专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006044860A3 THIADIAZOLE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：噻唑化合物和使用方法
公开(公告)号：WO2006044860A3
公开(公告)日：2007-07-05
申请号：PCT/US2005037374
申请日：2005-10-18
申请人： AMGEN INC , ZENG QINGPING , YAO GUOMIN , WOHLHIETER GEORGE ERICH , VISWANADHAN VELLARKAD N , TASKER ANDREW , RIDER JAMES THOMAS , MONENSCHEIN HOLGER , DOMINGUEZ CELIA , BOURBEAU MATTHEW PAUL
发明人： ZENG QINGPING , YAO GUOMIN , WOHLHIETER GEORGE ERICH , VISWANADHAN VELLARKAD N , TASKER ANDREW , RIDER JAMES THOMAS , MONENSCHEIN HOLGER , DOMINGUEZ CELIA , BOURBEAU MATTHEW PAUL
IPC分类号： A61K31/433 , C07D285/12
CPC分类号： C07D417/14 , C07D417/04 , C07D471/04
摘要： The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译：本发明涉及可用于治疗由蛋白激酶B（PKB）介导的疾病的噻二唑化合物。本发明还涉及这种噻二唑化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。

2. 发明申请

WO2007084391A2 THIAZOLE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：噻唑化合物和使用方法
公开(公告)号：WO2007084391A2
公开(公告)日：2007-07-26
申请号：PCT/US2007000871
申请日：2007-01-11
申请人： AMGEN INC , ZENG QINGPING , ALLEN JOHN G , BOURBEAU MATTHEW P , DOMINGUEZ CELIA , FOTSCH CHRISTOPHER H , HAN NIANHE , HONG FANG-TSAO , HUANG XIN , LEE MATTHEW R , LI AIWEN , LIU QINGYIAN , RIDER JAMES T , TADESSE SEIFU , TASKER ANDREW S , VISWANADHAN VELLARKAD N , WANG XIANGHONG , WEILER KURT E , WOHLHIETER GEORGE E , YAO GUOMIN , YUAN CHESTER CHENGUANG
发明人： ZENG QINGPING , ALLEN JOHN G , BOURBEAU MATTHEW P , DOMINGUEZ CELIA , FOTSCH CHRISTOPHER H , HAN NIANHE , HONG FANG-TSAO , HUANG XIN , LEE MATTHEW R , LI AIWEN , LIU QINGYIAN , RIDER JAMES T , TADESSE SEIFU , TASKER ANDREW S , VISWANADHAN VELLARKAD N , WANG XIANGHONG , WEILER KURT E , WOHLHIETER GEORGE E , YAO GUOMIN , YUAN CHESTER CHENGUANG
IPC分类号： C07D417/04 , C07D277/42 , C07D277/54 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
CPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The invention relates to thiazole compounds of Formula (I) and Formula (II) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译：本发明涉及式（I）和式（II）的噻唑化合物及其组合物，其用于治疗由蛋白激酶B（PKB）介导的疾病，其中变量具有本文提供的定义。本发明还涉及这种噻唑化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。

3. 发明申请

WO2009011880A2 HETEROCYCLIC MODULATORS OF PKB 审中-公开
标题翻译： PKB的杂环调节剂
公开(公告)号：WO2009011880A2
公开(公告)日：2009-01-22
申请号：PCT/US2008008723
申请日：2008-07-16
申请人： AMGEN INC , ZENG QINGPING , ZHANG DAWEI , YAO GUOMIN , WOHLHIETER GEORGE E , WANG XIANGHONG , RIDER JAMES , REICHELT ANDREAS , MONENSCHEIN HOLGER , HONG FANG-TSAO , FALSEY JAMES R , DOMINGUEZ CELIA , BOURBEAU MATTHEW P , ALLEN JOHN G
发明人： ZENG QINGPING , ZHANG DAWEI , YAO GUOMIN , WOHLHIETER GEORGE E , WANG XIANGHONG , RIDER JAMES , REICHELT ANDREAS , MONENSCHEIN HOLGER , HONG FANG-TSAO , FALSEY JAMES R , DOMINGUEZ CELIA , BOURBEAU MATTHEW P , ALLEN JOHN G
IPC分类号： C07D263/48 , A61K31/41 , A61K31/5377 , A61P35/00 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04
CPC分类号： C07D413/04 , C07D263/48 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04
摘要： The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein Formula (I). The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译：本发明涉及式I的杂环化合物及其组合物，其用于治疗由蛋白激酶B（PKB）介导的疾病，其中变量具有本文提供的式（I）的定义。本发明还涉及这些化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。

