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1. 发明申请

WO2022204622A1 AXIAL LENGTH MEASUREMENT MONITOR 审中-公开
公开(公告)号：WO2022204622A1
公开(公告)日：2022-09-29
申请号：PCT/US2022/070125
申请日：2022-01-10
申请人： ACUCELA INC. , KUBOTA, Ryo , BUSCEMI, Philip M. , PFISTER, Matthias , WYDER, Stephan , GUPTA, Amitava
发明人： KUBOTA, Ryo , BUSCEMI, Philip M. , PFISTER, Matthias , WYDER, Stephan , GUPTA, Amitava
IPC分类号： A61B3/028 , A61B3/10 , A61B3/103 , A61B3/11
摘要： An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser ("VCSEL").

2. 发明申请

WO2008131368A2 STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：苯乙烯衍生物化合物治疗眼部疾病和病症
公开(公告)号：WO2008131368A2
公开(公告)日：2008-10-30
申请号：PCT/US2008/061073
申请日：2008-04-21
申请人： ACUCELA INC. , SCOTT, Ian, Leslie , KUKSA, Vladimir, Aleksandrovich , GALL, Anna , ORME, Mark, W. , GAGE, Jennifer , LITTLE, Thomas, L., Jr. , JIANG, Qin , ROSSITER, Lana, Michele , MCGEE, Kevin, F., Jr. , KUBOTA, Ryo
发明人： SCOTT, Ian, Leslie , KUKSA, Vladimir, Aleksandrovich , GALL, Anna , ORME, Mark, W. , GAGE, Jennifer , LITTLE, Thomas, L., Jr. , JIANG, Qin , ROSSITER, Lana, Michele , MCGEE, Kevin, F., Jr. , KUBOTA, Ryo
IPC分类号： C07C211/02 , A61K31/135 , C07D295/00 , A61K31/5375 , C07D207/04 , A61K31/40 , C07D211/06 , A61K31/445
CPC分类号： A61K31/5375 , A61K31/137 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/10 , C07C217/16 , C07C217/18 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/06 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07C323/33 , C07C2602/14 , C07C2602/16 , C07D207/06 , C07D211/14 , C07D295/03
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译：本发明总体上涉及用于治疗神经变性疾病和病症，特别是眼部疾病和病症的组合物和方法。本文提供了苯乙烯基衍生物化合物，包括但不限于芪衍生物化合物，以及包含这些化合物的组合物，其可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和Stargardt氏病。

3. 发明申请

WO2010028088A2 SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：用于治疗眼部疾病和病症的硫化合物
公开(公告)号：WO2010028088A2
公开(公告)日：2010-03-11
申请号：PCT/US2009/055785
申请日：2009-09-02
申请人： ACUCELA, INC. , SCOTT, Ian L. , KUKSA, Vladimir Aleksandrovich , KUBOTA, Ryo
发明人： SCOTT, Ian L. , KUKSA, Vladimir Aleksandrovich , KUBOTA, Ryo
IPC分类号： C07C323/32 , C07C317/32 , C07C311/37 , A61K31/10 , A61K31/18 , A61P27/02
CPC分类号： C07C323/32 , C07B2200/05 , C07C311/37 , C07C317/22 , C07C317/32 , C07C323/20 , C07C323/41 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18
摘要： Provided are sulphur-linked compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
摘要翻译：提供硫连接的化合物，其药物组合物以及使用所述化合物和组合物治疗眼科疾病和病症（例如年龄相关性黄斑变性和斯塔加特氏病）的方法。

4. 发明申请

WO2006105215A2 METHODS FOR ENHANCING NEURONAL CELL SURVIVAL AND TREATING NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：增强神经细胞存活和治疗神经损伤性疾病的方法
公开(公告)号：WO2006105215A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/011497
申请日：2006-03-28
申请人： ACUCELA, INC. , KUBOTA, Ryo
发明人： KUBOTA, Ryo
CPC分类号： A61K31/15
摘要： A method for treating neurodegenerative diseases and conditions, particularly retinal neurodegenerative diseases by administering a spin-trap antioxidant compound is provided. In one embodiment, the compound is a spin-trap antioxidant such as alpha-phenyl-N-tert-butyl nitrone (PBN), a derivative or analogue thereof, that enhances survival of photoreceptor cells and may be used for treatment of retinal neurodegenerative diseases, including the dry form of macular degeneration. Also provided are methods for identifying and measuring the activity of spin-trap antioxidant compounds that enhance survival of retinal neuronal cells, such as photoreceptor cells.
摘要翻译：提供了通过施用自旋捕获抗氧化剂治疗神经变性疾病和病症，特别是视网膜神经变性疾病的方法。在一个实施方案中，化合物是自旋捕获抗氧化剂，例如α-苯基-N-叔丁基硝酮（PBN），其衍生物或类似物，其可增强感光细胞的存活并且可用于治疗视网膜神经变性疾病，包括干燥形式的黄斑变性。还提供了用于鉴定和测量增强视网膜神经细胞如感光细胞的存活的自旋捕获抗氧化剂化合物的活性的方法。

