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1. 发明申请

WO2010148142A1 CHIMERIC FGF19 POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译： CHIMERIC FGF19多肽及其用途
公开(公告)号：WO2010148142A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/038894
申请日：2010-06-16
申请人： AMGEN INC. , LI, Yang , WU, Xinle , WANG, Zhulun
发明人： LI, Yang , WU, Xinle , WANG, Zhulun
IPC分类号： C07K14/50
CPC分类号： C07K14/50 , C07K16/22 , C07K2319/00
摘要： The disclosure provides nucleic acid molecules encoding chimeric polypeptides, chimeric polypeptides, pharmaceutical compositions comprising chimeric polypeptides, and methods for treating metabolic disorders such as diabetes and obesity using such nucleic acids, polypeptides, or pharmaceutical compositions.
摘要翻译：本公开内容提供了编码嵌合多肽的核酸分子，嵌合多肽，包含嵌合多肽的药物组合物，以及使用这种核酸，多肽或药物组合物治疗代谢性疾病如糖尿病和肥胖症的方法。

2. 发明申请

WO2012174534A2 METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING CLEC-2 审中-公开
标题翻译：使用CLEC-2治疗或改善代谢障碍的方法
公开(公告)号：WO2012174534A2
公开(公告)日：2012-12-20
申请号：PCT/US2012/042960
申请日：2012-06-18
申请人： AMGEN INC. , WU, Xinle , LI, Yang
发明人： WU, Xinle , LI, Yang
IPC分类号： C07K14/435
CPC分类号： C07K14/7056 , A61K38/178 , A61K2039/505 , C07K16/2851 , C07K2319/30
摘要： Methods of treating metabolic diseases and disorders using a Clec-2 extracellular domain are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, elevated glucose levels, elevated insulin levels and elevated triglyceride levels.
摘要翻译：提供了使用Clec-2细胞外结构域治疗代谢疾病和病症的方法。在各种实施方案中，代谢疾病或病症是2型糖尿病，葡萄糖水平升高，胰岛素水平升高和甘油三酯升高。

3. 发明申请

WO2012154263A1 METHOD OF IDENTIFYING COMPOUNDS THAT SPECIFICALLY MODULATE THE INTERACTION OF FGFR1 AND BETA-KLOTHO 审中-公开
标题翻译：鉴定化合物的方法，其特异性地调节FGFR1和BETA-KLOTHO的相互作用
公开(公告)号：WO2012154263A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/025815
申请日：2012-02-20
申请人： AMGEN INC. , LI, Yang , WU, Xinle , GE, Hongfei , BARIBAULT, Helene , LEMON, Bryan , SHENG, Jackie Zeqi , VONDERFECHT, Steven , WEISZMANN, Jennifer Veronica , GARDNER, Jonitha , LEE, Ki Jeong
发明人： LI, Yang , WU, Xinle , GE, Hongfei , BARIBAULT, Helene , LEMON, Bryan , SHENG, Jackie Zeqi , VONDERFECHT, Steven , WEISZMANN, Jennifer Veronica , GARDNER, Jonitha , LEE, Ki Jeong
IPC分类号： G01N33/566 , G01N33/74 , G01N33/50
CPC分类号： G01N33/74 , G01N33/5041 , G01N33/5044 , G01N33/5067 , G01N2333/50 , G01N2500/02
摘要： Methods of identifying compounds that specifically modulate the interaction of FGFR1 and β-Klotho are disclosed. Identified compounds can be useful in treating metabolic diseases and disorders that involve the interaction of FGFR1 and β-Klotho. In various embodiments the metabolic disease or disorder is diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
摘要翻译：公开了鉴定特异性调节FGFR1和ß-Klotho相互作用的化合物的方法。鉴定的化合物可用于治疗涉及FGFR1和ß-Klotho相互作用的代谢疾病和病症。在各种实施方案中，代谢疾病或病症是糖尿病，肥胖症，血脂异常，升高的葡萄糖水平，升高的胰岛素水平和糖尿病肾病。

