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1. 发明申请

WO2005066343A1 NUCLEIC ACID PURIFICATION CHIP 审中-公开
标题翻译：核酸净化芯片
公开(公告)号：WO2005066343A1
公开(公告)日：2005-07-21
申请号：PCT/IB2004/004397
申请日：2004-12-27
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , SAMPER, Victor , HONGMIAO, Ji , YU, Chen , KIAT, Heng, Chew , LIM, Tit, Meng
发明人： SAMPER, Victor , HONGMIAO, Ji , YU, Chen , KIAT, Heng, Chew , LIM, Tit, Meng
IPC分类号： C12N15/10
CPC分类号： C12N15/1003 , B01L3/5027 , B01L3/502753 , B01L2200/02 , B01L2200/0631 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/1883 , C12N15/1006 , C12Q1/6806 , G01N1/405 , C12Q2565/629
摘要： The present invention provides for a novel system of extracting and purifying nucleic acids (DNA, RNA, etc.) from cellular material like blood. Such a system of extraction and purification relies on novel monolithic microfluidic devices and methods of using these devices. Such devices comprise numerous components, monolithically-incorporated on an single chip, and further comprising novel nucleic acid binding materials. The present invention is also directed to method of preparing such novel nucleic binding materials.
摘要翻译：本发明提供从诸如血液的细胞材料提取和纯化核酸（DNA，RNA等）的新系统。这种提取和纯化系统依赖于新颖的单片微流体装置和使用这些装置的方法。这样的装置包括整体并入单个芯片上的许多组分，并且还包含新的核酸结合材料。本发明还涉及制备这种新型核结合材料的方法。

2. 发明申请

WO2005009616A1 MICROFLUIDICS PACKAGES AND METHODS OF USING SAME 审中-公开
标题翻译：微流控套件及其使用方法
公开(公告)号：WO2005009616A1
公开(公告)日：2005-02-03
申请号：PCT/SG2004/000223
申请日：2004-07-29
申请人： AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , SAMPER, Victor , CONG, Lin , JI Hongmiao
发明人： SAMPER, Victor , CONG, Lin , JI Hongmiao
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L7/52 , B01L2200/0689 , B01L2200/141 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , Y10T436/2575
摘要： Microfluidics packages and methods of use are described, comprising in one embodiment a substrate having a top surface and means to lower pressure on the top surface; a fluidics card having a bottom surface and means to allow fluids to traverse through the card; and a polymeric barrier film, the polymeric barrier film positioned between the top surface of the substrate and the bottom surface of the fluidics card.
摘要翻译：描述了微流体包装和使用方法，在一个实施方案中包括具有顶表面的基材和在顶表面上降低压力的装置; 具有底表面的流体卡和允许流体穿过卡的装置; 和聚合物阻挡膜，聚合物阻挡膜定位在基底的顶表面和流体卡的底表面之间。

3. 发明申请

WO2004108261A1 MICROMIXER APPARATUS AND METHODS OF USING SAME 审中-公开
标题翻译： MICROMIXER装置及其使用方法
公开(公告)号：WO2004108261A1
公开(公告)日：2004-12-16
申请号：PCT/SG2004/000167
申请日：2004-06-04
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , JI, Hongmiao , SAMPER, Victor
发明人： JI, Hongmiao , SAMPER, Victor
IPC分类号： B01F5/06
CPC分类号： B01F13/0059 , B01F5/0646 , B01F5/0647 , B01F2215/0431 , B01F2215/0495 , B01J19/0093 , B01J2219/00783 , B01J2219/00819 , B01J2219/00835 , B01J2219/00889 , B01J2219/00952 , B01J2219/00984 , B01J2219/00995 , B01L3/5027 , Y10S366/03
摘要： Microfluidics mixing apparatus and methods of using same are disclosed for mixing fluids using increasing centrifugal force as the fluids being mixed traverse a mixing channel. One inventive apparatus comprises a generally planar substrate having a top major surface and a bottom major surface generally parallel to the top major surface, and a cover plate over the top major surface. The substrate has at least one inlet port that routes fluid to the top major surface, and at least one outlet port for mixed fluid. The substrate comprises a mixing channel having a depth measured from the top surface and a width, the mixing channel adapted to route fluids to be mixed therein in laminar flow and in a substantially spiral flow pattern that is parallel to the top surface. Apparatus of the invention can mix fluids flowing serially, or two or more fluids entering the device from different feed channels.
摘要翻译：公开了微流体混合装置及其使用方法，用于当混合的流体穿过混合通道时，使用增加的离心力混合流体。一种本发明的装置包括具有顶部主表面和大体上平行于顶部主表面的底部主表面的大致平面的基底，以及在顶部主表面上的盖板。衬底具有至少一个将流体输送到顶部主表面的入口端口和用于混合流体的至少一个出口端口。衬底包括具有从顶表面测量的深度和宽度的混合通道，混合通道适于在层流中引导待混合的流体和平行于顶表面的基本上螺旋形的流动图案。本发明的装置可以混合串联流动的流体，或混合从不同进料通道进入装置的两种或更多种流体。

