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1. 发明申请

WO2007082893A1 VERFAHREN ZUR DIGITALISIERUNG DREIDIMENSIONALER BAUTEILE 审中-公开
标题翻译：方法三维成分数值化
公开(公告)号：WO2007082893A1
公开(公告)日：2007-07-26
申请号：PCT/EP2007/050432
申请日：2007-01-17
申请人： ALSTOM TECHNOLOGY LTD , FERRARESE, Claudio , MÖHLIG, Harald , HULME, Christopher, John , DIETRICH, Markus
发明人： FERRARESE, Claudio , MÖHLIG, Harald , HULME, Christopher, John , DIETRICH, Markus
IPC分类号： G06T17/00
CPC分类号： G06T17/10
摘要： In einem destruktiven Verfahren wird ein dreidimensionales Bauteil (1) mit einer Aussengeometrie und einer Innengeometrie digitalisiert. An der Aussenoberfläche des Bauteils (1) werden dreidimensionale Markierungskörper (30) angebracht. Die Aussengeometrie des Bauteils (1) mit den Markierungskörpern (30) wird sodann mit geeignetem Verfahren digitalisiert und ein Referenzdatensatz erstellt. Das Bauteil (1) wird in Segmente zerlegt, sodass alle Konturen der Innengeometrie offengelegt sind, wonach diese Segmente digitalisiert werden. Die digitalen Datensätze der Segmente werden schliesslich mit Hilfe des Referenzdatensatzes des Bauteils (1) mit Markierungsgeometrien (30) im Raum und zueinander korrekt ausgerichtet und zusammengesetzt. Das Verfahren eignet sich insbesondere für die Digitalisierung von Bauteilen (1) aus schwer durchstrahlbaren Werkstoffen und/oder mit grossen Wandstärken.
摘要翻译：在破坏性的方法，一个三维部件（1）具有外和内几何形状是数字化。在组分（1）的外表面安装有三维标记体（30）。与标记体（30）的部件（1）的外部几何形状，然后通过适当的方法进行数字化，并创建参考数据集。组分（1）被分成段，从而使内部几何形状的所有轮廓中公开，根据该这些段被数字化。最后使用的基准数据与在房间标记的几何形状（30）和彼此对准并组装设置组件（1）的链段的数字记录。该方法特别适用于由硬质材料的组分（1）的数字化被穿透和/或具有大的壁厚。

2. 发明申请

WO1998005327A1 SUBSTITUTED AROMATIC COMPOUNDS 审中-公开
标题翻译：取代的芳香化合物
公开(公告)号：WO1998005327A1
公开(公告)日：1998-02-12
申请号：PCT/US1997013343
申请日：1997-07-22
申请人： RHONE-POULENC RORER PHARMACEUTICALS INC. , HE, Wei , HULME, Christopher , HUANG, Fu-Chih , DJURIC, Stevan, W. , MORIARTY, Kevin , LABAUDINIERE, Richard
发明人： RHONE-POULENC RORER PHARMACEUTICALS INC.
IPC分类号： A61K31/44
CPC分类号： C07D207/08 , C07D207/26 , C07D213/30 , C07D213/89 , C07D401/06 , C07D401/08 , C07D401/12 , C07D401/14 , C07D403/04
摘要： This invention is directed to compound of formula (I) or hydrate thereof, solvate thereof, N-oxide thereof, prodrug thereof or a pharmaceutically acceptable salt thereof, which possess useful pharmaceutical properties. They are especially useful for inhibiting the production or physiological effects of TNF and inhibit cyclic AMP. The present invention is also directed to their pharmaceutical use, pharmaceutical compositions containing the compounds, and methods of their preparation.
摘要翻译：本发明涉及具有有用的药物性质的式（I）的化合物或其水合物，其溶剂合物，N-氧化物，其前药或其药学上可接受的盐。它们对于抑制TNF的产生或生理作用并抑制环AMP尤其有用。本发明还涉及其药物用途，含有该化合物的药物组合物及其制备方法。