4. 发明申请

WO2011130417A2 HUMAN FGF RECEPTOR AND β-KLOTHO BINDING PROTEINS 审中-公开
标题翻译：人FGF受体和ß-KLOTHO结合蛋白
公开(公告)号：WO2011130417A2
公开(公告)日：2011-10-20
申请号：PCT/US2011/032333
申请日：2011-04-13
申请人： AMGEN INC. , FACHINI, Roger , FOLTZ, Ian , HAN, Seog Joon , HARRIS, Susie Miki , HU, Shaw-Fen Sylvia , KING, Chadwick Terence , LI, Yang , LU, Ji , MICHAELS, Mark Leo , SUN, Jeonghoon
发明人： FACHINI, Roger , FOLTZ, Ian , HAN, Seog Joon , HARRIS, Susie Miki , HU, Shaw-Fen Sylvia , KING, Chadwick Terence , LI, Yang , LU, Ji , MICHAELS, Mark Leo , SUN, Jeonghoon
IPC分类号： C07K16/28
CPC分类号： A61K39/3955 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/32 , C07K2317/75 , C07K2317/92 , C07K2319/75
摘要： The present invention provides compositions and methods relating to or derived from antigen binding proteins and antigen binding protein-FGF21 fusions that specifically bind to β-Klotho, or β-Klotho and one or more of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins and antigen binding protein-FGF21 fusions induce FGF21-like signaling. In some embodiments, an antigen binding protein or antigen binding protein-FGF21 fusion antigen binding component is a fully human, humanized, or chimeric antibody, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to β-Klotho, or β-Klotho and one or more of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins and antigen binding protein-FGF21 fusions, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins and antigen binding protein-FGF21 fusions, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins and antigen binding protein-FGF21 fusions, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.
摘要翻译：本发明提供与抗原结合蛋白和特异性结合ß-Klotho或ß-Klotho以及FGFR1c，FGFR2c，FGFR3c和FGFR4中的一种或多种的抗原结合蛋白和抗原结合蛋白-FGF21融合物相关或衍生的组合物和方法。在一些实施方案中，抗原结合蛋白和抗原结合蛋白FGF21融合物诱导FGF21样信号传导。在一些实施方案中，抗原结合蛋白或抗原结合蛋白-FGF21融合抗原结合组分是完全人，人源化或嵌合抗体，这种抗体的结合片段和衍生物，以及特异性结合ß-Klotho或ß- Klotho和FGFR1c，FGFR2c，FGFR3c和FGFR4中的一种或多种。其他实施方案提供编码这种抗原结合蛋白和抗原结合蛋白-FGF21融合体的核酸，及其片段和衍生物，以及多肽，包含这种多核苷酸的细胞，制备这种抗原结合蛋白的方法和抗原结合蛋白-FGF21融合物，其衍生物和多肽，以及使用这种抗原结合蛋白和抗原结合蛋白-FGF21融合体，其片段和衍生物和多肽的方法，包括治疗或诊断患有2型糖尿病，肥胖症，NASH，代谢综合征和相关疾病或病症。

