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1. 发明申请

WO2008008539A2 FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE 审中-公开
标题翻译：熔融杂环衍生物及其使用方法
公开(公告)号：WO2008008539A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/016068
申请日：2007-07-13
申请人： AMGEN INC. , ALBRECHT, Brian , BAUER, David , BELLON, Steven , BODE, Christiane , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Derin , HARMANGE, Jean-Christophe , HIRAI, Satoko , HUNGATE, Randall , KIM, Tae-Seong , LEWIS, Richard , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark , POTASHMAN, Michele , SIEGMUND, Aaron , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin
发明人： ALBRECHT, Brian , BAUER, David , BELLON, Steven , BODE, Christiane , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Derin , HARMANGE, Jean-Christophe , HIRAI, Satoko , HUNGATE, Randall , KIM, Tae-Seong , LEWIS, Richard , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark , POTASHMAN, Michele , SIEGMUND, Aaron , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin
IPC分类号： C07D471/04 , C07D473/34 , C07D487/04 , A61K31/5025 , A61K31/52 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

2. 发明申请

WO2006116713A1 SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：取代的衍生物作为蛋白激酶抑制剂
公开(公告)号：WO2006116713A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/016344
申请日：2006-04-27
申请人： Amgen Inc. , KIM, Tae-Seong , BAUER, David , BELLON, Steven , BOEZIO, Alessandro , BOOKER, Shon , CHOQUETTE, Deborah , D'AMICO, Derin C. , D'ANGELO, Noel , DOMINGUEZ, Celia , FELLOWS, Ingrid M. , GERMAIN, Julie , GRACEFFA, Russell , HARMANGE, Jean-Christophe , HIRAI, Satoko , LA, Daniel , LEE, Matthew , LIU, Longbin , NORMAN, Mark H. , POTASHMAN, Michele , ROVETO, Philip , SIEGMUND, Aaron C. , XI, Ning , YANG, Kevin
发明人： KIM, Tae-Seong , BAUER, David , BELLON, Steven , BOEZIO, Alessandro , BOOKER, Shon , CHOQUETTE, Deborah , D'AMICO, Derin C. , D'ANGELO, Noel , DOMINGUEZ, Celia , FELLOWS, Ingrid M. , GERMAIN, Julie , GRACEFFA, Russell , HARMANGE, Jean-Christophe , HIRAI, Satoko , LA, Daniel , LEE, Matthew , LIU, Longbin , NORMAN, Mark H. , POTASHMAN, Michele , ROVETO, Philip , SIEGMUND, Aaron C. , XI, Ning , YANG, Kevin
IPC分类号： C07D401/14 , C07D401/12 , C07D405/14 , C07D417/14 , C07D413/14 , C07D495/04 , C07D487/04 , C07D403/12 , C07D409/14 , C07D413/12 , A61K31/435 , A61K31/495 , A61P35/00
CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

3. 发明申请

WO2008079291A2 SUBSTITUTED HETEROCYCLES AND METHODS OF USE 审中-公开
标题翻译：取代的杂交物和使用方法
公开(公告)号：WO2008079291A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/026063
申请日：2007-12-19
申请人： AMGEN INC. , BELLON, Steven , BOOKER, Shon , D'ANGELO, Noel , FELLOWS, Ingrid, M. , HARMANGE, Jean-Christophe , KIM, Tae-Seong , LEE, Matthew , LIU, Longbin , NORMAN, Mark, H.
发明人： BELLON, Steven , BOOKER, Shon , D'ANGELO, Noel , FELLOWS, Ingrid, M. , HARMANGE, Jean-Christophe , KIM, Tae-Seong , LEE, Matthew , LIU, Longbin , NORMAN, Mark, H.
CPC分类号： C07D401/14 , C07D401/12
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as c-met mediated diseases and/or HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：选择的化合物对于预防和治疗诸如c-met介导的疾病和/或HGF介导的疾病的疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

