专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008118100A1 METHOD OF ENHANCING MIGRATION OF NEURAL PRECURSOR CELLS 审中-公开
标题翻译：增强神经前体细胞迁移的方法
公开(公告)号：WO2008118100A1
公开(公告)日：2008-10-02
申请号：PCT/SG2008/000089
申请日：2008-03-20
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , JURVANSUU, Jaana
发明人： WANG, Shu , JURVANSUU, Jaana
IPC分类号： C12N15/00 , C12Q1/68 , A61P25/00
CPC分类号： C07K14/47
摘要： There is provided methods relating to enhancing migration of a neural precursor cell by augmenting levels of TMEM18 protein in the neural precursor cell. Such methods may be used in the treatment of disorders, including treatment of a glioma or a neurodegenerative disorder.
摘要翻译：提供了通过增加神经前体细胞中TMEM18蛋白的水平来增强神经前体细胞迁移的方法。这些方法可用于治疗疾病，包括治疗神经胶质瘤或神经变性疾病。

2. 发明申请

WO2012121678A1 METHOD OF USING CD1d OVER-EXPRESSION IN HUMAN DENDRITIC CELLS TO ENHANCE CD8+ T CELL-BASED AND INVARIANT NATURAL KILLER T CELL- BASED ANTITUMOR IMMUNITY 审中-公开
标题翻译：在人类细胞中使用CD1d超表达以增强基于CD8 + T细胞和不可逆的自然杀伤细胞基于细胞的抗体免疫的方法
公开(公告)号：WO2012121678A1
公开(公告)日：2012-09-13
申请号：PCT/SG2012/000080
申请日：2012-03-09
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , ZENG, Jieming
发明人： WANG, Shu , ZENG, Jieming
IPC分类号： A61K35/14 , A61P35/00 , A61P37/00 , C12N15/866
CPC分类号： C12N5/0639 , A61K39/0011 , A61K39/39 , A61K2039/5154 , C07K16/2833 , C07K2317/76 , C12N2710/14143
摘要： The manipulation of human dendritic cells (DCs) to induce potent anti-tumor immunity remains an essential subject of study. Here we report that the overexpression of CD1d in human DCs can enhance the priming of naïve CD8+ T cells against tumor antigen. We showed that CD1d can be overexpressed in the human DCs using baculoviral vector carrying the CD1d gene. This CD1d-overexpression is functional as demonstrated by the increased expansion of invariant natural killer T (iNKT) cells while using these modified DCs to present α-galactosylceramide (α-GC). Pulsed with tumor antigenic peptide, these CD1d-overexpressing human DCs showed enhanced capability to prime naïve CD8+ T cells. CD1d-overexpressing human DCs also induced a pro-inflammatory cytokine profile that may favor the priming. Moreover, this CD1d-overexpression strategy can be extrapolated to monocyte-derived human DCs. Therefore, our study suggest that overexpression of CD1d in human DCs may provide a novel strategy to enhance DC immunogenicity and the possible translation into human cancer immunotherapy.
摘要翻译：人类树突状细胞（DCs）的操纵诱导有效的抗肿瘤免疫仍然是研究的重要课题。我们报告说，CD1d在人类DCs中的过表达可以增强初始的CD8 + T细胞对肿瘤抗原的启动。我们显示CD1d可以使用携带CD1d基因的杆状病毒载体在人DC中过表达。这种CD1d过表达是功能性的，通过增加不变性天然杀伤T（iNKT）细胞的扩增，而使用这些修饰的DCs来呈递α-半乳糖神经酰胺（a-GC）。脉冲与肿瘤抗原肽，这些CD1d过表达的人类DCs显示增强的能力，以初始的初始CD8 + T细胞。 CD1d过表达的人DC也诱导促炎细胞因子谱，可能有利于引发。此外，这种CD1d过表达策略可以外推到单核细胞衍生的人类DCs。因此，我们的研究表明CD1d在人类DCs中的过表达可能提供增强DC免疫原性和可能转化为人类癌症免疫治疗的新策略。