4. 发明申请

WO2005010377A1 MICROFLUIDICS CHIPS AND METHODS OF USING SAME 审中-公开
标题翻译：微流感胶囊及其使用方法
公开(公告)号：WO2005010377A1
公开(公告)日：2005-02-03
申请号：PCT/SG2004/000224
申请日：2004-07-29
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , SAMPER, Victor , CONG, Lin , JI, Hongmiao
发明人： SAMPER, Victor , CONG, Lin , JI, Hongmiao
IPC分类号： F15C1/06
CPC分类号： B81C3/001 , B01L3/502707 , B01L2200/0689 , B01L2200/12 , B01L2200/141 , B01L2300/0887 , B01L2300/1827 , B81B2201/058 , Y10T137/2196 , Y10T156/10
摘要： Microfluidics chips and methods of use are described, comprising a pair of wafers (102, 108), at least one having a patterned surface (108), and two polymeric barrier films (104, 106) between the wafers conforming to the patterned surface. The polymeric barrier films allow the wafers of the inventive microfluidics chips to be reused without cleaning.
摘要翻译：描述了微流体芯片和使用方法，其包括一对晶片（102,108），至少一个晶片（102,108），其具有图案化表面（108），以及两个聚合物阻挡膜（104,106），其在符合图案化表面的晶片之间。聚合物阻挡膜允许本发明的微流体芯片的晶片在不进行清洁的情况下重复使用。

5. 发明申请

WO2005122194A1 MICROFABRICATED SYSTEM FOR MAGNETIC FIELD GENERATION AND FOCUSING 审中-公开
标题翻译：用于磁场生成和聚焦的微型化系统
公开(公告)号：WO2005122194A1
公开(公告)日：2005-12-22
申请号：PCT/SG2005/000184
申请日：2005-06-07
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NANYANG TECHNOLOGICAL UNIVERSITY , RAMADAN, Qasem , SAMPER, Victor , POENAR, Daniel Puiu , CHEN, Yu
发明人： RAMADAN, Qasem , SAMPER, Victor , POENAR, Daniel Puiu , CHEN, Yu
IPC分类号： H01F41/04
CPC分类号： H01F5/003 , H01F41/046 , H01F2007/062 , H01F2007/068 , H01F2017/0086 , H01H50/005 , H01L23/5227 , H01L23/645 , H01L2924/0002 , H01L2924/3011 , H01L2924/00
摘要： A method of forming, in or on a Si substrate, planar micro-coils with coil windings of high aspect ration (>3) and a wide variety of geometric shapes. The micro-coils may be formed on a Si substrate and be embedded in a dielectric, or they may be formed in trenches within a Si substrate. The micro-coils may have field enhancing ferromagnetic pillars rising above the micro-coil plane, formed at positions of maximum magnetic field strength and the micro-coils may also include magnetic layers formed beneath the substrate and contacting the pillars to form a substantially closed pathway for the magnetic flux. The substrate may be thinned to membrane proportions. These micro-coils produce strong magnetic fields with strong field gradients and can be used in a wide variety of processes that involve the exertion of strong magnetic forces at small distances or the creation of magnetic wells for trapping and manipulating small particles.
摘要翻译：在Si衬底中或其上形成具有高纵横比（> 3）的线圈绕组和各种几何形状的平面微型线圈的方法。微型线圈可以形成在Si衬底上并嵌入电介质中，或者它们可以形成在Si衬底内的沟槽中。微型线圈可以具有在微型线圈平面上方上升的场强增强的铁磁柱，形成在最大磁场强度的位置，并且微型线圈还可以包括形成在衬底下方的磁性层，并与柱体接触以形成基本封闭的通路用于磁通量。衬底可以被薄化成膜的比例。这些微型线圈产生具有强场梯度的强磁场，并且可以用于涉及在较小距离处施加强磁力或产生用于捕获和操纵小颗粒的磁阱的各种工艺。

