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1. 发明申请

WO2022204622A1 AXIAL LENGTH MEASUREMENT MONITOR 审中-公开
公开(公告)号：WO2022204622A1
公开(公告)日：2022-09-29
申请号：PCT/US2022/070125
申请日：2022-01-10
申请人： ACUCELA INC. , KUBOTA, Ryo , BUSCEMI, Philip M. , PFISTER, Matthias , WYDER, Stephan , GUPTA, Amitava
发明人： KUBOTA, Ryo , BUSCEMI, Philip M. , PFISTER, Matthias , WYDER, Stephan , GUPTA, Amitava
IPC分类号： A61B3/028 , A61B3/10 , A61B3/103 , A61B3/11
摘要： An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser ("VCSEL").

2. 发明申请

WO2011003103A3 PHARMACOLOGY OF VISUAL CYCLE MODULATORS 审中-公开
标题翻译：视频循环调制器的药理学
公开(公告)号：WO2011003103A3
公开(公告)日：2011-05-26
申请号：PCT/US2010040983
申请日：2010-07-02
申请人： ACUCELA INC , KUBOTA RYO , BOMAN NANCY , BAVIK CLAES , SCOTT IAN L
发明人： KUBOTA RYO , BOMAN NANCY , BAVIK CLAES , SCOTT IAN L
IPC分类号： A61K31/195 , A61K31/166 , A61K31/19 , A61P27/02
CPC分类号： A61K31/166 , A61K9/0048 , A61K9/5078 , A61K31/19 , A61K31/195
摘要： Described herein are methods for the treatment of an ophthalmic disease or disorder comprising the administration of non-retinoid visual cycle modulators.
摘要翻译：本文描述了治疗眼科疾病或病症的方法，其包括施用非类视黄醇视觉循环调节剂。

3. 发明申请

WO2010028088A2 SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：用于治疗眼部疾病和病症的硫化合物
公开(公告)号：WO2010028088A2
公开(公告)日：2010-03-11
申请号：PCT/US2009/055785
申请日：2009-09-02
申请人： ACUCELA, INC. , SCOTT, Ian L. , KUKSA, Vladimir Aleksandrovich , KUBOTA, Ryo
发明人： SCOTT, Ian L. , KUKSA, Vladimir Aleksandrovich , KUBOTA, Ryo
IPC分类号： C07C323/32 , C07C317/32 , C07C311/37 , A61K31/10 , A61K31/18 , A61P27/02
CPC分类号： C07C323/32 , C07B2200/05 , C07C311/37 , C07C317/22 , C07C317/32 , C07C323/20 , C07C323/41 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18
摘要： Provided are sulphur-linked compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
摘要翻译：提供硫连接的化合物，其药物组合物以及使用所述化合物和组合物治疗眼科疾病和病症（例如年龄相关性黄斑变性和斯塔加特氏病）的方法。

4. 发明申请

WO2006105215A2 METHODS FOR ENHANCING NEURONAL CELL SURVIVAL AND TREATING NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：增强神经细胞存活和治疗神经损伤性疾病的方法
公开(公告)号：WO2006105215A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/011497
申请日：2006-03-28
申请人： ACUCELA, INC. , KUBOTA, Ryo
发明人： KUBOTA, Ryo
CPC分类号： A61K31/15
摘要： A method for treating neurodegenerative diseases and conditions, particularly retinal neurodegenerative diseases by administering a spin-trap antioxidant compound is provided. In one embodiment, the compound is a spin-trap antioxidant such as alpha-phenyl-N-tert-butyl nitrone (PBN), a derivative or analogue thereof, that enhances survival of photoreceptor cells and may be used for treatment of retinal neurodegenerative diseases, including the dry form of macular degeneration. Also provided are methods for identifying and measuring the activity of spin-trap antioxidant compounds that enhance survival of retinal neuronal cells, such as photoreceptor cells.
摘要翻译：提供了通过施用自旋捕获抗氧化剂治疗神经变性疾病和病症，特别是视网膜神经变性疾病的方法。在一个实施方案中，化合物是自旋捕获抗氧化剂，例如α-苯基-N-叔丁基硝酮（PBN），其衍生物或类似物，其可增强感光细胞的存活并且可用于治疗视网膜神经变性疾病，包括干燥形式的黄斑变性。还提供了用于鉴定和测量增强视网膜神经细胞如感光细胞的存活的自旋捕获抗氧化剂化合物的活性的方法。