3. 发明申请

WO2005021758A1 RECOMBINANT POLYPEPTIDE USEFUL FOR NEUROTROPHIN RECEPTOR MEDIATED GENE DELIVERY AND AS NEUROTROPHIN AGONIST 审中-公开
标题翻译：用于神经营养因子受体介导的基因交付和神经营养因子的重组多肽
公开(公告)号：WO2005021758A1
公开(公告)日：2005-03-10
申请号：PCT/SG2004/000257
申请日：2004-08-25
申请人： AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH , WANG, Shu , HOWLAND, Shanshan Wu , ZENG, Jieming , MA, Nan
发明人： WANG, Shu , HOWLAND, Shanshan Wu , ZENG, Jieming , MA, Nan
IPC分类号： C12N15/12
CPC分类号： C07K16/40 , C07H21/04 , C07K14/475
摘要： The invention provides a novel recombinant polypeptide that comprises a nucleic acid binding element and a hairpin motif that selectively binds to a neurotrophin receptor. The recombinant polypeptide may be use for neurotrophin receptor mediated delivery of nucleic acid, including therapeutic DNA, bound to the recombinant polypeptide. In one embodiment, the hairpin motif is a hairpin motif of a neurotrophin, such as nerve growth factor, brain derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5. The hairpin motif is also a neurotrophin agonist and therefore may be used to treat any disorder responsive to neurotrophin treatment, such as neurological disorders and tumour. In one embodiment the agonist comprises a hairpin motif that selectively binds to a neurotrophin receptor and a positively charged binding domain which is believed to enhance receptor binding by binding to a negatively charged cell membrane.
摘要翻译：本发明提供了一种新型重组多肽，其包含选择性结合神经营养因子受体的核酸结合元件和发夹基序。重组多肽可用于与重组多肽结合的神经营养因子受体介导的核酸递送，包括治疗性DNA。在一个实施方案中，发夹基序是神经营养蛋白的发夹基序，例如神经生长因子，脑源性神经营养因子，神经营养蛋白3和神经营养蛋白4/5。发夹基序也是神经营养因子激动剂，因此可以用于治疗对神经营养因子治疗反应的任何病症，例如神经障碍和肿瘤。在一个实施方案中，激动剂包含选择性结合神经营养因子受体和带正电荷的结合结构域的发夹基序，其被认为通过结合到带负电荷的细胞膜来增强受体结合。

4. 发明申请

WO2004087926A1 A PROMOTER CONSTRUCT FOR GENE EXPRESSION IN NEURONAL CELLS 审中-公开
标题翻译：用于神经细胞中基因表达的促进剂构建体
公开(公告)号：WO2004087926A1
公开(公告)日：2004-10-14
申请号：PCT/SG2004/000076
申请日：2004-03-31
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , LIU, Beihui , WANG, Xu
发明人： WANG, Shu , LIU, Beihui , WANG, Xu
IPC分类号： C12N15/67
CPC分类号： A61K48/0058 , C07H21/04 , C12N15/86 , C12N2750/14143
摘要： The invention relates to a chimeric promoter construct useful for neuronal cell specific gene expression. The invention provides a recombinant nucleic acid molecule that comprises a neuronal cell specific promoter such as platelet-derived growth factor ß-chain promoter, operably linked to a heterologous enhancer which enhances the transcriptional activity of the promoter, such as cytomegalovirus immediate early gene enhancer. The promoter construct according to the invention can increase and prolong gene expression in neuronal cells and may be advantageously used in gene therapy of neuronal disorders.
摘要翻译：本发明涉及可用于神经细胞特异性基因表达的嵌合启动子构建体。本发明提供了重组核酸分子，其包含神经元细胞特异性启动子，例如血小板衍生生长因子β链启动子，可操作地连接到异源增强子，其增强启动子的转录活性，例如巨细胞病毒立即早期基因增强子。根据本发明的启动子构建体可以增加并延长神经元细胞中的基因表达，并可有利地用于神经元疾病的基因治疗。

