睛的囊袋内产生眼内的切口和撕囊; 将插管的至少一部分插入所述撕囊术中; 通过套管注射组合物以在囊袋和天然晶状体之间产生空间的方式将天然晶状体与囊袋分开; 将组合物保持在胶囊和天然晶状体之间的所述空间中足够的时间，以使所述组合物在所述空间中或附近有效地杀死或使非增殖性晶状体上皮细胞发生; 去除镜片和所述组合物; 将植入物插入囊袋中。

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