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1. 发明申请

WO2009080810A1 NEW POLYPEPTIDES HAVING AFFINITY FOR HER2 审中-公开
标题翻译：具有HER2感染力的新型多肽
公开(公告)号：WO2009080810A1
公开(公告)日：2009-07-02
申请号：PCT/EP2008/068167
申请日：2008-12-22
申请人： AFFIBODY AB , ABRAHMSÉN, Lars , HERNE, Nina , FELDWISCH, Joachim , LENDEL, Christofer , TOLMACHEV, Vladimir
发明人： ABRAHMSÉN, Lars , HERNE, Nina , FELDWISCH, Joachim , LENDEL, Christofer , TOLMACHEV, Vladimir
IPC分类号： C07K14/31 , C07K14/485 , A61K38/18 , A61K51/08 , A61P35/00 , G01N33/68
CPC分类号： A61K51/08 , A61K38/00 , A61K51/088 , C07K16/32
摘要： HER2 binding polypeptides comprising the amino acid sequence EX 1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX 2 E AKKLNDSQ wherein X 1 in position 2 is M, I or L, and X 2 in position 39 is S or C (SEQ ID NO:1 ) are disclosed. Moreover, such peptides comprising a chelating environment are disclosed. Also radiolabeled polypeptides formed by the peptides comprising a chelating environment and radionuclides are disclosed. Furthermore, methods of in vivo imaging of the body of a mammalian subject having or suspected of having a cancer characterized by overexpression of HER2 comprising administration of such a radiolabeled polypeptide followed by obtainment of an image of the body using a medical imaging instrument and also methods of treating such cancer are disclosed. Furthermore, the use of such a radiolabeled polypeptide in diagnosis and treatment of cancer characterized by overexpression of HER2. Nucleic acids encoding the polypeptides, expression vectors comprising the nucleic acids and host cells comprising the expression vectors are also disclosed.
摘要翻译： HER2结合多肽包含氨基酸序列EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ，其中位置2中的X1是M，I或L，而位置39的X2是S或C（SEQ ID NO：1）。此外，公开了包含螯合环境的这些肽。还公开了由包含螯合环境和放射性核素的肽形成的放射性标记的多肽。此外，具有或怀疑具有HER2过表达的哺乳动物受试者的身体的体内成像方法包括施用这种放射性标记的多肽，然后使用医学成像仪获得身体的图像，以及方法公开了治疗这种癌症的方法。此外，这种放射性标记的多肽在诊断和治疗HER2过表达的癌症中的应用。还公开了编码多肽的核酸，包含核酸的表达载体和包含表达载体的宿主细胞。

2. 发明申请

WO2009080811A1 POLYPEPTIDE LIBRARIES WITH A PREDETERMINED SCAFFOLD 审中-公开
标题翻译：具有预测SCAFFOLD的多肽图书馆
公开(公告)号：WO2009080811A1
公开(公告)日：2009-07-02
申请号：PCT/EP2008/068168
申请日：2008-12-22
申请人： AFFIBODY AB , ABRAHMSÉN, Lars , HERNE, Nina , LENDEL, Christofer , FELDWISCH, Joachim
发明人： ABRAHMSÉN, Lars , HERNE, Nina , LENDEL, Christofer , FELDWISCH, Joachim
IPC分类号： C07K1/04 , C12N15/10 , G01N33/68 , C12Q1/68
CPC分类号： C07K14/31 , C07K1/047 , C12N15/1037 , C12N15/1041 , C12N15/1044 , C12N15/1075 , C40B40/10 , G01N33/6845 , G01N2333/31
摘要： Populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ or AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q, wherein each X individually corresponds to an amino acid residue which is varied in the population are disclosed. Also populations of polynucleotides, wherein each member encodes a member of a polypeptide population are disclosed. Furthermore, combinations of such polypeptide populations and such polynucleotide populations are disclosed, wherein each member of polypeptide population is physically or spatially associated with the polynucleotide encoding that member via means for genotype-phenotype coupling. Furthermore, methods for selecting a desired polypeptide having an affinity for a predetermined target from a population of polypeptides, isolation of a polynucleotide encoding a desired polypeptide having an affinity for a predetermined target, identifying a desired polypeptide having an affinity for a predetermined target, selecting and identifying a desired polypeptide having affinity for a predetermined target, and production of a desired polypeptide having an affinity for a predetermined target are disclosed.
摘要翻译：基于常见支架的多肽变体群体，群体中的每个多肽包含支架氨基酸序列EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ或AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q，其中每个X分别对应于在群体中变化的氨基酸残基被披露。还公开了多核苷酸的种群，其中每个成员编码多肽群体的成员。此外，公开了这样的多肽群体和这种多核苷酸群体的组合，其中多肽群体的每个成员通过用于基因型 - 表型偶联的方法与编码该成员的多核苷酸物理或空间相关联。此外，从多肽群体中选择对预定靶标具有亲和性的期望多肽的方法，分离编码对预定靶标具有亲和性的期望多肽的多核苷酸，鉴定对预定靶标具有亲和性的期望多肽，选择并鉴定对预定靶标具有亲和力的所需多肽，以及对预定靶标具有亲和性的所需多肽的制备。