5. 发明申请

WO2011071783A1 HUMAN ANTIGEN BINDING PROTEINS THAT BIND BETA-KLOTHO, FGF RECEPTORS AND COMPLEXES THEREOF 审中-公开
标题翻译：人类抗原结合蛋白，其结合BETA-KLOTHO，FGF受体及其复合物
公开(公告)号：WO2011071783A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/058984
申请日：2010-12-03
申请人： AMGEN INC. , HU, Shaw-Fen, Sylvia , FOLTZ, Ian , KING, Chadwick Terence , LI, Yang , ARORA, Taruna
发明人： HU, Shaw-Fen, Sylvia , FOLTZ, Ian , KING, Chadwick Terence , LI, Yang , ARORA, Taruna
IPC分类号： C07K16/28 , C07K16/18 , A61K39/395 , A61P3/04 , C07K19/00 , C07K14/71
CPC分类号： C07K16/2863 , A61K2039/505 , C07K14/71 , C07K16/18 , C07K16/28 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/75 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides compositions and methods relating to or derived from antigen binding proteins activate FGF21 -mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) β -Klotho; (ii) FGFRIc, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β -Klotho and one of FGFRIc, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, the antigen binding proteins are fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to (i) β -Klotho; (ii) FGFRIc, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β -Klotho and one of FGFRIc, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.
摘要翻译：本公开提供了与抗原结合蛋白相关或衍生自组合物和方法激活FGF21介导的信号传导。在实施方案中，抗原结合蛋白特异性结合（i）β-Klotho; （ii）FGFRIc，FGFR2c，FGFR3c或FGFR4; 或（iii）包含β-Klotho和FGFRIc，FGFR2c，FGFR3c和FGFR4之一的复合物。在一些实施方案中，抗原结合蛋白诱导FGF21样信号传导。在一些实施方案中，抗原结合蛋白是完全人，人源化或嵌合抗体，所述抗体的结合片段和衍生物，以及特异性结合（i）β-Klotho的多肽; （ii）FGFRIc，FGFR2c，FGFR3c或FGFR4; 或（iii）包含β-Klotho和FGFRIc，FGFR2c，FGFR3c和FGFR4之一的复合物。其它实施方案提供了编码这种抗原结合蛋白的核酸及其片段和衍生物，以及多肽，包含这种多核苷酸的细胞，制备此类抗原结合蛋白的方法及其片段和衍生物以及多肽，以及使用这些抗原结合蛋白的方法，其片段及其衍生物和多肽，包括治疗或诊断患有2型糖尿病，肥胖症，NASH，代谢综合征和相关疾病或病症的受试者的方法。

6. 发明申请

WO2012170438A3 HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO A COMPLEX COMPRISING β-KLOTHO AND AN FGF RECEPTOR 审中-公开
公开(公告)号：WO2012170438A3
公开(公告)日：2012-12-13
申请号：PCT/US2012/040941
申请日：2012-06-05
申请人： AMGEN INC. , LI, Yang , STEVENS, Jennitte , KING, Chadwick, Terence , FOLTZ, Ian , KANNAN, Gunasekaran , YIE, Junming , HU, Shaw-Fen, Sylvia
发明人： LI, Yang , STEVENS, Jennitte , KING, Chadwick, Terence , FOLTZ, Ian , KANNAN, Gunasekaran , YIE, Junming , HU, Shaw-Fen, Sylvia
IPC分类号： C07K16/28 , A61P3/00 , A61P3/04 , A61P3/10 , C07K14/71
摘要： The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

7. 发明申请

WO2012138919A2 METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING GROWTH DIFFERENTIATION FACTOR 15 (GDF-15) 审中-公开
标题翻译：使用生长差异因子15（GDF-15）治疗或改善代谢障碍的方法
公开(公告)号：WO2012138919A2
公开(公告)日：2012-10-11
申请号：PCT/US2012/032415
申请日：2012-04-05
申请人： AMGEN INC. , XIONG, YuMei , LI, Yang , YEH, Wen-Chen , SHAN, Bei , SHENG, Jackie Zeqi
发明人： XIONG, YuMei , LI, Yang , YEH, Wen-Chen , SHAN, Bei , SHENG, Jackie Zeqi
IPC分类号： A61K38/18
CPC分类号： C07K14/495 , A61K38/00 , A61K38/18
摘要： Methods of treating metabolic diseases and disorders using a GDF15 polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
摘要翻译：提供了使用GDF15多肽治疗代谢疾病和病症的方法。在各种实施方案中，代谢疾病或病症是2型糖尿病，肥胖症，血脂异常，升高的葡萄糖水平，升高的胰岛素水平和糖尿病性肾病。

