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1. 发明申请

WO2007087626A3 METHOD OF NEUROSIMULATION OF DISTINCT NEURAL STRUCTURES USING SINGLE PADDLE LEAD 审中-公开
公开(公告)号：WO2007087626A3
公开(公告)日：2007-08-02
申请号：PCT/US2007/061126
申请日：2007-01-26
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC. , FELER, Claudio, A. , ERICKSON, John, H.
发明人： FELER, Claudio, A. , ERICKSON, John, H.
IPC分类号： A61N1/05
摘要： In some embodiments, a paddle lead is implanted within a patient such that the electrodes are positioned within the cervical or thoracic spinal levels. An electrode combination on a first row of electrodes can be determined that is effective for a first pain location with minimal effects on other regions of the body. The first pain location can be addressed by stimulating a first dorsal column fiber due to the relatively fine electrical field resolution achievable by the multiple columns. Then, another electrode combination on a second row of electrodes can be determined for a second pain location with minimal effects on other regions. The second pain location could be addressed by stimulating a second dorsal column fiber. After the determination of the appropriate electrodes for stimulation, the patient's IPG can be programmed to deliver pulses using the first and second rows according to the determined electrode combinations.

2. 发明申请

WO2006128037A2 SYSTEMS AND METHODS FOR USE IN PULSE GENERATION 审中-公开
标题翻译：用于脉冲发生的系统和方法
公开(公告)号：WO2006128037A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/020562
申请日：2006-05-26
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC. , ERICKSON, John, H. , VARRICHIO, Anthony, J. , TRANCHINA, Benjamin, A.
发明人： ERICKSON, John, H. , VARRICHIO, Anthony, J. , TRANCHINA, Benjamin, A.
CPC分类号： A61N1/3787 , A61N1/36071 , H02J7/025 , H02J50/20 , H02J50/80
摘要： In one embodiment, an implantable medical device comprises: a rechargeable battery for powering the implantable medical device; an antenna for receiving RF power; and circuitry for charging the rechargeable battery using power received via the antenna, wherein the circuitry for charging comprises control circuitry that causes the circuitry for charging to recharge the rechargeable battery using multiple current levels applied in succession, and wherein the circuitry for charging switches from at least one of the current levels to another current level when a charging voltage of the rechargeable battery reaches a threshold value that is varied by the control circuitry over a lifespan of the rechargeable battery.
摘要翻译：在一个实施例中，可植入医疗装置包括：用于为可植入医疗装置供电的可再充电电池; 用于接收RF功率的天线; 以及用于通过天线接收的功率对可再充电电池充电的电路，其中用于充电的电路包括控制电路，其使所述电路进行充电以使用连续施加的多个电流电平对所述可充电电池进行再充电，并且其中所述用于从当可再充电电池的充电电压达到在可再充电电池的寿命期间由控制电路改变的阈值时，当前电平中的至少一个电平达到另一电流水平。

3. 发明申请

WO2005053789A3 DIRECTIONAL STIMULATION LEAD AND ORIENTATION SYSTEM, AND IMPROVED PERCUTANEOUS-INSERTION NEEDLE AND METHOD OF IMPLANTING A LEAD 审中-公开
标题翻译：定向刺激引导和定向系统，以及改进的经皮插入针和植入引线的方法
公开(公告)号：WO2005053789A3
公开(公告)日：2005-08-04
申请号：PCT/US2004039425
申请日：2004-11-24
申请人： ADVANCED NEUROMODULATION SYS , DAGLOW TERRY , FRANZ BRIAN , ERICKSON JOHN H , HOOPER SANDY , JONES TIM
发明人： DAGLOW TERRY , FRANZ BRIAN , ERICKSON JOHN H , HOOPER SANDY , JONES TIM
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0529
摘要： A lead, method of manufacturing same, and system for stimulation is provided. The lead (10) includes an insulative member or layer (50a, 50b) that masks a portion of the electrode(s) (18) to effectively generate a directional lead that focuses or directs the stimulation to desired location(s). In another embodiment, the lead further includes a marking system (600) to allow a clinician to orient the directional lead, as desired, while the lead is within a body. An improved needle (800) for use in percutaneous insertion of a lead, and method for insertion of same, is provided. The needle includes a flare or lip (812) on the needle heel (814) proximate the needle orifice (808).
摘要翻译：提供了一种引线，制造该引线的方法和用于刺激的系统。引线（10）包括遮蔽一个或多个电极（18）的一部分的绝缘构件或层（50a，50b）以有效地产生定向引线，该定向引线将刺激聚焦或引导至期望位置。在另一个实施例中，引线还包括标记系统（600），以允许临床医生根据需要定向定向引线，同时引线位于身体内。提供了一种用于经皮插入引线的改进的针（800）及其插入方法。针在靠近针孔（808）的针踵（814）上包括喇叭口或唇（812）。

