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1. 发明申请

WO2005118510A1 STABLE INITIATIVECOMPOSITIONS AND IGNITERS 审中-公开
标题翻译：稳定的倡议和IGNITERS
公开(公告)号：WO2005118510A1
公开(公告)日：2005-12-15
申请号：PCT/US2004/016248
申请日：2004-05-20
申请人： ALEXZA PHARMACEUTICALS, INC. , HALE, Ron, L. , LEI, Mingzu , PETTIT, Hilary, N. , SOLAS, Dennis, W. , SONG, Soonho , TOM, Curtis
发明人： HALE, Ron, L. , LEI, Mingzu , PETTIT, Hilary, N. , SOLAS, Dennis, W. , SONG, Soonho , TOM, Curtis
IPC分类号： C06B33/00
CPC分类号： C06B33/00 , C06B45/02 , C06C9/00 , F42B3/113 , F42B3/124 , F42B3/14 , F42B3/195 , F42B3/198
摘要： High sparking initiator compositions (718) with a controlled amount of power are disclosed. The initiator compositions comprise a metal containing oxidizing agent, at least one metal reducing agent, and a non-explosive binder. Low voltage igniters that provide bidirectional plumes upon ignition are also disclosed. These igniters have a electrically resistive element (716) positioned across a hole (713) in a support (712) which directs the plume. These igniters and compositions are useful in the actuation of solid fuel heating unit, in particular, sealed heating units.
摘要翻译：公开了具有受控量的高火花引发剂组合物（718）。引发剂组合物包含含金属的氧化剂，至少一种金属还原剂和非爆炸性粘合剂。还公开了在点火时提供双向羽流的低电压点火器。这些点火器具有定位在引导羽流的支撑件（712）中的孔（713）上的电阻元件（716）。这些点火器和组合物在固体燃料加热单元，特别是密封加热单元的致动中是有用的。

2. 发明申请

WO2004104490A1 SELF-CONTAINED HEATING UNIT AND DRUG-SUPPLY UNIT EMPLOYING SAME 审中-公开
标题翻译：自含加热单元和使用相同的药物供应单元
公开(公告)号：WO2004104490A1
公开(公告)日：2004-12-02
申请号：PCT/US2004/016077
申请日：2004-05-20
申请人： ALEXZA MOLECULAR DELIVERY CORPORATION , DAMANI, Ramesh , HALE, Ron, L. , MYERS, Daniel, J. , QUINTANA, Reynaldo, J. , SOLAS, Dennis, W. , SONG, Soonho , SONI, Pravin , TOM, Curtis
发明人： DAMANI, Ramesh , HALE, Ron, L. , MYERS, Daniel, J. , QUINTANA, Reynaldo, J. , SOLAS, Dennis, W. , SONG, Soonho , SONI, Pravin , TOM, Curtis
IPC分类号： F24J1/00
CPC分类号： A61M11/00 , A61M11/041 , A61M11/042 , A61M11/047 , A61M11/048 , A61M15/06 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/36 , A61M2205/364 , A61M2205/3653 , A61M2205/8268 , B01B1/005 , B65B29/10 , C06B33/00 , C06B45/14 , C09K5/18 , F23B2900/00003 , F23C2900/99008 , F24V30/00 , Y02E20/346
摘要： Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units (10, 60) comprising a substrate (12, 62) and a solid fuel (20, 80) capable of undergoing an exothermic metal oxidation reaction disposed within the substrate (12, 62) are disclosed. Drug supply units (100) and drug delivery articles (162) wherein a solid fuel (114, 174) is configured to heat a substrate (64, 164) to a temperature sufficient to rapidly thermally vaporize a drug (110, 166) disposed thereon are also disclosed.
摘要翻译：公开了能够快速加热的加热单元，药物供应单元和药物输送物品。公开了一种包括基板（12,62）和能够经受发生在基板（12,62）内的放热金属氧化反应的固体燃料（20,80）的加热单元（10,60）。药物供应单元（100）和药物递送制品（162），其中固体燃料（114,174）构造成将基底（64,164）加热至足以快速热蒸发其上所配置的药物（110,166）的温度也被披露。