5. 发明申请

WO2006091796A2 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING RETINAL DISEASES 审中-公开
标题翻译：用于诊断和治疗感染性疾病的组合物和方法
公开(公告)号：WO2006091796A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/006561
申请日：2006-02-22
申请人： ACUCELA, INC. , KUBOTA, Ryo , PALCZEWSKI, Krzysztof , GALL, Anna
发明人： KUBOTA, Ryo , PALCZEWSKI, Krzysztof , GALL, Anna
IPC分类号： C07D213/20 , C07D213/50 , C07D213/38 , C07D213/56 , A61K39/00 , A61P27/02 , C07K16/18
CPC分类号： A61K39/0007 , A61K2039/6031 , C07D213/20 , C07D213/38 , C07D213/50 , C07D213/56 , C07K16/44
摘要： The present invention relates generally to the preparation and use of retinoid N-retinylidene-N-retinyl-ethanolamine (A2E) conjugated to a carrier polypeptide and to the preparation and use of antibodies that bind specifically to A2E. The invention relates to the use of A2E conjugates as immunogens or vaccines and to the use of A2E specific antibodies for treatment of ophthalmic diseases. Provided herein are methods for enhancing retinal neuronal cell survival, including photoreceptor cell survival, using antibodies that specifically bind to A2E or by inducing an immune response using an A2E immunoconjugate. Enhancing survival of photoreceptor cells or decreasing accumulation of A2E in the eye using the A2E immunoconjugates or A2E specific antibodies is useful for treatment of ophthalmic diseases such as macular degeneration.
摘要翻译：本发明一般涉及与载体多肽缀合的类视黄醇N-亚视黄基-N-视黄醇 - 乙醇胺（A2E）的制备和用途，以及制备和使用与A2E特异性结合的抗体。本发明涉及使用A2E缀合物作为免疫原或疫苗，以及使用A2E特异性抗体治疗眼科疾病。本文提供了使用特异性结合A2E的抗体或通过使用A2E免疫缀合物诱导免疫应答来增强视网膜神经元细胞存活的方法，包括感光细胞存活。使用A2E免疫缀合物或A2E特异性抗体增强感光细胞的存活或减少A2E在眼中的积累，可用于治疗眼部疾病如黄斑变性。

6. 发明申请

WO2011003103A2 PHARMACOLOGY OF VISUAL CYCLE MODULATORS 审中-公开
标题翻译：视觉循环调制器的药理学
公开(公告)号：WO2011003103A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040983
申请日：2010-07-02
申请人： ACUCELA, INC. , KUBOTA, Ryo , BOMAN, Nancy , BAVIK, Claes , SCOTT, Ian, L.
发明人： KUBOTA, Ryo , BOMAN, Nancy , BAVIK, Claes , SCOTT, Ian, L.
IPC分类号： A61K31/195 , A61K31/19 , A61K31/166 , A61P27/02
CPC分类号： A61K31/166 , A61K9/0048 , A61K9/5078 , A61K31/19 , A61K31/195
摘要： Described herein are methods for the treatment of an ophthalmic disease or disorder comprising the administration of non-retinoid visual cycle modulators.
摘要翻译：本文描述了用于治疗眼科疾病或病症的方法，其包括施用非类视黄醇视觉循环调节剂。