5. 发明申请

WO2021146748A1 DATABASE OF RETINAL PHYSIOLOGY DERIVED FROM OPHTHALMIC MEASUREMENTS PERFORMED BY PATIENTS 审中-公开
公开(公告)号：WO2021146748A1
公开(公告)日：2021-07-22
申请号：PCT/US2021/070023
申请日：2021-01-12
申请人： ACUCELA INC. , KUBOTA, Ryo , BUSCEMI, Philip M.
发明人： JUNGHANS, Martin , TROLLER, Stefan , PFISTER, Matthias
IPC分类号： A61B3/10 , G16H10/60
摘要： A homebased retinal monitoring system comprises a retinal scanning module and a visual acuity assessment module. The modules are operated by a software system that is interfaced with a web portal. The web portal interfaces a web-based server and a database that is compliant with one or more of the Health Insurance Portability and Accountability Act or General Data Protection Regulation.

6. 发明申请

WO2008131368A2 STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：苯乙烯衍生物化合物治疗眼部疾病和病症
公开(公告)号：WO2008131368A2
公开(公告)日：2008-10-30
申请号：PCT/US2008/061073
申请日：2008-04-21
申请人： ACUCELA INC. , SCOTT, Ian, Leslie , KUKSA, Vladimir, Aleksandrovich , GALL, Anna , ORME, Mark, W. , GAGE, Jennifer , LITTLE, Thomas, L., Jr. , JIANG, Qin , ROSSITER, Lana, Michele , MCGEE, Kevin, F., Jr. , KUBOTA, Ryo
发明人： SCOTT, Ian, Leslie , KUKSA, Vladimir, Aleksandrovich , GALL, Anna , ORME, Mark, W. , GAGE, Jennifer , LITTLE, Thomas, L., Jr. , JIANG, Qin , ROSSITER, Lana, Michele , MCGEE, Kevin, F., Jr. , KUBOTA, Ryo
IPC分类号： C07C211/02 , A61K31/135 , C07D295/00 , A61K31/5375 , C07D207/04 , A61K31/40 , C07D211/06 , A61K31/445
CPC分类号： A61K31/5375 , A61K31/137 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/10 , C07C217/16 , C07C217/18 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/06 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07C323/33 , C07C2602/14 , C07C2602/16 , C07D207/06 , C07D211/14 , C07D295/03
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译：本发明总体上涉及用于治疗神经变性疾病和病症，特别是眼部疾病和病症的组合物和方法。本文提供了苯乙烯基衍生物化合物，包括但不限于芪衍生物化合物，以及包含这些化合物的组合物，其可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和Stargardt氏病。

7. 发明申请

WO2006105215A3 THE USE OF A SPIN TRAP FOR ENHANCING RETINAL CELL SURVIVAL AND TREATING RETINAL DEGENERATIVE DISEASES 审中-公开
标题翻译：用于增强视网膜细胞存活和治疗视网膜变性疾病
公开(公告)号：WO2006105215A3
公开(公告)日：2007-07-12
申请号：PCT/US2006011497
申请日：2006-03-28
申请人： ACUCELA INC , KUBOTA RYO
发明人： KUBOTA RYO
IPC分类号： A61K31/15
CPC分类号： A61K31/15
摘要： A method for treating neurodegenerative diseases and conditions, particularly retinal neurodegenerative diseases by administering a spin-trap antioxidant compound is provided. In one embodiment, the compound is a spin-trap antioxidant such as alpha-phenyl-N-tert-butyl nitrone (PBN), a derivative or analogue thereof, that enhances survival of photoreceptor cells and may be used for treatment of retinal neurodegenerative diseases, including the dry form of macular degeneration. Also provided are methods for identifying and measuring the activity of spin-trap antioxidant compounds that enhance survival of retinal neuronal cells, such as photoreceptor cells.
摘要翻译：提供了通过施用自旋捕获抗氧化剂治疗神经变性疾病和病症，特别是视网膜神经变性疾病的方法。在一个实施方案中，化合物是自旋捕获抗氧化剂，例如α-苯基-N-叔丁基硝酮（PBN），其衍生物或类似物，其可增强感光细胞的存活并且可用于治疗视网膜神经变性疾病，包括干燥形式的黄斑变性。还提供了用于鉴定和测量增强视网膜神经细胞如感光细胞的存活的自旋捕获抗氧化剂化合物的活性的方法。