4. 发明申请

WO2005030320A1 SYSTEM AND METHOD FOR IMPLANTABLE STIMULATION LEAD EMPLOYING OPTICAL FIBERS 审中-公开
标题翻译：用于植入光学纤维的可植入刺激的系统和方法
公开(公告)号：WO2005030320A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031192
申请日：2004-09-23
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC. , ERICKSON, John, H.
发明人： ERICKSON, John, H.
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/3718
摘要： An implantable lead, and method of manufacturing same, and a system and method for stimulation. The lead (104, 204) has proximal and distal ends (122, 230) having, respectively, a connector portion (114, 218) with a terminal (116, 220, 222) and an electrode (126, 240, 242). An optically switched device (124, 232, 234, 236, 238) is electrically connected to the electrode and to the terminal. An optical fiber (120, 228) is optically coupled to the connector portion (114, 218) at one end and to the optically switched device (124, 232, 234, 236, 238) at another end. The optically switched device (124, 232, 234, 236, 238) conducts a stimulus from the terminal (116, 220, 222) to the electrode (126, 240, 242) in response to an optical signal transmitted over the optical fiber (120, 228).
摘要翻译：可植入引线及其制造方法，以及用于刺激的系统和方法。引线（104,204）具有分别具有端子（116,220,222）和电极（126,240,242）的连接器部分（114,218）的近端和远端（122,230）。光电开关器件（124,232,234,236,238）电连接到电极和端子。光纤（120,228）在一端光耦合到连接器部分（114,218），并且在另一端光耦合到光开关器件（124,232,234,236,238）。响应于通过光纤传输的光信号，光学开关器件（124,232,234,236,238）将来自端子（116,220,222）的刺激传导到电极（126,240,242） 120,228）。

5. 发明申请

WO2005007236A3 SYSTEM AND METHOD FOR IMPLANTABLE PULSE GENERATOR WITH MULTIPLE TREATMENT PROTOCOLS 审中-公开
标题翻译：具有多种处理方案的可植入脉冲发生器的系统和方法
公开(公告)号：WO2005007236A3
公开(公告)日：2005-03-24
申请号：PCT/US2004021293
申请日：2004-07-01
申请人： ADVANCED NEUROMODULATION SYS , CULLEN PATRICK M , ERICKSON JOHN H , SMITH GALEN L
发明人： CULLEN PATRICK M , ERICKSON JOHN H , SMITH GALEN L
IPC分类号： A61N1/08 , A61N1/34 , A61N1/372 , A61N1/378 , A61N1/36
CPC分类号： A61N1/37211 , A61N1/3787
摘要： A system, method, and implantable pulse generator (IPG) device [100] that stores, on the implantable device, two or more treatment-protocol stimulus programs [240], preferably as prescribed by a physician. The IPG [100], whether it is a self-contained implantable pulse generator (SCIPG) or externally-powered implantable pulse generator (EPIPG), communicates with an external patient programmer (EPP) [115] to determine which of the stimulus programs should be run at any given time. An advanced programmer is used to read and write program instructions to the IPG. In this way, the patient is capable of carrying two or more program options with him, and if the patient uses an EPIPG, he can use any available EPP to power and operate the EPIPG.
摘要翻译：一种系统，方法和植入式脉冲发生器（IPG）装置，其在可植入装置上存储两个或多个治疗方案刺激程序[240]，优选地由医师规定。 IPG [100]，无论是独立的可植入脉冲发生器（SCIPG）还是外部供电的可植入脉冲发生器（EPIPG），与外部患者编程器（EPP）[115]通信，以确定哪些刺激程序应该在任何给定的时间运行。高级程序员用来读写程序指令给IPG。以这种方式，患者能够与他携带两个或多个程序选项，并且如果患者使用EPIPG，则他可以使用任何可用的EPP来为EPIPG供电和操作。