8. 发明申请

WO2011068893A1 BINDING PROTEINS THAT BIND TO HUMAN FGFR1C, HUMAN β-KLOTHO AND BOTH HUMAN FGFR1C AND HUMANβ-KLOTHO 审中-公开
标题翻译：结合人FGFR1C，人ß-KLOTHO和人类FGFR1C和HUMANβ-KLOTHO的结合蛋白
公开(公告)号：WO2011068893A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058587
申请日：2010-12-01
申请人： AMGEN INC. , SMITH, Richard , BAKKER, Alice , DUGUAY, Amy, N. , LI, Peng , LI, Yang
发明人： SMITH, Richard , BAKKER, Alice , DUGUAY, Amy, N. , LI, Peng , LI, Yang
IPC分类号： A61K38/00 , A61K38/18 , C07K14/475
CPC分类号： C07K14/001 , A61K38/00 , C07K14/50 , C07K14/705 , C07K2319/70 , C07K2319/75
摘要： Binding proteins that specifically bind to β-Klotho or portions thereof, FGFR1c or portions thereof, or both FGFR1c and β-Klotho, and optionally other proteins as well are provided. Coding sequences, methods of treatment and pharmaceutical compositions are also provided.
摘要翻译：提供了特异性结合ß-Klotho或其部分，FGFR1c或其部分或FGFR1c和ß-Klotho以及任选的其它蛋白质的结合蛋白。还提供了编码序列，治疗方法和药物组合物。

9. 发明申请

WO2018107425A1 COMPOSITION COMPRISING RESIN AND DYE MIXTURE USED FOR COLOR FILTER OF LCD 审中-公开
公开(公告)号：WO2018107425A1
公开(公告)日：2018-06-21
申请号：PCT/CN2016/110079
申请日：2016-12-15
申请人： DOW GLOBAL TECHNOLOGIES LLC , HE, Chao , LIAO, Guihong , HU, Xiaolian , LI, Yang , REN, Hua , LIU, Juelin , TAI, Xiangyang
发明人： HE, Chao , LIAO, Guihong , HU, Xiaolian , LI, Yang , REN, Hua , LIU, Juelin , TAI, Xiangyang
IPC分类号： C09B47/04 , G03F7/004 , G02B5/23 , C07F1/08 , C07F3/06 , C07F15/04
CPC分类号： C09B47/04 , C09B47/20 , C09B67/0032 , C09B67/0033 , G02B5/23 , G03F7/0007 , G03F7/105
摘要： A composition comprising resin and dye mixture, an article having a polymer layer formed from the composition, and a color filter formed from the composition are developed. The dye mixture contains a phthalocyanine compound and another dye, and it has higher light transmittance at specific color coordinates suitable for a blue color filter.

10. 发明申请

WO2017079911A1 LIGHT EMITTING NANOPARTICLES AND PROCESS OF MAKING THE SAME 审中-公开
标题翻译：发光纳米颗粒及其制备方法
公开(公告)号：WO2017079911A1
公开(公告)日：2017-05-18
申请号：PCT/CN2015/094262
申请日：2015-11-11
申请人： DOW GLOBAL TECHNOLOGIES LLC , ROHM AND HAAS ELECTRONIC MATERIALS LLC , WANG, Xiuyan , LV, Bo , LI, Yang , HU, Nan , REN, Xiaofan , TREFONAS, Peter III , RAO, Yuanqiao
发明人： WANG, Xiuyan , LV, Bo , LI, Yang , HU, Nan , REN, Xiaofan , TREFONAS, Peter III , RAO, Yuanqiao
IPC分类号： C09K11/06 , C09K11/07 , H01L51/54
CPC分类号： C09K11/06 , C09K2211/1029 , H01L51/52
摘要： Nanoparticles have a core covalently bonded with a luminophore and a hybrid shell at least partially encapsulating the core. The nanoparticles provide improved photostability, thermal stability and emission properties than light emitting materials that the luminophore derives from.
摘要翻译：纳米颗粒具有与发光团共价结合的核和至少部分包封核的混合壳。纳米颗粒比发光材料来源的发光材料提供改进的光稳定性，热稳定性和发射性能。

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