6. 发明申请

WO2013003530A1 DEVICES AND METHODS FOR REDUCING RADIOLYSIS OF RADIOLABELED COMPOUNDS 审中-公开
标题翻译：用于减少放射性化合物的放射性的装置和方法
公开(公告)号：WO2013003530A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/044527
申请日：2012-06-28
申请人： GENERAL ELECTRIC COMPANY , RENSCH, Christian , BALLER, Marko , BOELD, Christoph , HORVATH-KLEIN, Ruben Julian , SAMPER, Victor , ULIN, Johan
发明人： RENSCH, Christian , BALLER, Marko , BOELD, Christoph , HORVATH-KLEIN, Ruben Julian , SAMPER, Victor , ULIN, Johan
IPC分类号： C07B59/00 , B01J19/00
CPC分类号： C07B59/00 , G21F9/06 , G21F9/12
摘要： Disclosed are devices and methods for reducing radiolysis of radiopharmaceuticals during filtration, concentration and purification. The devices comprises two or more confining geometry having a cross-section dimension below the beta(+) or beta(-) range of the radioisotope in use, when containing the radioisotope, and configured in such a way that neighboring geometries are isolated from its nearest neighbor such that no measurable kinetic positron energy transfer occurs between the confining geometries when containing the radioisotope. Methods of filtration of radioisotope containing mixtures are also disclosed.
摘要翻译：公开了用于在过滤，浓缩和纯化期间减少放射性药物的放射分解的装置和方法。这些装置包括两个或更多个约束几何形状，其在使用时具有低于放射性同位素的β（+）或β（ - ）范围的横截面尺寸，当包含放射性同位素时，并且以这样一种方式构造相邻几何形状最近邻居，使得当包含放射性同位素时，在约束几何之间不发生可测量的动能正电子能量转移。还公开了含有放射性同位素的混合物的过滤方法。

7. 发明申请

WO2012015856A1 FLUID CONNECTOR DEVICES AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：流体连接器装置及其制造和使用方法
公开(公告)号：WO2012015856A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045443
申请日：2011-07-27
申请人： GENERAL ELECTRIC COMPANY , BALLER, Marko , RENSCH, Christian , SAMPER, Victor
发明人： BALLER, Marko , RENSCH, Christian , SAMPER, Victor
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00806 , B01J2219/00813 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0861 , B01L2300/123 , B01L2300/161
摘要： A fluid connector device (10) is provided. The fluid connector device includes a coupling substrate (12) having a conformal recess (20), a reconnectable fitting (18) disposed in the recess to provide a first passageway, and a force applying element (16) operatively coupled to the reconnectable fitting (18), or the coupling substrate (12), or both the reconnectable fitting (18) and the coupling substrate (12) to at least partially provide a sealing force between the reconnectable fitting (18) and the coupling substrate (12), wherein at least one of the force applying element (16), the reconnectable fitting (18), and the coupling substrate (12) comprises one or more degrees of freedom for self alignment of the reconnectable fitting (18) and the conformal recess (12).
摘要翻译：提供了一种流体连接器装置（10）。流体连接器装置包括具有共形凹槽（20）的联接基板（12），设置在凹槽中以提供第一通道的可重新连接的配件（18），以及可操作地连接到可重新连接的配件 18）或耦合衬底（12），或者可重新连接的配件（18）和耦合衬底（12）两者至少部分地提供可重新连接的配件（18）和耦合衬底（12）之间的密封力，其中施力元件（16），可重新连接的配件（18）和联接基板（12）中的至少一个包括用于可重新连接的配件（18）和保形凹部（12）的自对准的一个或多个自由度，。