3. 发明申请

WO2004104492A2 OPTICALLY IGNITED OR ELECTRICALLY IGNITED SELF-CONTAINED HEATING UNIT AND DRUG-SUPPLY UNIT EMPLOYING SAME 审中-公开
标题翻译：光电式或电动点火自加热单元及其使用的药液供应单元
公开(公告)号：WO2004104492A2
公开(公告)日：2004-12-02
申请号：PCT/US2004/016245
申请日：2004-05-20
申请人： ALEXZA MOLECULAR DELIVERY CORPORATION , HALE, Ron, L. , SOLAS, Dennis , SONG, Soonho , TOM, Curtis
发明人： HALE, Ron, L. , SOLAS, Dennis , SONG, Soonho , TOM, Curtis
IPC分类号： F24J1/00
CPC分类号： A61M11/00 , A61M11/041 , A61M11/042 , A61M11/047 , A61M11/048 , A61M15/06 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/36 , A61M2205/364 , A61M2205/3653 , A61M2205/8268 , B01B1/005 , B65B29/10 , C06B33/00 , C06B45/14 , C09K5/18 , F23B2900/00003 , F23C2900/99008 , F24V30/00 , Y02E20/346
摘要： Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance or by optical ignition. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
摘要翻译：公开了能够快速加热的加热单元，药物供应单元和药物输送物品。公开了一种加热单元，其包括基板和能够经受放置在基板内的放热金属氧化反应的固体燃料。这些加热单元可以通过电阻或光学点火来启动。还公开了药物供应单元和药物递送物品，其中固体燃料构造成将基底加热到足以快速热蒸发其上设置的药物的温度。

4. 发明申请

WO2005120614A1 MULTIPLE DOSE CONDENSATION AEROSOL DEVICES AND METHODS OF FORMING CONDENSATION AEROSOLS 审中-公开
标题翻译：多剂量浓缩气溶胶装置及形成冷凝剂的方法
公开(公告)号：WO2005120614A1
公开(公告)日：2005-12-22
申请号：PCT/US2004/018015
申请日：2004-06-03
申请人： ALEXZA MOLECULAR DELIVERY CORPORATION , CROSS, Steven, D. , HERBETTE, Matthieu , KELLY, Andrew, J., G. , MYERS, Daniel, J. , SHEN, William, W. , TIMMONS, Ryan, D. , TOM, Curtis , VIRGILI, Justin, M. , WENSLEY, Martin, J.
发明人： CROSS, Steven, D. , HERBETTE, Matthieu , KELLY, Andrew, J., G. , MYERS, Daniel, J. , SHEN, William, W. , TIMMONS, Ryan, D. , TOM, Curtis , VIRGILI, Justin, M. , WENSLEY, Martin, J.
IPC分类号： A61M11/04
CPC分类号： A61M15/0045 , A61M11/002 , A61M11/041 , A61M11/042 , A61M15/002 , A61M15/0048 , A61M15/008 , A61M15/0081
摘要： Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.
摘要翻译：公开了在气流中夹带物质的装置和方法。冷凝气溶胶输送装置和一贯生产多剂量物质（例如药物）的方法，其具有高纯度，高产率，其特征在于适于肺部输送的粒度分布，并且其可以以单剂量施用于使用者也被披露。

5. 发明申请

WO2009075752A2 SYSTEMS AND METHODS FOR THERMAL TREATMENT OF BODY TISSUE 审中-公开
标题翻译：用于热处理身体组织的系统和方法
公开(公告)号：WO2009075752A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/013320
申请日：2008-12-03
申请人： TESSARON MEDICAL, INC. , TOM, Curtis , SUBRAMANIAM, Raj , HERBETTE, Mathieu , MADAYAG, Chrysbe
发明人： TOM, Curtis , SUBRAMANIAM, Raj , HERBETTE, Mathieu , MADAYAG, Chrysbe
IPC分类号： A61F7/00 , A61N2/00
CPC分类号： A61B18/18 , A61B18/1815 , A61B2017/00084 , A61B2017/4216 , A61B2018/1861 , A61B2090/3925 , A61K41/0052 , A61K49/1818 , A61N1/406 , B82Y5/00
摘要： Apparatus and methods for treating body tissue by use of thermal treatment material are provided. The thermal treatment material to be injected into target tissue of a body includes: a carrier substrate; a plurality of first particles operative to generate thermal energy in response to an alternating electromagnetic field applied external to the body; and a plurality of second particles, each of the second particles having a core and a coating surrounding the core. The coating is dissolved at a preset temperature by the thermal energy so that the visibility of the core in an external imaging system is affected as the coating is dissolved to expose the core. The variation of the visibility can be used as an indicator to determine if the material has reached the preset temperature.
摘要翻译：提供了通过使用热处理材料来处理身体组织的设备和方法。待注射到人体的目标组织中的热处理材料包括：载体基底; 多个第一颗粒，响应于施加在所述主体外部的交变电磁场而操作以产生热能; 以及多个第二颗粒，每个第二颗粒具有芯和包围该芯的涂层。涂层通过热能在预设温度下溶解，以便当涂层溶解以暴露芯时，芯在外部成像系统中的可见性受到影响。可见度的变化可以作为一个指标，以确定材料是否已经达到预设温度。