3. 发明申请

WO2005019240A3 MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS 审中-公开
标题翻译：褪黑素浓集激素受体拮抗剂
公开(公告)号：WO2005019240A3
公开(公告)日：2005-05-06
申请号：PCT/US2004025970
申请日：2004-08-11
申请人： AMGEN INC , TEMPEST PAUL , HULME CHRISTOPHER , MA VU
发明人： TEMPEST PAUL , HULME CHRISTOPHER , MA VU
IPC分类号： A61K31/40 , A61K31/445 , C07D207/06 , C07D207/09 , C07D207/30 , C07D213/75 , C07D215/08 , C07D233/32 , C07D295/13 , C07K20060101
CPC分类号： C07D207/09 , C07D213/75 , C07D215/08 , C07D233/32 , C07D295/13
摘要： Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula (I) (I) wherein W, X, Y, Z, R -R , and R are as defined in the specification, are provided. Also provided are methods of treating or preventing a melanin concentrating hormone-mediated disorder in a subject, comprising administering to a subject in need of such treatment or prevention a compound of Formula I.
摘要翻译：式（I）（I）的新化合物或其药学上可接受的盐，互变异构体或前药其中W，X，Y，Z，R 3 -R 6和R 11如规格说明。还提供了治疗或预防受试者中黑色素浓集激素介导的病症的方法，其包括向需要这种治疗或预防的受试者施用式I化合物。

4. 发明申请

WO2004014871A1 VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS 审中-公开
标题翻译：香草酸受体配体及其在治疗中的应用
公开(公告)号：WO2004014871A1
公开(公告)日：2004-02-19
申请号：PCT/US2003/025191
申请日：2003-08-08
申请人： AMGEN INC. , CHKRABARTI, Partha, P , CHEN, Ning , DOHERTY, Elisabeth, M. , DOMINGUEZ, Celia , FALSEY, James, Richard , FOTSH, Christopher, H. , HULME, Christopher , KATON, Jodie , NIXEY, Thomas , NORMAN, Mark, H. , OGNYANOV, Vassil, I. , PETTUS, Liping, H. , RZASA, Robert, Michael , STEC, Markian , WANG, Hui-Ling , ZHU, Jiawang
发明人： CHKRABARTI, Partha, P , CHEN, Ning , DOHERTY, Elisabeth, M. , DOMINGUEZ, Celia , FALSEY, James, Richard , FOTSH, Christopher, H. , HULME, Christopher , KATON, Jodie , NIXEY, Thomas , NORMAN, Mark, H. , OGNYANOV, Vassil, I. , PETTUS, Liping, H. , RZASA, Robert, Michael , STEC, Markian , WANG, Hui-Ling , ZHU, Jiawang
IPC分类号： C07D239/34
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：具有通用结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙齿疼痛，一般性头痛，偏头痛，丛集性头痛，混合血管和非血管性综合征，张力头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，具有炎性成分的皮肤病，慢性炎症，炎性疼痛和相关的痛觉过敏和异常性疼痛，神经性疼痛和相关痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经维持性疼痛，传入神经缺失综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸系统，泌尿生殖系统，胃肠或血管区域内脏运动障碍，伤口，瘙痒症，白癜风，一般胃肠道 l溃疡，胃溃疡，十二指肠溃疡，腹泻，由坏死物质诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

5. 发明申请

WO1997048697A1 SUBSTITUTED AZABICYLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF THE PRODUCTION OF TNF AND CYCLIC AMP PHOSPHODIESTERASE 审中-公开
标题翻译：取代的氨基甲酸酯化合物及其作为TNF和环磷酰胺酶的生产抑制剂
公开(公告)号：WO1997048697A1
公开(公告)日：1997-12-24
申请号：PCT/GB1997001639
申请日：1997-06-19
申请人： RHONE-POULENC RORER LIMITED , COX, Paul, Joseph , BOWER, Shelley , ALDOUS, David, John , ASTLES, Peter, Charles , McGARRY, Daniel, Gerard , HULME, Christopher , REGAN, John, Robinson , HUANG, Fu-Chih , DJURIC, Stevan, Wakefield , MORIARTY, Kevin, Joseph , MATHEW, Rose, Mappilakunnel , POLI, Gregory, Bernard
发明人： RHONE-POULENC RORER LIMITED
IPC分类号： C07D401/12
CPC分类号： C07D235/24 , C07D209/12 , C07D209/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： This invention is directed to physiologically active compounds of formula (I) wherein (i) represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring (ii) is an azaheterocycle, and the ring (iii) represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; wherein R -R , A , Z , m and n are as defined herein. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions comprising compounds of formula (I), their pharmaceutical use and methods for their preparation.
摘要翻译：本发明涉及式（I）的生理活性化合物，其中（i）表示双环体系，约10至约13个环成员，其中环（ii）是氮杂环，并且环（iii）表示氮杂杂芳基环，或任选卤素取代的苯环; 其中R 1 -R 3，A 1，Z 1，m和n如本文所定义。这些化合物抑制TNF的产生或生理作用并抑制环AMP磷酸二酯酶。本发明还涉及包含式（I）化合物的药物组合物，其药物用途及其制备方法。

