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1. 发明申请

WO2006126972A1 METHOD OF DELIVERING NUCLEIC ACID MOLECULES INTO EMBRYONIC STEM CELLS USING BACULOVIRAL VECTORS 审中-公开
标题翻译：将核酸分子送入使用细菌病毒载体的胚胎干细胞的方法
公开(公告)号：WO2006126972A1
公开(公告)日：2006-11-30
申请号：PCT/SG2006/000133
申请日：2006-05-26
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , ZENG, Jieming
发明人： WANG, Shu , ZENG, Jieming
IPC分类号： C12N15/866 , A61K31/713
CPC分类号： C12N15/86 , C12N2710/14143
摘要： There is provided a method of delivering a nucleic acid molecule to an embryonic stem cell, including a human embryonic stem cell, by infecting the embryonic stem cell with a baculoviral vector comprising the nucleic acid molecule. Embryonic stem cells transduced by this method are useful for treating a disease or disorder in a subject.
摘要翻译：提供了通过用包含核酸分子的杆状病毒载体感染胚胎干细胞来将核酸分子递送至胚胎干细胞（包括人胚胎干细胞）的方法。通过该方法转导的胚胎干细胞可用于治疗受试者的疾病或病症。

2. 发明申请

WO2012121678A1 METHOD OF USING CD1d OVER-EXPRESSION IN HUMAN DENDRITIC CELLS TO ENHANCE CD8+ T CELL-BASED AND INVARIANT NATURAL KILLER T CELL- BASED ANTITUMOR IMMUNITY 审中-公开
标题翻译：在人类细胞中使用CD1d超表达以增强基于CD8 + T细胞和不可逆的自然杀伤细胞基于细胞的抗体免疫的方法
公开(公告)号：WO2012121678A1
公开(公告)日：2012-09-13
申请号：PCT/SG2012/000080
申请日：2012-03-09
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , ZENG, Jieming
发明人： WANG, Shu , ZENG, Jieming
IPC分类号： A61K35/14 , A61P35/00 , A61P37/00 , C12N15/866
CPC分类号： C12N5/0639 , A61K39/0011 , A61K39/39 , A61K2039/5154 , C07K16/2833 , C07K2317/76 , C12N2710/14143
摘要： The manipulation of human dendritic cells (DCs) to induce potent anti-tumor immunity remains an essential subject of study. Here we report that the overexpression of CD1d in human DCs can enhance the priming of naïve CD8+ T cells against tumor antigen. We showed that CD1d can be overexpressed in the human DCs using baculoviral vector carrying the CD1d gene. This CD1d-overexpression is functional as demonstrated by the increased expansion of invariant natural killer T (iNKT) cells while using these modified DCs to present α-galactosylceramide (α-GC). Pulsed with tumor antigenic peptide, these CD1d-overexpressing human DCs showed enhanced capability to prime naïve CD8+ T cells. CD1d-overexpressing human DCs also induced a pro-inflammatory cytokine profile that may favor the priming. Moreover, this CD1d-overexpression strategy can be extrapolated to monocyte-derived human DCs. Therefore, our study suggest that overexpression of CD1d in human DCs may provide a novel strategy to enhance DC immunogenicity and the possible translation into human cancer immunotherapy.
摘要翻译：人类树突状细胞（DCs）的操纵诱导有效的抗肿瘤免疫仍然是研究的重要课题。我们报告说，CD1d在人类DCs中的过表达可以增强初始的CD8 + T细胞对肿瘤抗原的启动。我们显示CD1d可以使用携带CD1d基因的杆状病毒载体在人DC中过表达。这种CD1d过表达是功能性的，通过增加不变性天然杀伤T（iNKT）细胞的扩增，而使用这些修饰的DCs来呈递α-半乳糖神经酰胺（a-GC）。脉冲与肿瘤抗原肽，这些CD1d过表达的人类DCs显示增强的能力，以初始的初始CD8 + T细胞。 CD1d过表达的人DC也诱导促炎细胞因子谱，可能有利于引发。此外，这种CD1d过表达策略可以外推到单核细胞衍生的人类DCs。因此，我们的研究表明CD1d在人类DCs中的过表达可能提供增强DC免疫原性和可能转化为人类癌症免疫治疗的新策略。

3. 发明申请

WO2005021758A1 RECOMBINANT POLYPEPTIDE USEFUL FOR NEUROTROPHIN RECEPTOR MEDIATED GENE DELIVERY AND AS NEUROTROPHIN AGONIST 审中-公开
标题翻译：用于神经营养因子受体介导的基因交付和神经营养因子的重组多肽
公开(公告)号：WO2005021758A1
公开(公告)日：2005-03-10
申请号：PCT/SG2004/000257
申请日：2004-08-25
申请人： AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH , WANG, Shu , HOWLAND, Shanshan Wu , ZENG, Jieming , MA, Nan
发明人： WANG, Shu , HOWLAND, Shanshan Wu , ZENG, Jieming , MA, Nan
IPC分类号： C12N15/12
CPC分类号： C07K16/40 , C07H21/04 , C07K14/475
摘要： The invention provides a novel recombinant polypeptide that comprises a nucleic acid binding element and a hairpin motif that selectively binds to a neurotrophin receptor. The recombinant polypeptide may be use for neurotrophin receptor mediated delivery of nucleic acid, including therapeutic DNA, bound to the recombinant polypeptide. In one embodiment, the hairpin motif is a hairpin motif of a neurotrophin, such as nerve growth factor, brain derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5. The hairpin motif is also a neurotrophin agonist and therefore may be used to treat any disorder responsive to neurotrophin treatment, such as neurological disorders and tumour. In one embodiment the agonist comprises a hairpin motif that selectively binds to a neurotrophin receptor and a positively charged binding domain which is believed to enhance receptor binding by binding to a negatively charged cell membrane.
摘要翻译：本发明提供了一种新型重组多肽，其包含选择性结合神经营养因子受体的核酸结合元件和发夹基序。重组多肽可用于与重组多肽结合的神经营养因子受体介导的核酸递送，包括治疗性DNA。在一个实施方案中，发夹基序是神经营养蛋白的发夹基序，例如神经生长因子，脑源性神经营养因子，神经营养蛋白3和神经营养蛋白4/5。发夹基序也是神经营养因子激动剂，因此可以用于治疗对神经营养因子治疗反应的任何病症，例如神经障碍和肿瘤。在一个实施方案中，激动剂包含选择性结合神经营养因子受体和带正电荷的结合结构域的发夹基序，其被认为通过结合到带负电荷的细胞膜来增强受体结合。

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