6. 发明申请

WO2009005656A2 SYSTEMS AND METHODS FOR INDUCTIVE HEAT TREATMENT OF BODY TISSUE 审中-公开
标题翻译：用于身体组织感染热处理的系统和方法
公开(公告)号：WO2009005656A2
公开(公告)日：2009-01-08
申请号：PCT/US2008/007890
申请日：2008-06-24
申请人： TESSARON MEDICAL, INC. , HERBETTE, Mathieu , TOM, Curtis
发明人： HERBETTE, Mathieu , TOM, Curtis
IPC分类号： A61B18/18 , A61N5/00 , A61B5/055 , A61F7/00
CPC分类号： A61B18/18 , A61N1/08 , A61N1/406 , G01K7/38
摘要： An apparatus (110) for treating body tissue (111) by heat energy includes: a coil (136) for transmitting an alternating electrical current therethrough to generate an alternating electromagnetic field that is capable of exciting material positioned in the body, the material being operative to inductively generate the heat energy in response to the electromagnetic field; means for measuring an amplitude of the current; and means for mapping the amplitude into a temperature of the magnetic material.
摘要翻译：用于通过热能处理身体组织（111）的装置（110）包括：线圈（136），用于传递交流电流通过其中以产生能够激发位于身体中的材料的交变电磁场，该材料是可操作的响应于电磁场感应地产生热能; 用于测量电流幅度的装置; 以及用于将振幅映射到磁性材料的温度的装置。

7. 发明申请

WO2019126803A1 ERROR REMOVAL USING IMPROVED LIBRARY PREPARATION METHODS 审中-公开
公开(公告)号：WO2019126803A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/067386
申请日：2018-12-21
申请人： GRAIL, INC. , VIJAYA SATYA, Ravi , GNERRE, Sante , EATTOCK, Nicholas , JI, Lijuan , TOM, Curtis
发明人： VIJAYA SATYA, Ravi , GNERRE, Sante , EATTOCK, Nicholas , JI, Lijuan , TOM, Curtis
IPC分类号： C12Q1/6855 , C12Q1/6848
CPC分类号： G16B35/10 , C12Q1/6848 , C12Q1/6855 , C12Q1/6881 , C12Q1/6886 , G16B25/20 , G16B30/00 , C12Q2521/325 , C12Q2521/531 , C12Q2525/155 , C12Q2525/173 , C12Q2525/191 , C12Q2527/101 , C12Q2535/122 , C12Q2563/179
摘要： Methods for preparing sequencing libraries from a DNA-containing test sample, as well as methods for reducing the occurrence of edge errors prior to sequencing, are provided.

8. 发明申请

WO2009005659A1 SYSTEMS AND METHODS FOR DELIVERING PARTICLES INTO PATIENT BODY 审中-公开
标题翻译：将颗粒递送到患者体内的系统和方法
公开(公告)号：WO2009005659A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/007896
申请日：2008-06-24
申请人： TESSARON MEDICAL, INC. , HERBETTE, Mathieu , TOM, Curtis
发明人： HERBETTE, Mathieu , TOM, Curtis
IPC分类号： A61M31/00 , A61M5/00 , A61B18/18
CPC分类号： A61M5/16827 , A61M5/16854 , A61M5/44 , A61M25/003 , A61M25/0071 , A61M25/0084 , A61M25/10 , A61M2025/0037 , A61M2025/1052
摘要： An apparatus (100) for delivering particles to a target region in a patient's body (122) includes a hub (102) and a catheter (112) having a proximal end coupled to and in fluid communication with the hub (102). The distal end of the catheter (112) is inserted into the target region. The apparatus (100) also includes: means for directing substrate to the target region, the means (116a-b) being coupled to the hub (102) and in fluid communication with the catheter (112); a pressure sensor (218) for measuring a pressure of the substrate and generating a signal commensurate with the pressure; and a pressure display (104) for displaying the pressure in response to the signal.
摘要翻译：用于将颗粒递送到患者体内（122）中的目标区域的装置（100）包括轮毂（102）和导管（112），所述导管（112）具有联接到所述轮毂（102）并与所述轮毂（102）流体连通的近端。导管（112）的远端插入目标区域。装置（100）还包括：用于将基板引导到目标区域的装置，所述装置（116a-b）联接到所述毂（102）并与所述导管（112）流体连通; 压力传感器（218），用于测量所述衬底的压力并产生与所述压力相称的信号; 以及用于响应于该信号显示压力的压力显示（104）。

