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1. 发明申请

WO2006088427A1 MICROFLUIDICS PACKAGE AND METHOD OF FABRICATING THE SAME 审中-公开
标题翻译：微流控封装及其制造方法
公开(公告)号：WO2006088427A1
公开(公告)日：2006-08-24
申请号：PCT/SG2005/000038
申请日：2005-02-15
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , CHONG, Ser, Choong , XIE, Ling , JI, Hongmiao , LI, Jing , CHEN, Yu , YOBAS, Levent
发明人： CHONG, Ser, Choong , XIE, Ling , JI, Hongmiao , LI, Jing , CHEN, Yu , YOBAS, Levent
IPC分类号： B81B1/00 , B01L3/00
CPC分类号： B81B7/0061 , B01F5/0603 , B01F13/0059 , B01L3/502707 , B01L3/502715 , B01L9/527 , B01L2200/028 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B81B2201/051 , B81B2201/058
摘要： A microfluidics package (1) comprising a substrate (6) having a top surface, said top surface comprises at least one fluid channel (11, 12), at least one fluidic chip (2) having a top surface, a bottom surface, at least one side surface, and at least one passage to allow a fluid to traverse from the top surface or any side surface to the bottom surface of the chip; and a sheet (4) of which both sides are adhesive, wherein the first adhesive side of the sheet (4) is secured to the substrate (6), and the at least one fluidic chip (2) is secured by the second adhesive side of the sheet (4), said fluidic chip (2) being arranged such that the at least one passage of the fluidic chip is in fluid communication with the at least one fluid channel (11, 12) of the substrate.
摘要翻译：一种微流体封装（1），包括具有顶表面的衬底（6），所述顶表面包括至少一个流体通道（11,12），至少一个流体芯片（2），其具有顶表面，底表面至少一个侧表面和至少一个通道，以允许流体从所述芯片的顶表面或任何侧表面穿过所述底表面; 和其中两侧是粘合剂的片材（4），其中片材（4）的第一粘合剂侧固定到基底（6）上，并且至少一个流体碎片（2）由第二粘合剂侧所述流体芯片（2）布置成使得流体芯片的至少一个通道与基板的至少一个流体通道（11,12）流体连通。

2. 发明申请

WO2007126392A1 ANTIMICROBIAL PEPTIDES 审中-公开
标题翻译：抗菌肽
公开(公告)号：WO2007126392A1
公开(公告)日：2007-11-08
申请号：PCT/SG2007/000121
申请日：2007-04-27
申请人： SINGAPORE HEALTH SERVICES PTE LTD , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , BEUERMAN, Roger , ZHOU, Lei , LIU, Shouping , LI, Jing , SURESH, Anita , VERMA, Chandra Shekhar , TAN, Donald
发明人： BEUERMAN, Roger , ZHOU, Lei , LIU, Shouping , LI, Jing , SURESH, Anita , VERMA, Chandra Shekhar , TAN, Donald
IPC分类号： C07K14/435 , C07K14/47 , A61P17/02 , A61P27/00 , A61P31/04 , A61P31/12 , A61K38/16
CPC分类号： A61K38/1729 , A61K38/00 , C07K14/4723 , Y02A50/473
摘要： There is provided at least one isolated antimicrobial peptide, wherein the peptide is a linear analog of hBD3 or a fragment thereof. In particular, there is provided a linear analog of hBD3 wherein the peptide has a reduced cytotoxicity to at least one cell compared to the wild type hBD3.
摘要翻译：提供至少一种分离的抗微生物肽，其中肽是hBD3的线性类似物或其片段。特别地，提供hBD3的线性类似物，其中与野生型hBD3相比，肽对至少一种细胞的细胞毒性降低。

3. 发明申请

WO2008121075A1 OPTICAL INTERCONNECT STRUCTURE AND METHOD 审中-公开
标题翻译：光学互连结构与方法
公开(公告)号：WO2008121075A1
公开(公告)日：2008-10-09
申请号：PCT/SG2007/000086
申请日：2007-03-30
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , LEE, Sik Pong, Bryan , PAMIDIGHANTAM, Venkata Ramana , LI, Jing , KURUVEETTIL, Haridas
发明人： LEE, Sik Pong, Bryan , PAMIDIGHANTAM, Venkata Ramana , LI, Jing , KURUVEETTIL, Haridas
IPC分类号： G02B6/42
CPC分类号： G02B6/12002 , G02B6/43
摘要： An optical interconnect structure and method, The interconnect structure comprises a waveguide formed on or embedded in a substrate; two openings formed in the waveguide such that a pair of an internal total reflection mirror and a free space mirror are formed at each opening; two transceiver modules mounted on the substrate, each transceiver module comprising a light source element and a photo detector element; wherein the light source elements of the respective transceiver modules are aligned with the free space mirrors at the respective openings and the photo detector elements of the respective transceiver modules are aligned with the internal total reflection mirrors at the respective openings.
摘要翻译：光学互连结构和方法，所述互连结构包括形成在衬底上或嵌入衬底中的波导; 在波导管中形成两个开口，使得在每个开口处形成一对内部全反射镜和自由空间反射镜; 两个收发器模块安装在基板上，每个收发器模块包括光源元件和光电检测元件; 其中各个收发器模块的光源元件与相应开口处的自由空间反射镜对准，并且各个收发器模块的光电检测器元件与相应开口处的内部全反射镜对齐。

