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1. 发明申请

WO2005021758A1 RECOMBINANT POLYPEPTIDE USEFUL FOR NEUROTROPHIN RECEPTOR MEDIATED GENE DELIVERY AND AS NEUROTROPHIN AGONIST 审中-公开
标题翻译：用于神经营养因子受体介导的基因交付和神经营养因子的重组多肽
公开(公告)号：WO2005021758A1
公开(公告)日：2005-03-10
申请号：PCT/SG2004/000257
申请日：2004-08-25
申请人： AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH , WANG, Shu , HOWLAND, Shanshan Wu , ZENG, Jieming , MA, Nan
发明人： WANG, Shu , HOWLAND, Shanshan Wu , ZENG, Jieming , MA, Nan
IPC分类号： C12N15/12
CPC分类号： C07K16/40 , C07H21/04 , C07K14/475
摘要： The invention provides a novel recombinant polypeptide that comprises a nucleic acid binding element and a hairpin motif that selectively binds to a neurotrophin receptor. The recombinant polypeptide may be use for neurotrophin receptor mediated delivery of nucleic acid, including therapeutic DNA, bound to the recombinant polypeptide. In one embodiment, the hairpin motif is a hairpin motif of a neurotrophin, such as nerve growth factor, brain derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5. The hairpin motif is also a neurotrophin agonist and therefore may be used to treat any disorder responsive to neurotrophin treatment, such as neurological disorders and tumour. In one embodiment the agonist comprises a hairpin motif that selectively binds to a neurotrophin receptor and a positively charged binding domain which is believed to enhance receptor binding by binding to a negatively charged cell membrane.
摘要翻译：本发明提供了一种新型重组多肽，其包含选择性结合神经营养因子受体的核酸结合元件和发夹基序。重组多肽可用于与重组多肽结合的神经营养因子受体介导的核酸递送，包括治疗性DNA。在一个实施方案中，发夹基序是神经营养蛋白的发夹基序，例如神经生长因子，脑源性神经营养因子，神经营养蛋白3和神经营养蛋白4/5。发夹基序也是神经营养因子激动剂，因此可以用于治疗对神经营养因子治疗反应的任何病症，例如神经障碍和肿瘤。在一个实施方案中，激动剂包含选择性结合神经营养因子受体和带正电荷的结合结构域的发夹基序，其被认为通过结合到带负电荷的细胞膜来增强受体结合。

2. 发明申请

WO2011003766A1 BIODEGRADABLE COPOLYMER COMPRISING AMYLOPECTIN OR GLYCOGEN SUITABLE FOR DELIVERING NUCLEIC ACID MATERIALS INTO CELLS 审中-公开
标题翻译：包含适用于将核酸物质输送到细胞中的氨基酸或GLYCOGG的可生物降解的共聚物
公开(公告)号：WO2011003766A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059134
申请日：2010-06-28
申请人： UNIVERSITY OF ROSTOCK , WANG, Weiwei , LI, Wenzhong , MA, Nan , STEINHOFF, Gustav
发明人： WANG, Weiwei , LI, Wenzhong , MA, Nan , STEINHOFF, Gustav
IPC分类号： A61K9/00 , A61K47/48 , A61K48/00 , A61K47/34 , A61K47/36
CPC分类号： A61K9/0019 , A61K9/08 , A61K47/34 , A61K47/36 , A61K47/59 , A61K47/61 , C12N15/87
摘要： The invention is related to a biodegradable copolymer, which is suitable for delivering nucleic acid materials into cells, and which comprises a amylopectin or glycogen and at least one cationic polymer or cationic monomer having amino functions, which is bound to the amylopectin or glycogen by ester linkage between at least one free hydroxyl group of the amylopectin or glycogen and at least one amino group of the cationic polymer or cationic monomer forming an -O-C=O-NH- bond. The biodegradable copolymer is capable of delivering nucleic acid molecules into the cells in a high efficient way with extremely low cytotoxicity.
摘要翻译：本发明涉及可生物降解的共聚物，其适于将核酸材料递送到细胞中，并且其包含支链淀粉或糖原和至少一种具有氨基功能的阳离子聚合物或阳离子单体，其通过酯与支链淀粉或糖原结合支链淀粉或糖原的至少一个游离羟基与形成-OC = O-NH-键的阳离子聚合物或阳离子单体的至少一个氨基之间的连接。可生物降解的共聚物能够以非常低的细胞毒性以高效的方式将核酸分子递送到细胞中。

3. 发明申请

WO2006067080A1 MAGNETIC POLE MATRICES USEFUL FOR TISSUE ENGINEERING AND TREATMENT OF DISEASE 审中-公开
标题翻译：用于组织工程和疾病治疗的磁性矩阵
公开(公告)号：WO2006067080A1
公开(公告)日：2006-06-29
申请号：PCT/EP2005/056804
申请日：2005-12-15
申请人： STEINBEIS-TRANSFERZENTRUM FÜR HERZ-KREISLAUFFORSCHUNG , STEINHOFF, Gustav , STEINHOFF, Kurt , LI, Wenzhong , MA, Nan
发明人： STEINHOFF, Gustav , STEINHOFF, Kurt , LI, Wenzhong , MA, Nan
IPC分类号： A61M35/00
CPC分类号： A61K48/0075 , A61K47/543 , A61K47/6923 , A61M35/00 , A61N2/00
摘要： A method relates to magnetic pole matrices suitable for tissue engineering and targeting systematic therapy for cardiovascular disease using magnetic polymer nanoparticles gene/drug (various cytokines/growth factors/synthetic chemicals) delivery. The magnetic pole matrices used in the present invention possesses advantages, such as distributing the magnetic nanoparticles conjugated with gene/drug (various cytokines/growth factors/synthetic chemicals) locally and uniformly on the artificial surface regulated by self-organizing behavior benefited from the magnetic pole matrices, which essentially solved the blood vessel blocking problem related to systematic therapy by magnetic nanoparticles gene/drug delivery for cardiovascular disease; promoting the adhesion of the cells (stem cells/epithelial cells/endothelial cells) labeled with magnetic beads on specific location of the artificial surface, which is very important for tissue engineering.
摘要翻译：一种方法涉及适用于组织工程和使用磁性聚合物纳米颗粒基因/药物（各种细胞因子/生长因子/合成化学品）递送的用于心血管疾病的系统治疗的磁极基质。在本发明中使用的磁极矩阵具有如下优点：将由基因/药物（各种细胞因子/生长因子/合成化学品）共轭的磁性纳米颗粒局部均匀地分布在受益于磁性的自组织行为调节的人造表面上极性基质，其基本上解决了通过磁性纳米颗粒基因/药物递送用于心血管疾病的系统治疗相关的血管阻塞问题; 促进用磁珠标记的细胞（干细胞/上皮细胞/内皮细胞）在人造表面的特定位置的粘附，这对于组织工程非常重要。

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