4. 发明申请

WO2009011871A2 THIADIAZOLE MODULATORS OF PKB 审中-公开
标题翻译： PKB的三唑调节剂
公开(公告)号：WO2009011871A2
公开(公告)日：2009-01-22
申请号：PCT/US2008008690
申请日：2008-07-15
申请人： AMGEN INC , ALLEN JOHN G , BOURBEAU MATTHEW P , DOMINGUEZ CELIA , FOTSCH CHRISTOPHER H , HAN NIANHE , HONG FANG-TSAO , HUANG XIN , LEE MATTHEW R , LIU QINGYIAN , REICHELT ANDREAS , TADESSE SEIFU , WANG XIANGHONG , YAO GUOMIN , YUAN CHESTER CHENGUANG , ZENG QINGPING
发明人： ALLEN JOHN G , BOURBEAU MATTHEW P , DOMINGUEZ CELIA , FOTSCH CHRISTOPHER H , HAN NIANHE , HONG FANG-TSAO , HUANG XIN , LEE MATTHEW R , LIU QINGYIAN , REICHELT ANDREAS , TADESSE SEIFU , WANG XIANGHONG , YAO GUOMIN , YUAN CHESTER CHENGUANG , ZENG QINGPING
IPC分类号： C07D471/02 , A61K31/433 , A61P29/00 , A61P35/00 , C07D285/125 , C07D285/135
CPC分类号： C07D285/135 , C07D417/04 , C07D417/14 , C07D495/04
摘要： The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译：本发明涉及式I和式II的噻唑化合物及其用于治疗由蛋白激酶B（PKB）介导的疾病的组合物，其中变量具有本文提供的定义。本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。

5. 发明申请

WO2007005668A2 BIS-ARYL KINASE INHIBITORS AND METHOD 审中-公开
标题翻译： BIS-ARYL激酶抑制剂和方法
公开(公告)号：WO2007005668A2
公开(公告)日：2007-01-11
申请号：PCT/US2006025699
申请日：2006-06-29
申请人： AMGEN INC , KIM TAE-SEONG , HARMANGE JEAN-CHRISTOPHE , BOOKER SHON , D ANGELO NOEL , DOMINGUEZ CELIA , FELLOWS INGRID M , LIU LONGBIN , TASKER ANDREW , BELLON STEVEN , HARVEY TIMOTHY S , LEE MATTHEW , GERMAIN JULIE , PATEL VINOD F , KIM JOSEPH L
发明人： KIM TAE-SEONG , HARMANGE JEAN-CHRISTOPHE , BOOKER SHON , D ANGELO NOEL , DOMINGUEZ CELIA , FELLOWS INGRID M , LIU LONGBIN , TASKER ANDREW , BELLON STEVEN , HARVEY TIMOTHY S , LEE MATTHEW , GERMAIN JULIE , PATEL VINOD F , KIM JOSEPH L
IPC分类号： C07D409/12 , C07D333/38 , C07D401/10 , C07D401/12
CPC分类号： C07D333/38 , C07D217/02 , C07D217/24 , C07D401/10 , C07D401/12 , C07D409/12 , C07D417/10 , C07D417/12
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

6. 发明申请

WO2006060318A2 SUBSTITUTED HETEROCYCLES AND METHODS OF USE 审中-公开
标题翻译：取代的杂交物和使用方法
公开(公告)号：WO2006060318A2
公开(公告)日：2006-06-08
申请号：PCT/US2005042935
申请日：2005-11-29
申请人： AMGEN INC , KIM TAE-SEONG , BELLON STEVEN , BOOKER SHON , D ANGELO NOEL , DOMINGUEZ CELIA , FELLOWS INGRID , LEE MATTHEW , LIU LONGBIN , RAINBEAU ELIZABETH , SIEGMUND AARON C , TASKER ANDREW , XI NING , CHENG YUAN
发明人： KIM TAE-SEONG , BELLON STEVEN , BOOKER SHON , D ANGELO NOEL , DOMINGUEZ CELIA , FELLOWS INGRID , LEE MATTHEW , LIU LONGBIN , RAINBEAU ELIZABETH , SIEGMUND AARON C , TASKER ANDREW , XI NING , CHENG YUAN
IPC分类号： A61K31/4709 , A61P35/00 , C07D401/12 , C07D401/14
CPC分类号： C07D401/14 , C07D215/233 , C07D401/12 , C07D409/14 , C07D413/12
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

