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1. 发明申请

WO2006121424A2 PROGRAMMABLE SWITCHING DEVICE FOR IMPLANTABLE DEVICE 审中-公开
标题翻译：可编程器件可编程开关器件
公开(公告)号：WO2006121424A2
公开(公告)日：2006-11-16
申请号：PCT/US2005/013390
申请日：2005-04-20
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC.
发明人： ERICKSON, John, H. , VARRICHIO, Anthony, J.
IPC分类号： A61N1/18 , A61N1/36
CPC分类号： A61N1/36185 , A61N1/3686
摘要： A device and method for generating electrical stimulation. The implantable device includes a programmable switching device or array that receives at least one pulse generator output coupled through at least one coupling capacitor. The switching device selectively connects at least one pulse generator output to a plurality of electrode terminals via at least one coupling capacitor. Electrical stimulation signals may be applied directly from the electrode terminals, or are applied through a lead or lead extension having corresponding electrodes electrically connected to the electrode terminals.
摘要翻译：一种用于产生电刺激的装置和方法。可植入装置包括可编程开关装置或阵列，其接收通过至少一个耦合电容耦合的至少一个脉冲发生器输出。开关装置经由至少一个耦合电容器选择性地将至少一个脉冲发生器输出连接到多个电极端子。电刺激信号可以直接从电极端子施加，或者通过电连接到电极端子的具有相应电极的引线延伸部分施加。

2. 发明申请

WO2006128037A2 SYSTEMS AND METHODS FOR USE IN PULSE GENERATION 审中-公开
标题翻译：用于脉冲发生的系统和方法
公开(公告)号：WO2006128037A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/020562
申请日：2006-05-26
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC. , ERICKSON, John, H. , VARRICHIO, Anthony, J. , TRANCHINA, Benjamin, A.
发明人： ERICKSON, John, H. , VARRICHIO, Anthony, J. , TRANCHINA, Benjamin, A.
CPC分类号： A61N1/3787 , A61N1/36071 , H02J7/025 , H02J50/20 , H02J50/80
摘要： In one embodiment, an implantable medical device comprises: a rechargeable battery for powering the implantable medical device; an antenna for receiving RF power; and circuitry for charging the rechargeable battery using power received via the antenna, wherein the circuitry for charging comprises control circuitry that causes the circuitry for charging to recharge the rechargeable battery using multiple current levels applied in succession, and wherein the circuitry for charging switches from at least one of the current levels to another current level when a charging voltage of the rechargeable battery reaches a threshold value that is varied by the control circuitry over a lifespan of the rechargeable battery.
摘要翻译：在一个实施例中，可植入医疗装置包括：用于为可植入医疗装置供电的可再充电电池; 用于接收RF功率的天线; 以及用于通过天线接收的功率对可再充电电池充电的电路，其中用于充电的电路包括控制电路，其使所述电路进行充电以使用连续施加的多个电流电平对所述可充电电池进行再充电，并且其中所述用于从当可再充电电池的充电电压达到在可再充电电池的寿命期间由控制电路改变的阈值时，当前电平中的至少一个电平达到另一电流水平。

3. 发明申请

WO2005099813A1 ACTIVE DISCHARGE SYSTEMS AND METHODS 审中-公开
标题翻译：主动放电系统和方法
公开(公告)号：WO2005099813A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/012480
申请日：2005-04-12
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC.
发明人： VARRICHIO, Anthony, J. , TRANCHINA, Benjamin, A.
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61N1/14 , A61N1/36125 , A61N1/3782
摘要： To avoid charge accumulation on capacitive connections to implanted electrodes during delivery of stimulation pulses, stimulation pulses are followed by active discharge pulses having opposite polarity of the stimulation pulses. The active discharge pulses preferably have at least one pulse attribute magnitude (e.g., duration, voltage, and/or current) different than a corresponding stimulation pulse and are preferably programmable. Approximately the same total net current flow is delivered during active discharge pulses as during the stimulation pulses, but in the opposite direction and optionally at a lower amplitude. In addition, by reducing the driving voltage and a variable load within the electrical path for delivery of the pulses, power dissipation during active discharge is preferably reduced.
摘要翻译：为了避免在递送刺激脉冲期间对植入电极的电容连接上的电荷积累，刺激脉冲之后是具有相反极性的刺激脉冲的有效放电脉冲。有效放电脉冲优选地具有与相应的刺激脉冲不同的至少一个脉冲属性量值（例如，持续时间，电压和/或电流），并且优选地是可编程的。在激活脉冲期间，在激活的放电脉冲期间传递大约相同的总净电流，但是在相反方向，并且可选地以较低的振幅。此外，通过降低驱动电压和用于传送脉冲的电路内的可变负载，优选地减少有效放电期间的功率耗散。

