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1. 发明申请

WO2011129494A1 NUCLEOLIN SPECIFIC APTAMER AND USE THEREOF 审中-公开
标题翻译：核蛋白特异性APTAMER及其用途
公开(公告)号：WO2011129494A1
公开(公告)日：2011-10-20
申请号：PCT/KR2010/006311
申请日：2010-09-15
申请人： POSTECH ACADEMY-INDUSTRY FOUNDATION , POSCO , LEE, Jung-Hwan , KIM, Soon-Hag , KWON, Mi-Jin , KANG, Hyun-Gu , RYU, Sung-Ho , KIM, Jong-In , KIM, Youn-Dong , CHAE, Young-Chan , JANG, Sung-Key , IM, Jong-Hun , LEE, Sun-Hak , LEE, Hye-Jung , JANG, Eun-Jung , KIM, Ki Seok
发明人： LEE, Jung-Hwan , KIM, Soon-Hag , KWON, Mi-Jin , KANG, Hyun-Gu , RYU, Sung-Ho , KIM, Jong-In , KIM, Youn-Dong , CHAE, Young-Chan , JANG, Sung-Key , IM, Jong-Hun , LEE, Sun-Hak , LEE, Hye-Jung , JANG, Eun-Jung , KIM, Ki Seok
IPC分类号： C12N15/115 , C12Q1/68 , G01N33/574 , A61K31/7088 , A61P35/00
CPC分类号： G01N33/57496 , C12N15/115 , C12N2310/16 , C12N2310/335
摘要： Improved G-rich oligonucleotide (GRO) aptamers specific to nucleolin, a method of preparing the aptamers, and a use of the aptamers for diagnosing and/or treating a nucleolin-associated disease, are provided.
摘要翻译：提供了改进的对核仁林特异性的富G寡核苷酸（GRO）适配体，制备适体的方法，以及适配体用于诊断和/或治疗核仁素相关疾病的用途。

2. 发明申请

WO2006132491A1 INSOLE FOR PERFORMING ACUPRESSURE ON ACUPUNCTURE POINTS OF FOOT-BOTTOM 审中-公开
标题翻译：用于在脚底的穴位上执行ACUPRESSURE的工具
公开(公告)号：WO2006132491A1
公开(公告)日：2006-12-14
申请号：PCT/KR2006/002176
申请日：2006-06-07
申请人： LESTE Co., Ltd. , KIM, Yong Jin , LEE, Hye Jung , KIM, Soo Yong
发明人： KIM, Yong Jin , LEE, Hye Jung , KIM, Soo Yong
IPC分类号： A43B17/00
CPC分类号： A43B7/142 , A43B7/1425 , A43B7/1435 , A43B7/144 , A43B7/145 , A43B7/146 , A43B17/02
摘要： The present invention provides an acupressure insole, which includes acupressure areas, each of which is provided with an acupressure boss and/or an acupressure protrusion to stimulate reflex points. The acupressure insole includes a first acupressure area 101 stimulating reflex points of the brain, a second acupressure area 103 stimulating reflex points of the eyes, a third acupressure area 104 stimulating reflex points of the ears, a fifth acupressure area 106 stimulating reflex points of the respiratory organs, a seventh acupressure area 108 stimulating reflex points of the adrenal gland and the kidney, and eighth through tenth acupressure areas 109 through 110 stimulating reflex points of the stomach, the pancreas and the duodenum. Preferably, when a foot length of the insole is designated as L, the first acupressure area is provided between 0.99L and 0.66L, the second, third and fifth acupressure areas are provided between 0.85L and 0.58L, the seventh acupressure area is provided between 0.69L and 0.55L, and the eight through tenth acupressure areas are provided between 0.67L and 0.38L. The present invention effectively stimulates acupuncture points of a foot, so that the health of the foot can be maintained when shoes having the acupressure insoles are merely worn. In particular, the present invention has the effect of improving the health of a patient who has a cerebral, eyesight, respiratory, digestive or kidney disorder, or of maintaining the health of a healthy person.
摘要翻译：本发明提供一种指压内底，其包括指压区域，每个按摩区域设置有指压凸起和/或用于刺激反射点的指压突起。指压鞋垫包括：刺激大脑反射点的第一指压区域101，刺激眼睛反射点的第二指压区域103;刺激耳朵反射点的第三指压区域104;刺激眼睛反射点的第五指压区域106; 呼吸器官，刺激肾上腺和肾脏的反射点的第七指压区域108，以及刺激胃，胰腺和十二指肠的反射点的第八至第十指压区域109至110。优选地，当鞋垫的脚长度被指定为L时，第一指压区域设置在0.99L和0.66L之间，第二，第三和第五指压区域设置在0.85L和0.58L之间，提供第七指压区域在0.69L和0.55L之间，八至十个指压区域在0.67L和0.38L之间。本发明有效地刺激了脚的针刺点，从而当具有指压鞋垫的鞋子仅仅穿着时，可以保持足部的健康。特别地，本发明具有改善患有脑，视力，呼吸，消化或肾脏障碍或维持健康人的健康的患者的健康的效果。