3. 发明申请

WO2009146755A1 POLYPEPTIDE 审中-公开
标题翻译：多肽
公开(公告)号：WO2009146755A1
公开(公告)日：2009-12-10
申请号：PCT/EP2008/062754
申请日：2008-09-24
申请人： BLOMQVIST, Anders , BERGMAN, Thomas , ABRAHMSÉN, Lars , LENDEL, Christofer , NORD, Karin , AFFIBODY AB
发明人： BLOMQVIST, Anders , BERGMAN, Thomas , ABRAHMSÉN, Lars , LENDEL, Christofer , NORD, Karin
IPC分类号： C07K14/00 , C07K14/31
CPC分类号： C12N15/1086 , C07K14/00 , C07K14/31 , C07K17/02 , C07K2317/52
摘要： The invention provides an immunoglobulin G Fc region binding polypeptide, which polypeptide comprises an immunoglobulin G Fc region binding motif, BM, consisting of an amino acid sequence selected from: i) EQQX 4 AFYEIL HLPNLTEX 18 QX 20 X 21 AFIX 25 X 26 LRX 29 , and ii) an amino acid sequence which has at least 85 % identity to the sequence defined in i). Also provided are methods of isolation or production of IgG Fc- containing molecules.
摘要翻译：本发明提供免疫球蛋白G Fc区结合多肽，该多肽包含免疫球蛋白G Fc区结合基序BM，其由选自以下的氨基酸序列组成：i）EQQX4AFYEIL HLPNLTEX18QX20X21AFIX25X26LRX29，和ii）具有至少85个氨基酸序列的氨基酸序列与i）中定义的序列具有％同一性。还提供了分离或产生含有IgG Fc的分子的方法。

4. 发明申请

WO2012004384A2 POLYPEPTIDES 审中-公开
标题翻译：多肽
公开(公告)号：WO2012004384A2
公开(公告)日：2012-01-12
申请号：PCT/EP2011/061623
申请日：2011-07-08
申请人： AFFIBODY AB , EKBLAD, Caroline , ABRAHMSÉN, Lars
发明人： EKBLAD, Caroline , ABRAHMSÉN, Lars
IPC分类号： C07K14/195
CPC分类号： C07K14/315 , A61K38/00 , A61K51/081 , C07K14/001 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/70 , Y02A50/473
摘要： The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for treatment or diagnosis of disease in mammals including humans.
摘要翻译：本公开涉及对白蛋白具有结合亲和力的一类工程化多肽。它还涉及利用这些化合物和其他化合物在不同情况下与白蛋白结合的新方法和用途，其中一些对于哺乳动物包括人类中的疾病的治疗或诊断具有重要意义。