4. 发明申请

WO2005101660A1 VOLTAGE LIMITED SYSTEMS AND METHODS 审中-公开
标题翻译：电压有限系统和方法
公开(公告)号：WO2005101660A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/012361
申请日：2005-04-12
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC.
发明人： VARRICHIO, Anthony, J. , TRANCHINA, Benjamin, A.
IPC分类号： H03K5/02
CPC分类号： H02M3/073 , A61N1/36125 , A61N1/36153 , A61N1/3782 , H02M3/07 , H02M2003/072
摘要： In delivering constant current electrical stimulation pulses to electrodes implanted near a stimulation site, a programmable voltage limited mode of operation according to embodiments precludes unsafe voltage spikes upon substantial changes in resistance due to, for example, patient movement. A voltage multiplier of one embodiment is driven by a clock signal stopped whenever an output voltage reaches a predetermined level, and resumed when the output voltage drops below that level. A compurgator receiving a voltage-divided output from the voltage multiplier and a variable input control signal from a digital-to-analog converter controls generation of the clock signal according to embodiments.
摘要翻译：在将恒定的电刺激脉冲传送到植入在刺激部位附近的电极的情况下，根据实施例的可编程电压限制操作模式排除了由于例如患者运动导致的电阻显着变化时的不安全电压尖峰。一个实施例的电压倍增器由输出电压达到预定电平时停止的时钟信号驱动，并且当输出电压下降到该电平以下时恢复。接收来自电压倍增器的分压输出的加压器和来自数模转换器的可变输入控制信号根据实施例控制时钟信号的产生。

5. 发明申请

WO2005101662A1 SYSTEMS AND METHODS FOR PRECHARGING CIRCUITRY FOR PULSE GENERATION 审中-公开
标题翻译：用于脉冲发生预加电路的系统和方法
公开(公告)号：WO2005101662A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/012253
申请日：2005-04-12
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC.
发明人： VARRICHIO, Anthony, J. , TRANCHINA, Benjamin, A.
IPC分类号： H03K17/041
CPC分类号： H02M3/073 , A61N1/36125 , A61N1/36153 , A61N1/3782 , H02M3/07 , H02M2003/072
摘要： A low power (and lower cost) implementation for amplifier used in delivering a stimulation pulse is provided according to embodiments through use of a pre-charge period for each pulse. For example, a voltage at a variable output terminal of a digital-to-analog converter is increased on the leading edge of PULSE and INVERTCLK signals to result in an output of an operational amplifier increasing to a predetermined voltage prior to output of a stimulation pulse, according to an embodiment. A shunt path may be implemented to shunt current away from a load during the pre-charge period.
摘要翻译：根据实施例，通过对每个脉冲使用预充电周期来提供用于递送刺激脉冲的放大器的低功率（和较低成本）实现。例如，数字 - 模拟转换器的可变输出端子处的电压在PULSE和INVERTCLK信号的前沿被增加，以在输出刺激脉冲之前导致运算放大器的输出增加到预定电压，根据一个实施例。可以实现分流路径，以在预充电期间将电流从负载分流。