3. 发明申请

WO2005041808A1 DENTAL SCALER 审中-公开
标题翻译：牙科诊所
公开(公告)号：WO2005041808A1
公开(公告)日：2005-05-12
申请号：PCT/KR2004/002780
申请日：2004-10-30
申请人： LEE, Pal-Hyung , LEE, Hye-Jung , LEE, Jae-Heon
发明人： LEE, Pal-Hyung , LEE, Hye-Jung , LEE, Jae-Heon
IPC分类号： A61C17/34
CPC分类号： A61C17/16 , A61C1/07 , A61C17/20 , A61C17/3463
摘要： Disclosed herein is a dental scaler for removing accumulated deposits from the teeth, having a low manufacturing cost so as to be widely used at home. The dental scaler includes a first casing adapted to serve a grip; a power supply-receiving section and a motor installed at the inside of a first casing serving as a grip, wherein the power supply-receiving section is adapted to contain a power supply device therein and a rotating speed of the motor is adjustable by a first switch. A vibrator is eccentrically installed at a driving shaft of the motor to be selectively in electrical contact with a second switch for connecting or disconnecting a power of an electromagnet. An electromagnet-receiving section is formed at the front end portion of the first casing, for containing the electromagnet therein.
摘要翻译：本文公开了一种用于从牙齿中去除累积的沉积物的牙科定标器，具有低制造成本以便在家中广泛使用。牙科定标器包括适于用于抓握的第一壳体; 电源接收部和安装在作为把手的第一壳体的内部的电动机，其中所述电源接收部适于在其中容纳电源装置，并且所述电动机的转速可由第一开关。振动器偏心地安装在电动机的驱动轴上，以选择性地与用于连接或断开电磁铁功率的第二开关电接触。在第一壳体的前端部形成有电磁体收纳部，用于容纳电磁体。

4. 发明申请

WO9707788A3 COMPOSITION FOR SUSTAINED RELEASE OF AN AGENT 审中-公开
标题翻译：用于持续发行代理的组合物
公开(公告)号：WO9707788A3
公开(公告)日：1997-04-17
申请号：PCT/US9613787
申请日：1996-08-29
申请人： ALKERMES INC , LEE HYE JUNG , JOHNSON OLUFUNMI L , ZALE STEPHEN E , TRACY MARK A
发明人： LEE HYE-JUNG , JOHNSON OLUFUNMI L , ZALE STEPHEN E , TRACY MARK A
IPC分类号： A61K9/54 , A61K9/16 , A61K9/50 , A61K9/52 , A61K47/30
CPC分类号： A61K9/5084 , A61K9/1647
摘要： Composition for the sustained release of a biologically active agent in vivo. The composition comprises microcarriers containing a first solid-phase biocompatible material and a biologically active agent, wherein said microcarriers sustain in vivo release of the biologically active agent. The composition also contains particles of a second biocompatible solid-phase material wherein the second solid-phase material further sustains the in vivo release of the biologically active agent. The invention also relates to a method for sustaining effective serum levels of a biologically active agent in a subject, including forming an injectable dose containing an effective amount of a biologically active agent, wherein the agent is contained in a microcarrier, with a release-period sustaining amount of a solid-phase material. The method further includes administering the injectable dose to the subject.