4. 发明申请

WO2007005668A3 BIS-ARYL KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF INFLAMMATION, ANGIOGENESIS AND CANCER 审中-公开
公开(公告)号：WO2007005668A3
公开(公告)日：2007-01-11
申请号：PCT/US2006/025699
申请日：2006-06-29
申请人： AMGEN INC. , KIM, Tae-Seong , HARMANGE, Jean-Christophe , BOOKER, Shon , D'ANGELO, Noel , DOMINGUEZ, Celia , FELLOWS, Ingrid, M. , LIU, Longbin , TASKER, Andrew , BELLON, Steven , HARVEY, Timothy, S. , LEE, Matthew , GERMAIN, Julie , PATEL, Vinod, F. , KIM, Joseph, L.
发明人： KIM, Tae-Seong , HARMANGE, Jean-Christophe , BOOKER, Shon , D'ANGELO, Noel , DOMINGUEZ, Celia , FELLOWS, Ingrid, M. , LIU, Longbin , TASKER, Andrew , BELLON, Steven , HARVEY, Timothy, S. , LEE, Matthew , GERMAIN, Julie , PATEL, Vinod, F. , KIM, Joseph, L.
IPC分类号： C07D409/12 , C07D333/38 , C07D401/10 , C07D401/12 , C07D215/20 , C07D215/04 , C07D417/12 , A61K31/381 , A61K31/4725 , A61K31/416 , A61K31/4035 , A61P35/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

5. 发明申请

WO2011030935A1 ANTIBODIES AGAINST GLUCAGON RECEPTOR AND THEIR USE 审中-公开
标题翻译：抗GLUCAGON受体及其使用的抗体
公开(公告)号：WO2011030935A1
公开(公告)日：2011-03-17
申请号：PCT/KR2009/005084
申请日：2009-09-08
申请人： NEOPHARM CO., LTD. , LEE, Eunkyung , SEO, Seong-Kyung , KIM, Tae-Seong
发明人： LEE, Eunkyung , SEO, Seong-Kyung , KIM, Tae-Seong
IPC分类号： C07K16/28 , C07K16/46 , C12N5/12
CPC分类号： C07K16/2869 , A61K2039/505 , C07K2317/24 , C07K2317/515 , C07K2317/565 , C07K2317/76
摘要： Disclosed are immunological compositions and methods for reducing activity of glucagon signaling using antibodies against glucagon receptor.
摘要翻译：公开了使用抗胰高血糖素受体的抗体来降低胰高血糖素信号传导的活性的免疫学组合物和方法。

6. 发明申请

WO2011113536A1 KONDITIONIERUNGSMITTEL UND KONDITIONIERENDE SHAMPOO-ZUSAMMENSETZUNG ENTHALTEND PENTAERYTHRIT-ESTER 审中-公开
标题翻译：调理剂，并且成分含调理香波季戊四醇酯
公开(公告)号：WO2011113536A1
公开(公告)日：2011-09-22
申请号：PCT/EP2011/001097
申请日：2011-03-05
申请人： COGNIS IP MANAGEMENT GMBH , DIERKER, Markus , HAAKE, Hans-Martin , PRINZ, Daniela , KANO, Junko , DOKI, Kakushi , KIM, Tae-Seong , MASAKI, Koichi , CORNELSEN, Sybille
发明人： DIERKER, Markus , HAAKE, Hans-Martin , PRINZ, Daniela , KANO, Junko , DOKI, Kakushi , KIM, Tae-Seong , MASAKI, Koichi , CORNELSEN, Sybille
IPC分类号： A61K8/37 , A61K8/891 , A61K8/898 , A61Q5/02 , A61Q5/12
CPC分类号： A61K8/375 , A61K8/891 , A61K8/898 , A61Q5/02 , A61Q5/12
摘要： Vorgeschlagen wird eine kosmetische Zubereitung enthaltend (a) Ester von Fettsäuren mit 6 bis 12 Kohlenstoffatomen mit Pentraerythrit und (b) Silikone.
摘要翻译：本发明公开了包含（a）具有与季戊四醇和（b）硅氧烷6至12个碳原子的脂肪酸酯的化妆品制剂。