5. 发明申请

WO2006126972A1 METHOD OF DELIVERING NUCLEIC ACID MOLECULES INTO EMBRYONIC STEM CELLS USING BACULOVIRAL VECTORS 审中-公开
标题翻译：将核酸分子送入使用细菌病毒载体的胚胎干细胞的方法
公开(公告)号：WO2006126972A1
公开(公告)日：2006-11-30
申请号：PCT/SG2006/000133
申请日：2006-05-26
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , ZENG, Jieming
发明人： WANG, Shu , ZENG, Jieming
IPC分类号： C12N15/866 , A61K31/713
CPC分类号： C12N15/86 , C12N2710/14143
摘要： There is provided a method of delivering a nucleic acid molecule to an embryonic stem cell, including a human embryonic stem cell, by infecting the embryonic stem cell with a baculoviral vector comprising the nucleic acid molecule. Embryonic stem cells transduced by this method are useful for treating a disease or disorder in a subject.
摘要翻译：提供了通过用包含核酸分子的杆状病毒载体感染胚胎干细胞来将核酸分子递送至胚胎干细胞（包括人胚胎干细胞）的方法。通过该方法转导的胚胎干细胞可用于治疗受试者的疾病或病症。

6. 发明申请

WO2009142602A1 NUCLEIC ACID MOLECULE AND METHOD OF TARGETING GENE EXPRESSION TO GLIOMAS 审中-公开
标题翻译：核酸分子和靶向GLIOMAS的基因表达方法
公开(公告)号：WO2009142602A1
公开(公告)日：2009-11-26
申请号：PCT/SG2008/000423
申请日：2008-11-04
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , WU, Chunxiao
发明人： WANG, Shu , WU, Chunxiao
IPC分类号： C12N15/11 , A61P35/00
CPC分类号： C07K14/34 , A61K48/00 , C12N15/67 , C12N15/85 , C12N2830/008
摘要： There is presently provided a nucleic acid molecule comprising a glial-specific promoter; a coding sequence for a transgene; and a plurality of miRNA target sites. Each miRNA target site binds an miRNA that is down-regulated in a glioma cell compared to a normal glial cell, and the glial-specific promoter and the plurality of miRNA target sites are both operably linked to the coding sequence for the transgene.
摘要翻译：目前提供了包含胶质细胞特异性启动子的核酸分子; 转基因的编码序列; 和多个miRNA靶位点。每个miRNA靶位点与正常神经胶质细胞相比，结合在神经胶质瘤细胞中下调的miRNA，并且胶质细胞特异性启动子和多个miRNA靶位点都可操作地连接到转基因的编码序列。

7. 发明申请

WO2006078221A1 METHOD OF DELIVERY OF NUCLEIC ACIDS TO PERIPHERAL NEURONS 审中-公开
标题翻译：将核酸递送至外周神经元的方法
公开(公告)号：WO2006078221A1
公开(公告)日：2006-07-27
申请号：PCT/SG2005/000015
申请日：2005-01-20
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , WANG, Xu
发明人： WANG, Shu , WANG, Xu
IPC分类号： C12N15/64 , C12N15/87
CPC分类号： A61K48/0075 , A61K48/00 , C12N2799/025 , C12N2799/026 , C12N2830/008
摘要： The invention provides for methods for delivering a nucleic acid into a peripheral neuron by identifying a target neuron in a dorsal root ganglion and intrathecally delivering a vector comprising the nucleic acid to the dorsal root ganglion neuron. The nucleic acid may encode a neurotrophic factor that may be used to treat a peripheral neuropathy or, in conjunction with a nerve guide conduit, to treat a transected peripheral nerve.
摘要翻译：本发明提供了通过鉴定背根神经节中的目标神经元并将包含核酸的载体鞘内递送至背根神经节神经元来将核酸递送至周围神经元的方法。核酸可以编码可用于治疗周围神经病变的神经营养因子，或者与神经导管结合治疗横切的周围神经。

