基本信息:
- 专利标题： FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE
- 专利标题（中）：熔融杂环衍生物及其使用方法
- 申请号：PCT/US2008/011724 申请日：2008-10-14
- 公开(公告)号：WO2009091374A2 公开(公告)日：2009-07-23
- 发明人： ALBRECHT, Brian K. , BAUER, David , BELLON, Steven , BODE, Christiane M. , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Erin , HARMANGE, Jean-christophe , HIRAI, Satoko , HUNGATE, Randall W. , KIM, Tae-seong , LEWIS, Richard T. , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark H. , POTASHMAN, Michelle , SIEGMUND, Aaron C. , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin , PETERSON, Emily, A. , ROMERO, Karina , COPELAND, Katrina, W.
- 申请人： AMGEN INC. , ALBRECHT, Brian K. , BAUER, David , BELLON, Steven , BODE, Christiane M. , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Erin , HARMANGE, Jean-christophe , HIRAI, Satoko , HUNGATE, Randall W. , KIM, Tae-seong , LEWIS, Richard T. , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark H. , POTASHMAN, Michelle , SIEGMUND, Aaron C. , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin , PETERSON, Emily, A. , ROMERO, Karina , COPELAND, Katrina, W.
- 申请人地址： One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 专利权人： AMGEN INC.,ALBRECHT, Brian K.,BAUER, David,BELLON, Steven,BODE, Christiane M.,BOOKER, Shon,BOEZIO, Alessandro,CHOQUETTE, Deborah,D'AMICO, Erin,HARMANGE, Jean-christophe,HIRAI, Satoko,HUNGATE, Randall W.,KIM, Tae-seong,LEWIS, Richard T.,LIU, Longbin,LOHMAN, Julia,NORMAN, Mark H.,POTASHMAN, Michelle,SIEGMUND, Aaron C.,SPRINGER, Stephanie,STEC, Markian,XI, Ning,YANG, Kevin,PETERSON, Emily, A.,ROMERO, Karina,COPELAND, Katrina, W.
- 当前专利权人： AMGEN INC.,ALBRECHT, Brian K.,BAUER, David,BELLON, Steven,BODE, Christiane M.,BOOKER, Shon,BOEZIO, Alessandro,CHOQUETTE, Deborah,D'AMICO, Erin,HARMANGE, Jean-christophe,HIRAI, Satoko,HUNGATE, Randall W.,KIM, Tae-seong,LEWIS, Richard T.,LIU, Longbin,LOHMAN, Julia,NORMAN, Mark H.,POTASHMAN, Michelle,SIEGMUND, Aaron C.,SPRINGER, Stephanie,STEC, Markian,XI, Ning,YANG, Kevin,PETERSON, Emily, A.,ROMERO, Karina,COPELAND, Katrina, W.
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 代理机构： HERMENAU, Ronald S.
- 优先权： US12/009,123 20080115
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D487/04 ; C07D493/04 ; C07D495/04 ; C07D498/04 ; A61K31/4355
摘要：
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要（中）：
所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D471/00 | 在稠环系中含有氮原子作为仅有的杂环原子、其中至少1个环是含有1个氮原子的六元环的杂环化合物，C07D451/00至C07D463/00不包括的 |
| --------C07D471/02 | .在稠环系中含两个杂环 |
| ----------C07D471/04 | ..邻位稠环系 |