5. 发明申请

WO1997007788A2 COMPOSITION FOR SUSTAINED RELEASE OF AN AGENT 审中-公开
标题翻译：用于持续发行代理的组合物
公开(公告)号：WO1997007788A2
公开(公告)日：1997-03-06
申请号：PCT/US1996013787
申请日：1996-08-29
申请人： ALKERMES CONTROLLED THERAPEUTICS, INC. , LEE, Hye-Jung , JOHNSON, OluFunmi, L. , ZALE, Stephen, E. , TRACY, Mark, A.
发明人： ALKERMES CONTROLLED THERAPEUTICS, INC.
IPC分类号： A61K09/54
CPC分类号： A61K9/5084 , A61K9/1647
摘要： Composition for the sustained release of a biologically active agent in vivo. The composition comprises microcarriers containing a first solid-phase biocompatible material and a biologically active agent, wherein said microcarriers sustain in vivo release of the biologically active agent. The composition also contains particles of a second biocompatible solid-phase material wherein the second solid-phase material further sustains the in vivo release of the biologically active agent. The invention also relates to a method for sustaining effective serum levels of a biologically active agent in a subject, including forming an injectable dose containing an effective amount of a biologically active agent, wherein the agent is contained in a microcarrier, with a release-period sustaining amount of a solid-phase material. The method further includes administering the injectable dose to the subject.
摘要翻译：用于体内持续释放生物活性剂的组合物。该组合物包含含有第一固相生物相容性材料和生物活性剂的微载体，其中所述微载体维持生物活性剂的体内释放。该组合物还含有第二生物相容性固相材料的颗粒，其中第二固相材料进一步维持生物活性剂的体内释放。本发明还涉及一种用于维持受试者中生物活性剂有效血清水平的方法，包括形成含有有效量的生物活性剂的可注射剂量，其中所述试剂包含在微载体中，释放期维持量的固相材料。该方法还包括向受试者施用可注射剂量。

6. 发明申请

WO2010032945A3 IMMOBILIZATION OF BIOMOLECULES USING CHOLESTEROL 审中-公开
标题翻译：用胆固醇固定生物分子
公开(公告)号：WO2010032945A3
公开(公告)日：2010-06-24
申请号：PCT/KR2009005240
申请日：2009-09-15
申请人： POSTECH ACAD IND FOUND , POSCO , LEE JUNG-HWAN , KIM YOUN-DONG , CHAE YOUNG-CHAN , RYU SUNG-HO , KANG HYUN-GU , KWON MI-JIN , PARK SUNG-YOUNG , JANG SUNG-KEY , KIM JONG-IN , IM JONG-HUN , KIM IL-SHIN , LEE SEUNG-JIN , CHOI SEO-YOUNG , SEOK MIN-KYOUNG , LEE HYE-JUNG , JANG EUN-JUNG
发明人： LEE JUNG-HWAN , KIM YOUN-DONG , CHAE YOUNG-CHAN , RYU SUNG-HO , KANG HYUN-GU , KWON MI-JIN , PARK SUNG-YOUNG , JANG SUNG-KEY , KIM JONG-IN , IM JONG-HUN , KIM IL-SHIN , LEE SEUNG-JIN , CHOI SEO-YOUNG , SEOK MIN-KYOUNG , LEE HYE-JUNG , JANG EUN-JUNG
IPC分类号： G01N33/544 , C12Q1/68 , G01N33/53 , G01N37/00
CPC分类号： G01N33/54353 , C12Q1/6834 , G01N33/92
摘要： Provided are a method for immobilizing biomolecules on a solid surface through a cholesteryl group, a device for detecting biomolecules containing both a solid surface and a capture probe immobilized on the solid surface through a cholesteryl group, and a method for detecting biomolecules using the same.
摘要翻译：本发明提供通过胆甾醇基固定生物分子在固体表面上的方法，用于检测包含固体表面和通过胆甾醇基固定在固体表面上的捕获探针的生物分子的装置以及使用该装置检测生物分子的方法。

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