8. 发明申请

WO2005100577A1 METHOD FOR GENE DELIVERY TO NEURONAL CELLS 审中-公开
标题翻译：用于基因递送至神经细胞的方法
公开(公告)号：WO2005100577A1
公开(公告)日：2005-10-27
申请号：PCT/SG2004/000089
申请日：2004-04-14
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , YING, Li
发明人： WANG, Shu , YING, Li
IPC分类号： C12N15/866
CPC分类号： C12N15/86 , A61K47/6901 , A61K48/0075 , C12N2710/14143
摘要： The present invention relates to the use of axonal transport to deliver a baculorivus vector to a target neuronal cell by administering the vector to a site that is remote from the target cell. Such delivery allows for tracing of neuronal pathways and further a baculorivus vector may be used to deliver therapeutic gene to a target neuronal which may otherwise be not readily accessible, for the treatment of a neuronal disorder in a subject.
摘要翻译：本发明涉及轴突转运的用途，其通过将该载体施用于远离靶细胞的位点而将杆状病毒载体递送至目标神经元细胞。这种递送允许追踪神经元途径，此外，可以使用杆状病毒载体将治疗基因递送至否则不容易获得的靶神经元，用于治疗受试者的神经元病症。

9. 发明申请

WO2011010965A1 METHOD OF USING AN ESTABLISHED CELL LINE FOR GLIOMA THERAPY 审中-公开
标题翻译：使用建立细胞系进行GLIOMA治疗的方法
公开(公告)号：WO2011010965A1
公开(公告)日：2011-01-27
申请号：PCT/SG2010/000274
申请日：2010-07-20
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , ZHAO, Ying
发明人： WANG, Shu , ZHAO, Ying
IPC分类号： C12N5/16 , C12N5/095
CPC分类号： C12N5/0695 , C12N2501/385
摘要： The present invention relates to a method of generating pluripotent cells that show enhanced tumor-specific migration, isolated pluripotent cells with enhanced tumor-specific migration and pharmaceutical uses thereof.
摘要翻译：本发明涉及产生显示增强的肿瘤特异性迁移的多能细胞的方法，具有增强的肿瘤特异性迁移的分离的多能细胞及其药物用途。

10. 发明申请

WO2006101457A1 NOVEL NEURAL CELL SPECIFIC PROMOTER AND BACULOVIRUS AND METHOD FOR GENE DELIVERY 审中-公开
标题翻译：新型神经细胞特异性促进剂和细菌病毒和基因交付方法
公开(公告)号：WO2006101457A1
公开(公告)日：2006-09-28
申请号：PCT/SG2006/000067
申请日：2006-03-22
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , WANG, Chao Yang
发明人： WANG, Shu , WANG, Chao Yang
IPC分类号： C12N15/866 , C12N5/10 , C12N15/67 , C12N15/861
CPC分类号： C12N15/86 , A01K2267/0331 , C07K14/4746 , C12N2710/14143 , C12N2750/14143 , C12N2830/008
摘要： [00247] There is provided a novel hybrid promoter region that utilizes a neural specific promoter and an enhancer element, in one embodiment from a viral promoter, located upstream or downstream of the neural-specific promoter. The novel promoter can be used to create a viral vector, including a baculovirus vector, useful for gene delivery to neural cells.
摘要翻译：在一个实施方案中，提供了位于神经特异性启动子上游或下游的病毒启动子的新型杂合启动子区，其利用神经特异性启动子和增强子元件。新型启动子可用于产生病毒载体，包括可用于神经细胞基因递送的杆状病毒载体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式