8. 发明申请

WO2011082276A1 MICROVALVE 审中-公开
标题翻译：微型阀
公开(公告)号：WO2011082276A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/062453
申请日：2010-12-30
申请人： GENERAL ELECTRIC COMPANY , SAMPER, Victor , RENSCH, Christian , BOELD, Christoph , BALLER, Marko
发明人： SAMPER, Victor , RENSCH, Christian , BOELD, Christoph , BALLER, Marko
IPC分类号： F16K99/00
CPC分类号： F16K99/0001 , F16K99/0015 , F16K2099/008
摘要： A microvalve assembly (10) includes an elongate valve body (14) having opposed first and second major surfaces, the first major surface defining a valve recess (34) and the second major surface defining first and second fluid ports (20,22). Both the fluid input port and the fluid output port extend in fluid communication with the valve recess. A gasket (12) is freely positioned within the valve recess so as to extend in overlying registry with either or both of fluid ports. A valve cover (16) is bonded to the valve body and includes a first planar surface positioned in overlying registry with the valve recess so as to enclose the gasket therein. The valve cover is deflectable into the valve recess so as to cause the gasket to seal at least one of the fluid ports.
摘要翻译：微阀组件（10）包括具有相对的第一和第二主表面的细长阀体（14），所述第一主表面限定阀凹部（34），所述第二主表面限定第一和第二流体端口（20,22）。流体输入端口和流体输出端口都与阀门凹口流体连通地延伸。垫片（12）自由地定位在阀凹部内，以便在任一个或两个流体端口的上面对准中延伸。阀盖（16）与阀体结合并且包括位于与阀凹部对齐的第一平坦表面，以便将垫圈包围在其中。阀盖可偏转到阀门凹口中，以便使垫圈密封至少一个流体端口。

9. 发明申请

WO2011044453A2 MULTI-STREAM SPECTROPHOTOMETER MODULE 审中-公开
标题翻译：多流分光光度计模块
公开(公告)号：WO2011044453A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/051964
申请日：2010-10-08
申请人： GE HEALTHCARE LIMITED , GENERAL ELECTRIC COMPANY , FORTT, Robin , STEEL, Colin , SAMPER, Victor , BALLER, Marko
发明人： FORTT, Robin , STEEL, Colin , SAMPER, Victor , BALLER, Marko
IPC分类号： G01N21/33
CPC分类号： G01N30/74 , G01N21/05 , G01N21/33 , G01N21/85 , G01N30/466 , G01N30/88 , G01N2021/0321 , G01N2021/0346 , G01N2021/0357 , G01N2030/746 , G01N2030/8868 , G01N2030/8881 , G21H5/02
摘要： A multi- stream optical interrogation flow cell for a radiopharmaceutical includes a multiple flow cell body defining a first elongate fluid flowpath therethrough for individually conducting a radiopharmaceutical therethrough in fluid isolation from other of the flow cell bodies. Each flow cell body further defines a first and second aligned UV transparent optical guides and a first interrogation passageway extending between the first and second optical guides such that a portion of the elongate first fluid flowpath intersects the interrogation passageway such that the radiopharmaceutical flows in between the first and second optical guides. The first and second interrogation passageways of all of the flow cell bodies are optically aligned so that a single interrogation beam is able to extend through each of the interrogation passageways.
摘要翻译：用于放射性药物的多流光询问流动池包括多流通池体，其限定穿过其中的第一细长流体流动路径，用于单独地导引通过其与其它流动池体流体隔离的放射性药物。每个流动池主体还限定第一和第二对准的UV透明光导和在第一和第二光导之间延伸的第一询问通道，使得细长的第一流体流径的一部分与询问通道相交，使得放射性药物在第一和第二光导。所有流动池主体的第一和第二询问通道是光学对准的，使得单个询问梁能够延伸通过询问通道中的每一个。

10. 发明申请

WO2011044474A1 CHROMATOGRAPHY COMPONENTS 审中-公开
标题翻译：色谱成分
公开(公告)号：WO2011044474A1
公开(公告)日：2011-04-14
申请号：PCT/US2010/051998
申请日：2010-10-08
申请人： GE HEALTHCARE LIMITED , GENERAL ELECTRIC COMPANY , SAMPER, Victor , BALLER, Marko , DE MARCO, Emiliano , FRANCI, Xavier , DUMONT, Philippe , KUCI, Sali , STEEL, Colin , FORTT, Robin
发明人： SAMPER, Victor , BALLER, Marko , DE MARCO, Emiliano , FRANCI, Xavier , DUMONT, Philippe , KUCI, Sali , STEEL, Colin , FORTT, Robin
IPC分类号： G21H5/02 , G01N21/05 , G01N21/09 , B01D59/24
CPC分类号： G01N30/74 , G01N21/05 , G01N21/33 , G01N21/85 , G01N30/466 , G01N30/88 , G01N2021/0321 , G01N2021/0346 , G01N2021/0357 , G01N2030/746 , G01N2030/8868 , G01N2030/8881 , G21H5/02
摘要： Disposable components for a separation and purification system include a flow cell, an end cap for a chromatography column, and a chromatography column useful for medium-pressure liquid chromatography (MPLC).
摘要翻译：用于分离和纯化系统的一次性组分包括流动池，色谱柱的端盖和用于中压液相色谱（MPLC）的色谱柱。

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