6. 发明申请

WO2005019167A3 MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST 审中-公开
标题翻译：梅兰宁浓缩激素受体拮抗剂
公开(公告)号：WO2005019167A3
公开(公告)日：2005-12-01
申请号：PCT/US2004026021
申请日：2004-08-11
申请人： AMGEN INC , HULME CHRISTOPHER , TEMPEST PAUL , MA VU , NIXEY THOMAS , BALOW GUITY
发明人： HULME CHRISTOPHER , TEMPEST PAUL , MA VU , NIXEY THOMAS , BALOW GUITY
IPC分类号： A61K31/4025 , A61K31/495 , A61K31/496 , A61K31/66 , A61K31/675 , C07D20060101 , C07D257/04 , C07D401/14 , C07D403/06
CPC分类号： C07D257/04 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12
摘要： Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula (I) wherein A, W, X, Z, R -R , and R are as defined in the specification, are provided. Also provided are methods of treating or preventing a melanin concentrating hormone-mediated disorder in a subject, comprising administering to a subject in need of such treatment or prevention a compound of Formula (I).
摘要翻译：其中A，W，X，Z，R 1 -R 3和R 8如说明书中所定义的式（I）的新化合物或其药学上可接受的盐，互变异构体或前药，被提供。还提供了治疗或预防受试者中黑色素浓缩激素介导的病症的方法，其包括向需要这种治疗或预防的受试者施用式（I）的化合物。

7. 发明申请

WO2005019167A2 MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST 审中-公开
标题翻译：梅兰宁浓缩激素受体拮抗剂
公开(公告)号：WO2005019167A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/026021
申请日：2004-08-11
申请人： AMGEN, INC. , HULME, Christopher , TEMPEST, Paul , MA, Vu , NIXEY, Thomas , BALOW, Guity
发明人： HULME, Christopher , TEMPEST, Paul , MA, Vu , NIXEY, Thomas , BALOW, Guity
IPC分类号： C07D
CPC分类号： C07D257/04 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12
摘要： Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula I wherein A, W, X, Z, R1-R3, and R8 are as defined in the specification, are provided. Also provided are methods of treating or preventing a melanin concentrating hormone-mediated disorder in a subject, comprising administering to a subject in need of such treatment or prevention a compound of Formula I.
摘要翻译：其中A，W，X，Z，R 1 -R 3和R 8如说明书中所定义的式I的新化合物或其药学上可接受的盐，互变异构体或前药。还提供了治疗或预防受试者中黑色素浓缩激素介导的病症的方法，其包括向需要这种治疗或预防的受试者施用式I化合物。

