专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO9707788A3 COMPOSITION FOR SUSTAINED RELEASE OF AN AGENT 审中-公开
标题翻译：用于持续发行代理的组合物
公开(公告)号：WO9707788A3
公开(公告)日：1997-04-17
申请号：PCT/US9613787
申请日：1996-08-29
申请人： ALKERMES INC , LEE HYE JUNG , JOHNSON OLUFUNMI L , ZALE STEPHEN E , TRACY MARK A
发明人： LEE HYE-JUNG , JOHNSON OLUFUNMI L , ZALE STEPHEN E , TRACY MARK A
IPC分类号： A61K9/54 , A61K9/16 , A61K9/50 , A61K9/52 , A61K47/30
CPC分类号： A61K9/5084 , A61K9/1647
摘要： Composition for the sustained release of a biologically active agent in vivo. The composition comprises microcarriers containing a first solid-phase biocompatible material and a biologically active agent, wherein said microcarriers sustain in vivo release of the biologically active agent. The composition also contains particles of a second biocompatible solid-phase material wherein the second solid-phase material further sustains the in vivo release of the biologically active agent. The invention also relates to a method for sustaining effective serum levels of a biologically active agent in a subject, including forming an injectable dose containing an effective amount of a biologically active agent, wherein the agent is contained in a microcarrier, with a release-period sustaining amount of a solid-phase material. The method further includes administering the injectable dose to the subject.

2. 发明申请

WO9640074A3 DEVICE FOR RELEASING AGGREGATION-STABILIZED, BIOLOGICALLY ACTIVE AGENT 审中-公开
标题翻译：用于释放聚集稳定的生物活性剂的装置
公开(公告)号：WO9640074A3
公开(公告)日：1997-02-06
申请号：PCT/US9608526
申请日：1996-06-04
申请人： ALKERMES INC , BURKE PAUL A , ZALE STEPHEN E , TRACY MARK A , JOHNSON OLUFUNMI LILY , BERNSTEIN HOWARD , KHAN M AMIN , BRICKNER AVRAM , AUER HENRY
发明人： BURKE PAUL A , ZALE STEPHEN E , TRACY MARK A , JOHNSON OLUFUNMI LILY , BERNSTEIN HOWARD , KHAN M AMIN , BRICKNER AVRAM , AUER HENRY
IPC分类号： A61K9/10 , A61K9/00 , A61K9/16 , A61K38/18 , A61K38/27 , A61K47/02 , A61K47/26
CPC分类号： B82Y5/00 , A61K9/0019 , A61K9/1611 , A61K9/1647 , A61K38/1816 , A61K38/27 , A61K47/02 , A61K47/26
摘要： A device for the sustained release in vivo of a water soluble, biologically active agent wherein the agent is susceptible to aggregation comprising a drug delivery device and aggregation-stabilized, biologically active agent wherein the aggregation-stabilized agent is disposed within the drug delivery device.

3. 发明申请

WO2004034975A3 SUSTAINED RELEASE PROFILE MODIFICATION 审中-公开
标题翻译：可持续发布配置文件修改
公开(公告)号：WO2004034975A3
公开(公告)日：2005-06-02
申请号：PCT/US0332017
申请日：2003-10-08
申请人： ALKERMES INC , DASCH JAMES R , RILEY GARY M I , BURKE PAUL A , STEITZ-ABADI SUSAN A , ZALE STEPHEN E
发明人： DASCH JAMES R , RILEY GARY M I , BURKE PAUL A , STEITZ-ABADI SUSAN A , ZALE STEPHEN E
IPC分类号： A61K20060101 , A61K9/00 , A61K9/10 , A61K9/16 , A61K9/22 , A61K9/52 , A61K31/573 , A61K38/17 , A61K38/18 , A61K38/24 , A61K38/28 , A61K45/06 , A61K47/28 , A61K47/30
CPC分类号： A61K9/0024 , A61K9/1647 , A61K9/1694 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method for the sustained release in vivo of a biologically active labile agent comprising administering to a subject in need of treatment an effective amount of a sustained release composition comprising a biocompatible polymer having the biologically active labile agent incorporated therein, and a corticosteroid wherein the labile is released for a period of at least about two weeks. It is understood that the corticosteroid is present in an amount sufficient to modify the release profile of the biologically active labile agent from the sustained release composition. Pharmaceutical compositions suitable for use in the method of the invention are also disclosed.
摘要翻译：本发明涉及一种用于生物活性不稳定试剂体内持续释放的方法，其包括向需要治疗的受试者施用有效量的持续释放组合物，其包含其中掺入生物活性不稳定剂的生物相容性聚合物，和一种皮质类固醇，其中不稳定性释放至少约两周。应当理解，皮质类固醇以足以改变生物活性不稳定剂从持续释放组合物的释放曲线的量存在。还公开了适用于本发明方法的药物组合物。