7. 发明申请

WO2005123325A1 CONTINUOUS BUTT WELDING METHOD USING PLASMA AND LASER, AND METHOD FOR FABRICATING METAL TUBE USING THE SAME 审中-公开
标题翻译：使用等离子体和激光的连续的焊接方法以及使用其制造金属管的方法
公开(公告)号：WO2005123325A1
公开(公告)日：2005-12-29
申请号：PCT/KR2004/001466
申请日：2004-06-18
申请人： LS Cable Ltd. , Korea Advanced Institute of Science and Technology , LEE, Sang-Hoon , WON, Yong-Hee , KIM, Tae-Seong , LEE, Tae-Jung , BYUN, Jung-Hoon , NA, Suck-Joo , YOON, Suk-Hwan , HWANG, Jae-Ryun
发明人： LEE, Sang-Hoon , WON, Yong-Hee , KIM, Tae-Seong , LEE, Tae-Jung , BYUN, Jung-Hoon , NA, Suck-Joo , YOON, Suk-Hwan , HWANG, Jae-Ryun
IPC分类号： B23K31/02
CPC分类号： B23K26/1429 , B23K10/02 , B23K26/262 , B23K26/32 , B23K26/60 , B23K33/006 , B23K2201/06 , B23K2203/04 , B23K2203/05 , B23K2203/10 , B23K2203/12 , B23K2203/14 , B23K2203/50
摘要： A continuous butt welding method using plasma and laser, and a method for fabricating a metal tube using the butt welding method are disclosed. The butt welding method conducts a laser welding and a plasma welding together against an object to be welded, which has a very narrow butt space. In particular, the plasma is prior to the laser so that the object is preheated by the plasma, and then a preform is melted by a laser beam in order to accomplish the major welding. In addition, a metal sheet is bent to have a circular section so that its both ends are faced with each other, and then the faced both ends are welded using the aforementioned butt welding method, thereby fabricating a metal tube. The butt welding method and the metal tube fabricating method mentioned above remarkably improve a welding speed and productivity of metal tube.
摘要翻译：公开了使用等离子体和激光的连续对接焊接方法以及使用对接焊接方法制造金属管的方法。该对接焊接方法相对于具有非常窄的对接空间的待焊接物体进行激光焊接和等离子体焊接。特别地，等离子体在激光之前，使得物体被等离子体预热，然后通过激光束熔化预制件以实现主要的焊接。另外，将金属片弯曲成具有圆形部分，使得其两端彼此面对，然后使用上述对接焊接方法焊接面对的两端，从而制造金属管。上述对接焊接方法和金属管制造方法显着提高了金属管的焊接速度和生产率。

8. 发明申请

WO2004010590A2 OPTIMIZATION OF EXCITATION WAVEFORM FOR NONLINEAR TRANSMIT-RECEIVE SYSTEMS 审中-公开
标题翻译：非线性发射 - 接收系统激励波形的优化
公开(公告)号：WO2004010590A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/022531
申请日：2003-07-18
申请人： ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA , MARMARELIS, Vasilis, Z. , KIM, Tae-Seong
发明人： MARMARELIS, Vasilis, Z. , KIM, Tae-Seong
IPC分类号： H04B
CPC分类号： G01S15/102 , A61B8/0825 , G01S7/52046
摘要： A process for optimizing the excitation waveform that is delivered to a transmitter (103) that, together with a receiver (105), form part of a nonlinear transmission and reception system. The process may include delivering a transmission test signal to the transmitter (201), generating a receive test signal from the receiver that is a nonlinear function of the transmission test signal (203), developing a nonlinear model of the nonlinear function (205), and determining an optimum excitation signal based on the model (207). An application to ultrasonic imaging for breast mammography is also disclosed.
摘要翻译：用于优化传递到发射机（103）的激励波形的过程，所述发射机与接收机（105）一起构成非线性发射和接收系统的一部分。该过程可以包括将传输测试信号传递到发射机（201），从接收机产生作为传输测试信号（203）的非线性函数的接收测试信号，开发非线性函数（205）的非线性模型，并基于该模型确定最佳激励信号（207）。还公开了应用于乳房乳房X线照相的超声成像。

