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1. 发明申请

WO2010065649A1 INJECTION DEVICE 审中-公开
标题翻译：注射装置
公开(公告)号：WO2010065649A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/066427
申请日：2009-12-02
申请人： ALLERGAN, INC. , TEZEL, Ahmet , MCNERNEY, Kevin , MUDD, Christopher, S. , STORIE, Blake, R. , MANDAROUX, Bastien
发明人： TEZEL, Ahmet , MCNERNEY, Kevin , MUDD, Christopher, S. , STORIE, Blake, R. , MANDAROUX, Bastien
IPC分类号： A61M5/34
CPC分类号： A61M5/347 , A61M5/3293 , A61M2210/04
摘要： An injection device (10) includes a syringe (12) having a body (14) with a piston (18) disposed therein with an open end along with a viscous fluid disposed in the body for injection by the piston. A needle assembly (26) is provided which includes a cannula (30) having a luer connection engageable with the syringe distal end with the luer connector including a hub. Mating engagement is provided by way of internal threads at the syringe distal end and external treads of a hub with a pitch sufficient to prevent detachment of the hub from the syringe distal end during ejection of the viscous fluid. In addition, a stepped cavity, disposed in the hub, further prevents detachment of the hub from the syringe distal end during ejection of the viscous fluid.
摘要翻译：注射装置（10）包括具有本体（14）的注射器（12），其具有设置在其中的活塞（18），开口端与设置在主体中用于由活塞注射的粘性流体连接。提供一种针组件（26），其包括套管（30），所述套管具有可与注射器远端接合的鲁尔连接件，鲁尔连接器包括轮毂。配合接合通过注射器远端的内螺纹和具有足以防止在排出粘性流体期间将轮毂从注射器远端分离的间距的毂的外胎面提供。此外，设置在轮毂中的阶梯式空腔进一步防止在排出粘性流体期间轮毂从注射器远端脱离。

2. 发明申请

WO2009073437A1 POLYSACCHARIDE GEL FORMULATION 审中-公开
标题翻译：多糖凝胶配方
公开(公告)号：WO2009073437A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/084515
申请日：2008-11-24
申请人： ALLERGAN, INC. , STROUMPOULIS, Dimitrios , MUDD, Christopher, S. , TEZEL, Ahmet
发明人： STROUMPOULIS, Dimitrios , MUDD, Christopher, S. , TEZEL, Ahmet
IPC分类号： A61K8/60 , A61K8/73 , A61K8/04 , A61Q19/00 , A61Q19/08 , A61K9/10 , A61K31/738 , C08B37/00 , A61K9/00
CPC分类号： A61L27/26 , A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/183 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42 , A61K2800/522 , A61L27/505 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08K5/053 , C08L5/08 , C08L2205/02
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide. In some embodiments, the incorporating step comprises 1 ) mixing the at least one inhibitor with the at least one polysaccharide at a highly hydrated state thereby encapsulating the at least one inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network thereby controlling release kinetics or final swell ratio. In another embodiment, the incorporating step comprises 1) encapsulating at least one inhibitor into a biocompatible or biodegradable vessel and 2) combining the polysaccharide and the vessel into a gel formulation. The polysaccharide gel formulations described herein can be used for a variety of cosmetic applications.
摘要翻译：本文描述的是多糖凝胶制剂，其包括至少一种多糖降解抑制剂及其制备方法。本文描述的方法包括提供至少一种多糖并将至少一种降解抑制剂并入多糖中的步骤。在一些实施方案中，掺入步骤包括：1）以高水合状态将至少一种抑制剂与至少一种多糖混合，从而将至少一种抑制剂包封在多糖网络中，以及2）使多糖网络脱水从而控制释放动力学或最终膨胀比。在另一个实施方案中，掺入步骤包括：1）将至少一种抑制剂包封在生物相容性或可生物降解的容器中，和2）将多糖和血管结合成凝胶制剂。本文所述的多糖凝胶制剂可用于各种化妆品应用。

3. 发明申请

WO2013074347A1 INJECTION DEVICE HAVING AN ANGLED TIP PORTION 审中-公开
标题翻译：注射装置有一个提示提示部分
公开(公告)号：WO2013074347A1
公开(公告)日：2013-05-23
申请号：PCT/US2012/063853
申请日：2012-11-07
申请人： ALLERGAN, INC.
发明人： MUDD, Christopher, S. , BABKES, Mitchell, H. , DOMINGUEZ, Zachary, P. , PRICHARD, Michael, J. , LLEWELLYN, Martha, E. , QIU, Shaohui , POWERS, Lee, F. , JOHNSON, Brett, R.
IPC分类号： A61M5/19 , A61M5/20
CPC分类号： A61M5/2066 , A61M5/19 , A61M5/20 , A61M5/2053 , A61M5/24 , A61M5/31 , A61M2005/341 , A61M2205/50
摘要： The handheld injection device includes a first housing (102) having a first axis (105) and a second housing (109) having a second axis (113). The second housing is configured to support a needle. In one embodiment, the first axis and a second axis form an adjustable angle between about 180 degrees and about 90 degrees.
摘要翻译：手持式注射装置包括具有第一轴线（105）和具有第二轴线（113）的第二壳体（109）的第一壳体（102）。第二壳体构造成支撑针头。在一个实施例中，第一轴线和第二轴线在约180度和约90度之间形成可调节的角度。