4. 发明申请

WO2009054808A1 PACKAGED TUNABLE SEMICONDUCTOR LASER STRUCTURE AND ITS FABRICATION 审中-公开
标题翻译：包装可控半导体激光器结构及其制造
公开(公告)号：WO2009054808A1
公开(公告)日：2009-04-30
申请号：PCT/SG2007/000364
申请日：2007-10-26
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , PAMIDIGHANTAM, Venkata Ramana , LI, Jing , LAU, Hon-Shing, John , ZHANG, Jing , CHAI, Yi Yoon, Joey , LIM, Teck Guan , CHANDRAPPAN, Jayakrishnan , KWONG, Dim-Lee
发明人： PAMIDIGHANTAM, Venkata Ramana , LI, Jing , LAU, Hon-Shing, John , ZHANG, Jing , CHAI, Yi Yoon, Joey , LIM, Teck Guan , CHANDRAPPAN, Jayakrishnan , KWONG, Dim-Lee
IPC分类号： H01S5/022 , G02B6/42
CPC分类号： G02B6/4204 , G02B2006/12121 , G02B2006/12142 , H01S3/1055 , H01S5/005 , H01S5/0064 , H01S5/0085 , H01S5/02252 , H01S5/02284 , H01S5/02415 , H01S5/141 , H01S5/50
摘要： A packaged tuneable semiconductor laser (TSL) structure and a method of fabricating a packaged tuneable semiconductor laser (TSL) structure are provided. The TSL structure comprises a laser component, the laser component including a Micro-Electro-Mechanical Systems (MEMS) tuning structure for tuning a wavelength of a laser output signal from the laser component; and a modulator component provided separately from the laser component for modulating the laser output signal from the laser component; and an optical bench component for aligning the laser component and the modulator component for optical coupling therebetween.
摘要翻译：提供封装的可调谐半导体激光器（TSL）结构和制造封装的可调谐半导体激光器（TSL）结构的方法。 TSL结构包括激光组件，该激光组件包括用于调谐来自激光组件的激光输出信号的波长的微机电系统（MEMS）调谐结构; 以及调制器部件，与激光部件分开设置，用于调制来自激光部件的激光输出信号; 以及用于对准激光器部件和调制器部件以用于其间的光耦合的光学台部件。

5. 发明申请

WO2009131548A1 MULTIMERIC FORMS OF ANTIMICROBIAL PEPTIDES 审中-公开
标题翻译：抗微生物肽的多形式
公开(公告)号：WO2009131548A1
公开(公告)日：2009-10-29
申请号：PCT/SG2009/000144
申请日：2009-04-21
申请人： SINGAPORE HEALTH SERVICES PTE LTD , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , BEUERMAN, Roger, W. , LIU, Shouping , LI, Jing , ZHOU, Lei , VERMA, Chandra, Shekhar , TAN, Donald
发明人： BEUERMAN, Roger, W. , LIU, Shouping , LI, Jing , ZHOU, Lei , VERMA, Chandra, Shekhar , TAN, Donald
IPC分类号： C07K14/47 , C07K14/435 , C12N15/00 , A61K38/17 , A61P31/04
CPC分类号： C07K14/4723 , A61K38/00 , C07K2319/00
摘要： The invention relates to multimeric forms of antimicrobial peptides, for example, defensin peptides. The multimeric forms of defensin peptides possesses antimicrobial activity and may be formulated into antimicrobial compositions, pharmaceutical compositions, eyedrop composition, contact lens solution compositions for coating medical devices and the like. The invention also relates to the use of these multimeric forms of peptides, e.g. multimeric forms of defensin peptides for inhibiting and/or reducing the growth of microorganisms in general, including in a host. The invention further relates to a method of preparing multimers of peptides derived from defensins, for example hBD3.
摘要翻译：本发明涉及多聚体形式的抗微生物肽，例如防御素肽。防御素肽的多聚体形式具有抗微生物活性，并且可以配制成抗微生物组合物，药物组合物，滴眼剂组合物，用于涂覆医疗装置的隐形眼镜溶液组合物等。本发明还涉及这些多聚体形式的肽的用途，例如，用于抑制和/或减少微生物生长的多聚体形式的防御素肽通常包括在宿主中。本发明还涉及制备衍生自防御素例如hBD3的肽的多聚体的方法。