9. 发明申请

WO2003027057A1 METHOD FOR PREPARING OF CATIONIC SURFACTANTS AND FABRIC SOFTENER COMPOSITION USING THE SAME 审中-公开
标题翻译：用于制备阳离子表面活性剂的方法和使用它的织物皂化剂组合物
公开(公告)号：WO2003027057A1
公开(公告)日：2003-04-03
申请号：PCT/KR2002/001826
申请日：2002-09-27
申请人： LG HOUSEHOLD & HEALTH CARE LTD. , JEONG, Gug-In , HA, Jeong-Wook , YOON, Yeo-Kyeong , KIM, Tae-Seong , LEE, Eun-joo
发明人： JEONG, Gug-In , HA, Jeong-Wook , YOON, Yeo-Kyeong , KIM, Tae-Seong , LEE, Eun-joo
IPC分类号： C07C211/00
CPC分类号： C11D1/835 , C07C231/14 , C11D1/528 , C11D3/001 , D06M13/463 , D06M2200/50 , C07C233/36
摘要： The present invention relates to a process for the preparation of a cationic surfactant and a fiber softening composition comprising it and more particularly to a process for preparing a cationic surfactant comprising reacting a fatty acid and an amine, tertiarizing it and quaterizing with neutralization and a fiber softening composition using it. Also, the invention provides a process for preparing a cationic surfactant comprising the steps of reacting a fatty acid and an amine, tertiarizing it and quaternarizing it with dimethylsulfate or alkylhalide, and a fiber softening composition comprising it. The cationic surfactants prepared according to the methods of the present invention are excellent in solubility in water by possessing an amine group or hydroxyl group, which is hydrophilic, within molecules and have highly excellent physicochemical performances such as softening properties, anti-electrostratic properties, dispersion properties, etc, and accordingly they can provide a fiber softening composition having good softening effects to clothes and anti-electrostatic effects as well as having excellent dispersion in water and bio-degradable effects.
摘要翻译：本发明涉及一种制备阳离子表面活性剂的方法和包含它的纤维软化组合物，更具体地涉及一种制备阳离子表面活性剂的方法，其包括使脂肪酸和胺反应，将其三元化并用中和进行季铵化和纤维软化组合物使用它。此外，本发明提供了一种制备阳离子表面活性剂的方法，其包括使脂肪酸和胺反应，将其三元化并用硫酸二甲酯或烷基卤化物季铵化的步骤和包含它的纤维软化组合物的步骤。根据本发明方法制备的阳离子表面活性剂通过在分子内具有亲水性的胺基或羟基在水中的溶解性优异并且具有非常优异的物理化学性能，例如软化性，抗电离性，分散性性能等，因此可以提供对衣服具有良好的软化效果的纤维软化组合物和抗静电效果，以及具有优异的水分散性和生物降解效果。

10. 发明申请

WO2004007481A2 SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE 审中-公开
标题翻译：取代的胺衍生物和使用治疗血友病相关疾病的方法
公开(公告)号：WO2004007481A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/022275
申请日：2003-07-15
申请人： AMGEN INC.
发明人： PATEL, Vinod, F. , ASKEW, Benny , BOOKER, Shon , CHEN, Guoqing , DIPIETRO, Lucian, V. , GERMAIN, Julie , HABGOOD, Gregory, J. , HUANG, Qi , KIM, Tae-Seong , LI, Aiwen , NISHIMURA, Nobuko , NOMAK, Rana , RIAHI, Babak , YUAN, Chester, Chenguang , ELBAUM, Daniel
IPC分类号： C07D401/12
CPC分类号： C07D471/04 , A61K31/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：选择的胺对于预防和治疗疾病如血管生成介导的疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

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