5. 发明申请

WO2011110515A1 IMMUNOGLOBULIN G FC REGION BINDING POLYPEPTIDE 审中-公开
标题翻译：免疫球蛋白G区域结合多肽
公开(公告)号：WO2011110515A1
公开(公告)日：2011-09-15
申请号：PCT/EP2011/053362
申请日：2011-03-07
申请人： AFFIBODY AB , ABRAHMSÉN, Lars
发明人： ABRAHMSÉN, Lars
IPC分类号： B01D15/38 , C07K14/31 , C07K16/06
CPC分类号： C07K16/00 , B01D15/3804 , B01D15/3809 , B01J20/28033 , B01J20/285 , B01J20/286 , B01J20/3274 , C07K14/31 , C07K16/065
摘要： An immunoglobulin G Fc region binding polypeptide is provided, consisting of an amino acid sequence selected from i) and an amino acid sequence which has at least 95 % identity thereto. Also provided are methods for producing the polypeptide, compositions comprising the polypeptide, polynucleoties encoding the polypeptide, multimers of the polypeptide, and methods of using the polypeptide.
摘要翻译：提供免疫球蛋白G Fc区结合多肽，其由选自i）的氨基酸序列和与其具有至少95％同一性的氨基酸序列组成。还提供了产生多肽的方法，包含多肽的组合物，编码多肽的多核苷酸，多肽的多聚体以及使用多肽的方法。

6. 发明申请

WO2010054699A1 CONJUGATES OF ALBUMIN BINDING DOMAIN 审中-公开
标题翻译： ALBUMIN绑定域的结合
公开(公告)号：WO2010054699A1
公开(公告)日：2010-05-20
申请号：PCT/EP2008/065691
申请日：2008-11-17
申请人： AFFIBODY AB , ABRAHMSÉN, Lars , EKBLAD, Caroline
发明人： ABRAHMSÉN, Lars , EKBLAD, Caroline
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/643 , A61K47/66
摘要： The invention provides a capture molecule for modulation of pharmacokinetics (PK) and/or pharmacodynamics (PD) of a target having a biological function in a mammal, comprising i) at least one target binding moiety capable of interacting with a target, said interaction being characterized by a first K0 value; ii) at least one albumin binding moiety capable of binding to albumin, said binding being characterized by a second K0 value; wherein said interaction with a target at a pH value of 5.5 modulates PK and/or PD of said target in said mammal. Also provided are methods and uses of a capture molecule for the treatment of a mammal by PK/PD modulation of a target molecule.
摘要翻译：本发明提供了用于调节哺乳动物具有生物功能的靶的药代动力学（PK）和/或药效学（PD）的捕获分子，其包含i）至少一个能够与靶相互作用的靶结合部分，所述相互作用为其特征在于第一K0值; ii）至少一种能够结合白蛋白的白蛋白结合部分，所述结合的特征在于第二K0值; 其中所述与pH值为5.5的靶的相互作用调节所述哺乳动物中所述靶的PK和/或PD。还提供了捕获分子用于通过靶分子的PK / PD调节来治疗哺乳动物的方法和用途。

7. 发明申请

WO2009016043A3 NEW ALBUMIN BINDING COMPOSITIONS, METHODS AND USES 审中-公开
公开(公告)号：WO2009016043A3
公开(公告)日：2009-02-05
申请号：PCT/EP2008/059389
申请日：2008-07-17
申请人： AFFIBODY AB , ABRAHMSÉN, Lars , JONSSON, Andreas , DOGAN, Jakob , NYGREN, Per-Åke
发明人： ABRAHMSÉN, Lars , JONSSON, Andreas , DOGAN, Jakob , NYGREN, Per-Åke
IPC分类号： C07K14/195
摘要： The present invention relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for the treatment of disease in mammals including humans.

8. 发明申请

WO2002066669A1 METHOD FOR PURIFICATION OF SOLUBLE SSAO 审中-公开
标题翻译：纯化SSAO的方法
公开(公告)号：WO2002066669A1
公开(公告)日：2002-08-29
申请号：PCT/SE2002/000277
申请日：2002-02-18
申请人： BIOVITRUM AB , ABRAHMSÉN, Lars , NILSSON, Joakim
发明人： ABRAHMSÉN, Lars , NILSSON, Joakim
IPC分类号： C12P21/02
CPC分类号： C12N9/0022 , C07K2319/00 , C07K2319/02 , C07K2319/23 , C07K2319/50 , C12N15/62 , C12N15/625
摘要： The present invention relates to a recombinant construct comprising a nucleotide sequence encoding a fusion protein comprising a soluble form a human SSAO (Semicarbazide-Sensitive Amine Oxidase), a secretable fusion partner, a signal peptide; and a protease cleavage site. The said construct is useful in methods for purification of a soluble form of human SSAO.
摘要翻译：本发明涉及包含编码融合蛋白的核苷酸序列的重组构建体，所述融合蛋白包含可溶形式的人SSAO（氨基脲敏感性胺氧化酶），可分泌融合配偶体，信号肽; 和蛋白酶切割位点。所述构建体可用于纯化可溶形式的人SSAO的方法。

