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1. 发明申请

WO2008008539A2 FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE 审中-公开
标题翻译：熔融杂环衍生物及其使用方法
公开(公告)号：WO2008008539A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/016068
申请日：2007-07-13
申请人： AMGEN INC. , ALBRECHT, Brian , BAUER, David , BELLON, Steven , BODE, Christiane , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Derin , HARMANGE, Jean-Christophe , HIRAI, Satoko , HUNGATE, Randall , KIM, Tae-Seong , LEWIS, Richard , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark , POTASHMAN, Michele , SIEGMUND, Aaron , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin
发明人： ALBRECHT, Brian , BAUER, David , BELLON, Steven , BODE, Christiane , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Derin , HARMANGE, Jean-Christophe , HIRAI, Satoko , HUNGATE, Randall , KIM, Tae-Seong , LEWIS, Richard , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark , POTASHMAN, Michele , SIEGMUND, Aaron , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin
IPC分类号： C07D471/04 , C07D473/34 , C07D487/04 , A61K31/5025 , A61K31/52 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

2. 发明申请

WO2009091374A2 FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE 审中-公开
标题翻译：熔融杂环衍生物及其使用方法
公开(公告)号：WO2009091374A2
公开(公告)日：2009-07-23
申请号：PCT/US2008/011724
申请日：2008-10-14
申请人： AMGEN INC. , ALBRECHT, Brian K. , BAUER, David , BELLON, Steven , BODE, Christiane M. , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Erin , HARMANGE, Jean-christophe , HIRAI, Satoko , HUNGATE, Randall W. , KIM, Tae-seong , LEWIS, Richard T. , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark H. , POTASHMAN, Michelle , SIEGMUND, Aaron C. , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin , PETERSON, Emily, A. , ROMERO, Karina , COPELAND, Katrina, W.
发明人： ALBRECHT, Brian K. , BAUER, David , BELLON, Steven , BODE, Christiane M. , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Erin , HARMANGE, Jean-christophe , HIRAI, Satoko , HUNGATE, Randall W. , KIM, Tae-seong , LEWIS, Richard T. , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark H. , POTASHMAN, Michelle , SIEGMUND, Aaron C. , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin , PETERSON, Emily, A. , ROMERO, Karina , COPELAND, Katrina, W.
IPC分类号： C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , A61K31/4355
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

3. 发明申请

WO2006116713A1 SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：取代的衍生物作为蛋白激酶抑制剂
公开(公告)号：WO2006116713A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/016344
申请日：2006-04-27
申请人： Amgen Inc. , KIM, Tae-Seong , BAUER, David , BELLON, Steven , BOEZIO, Alessandro , BOOKER, Shon , CHOQUETTE, Deborah , D'AMICO, Derin C. , D'ANGELO, Noel , DOMINGUEZ, Celia , FELLOWS, Ingrid M. , GERMAIN, Julie , GRACEFFA, Russell , HARMANGE, Jean-Christophe , HIRAI, Satoko , LA, Daniel , LEE, Matthew , LIU, Longbin , NORMAN, Mark H. , POTASHMAN, Michele , ROVETO, Philip , SIEGMUND, Aaron C. , XI, Ning , YANG, Kevin
发明人： KIM, Tae-Seong , BAUER, David , BELLON, Steven , BOEZIO, Alessandro , BOOKER, Shon , CHOQUETTE, Deborah , D'AMICO, Derin C. , D'ANGELO, Noel , DOMINGUEZ, Celia , FELLOWS, Ingrid M. , GERMAIN, Julie , GRACEFFA, Russell , HARMANGE, Jean-Christophe , HIRAI, Satoko , LA, Daniel , LEE, Matthew , LIU, Longbin , NORMAN, Mark H. , POTASHMAN, Michele , ROVETO, Philip , SIEGMUND, Aaron C. , XI, Ning , YANG, Kevin
IPC分类号： C07D401/14 , C07D401/12 , C07D405/14 , C07D417/14 , C07D413/14 , C07D495/04 , C07D487/04 , C07D403/12 , C07D409/14 , C07D413/12 , A61K31/435 , A61K31/495 , A61P35/00
CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