6. 发明申请

WO2009158495A1 METHOD OF ELECTRICALLY STIMULATING TISSUE OF A PATIENT BY SHIFTING A LOCUS OF STIMULATION AND SYSTEM EMPLOYING THE SAME 审中-公开
标题翻译：通过移位刺激位置和使用其的系统的电刺激组织的方法
公开(公告)号：WO2009158495A1
公开(公告)日：2009-12-30
申请号：PCT/US2009/048653
申请日：2009-06-25
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC. , HUYNH, Jeffrey, C. , POWELL, Daniel , GAONKAR, Vikram , ERICKSON, John, H.
发明人： HUYNH, Jeffrey, C. , POWELL, Daniel , GAONKAR, Vikram , ERICKSON, John, H.
IPC分类号： A61N1/372 , A61N1/05
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/36185 , A61N1/37252 , G06F19/00
摘要： In one embodiment, a method for assisting programming a pulse generator comprises: defining a set of unique electrode combinations in the controller device, each electrode combination within the set providing a unique locus of stimulation for a single stimulation pulse applied at a base location relative to loci of stimulation of other electrode combinations, the set of unique electrode combinations defining a two-dimensional range of multiple loci of stimulation; providing one or more user interfaces to the clinician to control pulse generation and delivery by the single-source pulse generator; and processing input from the clinician related to relocation of a locus of stimulation, the processing comprising (i) automatically selecting an electrode combination from the set, and (ii) automatically modifying an electrode combination used by the single-source pulse generator to deliver electrical stimulation pulses to the selected electrode combination.
摘要翻译：在一个实施例中，用于辅助编程脉冲发生器的方法包括：在控制器设备中定义一组独特的电极组合，该组内的每个电极组合为相对于基底位置施加的单个刺激脉冲提供唯一的刺激轨迹刺激其他电极组合的位点，该组独特的电极组合定义了多个刺激位点的二维范围; 向所述临床医生提供一个或多个用户界面以控制所述单源脉冲发生器的脉冲产生和传递; 以及处理来自临床医生的与重新定位刺激点相关的输入，所述处理包括（i）从所述组中自动选择电极组合，以及（ii）自动修改由单源脉冲发生器使用的电极组合以传送电刺激脉冲到所选择的电极组合。

7. 发明申请

WO2005053789A2 DIRECTIONAL STIMULATION LEAD AND ORIENTATION SYSTEM, AND IMPROVED PERCUTANEOUS-INSERTION NEEDLE AND METHOD OF IMPLANTING A LEAD 审中-公开
标题翻译：方向刺激引导和定向系统，以及改进的PERCUTANEOUS插入针和引导方法
公开(公告)号：WO2005053789A2
公开(公告)日：2005-06-16
申请号：PCT/US2004/039425
申请日：2004-11-24
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC. , DAGLOW, Terry , FRANZ, Brian , ERICKSON, John, H. , HOOPER, Sandy , JONES, Tim
发明人： DAGLOW, Terry , FRANZ, Brian , ERICKSON, John, H. , HOOPER, Sandy , JONES, Tim
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0529
摘要： A lead, method of manufacturing same, and system for stimulation is provided. The lead (10) includes an insulative member or layer (50a, 50b) that masks a portion of the electrode(s) (18) to effectively generate a directional lead that focuses or directs the stimulation to desired location(s). In another embodiment, the lead further includes a marking system (600) to allow a clinician to orient the directional lead, as desired, while the lead is within a body. An improved needle (800) for use in percutaneous insertion of a lead, and method for insertion of same, is provided. The needle includes a flare or lip (812) on the needle heel (814) proximate the needle orifice (808).
摘要翻译：提供铅，制造方法和刺激系统。引线（10）包括掩蔽电极（18）的一部分的绝缘部件或层（50a，50b），以有效地产生将刺激聚焦或引导到所需位置的方向引线。在另一个实施例中，引线还包括标记系统（600），以允许临床医生根据需要定向引导线，同时引线在体内。提供了用于经皮插入引线的改进的针（800）及其插入方法。该针包括靠近针孔（808）的针脚跟（814）上的喇叭口或唇缘（812）。

8. 发明申请

WO2007087626A2 METHOD OF NEUROSTIMULATION OF DISTINCT NEURAL STRUCTURES USING SINGLE PADDLE LEAD TO TREAT MULTIPLE PAIN LOCATIONS AND MULTI-COLUMN, MULTI-ROW PADDLE LEAD FOR SUCH NEUROSTIMULATION 审中-公开
标题翻译：使用单个引导线治疗多发性疼痛位置和多列，多层导管对这样的神经细胞的神经元神经元的神经修复方法
公开(公告)号：WO2007087626A2
公开(公告)日：2007-08-02
申请号：PCT/US2007061126
申请日：2007-01-26
申请人： ADVANCED NEUROMODULATION SYS , FELER CLAUDIO A , ERICKSON JOHN H
发明人： FELER CLAUDIO A , ERICKSON JOHN H
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/36071 , A61N1/36185
摘要： In some embodiments, a paddle lead is implanted within a patient such that the electrodes are positioned within the cervical or thoracic spinal levels. An electrode combination on a first row of electrodes can be determined that is effective for a first pain location with minimal effects on other regions of the body. The first pain location can be addressed by stimulating a first dorsal column fiber due to the relatively fine electrical field resolution achievable by the multiple columns. Then, another electrode combination on a second row of electrodes can be determined for a second pain location with minimal effects on other regions. The second pain location could be addressed by stimulating a second dorsal column fiber. After the determination of the appropriate electrodes for stimulation, the patient's IPG can be programmed to deliver pulses using the first and second rows according to the determined electrode combinations.
摘要翻译：在一些实施例中，将桨引线植入患者体内，使得电极定位在子宫颈或胸部脊柱水平内。可以确定在第一排电极上的电极组合，对于第一疼痛位置是有效的，对身体的其他区域的影响最小。可以通过刺激第一背侧列纤维来解决第一个疼痛位置，这是由于多列可实现的相对精细的电场分辨率。然后，可以确定第二排电极上的另一电极组合用于第二疼痛位置，对其他区域的影响最小。可以通过刺激第二背侧纤维来解决第二个疼痛位置。在确定用于刺激的适当电极之后，可以根据所确定的电极组合，将患者的IPG编程为使用第一和第二行递送脉冲。