7. 发明申请

WO2004014871A8 VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS 审中-公开
标题翻译：香草酸受体配体及其在治疗中的应用
公开(公告)号：WO2004014871A8
公开(公告)日：2005-04-07
申请号：PCT/US0325191
申请日：2003-08-08
申请人： AMGEN INC , CHAKRABARTI PARTHA P , CHEN NING , DOHERTY ELIZABETH M , DOMINGUEZ CELIA , FALSEY JAMES RICHARD , FOTSH CHRISTOPHER H , HULME CHRISTOPHER , KATON JODIE , NIXEY THOMAS , NORMAN MARK H , OGNYANOV VASSIL I , PETTUS LIPING H , RZASA ROBERT MICHAEL , STEC MARKIAN , WANG HUI-LING , ZHU JIAWANG
发明人： CHKRABARTI PARTHA P , CHEN NING , DOHERTY ELIZABETH M , DOMINGUEZ CELIA , FALSEY JAMES RICHARD , FOTSH CHRISTOPHER H , HULME CHRISTOPHER , KATON JODIE , NIXEY THOMAS , NORMAN MARK H , OGNYANOV VASSIL I , PETTUS LIPING H , RZASA ROBERT MICHAEL , STEC MARKIAN , WANG HUI-LING , ZHU JIAWANG
IPC分类号： A61P29/00 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D239/34 , A61K31/4427 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/551 , C07D239/38 , C07D401/14 , C07D405/14 , C07D409/12 , C07D413/14 , C07D417/14 , C07D471/04
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：具有通用结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般性头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，具有炎性成分的皮肤病，慢性炎症，炎性疼痛和相关的痛觉过敏和异常性疼痛，神经性疼痛和相关的痛觉过敏和异常性疼痛，呼吸系统，泌尿生殖系统，胃肠或血管区域的伤害，伤口，烧伤，过敏性皮肤反应，瘙痒症，白癜风，一般性胃肠道疾病，躁狂症， G 牙周溃疡，十二指肠溃疡，腹泻，由坏死剂引起的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

8. 发明申请

WO2014047288A3 TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：转谷氨酰胺酶TG2抑制剂，药物组合物及其使用方法
公开(公告)号：WO2014047288A3
公开(公告)日：2014-06-26
申请号：PCT/US2013060620
申请日：2013-09-19
申请人： DOMINGUEZ CELIA , PRIME MICHAEL , MARSTON RICHARD , BROOKFIELD FREDERICK A , COURTNEY STEPHEN M , MACDONALD DOUGLAS , WITYAK JOHN , YARNOLD CHRISTOPHER JOHN , VAIDYA DARSHAN
发明人： DOMINGUEZ CELIA , PRIME MICHAEL , MARSTON RICHARD , BROOKFIELD FREDERICK A , COURTNEY STEPHEN M , MACDONALD DOUGLAS , WITYAK JOHN , YARNOLD CHRISTOPHER JOHN , VAIDYA DARSHAN
IPC分类号： C07C271/20
CPC分类号： C07D207/16 , C07D211/16 , C07D213/72 , C07D213/74 , C07D277/42 , C07D295/18 , C07D309/08 , C07D401/12
摘要： Certain compounds and pharmaceutically acceptable salts are provided herein. Also provided are pharmaceutical compositions comprising at least one compound or pharmaceutically acceptable salt therein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain disease states responsive to the inhibition of transglutaminase TG2 activity are described. These disease states include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound or pharmaceutically acceptable salt thereof as a single active agent or administering at least one compound or pharmaceutically acceptable salt thereof in combination with one or more other therapeutic agents.
摘要翻译：本文提供了某些化合物和药学上可接受的盐。还提供了包含至少一种化合物或其药学上可接受的盐和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对抑制转谷氨酰胺酶TG2活性有响应的某些疾病状态的患者的方法。这些疾病状态包括神经退行性疾病如亨廷顿病。还描述了治疗方法，包括施用至少一种化合物或其药学上可接受的盐作为单一活性剂或将至少一种化合物或其药学上可接受的盐与一种或多种其他治疗剂组合施用。