4. 发明申请

WO2007048070A2 COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：化合物和使用方法
公开(公告)号：WO2007048070A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/041562
申请日：2006-10-23
申请人： AMGEN INC. , GERMAIN, Julie , ASKEW, Benny, C., Jr. , BAUER, David , CHOQUETTE, Deborah , DIPIETRO, Lucian, V. , GRACEFFA, Russell , HARMANAGE, Jean-Christophe , HUANG, Qi , KIM, Joseph, L. , LA, Daniel , LI, Aiwen , NISHIMURA, Nobuko , NOMACK, Rana , PATEL, Vinod , POTASHMAN, Michele , RIAHI, Babak , STORZ, Thomas , VAN DER PLAS, Simon , YANG, Kevin , YUAN, Chester, C.
发明人： GERMAIN, Julie , ASKEW, Benny, C., Jr. , BAUER, David , CHOQUETTE, Deborah , DIPIETRO, Lucian, V. , GRACEFFA, Russell , HARMANAGE, Jean-Christophe , HUANG, Qi , KIM, Joseph, L. , LA, Daniel , LI, Aiwen , NISHIMURA, Nobuko , NOMACK, Rana , PATEL, Vinod , POTASHMAN, Michele , RIAHI, Babak , STORZ, Thomas , VAN DER PLAS, Simon , YANG, Kevin , YUAN, Chester, C.
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

5. 发明申请

WO2010003512A1 AN APPARATUS AND A METHOD OF MEASURING EROSION OF AN EDGE OF A TURBOMACHINE AEROFOIL 审中-公开
标题翻译：一种装置和一种测量涡轮机AEROFOIL边缘腐蚀的方法
公开(公告)号：WO2010003512A1
公开(公告)日：2010-01-14
申请号：PCT/EP2009/004314
申请日：2009-06-16
申请人： ROLLS-ROYCE PLC , ROBINSON, Craig , ROCHE, Stephen , FEE, Conall , BAUER, David
发明人： ROBINSON, Craig , ROCHE, Stephen , FEE, Conall , BAUER, David
IPC分类号： G01B11/24 , F01D5/14
CPC分类号： G01B11/24 , F01D5/005 , F01D5/141 , F01D25/285 , F02K3/04 , F04D27/0292 , F05D2230/80 , F05D2240/121 , F05D2240/303
摘要： An apparatus (40) for measuring erosion of an edge (32) of an aerofoil portion (30) of a fan blade (26) comprises a laser source (42) to direct light at a position on the edge (32) of the fan blade (26). A detector (44) detects light reflected from the position on the edge (32) of the fan blade (26). A computer (480 measures the distance from the laser source (42) to points on the edge (32) of the fan blade (26) to produce a profile of the edge (32) in terms of x and z coordinates. The computer (48) calculates the radial distances of points on the edge (32) of the fan blade (26) from a centroid of the profile. The computer (48) detects local peaks (P) in the distance of points from the centroid of the profile. The computer (48) selects two local peaks (P1, P2) with the greatest distance there between. The computer (48) determines the distance (D1) between the two local peaks (P1, P2) and compares the determined distance (D1) and a predetermined distance to determine if there is unacceptable erosion.
摘要翻译：用于测量风扇叶片（26）的机翼部分（30）的边缘（32）的侵蚀的装置（40）包括激光源（42），以将光引导到风扇的边缘（32）上的位置刀片（26）。检测器（44）检测从风扇叶片（26）的边缘（32）上的位置反射的光。计算机（480）测量从激光源（42）到风扇叶片（26）的边缘（32）上的点的距离，以便根据x和z坐标产生边缘（32）的轮廓。计算机计算机（48）根据轮廓的质心计算出风扇叶片（26）的边缘（32）上的点的径向距离，计算机（48）从轮廓的质心点的距离中检测局部峰值（P）计算机（48）选择距离最远的两个局部峰值（P1，P2），计算机（48）确定两个局部峰值（P1，P2）之间的距离（D1），并将确定的距离（D1 ）和预定距离以确定是否存在不可接受的侵蚀。