6. 发明申请

WO2016080918A1 METHOD FOR PREPARING AN OXIDE FILM ON A POLYMERIC SUBSTRATE 审中-公开
标题翻译：在聚合物基材上制备氧化膜的方法
公开(公告)号：WO2016080918A1
公开(公告)日：2016-05-26
申请号：PCT/SG2015/050466
申请日：2015-11-20
申请人： AGENCY FOR SCIENCE,TECHNOLOGY AND RESEARCH
发明人： GOH, Kia Liang Gregory , LI, Jing , LE, Hong Quang
IPC分类号： C08J7/04 , C08G77/18
CPC分类号： C09D183/06 , C08G77/14 , C08G77/26 , C08J7/06 , C08J2369/00 , C09D183/08 , C23C18/1216 , C23C18/1233
摘要： Various embodiments refer to a method for preparing an oxide film on a polymeric substrate, wherein the oxide film is a titanium oxide film (which is optionally niobium- or silicon- doped) or silicon oxide film. The method comprises contacting a polymeric substrate with a liquid reagent comprising a polyalkoxysilane such as 3-aminopropyltriethoxysilane to form a Iayer of the polyalkoxysilane on the polymeric substrate by self-assembly, and contacting said Iayer with an aqueous mixture comprising (i) titanium tetrafiuoride and/or a fluorine-containing titanium complex such as ammonium hexafluorotitanate and/or a fluorine-containing silicon complex such as ammonium hexafluorosilicate, and (ii) a fluorine scavenger such as boric acid, at a temperature of less than about 100 °C to obtained the oxide film on the polymeric substrate. An oxide film prepared by said method is also provided.
摘要翻译：各种实施方案涉及在聚合物基材上制备氧化膜的方法，其中所述氧化物膜是氧化钛膜（可选地是铌或硅掺杂的）或氧化硅膜。该方法包括使聚合物基质与包含聚烷氧基硅烷如3-氨基丙基三乙氧基硅烷的液体试剂接触，以通过自组装在聚合物基材上形成聚烷氧基硅烷的层，并使所述Iayer与含有（i）四氟化钛和 /或六氟钛酸铵和/或六氟硅酸铵等含氟硅配合物等含氟钛络合物和（ⅱ）氟清除剂如硼酸在低于约100℃的温度下反应，得到聚合物基底上的氧化膜。还提供了通过所述方法制备的氧化膜。

7. 发明申请

WO2020069010A1 CD40L ANTAGONIST AND USES THEREOF 审中-公开
公开(公告)号：WO2020069010A1
公开(公告)日：2020-04-02
申请号：PCT/US2019/052997
申请日：2019-09-25
申请人： DRAPPA, Jorn , ALBULESCU, Marius , LI, Jing , GRANT, Ethan , STREICHER, Katie , ILLEI, Gabor , WANG, Liangwei , REES, William
发明人： DRAPPA, Jorn , ALBULESCU, Marius , LI, Jing , GRANT, Ethan , STREICHER, Katie , ILLEI, Gabor , WANG, Liangwei , REES, William
IPC分类号： C07K14/78 , C07K16/28 , A61K39/395 , A61P37/06
摘要： A human CD40L-specific Tn3 molecule and therapeutic uses thereof.

8. 发明申请

WO2019238067A1 PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF 审中-公开
公开(公告)号：WO2019238067A1
公开(公告)日：2019-12-19
申请号：PCT/CN2019/090922
申请日：2019-06-12
申请人： BEIGENE, LTD. , LI, Jing
发明人： LI, Jing , WANG, Zhiwei , XU, Sanjia
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/4985
摘要： Disclosed herein is a compound of Formula (AIII) or (III), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.

9. 发明申请

WO2019047915A1 IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS 审中-公开
公开(公告)号：WO2019047915A1
公开(公告)日：2019-03-14
申请号：PCT/CN2018/104559
申请日：2018-09-07
申请人： BEIGENE, LTD. , LI, Jing
发明人： LI, Jing , ZHAO, Haibo , WANG, Zhiwei
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00 , A61P37/00
摘要： Disclosed is a compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating PI3Kδ related disorders or diseases by using the compound disclosed herein.

10. 发明申请

WO2018217894A8 FLUORINE-LABELLED HALICHONDRIN DERIVATIVES AND RELATED METHODS OF SYNTHESIS 审中-公开
公开(公告)号：WO2018217894A8
公开(公告)日：2018-11-29
申请号：PCT/US2018/034132
申请日：2018-05-23
申请人： of EISAI R&D MANAGEMENT CO., LTD. , CHASE, Charles, E. , LI, Jing , MAJUMDER, Utpal
发明人： CHASE, Charles, E. , LI, Jing , MAJUMDER, Utpal
IPC分类号： C07D307/20 , C07D493/04 , C07D493/22
摘要： The invention relates to halichondrin derivatives containing fluorine, e.g., fluorine-18, as well as methods of synthesizing the same.

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