4. 发明申请

WO2005107714A3 METHOD OF FORMING MICROPARTICLES THAT INCLUDE A BISPHOSPHONATE AND A POLYMER 审中-公开
标题翻译：形成包含二磷酸酯和聚合物的微生物的方法
公开(公告)号：WO2005107714A3
公开(公告)日：2006-09-28
申请号：PCT/US2005015757
申请日：2005-05-05
申请人： ALKERMES INC , FIGUEIREDO MARIA C , KUMAR RAJESH , MALONEY MAURA J , SCHER DAVID S , YEOH THEAN Y , ZALE STEPHEN E , PRINN KRISTIN , TROIANO GREGORY
发明人： FIGUEIREDO MARIA C , KUMAR RAJESH , MALONEY MAURA J , SCHER DAVID S , YEOH THEAN Y , ZALE STEPHEN E , PRINN KRISTIN , TROIANO GREGORY
IPC分类号： A61K9/16 , A61K9/14 , A61K9/19 , A61K9/50 , A61K31/66 , A61K31/675 , B01J13/02 , B01J13/04 , C08L23/08
CPC分类号： A61K9/1647 , A61K9/1641 , A61K9/1694 , A61K9/19 , C08L23/08 , C08L23/0815 , C08L2205/02 , C08L2666/06
摘要： Microparticles that includes a bisphosphonate and a polymer are produced by a method that includes forming a water-in-oil emulsion by mixing an aqueous solution of the bisphosphonate with a combination of a biocompatible polymer and a polymer solvent. At least one aqueous liquid can be mixed with the water-in-oil emulsion to form a water-in-oil-in-water emulsion and to extract the polymer solvent from the polymer, thereby forming the microparticles. Methods of treating a patient in need of therapy include administering the microparticles described to the patient. In one embodiment, the microparticles are formulated for the sustained release of the bisphosphonate.
摘要翻译：包括二膦酸盐和聚合物的微粒通过包括通过将二膦酸盐的水溶液与生物相容性聚合物和聚合物溶剂的组合混合形成油包水乳液的方法来制备。可以将至少一种含水液体与油包水乳液混合以形成水包油包水乳液，并从聚合物中提取聚合物溶剂，从而形成微粒。治疗需要治疗的患者的方法包括给患者描述的微粒进行给药。在一个实施方案中，将微粒配制成二膦酸盐的持续释放。