6. 发明申请

WO2006111245A1 GOLFTRAININGSHANDSCHUH 审中-公开
标题翻译：高尔夫训练手套
公开(公告)号：WO2006111245A1
公开(公告)日：2006-10-26
申请号：PCT/EP2006/002772
申请日：2006-03-27
申请人： BAUER, David
发明人： BAUER, David
IPC分类号： A63B71/14 , A63B69/36 , A61B5/22
CPC分类号： A61B5/225 , A61B5/4528 , A61B5/6806 , A63B69/3608 , A63B71/146 , A63B2220/51 , G06F1/163 , G06F3/014
摘要： Die Erfindung betrifft einen Golftrainingshandschuh mit Sensoren zur Auslösung eines wahrnehmbaren Signals bei fehlerhafter Grifftechnik des Golf Schlägers mit Fingerlingen zur Aufnahme von Daumen, Zeigefinger, Mittelfinger, Ringfinger und kleinem Finger. Um bei korrekter Grifftechnik Fehlsignalisierungen zu vermeiden, wird vorgeschlagen, dass die Sensoren zumindest an den Fingerlingen zur Aufnahme von Zeigefinger, Mittelfinger und Ringfinger angeordnet sind und das wahrnehmbare Signal bei einem zu hohen Griff druck auslösen. Es wird kein Sensor im Daumen des Golftraingshandschuhs angeordnet.
摘要翻译：本发明涉及一种具有传感器的高尔夫训练手套用于在高尔夫球杆技术与指套的不正确握的情况下触发感知的信号，用于接收拇指，食指，中指，无名指和小指。为了避免错误的信号时正确处理技术中，提出的是，传感器被布置成至少在指套，用于接收食指，中指和无名指，并触发在过高的压力手柄可察觉信号。有布置在高尔夫训练手套的拇指没有传感器。

7. 发明申请

WO2005073224A2 COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：化合物和使用方法
公开(公告)号：WO2005073224A2
公开(公告)日：2005-08-11
申请号：PCT/US2005/002304
申请日：2005-01-24
申请人： AMGEN INC
发明人： HARMANGE, Jean-Christophe , BOOKER, Shon , BAUER, David , KIM, Tae-Seong , CHENG, Yuan , XU, Shimin , XI, Ning , KIM, Joseph, L. , TASKER, Andrew
IPC分类号： C07D417/00
CPC分类号： C07D495/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

8. 发明申请

WO2015161152A1 POLYMORPHIC FORMS AND CO-CRYSTALS OF A C-MET INHIBITOR 审中-公开
标题翻译： C-MET抑制剂的多晶形态和共晶体
公开(公告)号：WO2015161152A1
公开(公告)日：2015-10-22
申请号：PCT/US2015/026296
申请日：2015-04-17
申请人： AMGEN INC.
发明人： BAUER, David , BIO, Matthew , COOKE, Melanie , COPELAND, Katrina, W. , PETERSON, Matthew , POTASHMAN, Michele , SHIMANOVICH, Roman , TAN, Helming
IPC分类号： C07D487/04 , A61K31/52
CPC分类号： C07D519/00 , A61K31/52 , C07B2200/13 , C07C55/10 , C07C55/12 , C07C57/10 , C07C57/145 , C07C275/02
摘要： Provided herein are novel polymorphic forms and co-crystals of a compound useful in the treatment, prevention, or amelioration of cancer. In particular, the invention provides polymorphs and co-crystals of 6-{ (1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazo1-4- y1)[1,2,4]triazolo[4,3-a]pyridin-3-y1]ethy1}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one, which is an inhibitor of c-Met.
摘要翻译：本文提供了可用于治疗，预防或改善癌症的化合物的新型多晶型物和共晶体。特别地，本发明提供了6 - {（1R）-1- [8-氟-6-（1-甲基-1H-吡唑-4-基）[1,2,4]三唑并[ 4,3-a]吡啶-3-基]乙基} -3-（2-甲氧基乙氧基）-1,6-萘啶-5（6H） - 酮，其为c-Met的抑制剂。

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