9. 发明申请

WO2014014900A8 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：组蛋白去乙酰化酶抑制剂和组合物及其使用方法
公开(公告)号：WO2014014900A8
公开(公告)日：2014-03-27
申请号：PCT/US2013050664
申请日：2013-07-16
申请人： CHDI FOUNDATION INC , DOMINGUEZ CELIA , LUCKHURST CHRISTOPHER A , BURLI ROLAND W , STOTT ANDREW J , BRECCIA PERLA
发明人： DOMINGUEZ CELIA , LUCKHURST CHRISTOPHER A , BURLI ROLAND W , STOTT ANDREW J , BRECCIA PERLA
IPC分类号： A01N37/08 , A61K31/15 , A61K31/19
CPC分类号： A61K31/505 , A61K31/165 , A61K31/357 , A61K31/421 , A61K31/426 , A61K31/4418 , C07B2200/07 , C07C259/08 , C07C2601/02 , C07D213/56 , C07D213/61 , C07D213/74 , C07D215/18 , C07D237/08 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D263/32 , C07D263/56 , C07D277/30 , C07D277/64 , C07D295/155 , C07D311/58 , C07D319/18 , C07D401/04 , C07D417/04
摘要： Provided are certain histone deacetylase (HDAC) inhibitors, compositions thereof, and methods of their use.
摘要翻译：提供了某些组蛋白脱乙酰酶（HDAC）抑制剂，其组合物及其使用方法。

10. 发明申请

WO2004022055B1 1, 4, 5-SUBSTITUTED 1, 2-DIHYDRO-PYRAZOL-3-ONE AND 3-ALKOXY-1H-PYRAZOLE DERIVATIVES S TNF-ALPHA AND INTERLEUKIN LOWERING AGENTS FOR THE TREATMENT OF INFLAMMATIONS 审中-公开
标题翻译： 1,4,5-取代的1,2-二氢吡喃-3-酮和3-烷氧基-1H-吡唑衍生物S TNF-ALPHA和白介素降低剂用于治疗炎症
公开(公告)号：WO2004022055B1
公开(公告)日：2005-01-13
申请号：PCT/US0328067
申请日：2003-09-08
申请人： AMGEN INC
发明人： DOMINGUEZ CELIA , ZHANG DAWEI , SHAM KELVIN K C , CAO GUO-QIANG
IPC分类号： C07D401/04 , C07D401/14 , A61K31/4152 , A61K31/4155
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention relates to compounds having the general formula (I) or a pharmaceutically acceptable salt thereof. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic beta cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis,Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
摘要翻译：本发明涉及具有通式（I）的化合物或其药学上可接受的盐。还包括预防或治疗炎症，类风湿性关节炎，斑节病，骨质疏松症，多发性骨髓瘤，葡萄膜炎，急性或慢性骨髓性白血病，胰腺β细胞破坏，骨关节炎，类风湿性脊椎炎，痛风性关节炎，炎性肠病，成人呼吸窘迫综合征（ARDS），牛皮癣，克罗恩病，过敏性鼻炎，溃疡性结肠炎，过敏反应，接触性皮炎，哮喘，肌肉退化，恶病质，赖特综合征，I型糖尿病，II型糖尿病，骨吸收疾病，移植物抗宿主反应，阿尔茨海默病，中风，心肌梗死，缺血再灌注损伤，动脉粥样硬化，脑外伤，多发性硬化，脑疟疾，败血症，败血性休克，中毒性休克综合征，发热，HIV-1，HIV-2，HIV-3，巨细胞病毒引起的肌痛（CMV），流感，腺病毒，哺乳动物中的疱疹病毒或带状疱疹感染，包括给予有效量的化合物作为de 如上所述。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式