6. 发明申请

WO2005079885A2 REDUCED SIZE PROGRAMMABLE DRUG PUMP 审中-公开
标题翻译：减少尺寸可编程药水泵
公开(公告)号：WO2005079885A2
公开(公告)日：2005-09-01
申请号：PCT/US2005/005431
申请日：2005-02-18
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC.
发明人： VARRICHIO, Anthony, J. , ERICKSON, John, H.
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M5/16881 , A61M5/172 , A61M2205/0244 , A61M2205/17 , A61M2205/3523
摘要： Systems and methods provide a programmable or controllable infusate delivery with minimal power consumption using controllable valves and with safe and reliable operation of the delivery system. Embodiments provide programmable control without the need for implantable power sources using multi-stable valves and/or mono-stable valves which are powered externally when activated. Embodiments provide for very low power programmable control, such as by employing micro-electromechanical system valves and a flow restrictor array. An external program controller may be utilized to provide a user interface and which may communicate with the controllable infusate delivery system using wireless links. Internal controller circuitry may provide for flow control changes for different activities or times of day and/or in response to changes in pressure, temperature, etcetera. A safety valve configuration may be implemented which provides a safety flow valve configuration which responds in an opposite manner to particular events than does a corresponding primary flow valve.
摘要翻译：系统和方法使用可控阀门以及输送系统的安全可靠的运行提供了可编程或可控的输液输送，功耗最小。实施例提供可编程控制，而不需要使用多个稳定阀和/或单稳态阀的可植入电源，这些阀在被激活时由外部供电。实施例提供了非常低功率的可编程控制，例如通过采用微机电系统阀和限流器阵列。可以使用外部程序控制器来提供用户界面，并且可以使用无线链路与可控制的输入输送系统进行通信。内部控制器电路可以为不同的活动或一天的时间和/或响应于压力，温度等的变化提供流量控制变化。可以实现安全阀构造，其提供安全流量阀构造，其以与相应的主流量阀相比的特定事件相反的方式进行响应。

7. 发明申请

WO2005101661A1 SYSTEMS AND METHODS FOR PROVIDING AMPLITUDE SELECTION FOR PULSE GENERATION 审中-公开
标题翻译：用于提供脉冲发生电平选择的系统和方法
公开(公告)号：WO2005101661A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/012477
申请日：2005-04-12
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC.
发明人： VARRICHIO, Anthony, J. , TRANCHINA, Benjamin, A.
IPC分类号： H03K5/02
CPC分类号： A61N1/36125 , A61N1/36146 , A61N1/3782
摘要： According to embodiments, amplitude for a stimulation pulse delivered to electrodes implanted within a patient is controlled by a scale circuit and a digital-toanalog converter. The scale circuit selects one of a plurality of overlapping, different sized stimulation pulse amplitude ranges while the digital-to-analog converter selects an amplitude within the selected range. Stimulation pulse amplitude adjustment resolution scales automatically with the selected range, and a lowest range including the desired amplitude is automatically selected.
摘要翻译：根据实施例，递送到植入患者体内的电极的刺激脉冲的振幅由刻度电路和数字 - 对数转换器控制。缩放电路选择多个重叠的不同大小的刺激脉冲幅度范围中的一个，同时数模转换器选择所选范围内的振幅。刺激脉冲幅度调整分辨率自动选择范围，并自动选择包括所需幅度的最低范围。

8. 发明申请

WO2005101627A1 FRACTIONAL VOLTAGE CONVERTER 审中-公开
标题翻译：分体电压转换器
公开(公告)号：WO2005101627A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/012254
申请日：2005-04-12
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC.
发明人： VARRICHIO, Anthony, J. , TRANCHINA, Benjamin, A.
IPC分类号： H02M3/07
CPC分类号： A61N1/36153 , A61N1/36125 , A61N1/3782 , H02M3/07 , H02M2003/072
摘要： Embodiments provide a capacitive voltage multiplier (311) for efficiently producing multiples (Vmult), including fractional multiples, of a power supply voltage (Vbatt) use high, medium and low voltage field effect transistors (SW1-SW7) for switching terminals of various capacitors (C1, C2, C3) into and out of connection with power supply (Vbatt) or ground voltages in charge mode and with an output or other capacitor terminals for series connection in pump mode. A single non-overlapping clock is level-shifted up to the maximum voltage level required for switching to produce a desired output, then level shifted back down to lower levels with delay added as necessary according to embodiments.
摘要翻译：实施例提供了一种电容式电压倍增器（311），用于有效地产生用于切换各种电容器的端子的高，中和低电压场效应晶体管（SW1-SW7）的电源电压（Vbatt）的倍数（Vmult）（包括分数倍）（C1，C2，C3）进入和退出与电源（Vbatt）或充电模式下的接地电压，以及在泵模式下串联连接的输出或其他电容端子。单个不重叠的时钟被电平移位直到切换产生期望的输出所需的最大电压电平，然后根据实施例根据需要将电平移位回到较低的电平并根据需要进行延迟。

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