5. 发明申请

WO2010005740A3 METHODS FOR THE PREPARATION OF TARGETING AGENT FUNCTIONALIZED DIBLOCK COPOLYMERS FOR USE IN FABRICATION OF THERAPEUTIC TARGETED NANOPARTICLES 审中-公开
标题翻译：制备靶向剂官能化二嵌段共聚物用于制备治疗性靶向纳米颗粒的方法
公开(公告)号：WO2010005740A3
公开(公告)日：2010-03-25
申请号：PCT/US2009047554
申请日：2009-06-16
申请人： BIND BIOSCIENCES INC , ALI MIR M , HRKACH JEFF , ZALE STEPHEN E
发明人： ALI MIR M , HRKACH JEFF , ZALE STEPHEN E
IPC分类号： A61K9/16 , A61K47/34 , A61P35/00
CPC分类号： A61K47/34 , A61K9/5153 , A61K47/60 , A61K47/6911
摘要： This application provides methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. These diblock copolymers comprise a poly(ethylene glycol) block bearing a targeting agent at its terminus and a second biocompatible and biodegradable hydrophobic polymer block (e.g. a poly(ester)). The poly(ethylene glycol) is hetero-bifunctional with a targeting moiety (agent) covalently bound to its a terminus and a polymerization initiating functional group (e.g., a hydroxyl group) present on its ? terminus. Ring opening polymerization yields the desired poly(ester)-poly(ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This "polymerization from" approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a "coupling to" that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses "orthogonal" chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest. Nanoparticles produced according to the disclosed methods as well as their use in the treatment of various diseases are also provided.
摘要翻译：本申请提供了使用预官能化聚（乙二醇）（也称为PEG）作为合成二嵌段共聚物的大分子引发剂制备纳米粒子的方法。这些二嵌段共聚物包含在其末端带有靶向剂的聚（乙二醇）嵌段和第二生物相容且可生物降解的疏水聚合物嵌段（例如聚（酯））。聚（乙二醇）是异双功能的，具有与其末端共价结合的靶向部分（试剂）和存在于其α位的聚合引发官能团（例如羟基）总站。开环聚合产生用于赋予治疗性纳米粒子靶向能力的所需聚（酯） - 聚（乙二醇） - 靶向剂聚合物。这种“聚合”方法通常使用靶向剂的前体，其中靶向剂的官能团的反应性使用保护基掩蔽。还描述了使用聚（乙二醇） - 靶向剂缀合物的“偶联到”，其中靶向剂保持其天然的未保护形式。该方法使用“正交”化学，其对通常在目标靶向剂内发现的官能团没有交叉反应性。还提供了根据所公开的方法生产的纳米颗粒以及它们在治疗各种疾病中的用途。

6. 发明申请

WO2008105773A2 SYSTEM FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于治疗药物的定向递送系统
公开(公告)号：WO2008105773A2
公开(公告)日：2008-09-04
申请号：PCT/US2007007927
申请日：2007-03-30
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL , FAROKHZAD OMID C , CHENG JIANJUN , TEPLEY BENJAMIN A , LANGER ROBERT S , ZALE STEPHEN E
发明人： FAROKHZAD OMID C , CHENG JIANJUN , TEPLEY BENJAMIN A , LANGER ROBERT S , ZALE STEPHEN E
IPC分类号： A61K9/14
CPC分类号： A61K47/4813 , A61K9/5031 , A61K9/5153 , A61K9/5192 , A61K31/337 , A61K47/482 , A61K47/48215 , A61K47/549 , A61K47/555 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937 , A61K51/0417 , A61K51/0491 , A61K51/0495 , A61K51/065
摘要： The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.
摘要翻译：本发明提供了用于将组合物，细胞和细胞内区室靶向递送含治疗剂的颗粒的药物递送系统。本发明提供了包含颗粒，一种或多种靶向部分和一种或多种待递送治疗剂和包含本发明靶向颗粒的药物组合物的靶向颗粒。本发明提供了设计，制造和使用本发明的靶向颗粒及其药物组合物的方法。

7. 发明申请

WO2012166923A3 DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：药物加载聚合物纳米粒子及其制备方法和使用方法
公开(公告)号：WO2012166923A3
公开(公告)日：2013-01-24
申请号：PCT/US2012040215
申请日：2012-05-31
申请人： BIND BIOSCIENCES , ZALE STEPHEN E
发明人： ZALE STEPHEN E
IPC分类号： A61K9/16 , A61K9/14 , A61K31/337 , A61K47/30 , A61K47/48
CPC分类号： A61K9/5153 , A61K9/1647 , A61K9/5192 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K47/26 , A61K47/593
摘要： The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.
摘要翻译：本公开内容通常涉及具有约0.2至约35重量％的治疗剂的纳米颗粒; 和约10至约99重量％的生物相容性聚合物，例如二嵌段聚（乳酸） - 聚（乙烯）二醇。本发明的其它方面包括制备这种纳米颗粒的方法。