8. 发明申请

WO2004007749A3 METHODS AND SYSTEMS FOR EXTENDED IN VITRO CULTURE OF NEURONAL CELLS 审中-公开
标题翻译：在神经细胞的体外培养中扩增的方法和系统
公开(公告)号：WO2004007749A3
公开(公告)日：2005-05-06
申请号：PCT/US0321968
申请日：2003-07-11
申请人： UNIV WASHINGTON , KUBOTA RYO , REH THOMAS A , FISCHER ANDREW J
发明人： KUBOTA RYO , REH THOMAS A , FISCHER ANDREW J
IPC分类号： C12N5/02 , C12N5/071 , C12N5/0793 , C12N5/00 , C12N5/06
CPC分类号： C12N5/0621 , C12N5/062 , C12N2502/08 , C12N2503/02
摘要： A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal cells and cells isolated from a ciliary body. Methods for identifying bioactive agents that alter neurodegeneration of neuronal retinal cells are also provided.
摘要翻译：提供了与成熟神经元细胞的延长的体外培养相关的细胞培养系统和用于制备细胞培养系统的方法。在优选的实施方案中，本发明提供了包含成熟神经元视网膜细胞和从睫状体分离的细胞的混合物的细胞培养系统。还提供了用于鉴定改变神经元视网膜细胞神经变性的生物活性剂的方法。

9. 发明申请

WO2004007749A2 METHODS AND SYSTEMS FOR EXTENDED IN VITRO CULTURE OF NEURONAL CELLS 审中-公开
标题翻译：在神经细胞的体外培养中扩增的方法和系统
公开(公告)号：WO2004007749A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/021968
申请日：2003-07-11
申请人： UNIVERSITY OF WASHINGTON , KUBOTA, Ryo , REH, Thomas, A. , FISCHER, Andrew, J.
发明人： KUBOTA, Ryo , REH, Thomas, A. , FISCHER, Andrew, J.
IPC分类号： C12Q
CPC分类号： C12N5/0621 , C12N5/062 , C12N2502/08 , C12N2503/02
摘要： A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal cells and cells isolated from a ciliary body. Methods for identifying bioactive agents that alter neurodegeneration of neuronal retinal cells are also provided.
摘要翻译：提供了与成熟神经元细胞的延长的体外培养相关的细胞培养系统和用于制备细胞培养系统的方法。在优选的实施方案中，本发明提供了包含成熟神经元视网膜细胞和从睫状体分离的细胞的混合物的细胞培养系统。还提供了用于鉴定改变神经元视网膜细胞神经变性的生物活性剂的方法。

10. 发明申请

WO2007089673A8 COMPOSITIONS AND METHODS FOR TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：用于治疗眼科疾病和病症的组合物和方法
公开(公告)号：WO2007089673A8
公开(公告)日：2008-04-10
申请号：PCT/US2007002330
申请日：2007-01-26
申请人： ACUCELA INC , KUBOTA RYO , FAWZI AHMAD , SCOTT IAN LESLIE , KUKSA VLADIMIR A
发明人： KUBOTA RYO , FAWZI AHMAD , SCOTT IAN LESLIE , KUKSA VLADIMIR A
IPC分类号： A61K31/21 , A61K31/16 , A61K31/215
CPC分类号： A61K31/137
摘要： Provided herein are compositions and methods for treating ophthalmic diseases and disorders. Compositions comprising retinylamine derivative compounds provided herein are useful for treating and preventing ophthalmic diseases and disorders, including diabetic retinopathy diabetic maculopathy, diabetic macular edema, retinal ischemia, ischemia-reperfusion related retinal injury, and metabolic optic neuropathy.
摘要翻译：本文提供了用于治疗眼科疾病和病症的组合物和方法。包含本文提供的视黄胺衍生物化合物的组合物可用于治疗和预防眼科疾病和病症，包括糖尿病视网膜病变糖尿病黄斑病变，糖尿病性黄斑水肿，视网膜缺血，缺血再灌注相关视网膜损伤和代谢性视神经病变。

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