4. 发明申请

WO2011084504A1 SYRINGE COMPRISING TWO PLUNGERS WITH LOCKING MEANS 审中-公开
标题翻译：包装两个枕头的锁紧装置
公开(公告)号：WO2011084504A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060553
申请日：2010-12-15
申请人： ALLERGAN, INC. , STROUMPOULIS, Dimitrios , MUDD, Christopher, S.
发明人： STROUMPOULIS, Dimitrios , MUDD, Christopher, S.
IPC分类号： A61M5/19 , A61M5/315 , A61F2/00
CPC分类号： A61M5/31501 , A61M5/19 , A61M5/31511 , A61M5/3158 , A61M5/31596 , A61M2005/31508 , A61M2005/31598
摘要： The syringe includes a syringe body (101) with a fluid chamber and with an extrusion opening (104) at the proximal end (401); a dividing wall disposed within the fluid chamber, defining a first fluid chamber (302) and a second fluid chamber (303), the first fluid chamber and the second fluid chamber in communication with the extrusion opening; a first plunger (102) disposed in a distal end of the first chamber, the first plunger including a first locking mechanism (402) configured to prevent the first plunger from sliding away from the proximal end of the syringe body, when the first plunger is in a first initial position and the second plunger is being depressed; and a second plunger disposed in a distal end of the second chamber, the second plunger including a second locking mechanism (402) configured to prevent the second plunger from sliding away from the proximal end of the syringe body when the second plunger is in a second initial position and the first plunger is being depressed.
摘要翻译：注射器包括具有流体室的注射器主体（101）和在近端（401）处的挤出开口（104）; 分隔壁，其设置在所述流体室内，限定第一流体室（302）和第二流体室（303），所述第一流体室和所述第二流体室与所述挤出口连通; 设置在所述第一腔室的远端中的第一柱塞（102），所述第一柱塞包括第一锁定机构（402），所述第一锁定机构构造成当所述第一柱塞为所述第一柱塞时，防止所述第一柱塞从所述注射器主体的近端滑离; 在第一初始位置和第二柱塞被压下; 以及设置在所述第二腔室的远端中的第二柱塞，所述第二柱塞包括第二锁定机构（402），所述第二锁定机构构造成当所述第二柱塞处于第二柱塞时，所述第二锁定机构被构造成防止所述第二柱塞从所述注射器主体的近端滑离初始位置和第一柱塞被压下。

5. 发明申请

WO2009158145A2 INJECTION DEVICE FOR SOFT-TISSUE AUGMENTATION FILLERS, BIOACTIVE AGENTS AND OTHER BIOCOMPATIBLE MATERIALS IN LIQUID OR GEL FORM 审中-公开
标题翻译：用于软组织填充填料，生物剂和液体或凝胶形式中的其他生物成分材料的注射装置
公开(公告)号：WO2009158145A2
公开(公告)日：2009-12-30
申请号：PCT/US2009/045831
申请日：2009-06-01
申请人： ALLERGAN, INC. , MUDD, Christopher, S. , TEZEL, Ahmet
发明人： MUDD, Christopher, S. , TEZEL, Ahmet
IPC分类号： A61M5/20
CPC分类号： A61M5/2053 , A61B5/150129 , A61M5/19 , A61M5/20 , A61M5/24 , A61M5/2448 , A61M5/31575 , A61M5/422 , A61M5/427 , A61M5/46 , A61M39/24 , A61M2005/2006 , A61M2005/2411 , A61M2005/3125 , A61M2005/3126 , A61M2005/3128 , A61M2005/31588 , A61M2202/0007 , A61M2202/049 , A61M2202/09 , A61M2202/20 , A61M2205/19 , A61M2205/3569 , A61M2205/36 , A61M2205/3606 , A61M2205/502 , A61M2205/52 , A61M2205/586 , A61M2205/587 , A61M2205/6045 , A61M2205/6063 , A61M2205/8206 , A61M2205/8212 , A61M2205/8237 , A61M2205/8243 , A61M2210/04
摘要： Described herein are injection devices capable of automatically injecting substances into the soft tissue of a patient. The devices can inject low to high viscosity materials at predetermined, user selected injection rates, allowing the operator more control than a traditional syringe. The devices can allow mixing of more than one substance and/or reconstitution of a solid substance for injection. The injection devices described herein can allow the operator to easily inject one or more low to high viscosity liquid or gel soft-tissue augmentation fillers, one or more drugs, one or more other biocompatible materials, or combinations thereof.
摘要翻译：这里描述的是能够将物质自动注射到患者的软组织中的注射装置。这些装置可以以预定的用户选择的注射速率注入低至高粘度的材料，使得操作者比传统注射器更加控制。该装置可以允许多于一种物质的混合和/或用于注射的固体物质的重建。本文所述的注射装置可以允许操作者容易地注入一种或多种低至高粘度液体或凝胶软组织增强填料，一种或多种药物，一种或多种其它生物相容性材料或其组合。

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