7. 发明申请

WO2005012506A2 EXTENDED PRIMARY RETINAL CELL CULTURE AND STRESS MODELS, AND METHODS OF USE 审中-公开
标题翻译：扩展的初级细胞培养和应激模型，以及使用方法
公开(公告)号：WO2005012506A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/024714
申请日：2004-07-30
申请人： ACUCELA, INC. , KUBOTA, Ryo
发明人： KUBOTA, Ryo
IPC分类号： C12N5/00
CPC分类号： C12N5/062 , C12N2503/02 , G01N33/5005 , G01N33/5014
摘要： A cell culture system related to extended in vitro culture of mature retinal cells and methods for preparing the cell culture system are provided. Also provided is a retinal cell culture stress model related to extended in vitro culture of mature retinal cells in the presence of a stressor and methods for using the cell culture stress model. The invention provides a cell culture system comprising a long-term culture of mature retinal cells, without requiring addition of other types of non-retinal cells such as purified glia, or cells isolated from ciliary bodies within the eye, and the addition of a stressor such as light, A2E, cigarette smoke condensate, glutamate, or hydrostatic pressure. Methods for identifying bioactive agents that alter viability, neurodegeneration, or survival of retinal cells using the retinal cell culture stress system are also provided.
摘要翻译：提供了与成熟视网膜细胞的延长体外培养相关的细胞培养系统和用于制备细胞培养系统的方法。还提供了一种视网膜细胞培养应激模型，其涉及在应激源存在下成熟视网膜细胞的延长体外培养和使用细胞培养应激模型的方法。本发明提供一种包含成熟视网膜细胞的长期培养物的细胞培养系统，而不需要添加其它类型的非视网膜细胞，例如纯化的神经胶质细胞，或从眼睛内的睫状体分离的细胞，以及加入应激物如光，A2E，香烟烟雾凝结物，谷氨酸或静水压力。还提供了用于鉴定使用视网膜细胞培养应激系统改变视网膜细胞的存活力，神经变性或存活的生物活性剂的方法。

8. 发明申请

WO2010048332A3 COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS 审中-公开
公开(公告)号：WO2010048332A3
公开(公告)日：2010-04-29
申请号：PCT/US2009/061545
申请日：2009-10-21
申请人： ACUCELA, INC. , SCOTT, Ian L. , KUKSA, Vladimir A. , HONG, Feng , KUBOTA, Ryo , GAGE, Jennifer
发明人： SCOTT, Ian L. , KUKSA, Vladimir A. , HONG, Feng , KUBOTA, Ryo , GAGE, Jennifer
IPC分类号： C07C311/33 , C07C311/08 , C07C311/36 , C07C237/20 , A61K31/18 , A61K31/167 , A61P27/02
摘要： Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

9. 发明申请

WO2009058216A1 AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：用于治疗眼睛疾病和疾病的胺衍生化合物
公开(公告)号：WO2009058216A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/012060
申请日：2008-10-22
申请人： ACUCELA, INC. , SCOTT, Ian, L. , KUKSA, Vladimir, A. , ORME, Mark, W. , HONG, Feng , LITTLE, Thomas, L., Jr. , KUBOTA, Ryo
发明人： SCOTT, Ian, L. , KUKSA, Vladimir, A. , ORME, Mark, W. , HONG, Feng , LITTLE, Thomas, L., Jr. , KUBOTA, Ryo
IPC分类号： A61K31/135 , A61K31/18 , A61P11/06
CPC分类号： A61K31/382 , A61K31/138 , A61K31/165 , A61K31/351 , C07C211/27 , C07C213/00 , C07C215/20 , C07C215/28 , C07C215/30 , C07C215/42 , C07C217/16 , C07C217/48 , C07C217/54 , C07C217/72 , C07C217/74 , C07C219/22 , C07C225/16 , C07C225/18 , C07C233/18 , C07C235/34 , C07C235/54 , C07C237/20 , C07C237/38 , C07C237/40 , C07C257/14 , C07C279/08 , C07C317/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D213/30 , C07D213/38 , C07D309/06 , C07D333/16 , C07D333/20 , C07D335/02
摘要： Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
摘要翻译：提供的是胺衍生物化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和失调症的方法，例如年龄相关性黄斑变性和Stargardt氏病。

10. 发明申请

WO2007089673A2 COMPOSITIONS AND METHODS FOR TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：用于治疗眼病和疾病的组合物和方法
公开(公告)号：WO2007089673A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/002330
申请日：2007-01-26
申请人： ACUCELA, INC. , KUBOTA, Ryo , FAWZI, Ahmad , SCOTT, Ian, Leslie
发明人： KUBOTA, Ryo , FAWZI, Ahmad , SCOTT, Ian, Leslie
IPC分类号： A61K36/8962
CPC分类号： A61K31/137
摘要： Provided herein are compositions and methods for treating ophthalmic diseases and disorders. Compositions comprising retinylamine derivative compounds provided herein are useful for treating and preventing ophthalmic diseases and disorders, including diabetic retinopathy diabetic maculopathy, diabetic macular edema, retinal ischemia, ischemia-reperfusion related retinal injury, and metabolic optic neuropathy.
摘要翻译：本文提供了用于治疗眼科疾病和病症的组合物和方法。包含本文提供的视黄醇衍生物化合物的组合物可用于治疗和预防眼科疾病和病症，包括糖尿病性视网膜病，糖尿病性黄斑变性，糖尿病性黄斑水肿，视网膜缺血，缺血再灌注相关的视网膜损伤和代谢性视神经病变。

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