8. 发明申请

WO2011072218A3 STABLE FORMULATIONS FOR LYOPHILIZING THERAPEUTIC PARTICLES 审中-公开
标题翻译：冻干治疗用颗粒的稳定配方
公开(公告)号：WO2011072218A3
公开(公告)日：2011-10-20
申请号：PCT/US2010059879
申请日：2010-12-10
申请人： BIND BIOSCIENCES , TROIANO GREG , ZALE STEPHEN E , WRIGHT JAMES , VAN GEEN UOVEN TINA , SONG YOUNG-HO
发明人： TROIANO GREG , ZALE STEPHEN E , WRIGHT JAMES , VAN GEEN UOVEN TINA , SONG YOUNG-HO
IPC分类号： A61K47/40 , A61K31/335 , A61K47/02 , A61K47/30 , A61K47/36 , A61P35/00
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/16 , A61K9/19 , A61K9/5123 , A61K9/5153 , A61K9/5161 , A61K9/5192 , A61K31/335 , A61K47/26 , A61K47/34 , A61K47/40 , C08G63/664 , Y10S977/906
摘要： The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.
摘要翻译：本公开总体上涉及包含聚合物纳米颗粒的冻干药物组合物，其在重构时具有低水平的大于10微米大小的颗粒。本发明的其他方面包括制造这种纳米颗粒的方法。

9. 发明申请

WO2010005725A3 THERAPEUTIC POLYMERIC NANOPARTICLES COMPRISING VINCA ALKALOIDS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：包含VINCA碱性物质的治疗性聚合物纳米颗粒及其制备方法和使用方法
公开(公告)号：WO2010005725A3
公开(公告)日：2010-04-22
申请号：PCT/US2009047517
申请日：2009-06-16
申请人： BIND BIOSCIENCES INC , ZALE STEPHEN E , TROIANO GREG , ALI MIR MUKKARAM , HRKACH JEFF , WRIGHT JAMES
发明人： ZALE STEPHEN E , TROIANO GREG , ALI MIR MUKKARAM , HRKACH JEFF , WRIGHT JAMES
IPC分类号： A61K9/16 , A61K31/475 , A61K47/34 , A61P35/00
CPC分类号： A61K9/1647 , A61K9/14 , A61K9/1694 , A61K9/19 , A61K9/5153 , A61K31/4745 , A61K31/475 , A61K31/55 , A61K47/26
摘要： The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a vinca alkaloid; and about 50 to about 99 weight percent biocompatible polymer.
摘要翻译：本公开一般涉及治疗性纳米颗粒。本文公开的示例性纳米颗粒可包括约1至约20重量％的长春花生物碱; 和约50至约99重量％的生物相容性聚合物。

10. 发明申请

WO2010068866A3 THERAPEUTIC PARTICLES SUITABLE FOR PARENTERAL ADMINISTRATION AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：适用于外部管理的治疗颗粒及其制备和使用方法
公开(公告)号：WO2010068866A3
公开(公告)日：2010-10-21
申请号：PCT/US2009067672
申请日：2009-12-11
申请人： BIND BIOSCIENCES , GRAYSON AMY , ZALE STEPHEN E , DEWITT DAVID
发明人： GRAYSON AMY , ZALE STEPHEN E , DEWITT DAVID
IPC分类号： A61K31/21 , A61K9/14 , A61K9/16 , A61K31/4353 , A61K47/34 , A61P9/00
CPC分类号： A61K47/48346 , A61K9/0019 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/00 , A61K31/21 , A61K31/337 , A61K31/4353 , A61K47/62 , A61K47/66 , A61K47/6937 , B82Y5/00
摘要： Disclosed herein are therapeutic compositions for treating and preventing diseases such as neointimal hyperplasia (NIH), where the compositions comprise a therapeutic particle that has a localized association with a blood vessel and a therapeutic agent, such as an anti-NIH agent. Methods of use of the therapeutic compositions are also disclosed.
摘要翻译：本文公开了用于治疗和预防诸如新内膜增生（NIH）的疾病的治疗组合物，其中组合物包含与血管局部相关的治疗颗粒和治疗剂如抗NIH药剂。还公开了治疗组合物的使用方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式