9. 发明申请

WO2008140773A1 SYSTEMS AND METHODS FOR TREATING BODY TISSUE 审中-公开
标题翻译：用于治疗身体组织的系统和方法
公开(公告)号：WO2008140773A1
公开(公告)日：2008-11-20
申请号：PCT/US2008/005979
申请日：2008-05-08
申请人： TESSARON MEDICAL, INC. , HERBETTE, Mathieu , TOM, Curtis
发明人： HERBETTE, Mathieu , TOM, Curtis
IPC分类号： A61B18/04 , A61B18/18
CPC分类号： A61B18/08 , A61N1/403
摘要： A device (114) for treating body tissue (105) includes: an elongated cylindrical guide portion (122) having a distal end and a proximal end; and one or more heat generators (120) securely attached to the elongated guide portion (122). The heat generators (120) are operative to inductively generate heat energy in response to an electromagnetic field externally applied thereto. One or more of the heat generators (120) are disposed near target tissue (105) so that the heat energy generated by the heat generators (120) is used to treat the target tissue (105) during operation.
摘要翻译：一种用于治疗身体组织（105）的装置（114）包括：具有远端和近端的细长圆柱形引导部分（122）和一个或多个热量发生器（120）牢固地连接到细长导向部分（122）。热发生器（120）可操作以响应于外部施加到其上的电磁场而感应地产生热能。一个或多个热发生器（120）设置在目标组织（105）附近，使得由热发生器（120）产生的热能用于在操作期间治疗目标组织（105）。

10. 发明申请

WO2007008879A2 CLOSED-LOOP CONTROL OF ULTRAVIOLET (UV) STERILIZATION SYSTEMS 审中-公开
标题翻译：超紫外线（UV）灭菌系统的闭环控制
公开(公告)号：WO2007008879A2
公开(公告)日：2007-01-18
申请号：PCT/US2006/026858
申请日：2006-07-10
申请人： AMARANTE TECHNOLOGIES, INC. , TOM, Curtis , HERBETTE, Mathieu , WEIHE, Orion
发明人： TOM, Curtis , HERBETTE, Mathieu , WEIHE, Orion
IPC分类号： A61L2/10 , A61L2/24
CPC分类号： A61L2/10 , A61L2/24 , A61L2/28
摘要： Devices (100) and methods for controlling an ultraviolet (UV) sterilization system that has one or more UV sources to achieve proper sterilization. The UV sources (112) are operated according to a set of control parameters including intensity of the UV light energy and an exposure time. The device (100) may include: one or more sensors (124, 128) that are configured to measure UV light energy emitted by the UV sources (112) and develop one or more signals; and a microcontroller (314) that has an access to information of UV energy doses for various types of microorganisms. The microcontroller (314) is configured to receive the signals from the sensors (124, 128), determine a set of optimum values corresponding to the set of control parameters using the signals and the information, and send the set of optimum values to the UV sources (112) to control the UV sources.
摘要翻译：用于控制具有一个或多个UV源以实现适当灭菌的紫外线（UV）灭菌系统的装置（100）和方法。 UV源（112）根据包括UV光能的强度和曝光时间的一组控制参数来操作。设备（100）可以包括：一个或多个传感器（124,128），其被配置成测量由UV源（112）发射的UV光能量并且开发一个或多个信号; 以及具有访问各种微生物的紫外线能量剂量的信息的微控制器（314）。微控制器（314）被配置为从传感器（124,128）接收信号，使用信号和信息来确定与该组控制参数对应的一组最佳值，并将该组最优值发送到UV 来源（112）来控制UV源。

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