9. 发明申请

WO2006128037A3 SYSTEMS AND METHODS FOR USE IN PULSE GENERATION 审中-公开
标题翻译：用于脉冲发生的系统和方法
公开(公告)号：WO2006128037A3
公开(公告)日：2007-03-29
申请号：PCT/US2006020562
申请日：2006-05-26
申请人： ADVANCED NEUROMODULATION SYS , ERICKSON JOHN H , VARRICHIO ANTHONY J , TRANCHINA BENJAMIN A
发明人： ERICKSON JOHN H , VARRICHIO ANTHONY J , TRANCHINA BENJAMIN A
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/36071 , H02J7/025 , H02J50/20 , H02J50/80
摘要： In one embodiment, an implantable medical device comprises: a rechargeable battery for powering the implantable medical device; an antenna for receiving RF power; and circuitry for charging the rechargeable battery using power received via the antenna, wherein the circuitry for charging comprises control circuitry that causes the circuitry for charging to recharge the rechargeable battery using multiple current levels applied in succession, and wherein the circuitry for charging switches from at least one of the current levels to another current level when a charging voltage of the rechargeable battery reaches a threshold value that is varied by the control circuitry over a lifespan of the rechargeable battery.
摘要翻译：在一个实施例中，可植入医疗装置包括：用于为可植入医疗装置供电的可再充电电池; 用于接收RF功率的天线; 以及用于通过天线接收的功率对可再充电电池充电的电路，其中用于充电的电路包括控制电路，其使所述电路进行充电以使用连续施加的多个电流电平对所述可充电电池进行再充电，并且其中所述用于从当可再充电电池的充电电压达到在可再充电电池的寿命期间由控制电路改变的阈值时，当前电平中的至少一个电平达到另一电流水平。

10. 发明申请

WO2005007236A2 SYSTEM AND METHOD FOR IMPLANTABLE PULSE GENERATOR WITH MULTIPLE TREATMENT PROTOCOLS 审中-公开
标题翻译：具有多处理协议的可植入脉冲发生器的系统和方法
公开(公告)号：WO2005007236A2
公开(公告)日：2005-01-27
申请号：PCT/US2004/021293
申请日：2004-07-01
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC. , CULLEN, Patrick, M. , ERICKSON, John, H. , SMITH, Galen, L.
发明人： CULLEN, Patrick, M. , ERICKSON, John, H. , SMITH, Galen, L.
IPC分类号： A61N1/00
CPC分类号： A61N1/37211 , A61N1/3787
摘要： A system, method, and implantable pulse generator (IPG) device [100] that stores, on the implantable device, two or more treatment-protocol stimulus programs [240], preferably as prescribed by a physician. The IPG [100], whether it is a self-contained implantable pulse generator (SCIPG) or externally-powered implantable pulse generator (EPIPG), communicates with an external patient programmer (EPP) [115] to determine which of the stimulus programs should be run at any given time. An advanced programmer is used to read and write program instructions to the IPG. In this way, the patient is capable of carrying two or more program options with him, and if the patient uses an EPIPG, he can use any available EPP to power and operate the EPIPG.
摘要翻译：一种在可植入装置上存储两个或更多个治疗方案刺激程序[240]的系统，方法和可植入脉冲发生器（IPG）装置[100]，优选如医师。 IPG [100]（无论是独立的植入式脉冲发生器（SCIPG）还是外部供电的植入式脉冲发生器（EPIPG））与外部患者编程器（EPP）[115]通信以确定哪个刺激程序应在任何特定时间运行。高级程序员用于读取和写入IPG的程序指令。通过这种方式，患者可以随身携带两种或更多种程序选项，如果患者使用EPIPG，他可以使用任何可用的EPP来为EPIPG供电和操作。

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