8. 发明申请

WO2008083889A1 METHOD AND DEVICE FOR PIN REMOVAL IN A CONFINED SPACE 审中-公开
标题翻译：用于在限定空间中删除密码的方法和设备
公开(公告)号：WO2008083889A1
公开(公告)日：2008-07-17
申请号：PCT/EP2007/063763
申请日：2007-12-12
申请人： ALSTOM TECHNOLOGY LTD , MOSER, Roland , HULME, Christopher John
发明人： MOSER, Roland , HULME, Christopher John
IPC分类号： B23P6/00 , B24C5/02 , B24C5/04 , B26F3/00
CPC分类号： B23P6/002 , B24C1/045 , B26F3/004 , F01D5/005 , F01D5/3053 , Y10T83/0591 , Y10T83/364
摘要： A method for drilling or cutting a pin (31) surrounded by solid material (32) includes the use of a water jet tool (10) having a nozzle (11) that is arranged at an angle with respect to a main body (12) of the water jet tool (10). The water jet is directed over a portion of the surface of thepin (31), and removes that portion thereby fragmenting the pin (31). In order to minimise damage to the surrounding material, the portions removed touches the interface between the pin and the surrounding solid material at a minimal number of points and over a minimal extent of the interface. The method is applicable in particular to the removal of pins (31) used in a press-fit for the securing of blades (3) on a turbine rotor (1). The method facilitates "in situ" removal of pins within a confined space ina short time and at reduced cost.
摘要翻译：用于钻削或切割由固体材料（32）围绕的销（31）的方法包括使用具有相对于主体（12）成一定角度布置的喷嘴（11）的喷水工具（10）的喷水工具（10）。水射流被引导到销（31）的表面的一部分上，并且去除该部分，从而使销（31）分裂。为了最小化对周围材料的损害，所消除的部分以最小数量的点和界面的最小程度触及销和周围固体材料之间的界面。该方法特别适用于去除在压配合中用于将叶片（3）固定在涡轮转子（1）上的销（31）。该方法有助于在短时间内以降低的成本在狭窄的空间内“原位”去除销。

9. 发明申请

WO2004014871A8 VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS 审中-公开
标题翻译：香草酸受体配体及其在治疗中的应用
公开(公告)号：WO2004014871A8
公开(公告)日：2005-04-07
申请号：PCT/US0325191
申请日：2003-08-08
申请人： AMGEN INC , CHAKRABARTI PARTHA P , CHEN NING , DOHERTY ELIZABETH M , DOMINGUEZ CELIA , FALSEY JAMES RICHARD , FOTSH CHRISTOPHER H , HULME CHRISTOPHER , KATON JODIE , NIXEY THOMAS , NORMAN MARK H , OGNYANOV VASSIL I , PETTUS LIPING H , RZASA ROBERT MICHAEL , STEC MARKIAN , WANG HUI-LING , ZHU JIAWANG
发明人： CHKRABARTI PARTHA P , CHEN NING , DOHERTY ELIZABETH M , DOMINGUEZ CELIA , FALSEY JAMES RICHARD , FOTSH CHRISTOPHER H , HULME CHRISTOPHER , KATON JODIE , NIXEY THOMAS , NORMAN MARK H , OGNYANOV VASSIL I , PETTUS LIPING H , RZASA ROBERT MICHAEL , STEC MARKIAN , WANG HUI-LING , ZHU JIAWANG
IPC分类号： A61P29/00 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D239/34 , A61K31/4427 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/551 , C07D239/38 , C07D401/14 , C07D405/14 , C07D409/12 , C07D413/14 , C07D417/14 , C07D471/04
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：具有通用结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般性头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，具有炎性成分的皮肤病，慢性炎症，炎性疼痛和相关的痛觉过敏和异常性疼痛，神经性疼痛和相关的痛觉过敏和异常性疼痛，呼吸系统，泌尿生殖系统，胃肠或血管区域的伤害，伤口，烧伤，过敏性皮肤反应，瘙痒症，白癜风，一般性胃肠道疾病，躁狂症， G 牙周溃疡，十二指肠溃疡，腹泻，由坏死剂引起的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

10. 发明申请

WO2005019240A2 MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS 审中-公开
标题翻译：梅拉宁浓度HORMONE受体拮抗剂
公开(公告)号：WO2005019240A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/025970
申请日：2004-08-11
申请人： AMGEN, INC. , TEMPEST, Paul , HULME, Christopher , MA, Vu
发明人： TEMPEST, Paul , HULME, Christopher , MA, Vu
IPC分类号： C07K
CPC分类号： C07D207/09 , C07D213/75 , C07D215/08 , C07D233/32 , C07D295/13
摘要： Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula (I) (I) wherein W, X, Y, Z, R 3 -R 6 , and R 11 are as defined in the specification, are provided. Also provided are methods of treating or preventing a melanin concentrating hormone-mediated disorder in a subject, comprising administering to a subject in need of such treatment or prevention a compound of Formula I.
摘要翻译：式（I）（I）的新化合物或其药学上可接受的盐，互变异构体或前药，其中W，X，Y，Z，R 3 -R 6和R 11如提供规格。还提供了治疗或预防受试者中黑色素浓缩激素介导的病症的方法，其包括向需要这种治疗或预防的受试者施用式I化合物。

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