9. 发明申请

WO2005068646A1 METHODS FOR THE PROTEIN PRODUCTION AND PURIFICATION OF SOLUBLE RECOMBINANT POLYPEPTIDES 审中-公开
标题翻译：蛋白质生产和纯化可溶性重组多肽的方法
公开(公告)号：WO2005068646A1
公开(公告)日：2005-07-28
申请号：PCT/SE2005/000047
申请日：2005-01-18
申请人： BIOVITRUM AB , ABRAHMSÉN, Lars , NILSSON, Joakim , OPPERMAN, Udo , SVENSSON, Stefan
发明人： ABRAHMSÉN, Lars , NILSSON, Joakim , OPPERMAN, Udo , SVENSSON, Stefan
IPC分类号： C12P21/02
CPC分类号： C12N9/0006 , C12P21/02 , C12Y101/01146
摘要： The present invention relates to process for the production of a soluble polypeptide , such as 11β-hydroxysteroid dehydrogenase type 1, having at least one ligand binding site, the process comprising (i) providing a host cell comprising a nucleic acid sequence encoding the soluble polypeptide; (ii) culturing the host cell under conditions whereby the polypeptide is produced, wherein the cell culture medium comprises a non-proteinaceous ligand capable of binding to a ligand binding site of the polypeptide; and (iii) recovering said polypeptide.
摘要翻译：本发明涉及生产具有至少一个配体结合位点的可溶性多肽例如11β-羟类固醇脱氢酶1的方法，该方法包括（i）提供宿主细胞，其包含编码可溶性多肽的核酸序列 ; （ii）在产生多肽的条件下培养宿主细胞，其中所述细胞培养基包含能够结合所述多肽的配体结合位点的非蛋白质配体; 和（iii）回收所述多肽。

10. 发明申请

WO2016042083A1 NEW POLYPEPTIDES 审中-公开
标题翻译：新的多糖
公开(公告)号：WO2016042083A1
公开(公告)日：2016-03-24
申请号：PCT/EP2015/071339
申请日：2015-09-17
申请人： AFFIBODY AB
发明人： ABRAHMSÉN, Lars , EKBLAD, Caroline , GUNNERIUSSON, Elin , GRÄSLUND, Torbjörn , SEIJSING, Johan , LÖFBLOM, John , LINDBORG, Malin , FREJD, Fredrik , GUDMUNDSDOTTER, Lindvi
IPC分类号： A61K39/395 , C07K14/735 , C07K14/74 , C07K14/31 , A61K39/00
CPC分类号： C07K14/00 , A61K38/00 , C07K14/31 , C07K14/70535 , C07K14/70539 , C07K2319/00 , C07K2319/30 , C07K2319/74
摘要： The present disclosure relates to dimers of engineered polypeptides having a binding affinity for the neonatal Fc receptor FcRn, and provides an FcRn binding dimer, comprising a first monomer unit, a second monomer unit and an amino acid linker, wherein said first and second monomer unitseach comprisesan FcRn binding motif. Said FcRn binding dimerbinds FcRn with higher capacity compared to said first monomer unitor second monomer unit alone.The present disclosure also relates to the use of said FcRn binding dimeras an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
摘要翻译：本公开涉及具有对新生儿Fc受体FcRn的结合亲和力的工程化多肽的二聚体，并提供包含第一单体单元，第二单体单元和氨基酸接头的FcRn结合二聚体，其中所述第一和第二单体单元包括FcRn结合基序。所述FcRn结合二聚体与单独的所述第一单体单体或第二单体单元相比，具有更高容量的FcRn。本公开还涉及所述FcRn结合二聚体用于改变药代动力学和药效学性质以及作为治疗剂的用途。

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