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1. 发明申请

WO2008076443A3 COMBINATION THERAPY FOR TREATING HEPATITIS C INFECTIONS 审中-公开
公开(公告)号：WO2008076443A3
公开(公告)日：2008-06-26
申请号：PCT/US2007/025907
申请日：2007-12-17
申请人： ACHILLION PHARMACEUTICALS, INC. , HUANG, Mingjun , FABRYCKI, Joanne , YANG, Wengang , NIE, Xingtie , PHADKE, Avinash , DESHPANDE, Milind
发明人： HUANG, Mingjun , FABRYCKI, Joanne , YANG, Wengang , NIE, Xingtie , PHADKE, Avinash , DESHPANDE, Milind
IPC分类号： A61K31/17
摘要： The invention provides a method of treating hepatitis C, by providing compound of Formula I (shown below) in combination with a second active agent to a patient infected with the hepatitis C virus. Also provided herein are pharmaceutical combinations comprising a compound of Formula I and a second active agent. The pharmaceutical combination may be a unit dosage form or a packaged pharmaceutical composition. Packaged pharmaceutical combinations include a compound of Formula I and a second active agent in a package with instructions for using the formulation to treat a hepatitis C infection.

2. 发明申请

WO2006083271A3 SUBSTITUTED ARYL ACYLTHIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION 审中-公开
公开(公告)号：WO2006083271A3
公开(公告)日：2006-08-10
申请号：PCT/US2005/017308
申请日：2005-05-17
申请人： ACHILLION PHARMACEUTICALS, INC. , PHADKE, Avinash , CHEN, Dawei , DESHPANDE, Milind , THURKAUF, Andrew , WANG, Xiangzhu , SHEN, Yiping , LIU, Cuixian , QUINN, Jesse , LI, Shouming , OHKANDA, Junko
发明人： PHADKE, Avinash , CHEN, Dawei , DESHPANDE, Milind , THURKAUF, Andrew , WANG, Xiangzhu , SHEN, Yiping , LIU, Cuixian , QUINN, Jesse , LI, Shouming , OHKANDA, Junko
IPC分类号： C07C335/26 , A61K31/17 , A61P31/12 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/64 , C07D211/78 , C07D213/56 , C07D213/82 , C07D215/54 , C07D231/14 , C07D233/54 , C07D233/90 , C07D237/24
摘要： The invention provides certain acylthiourea derivatives and pharmaceutically acceptable salts thereof. These compounds possess potent antiviral activity. The invention particularly provides compounds that are potent and/or selective inhibitors of hepatitis C virus replication. The invention also provides pharmaceutical compositions containing a compound of the invention and at least one pharmaceutically acceptable excipient and packaged pharmaceutical compositions comprising such a pharmaceutical composition in a container together with instructions for using the composition to treat a viral infection. The invention further comprises a method of inhibiting hepatitis C virus replication by contacting a compound of the invention with a cell that is infected by hepatitis C virus and a method of treating or preventing hepatitis C viral infection by administering an amount of a compound of the invention to a subject in need thereof.

3. 发明申请

WO2004046095A1 SUBSTITUTED ARYL THIOUREAS AND RELEATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION 审中-公开
标题翻译：取代的芳香化合物和相关化合物; VIRAL REPLICATION的抑制剂
公开(公告)号：WO2004046095A1
公开(公告)日：2004-06-03
申请号：PCT/US2003/036809
申请日：2003-11-18
申请人： ACHILLION PHARMACEUTICALS, INC. , CHEN, Dawei , DESHPANDE, Milind , THURKAUF, Andrew , PHADKE, Avinash , WANG, Xiangzhu , SHEN, Yiping , LIU, Cuixian , QUINN, Jesse , OHKANDA, Junko , LI, Shouming
发明人： CHEN, Dawei , DESHPANDE, Milind , THURKAUF, Andrew , PHADKE, Avinash , WANG, Xiangzhu , SHEN, Yiping , LIU, Cuixian , QUINN, Jesse , OHKANDA, Junko , LI, Shouming
IPC分类号： C07C335/26
CPC分类号： C07D209/48 , C07C335/26 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D207/16 , C07D207/34 , C07D207/416 , C07D209/42 , C07D211/14 , C07D211/62 , C07D211/70 , C07D211/86 , C07D213/64 , C07D213/65 , C07D213/81 , C07D215/06 , C07D215/48 , C07D217/04 , C07D231/14 , C07D233/42 , C07D233/90 , C07D239/26 , C07D241/24 , C07D241/44 , C07D249/06 , C07D257/04 , C07D261/18 , C07D263/34 , C07D263/57 , C07D271/08 , C07D271/12 , C07D277/56 , C07D277/66 , C07D277/68 , C07D285/06 , C07D295/135 , C07D295/15 , C07D307/52 , C07D307/68 , C07D307/85 , C07D311/24 , C07D311/66 , C07D317/66 , C07D319/20 , C07D333/20 , C07D333/34 , C07D333/38 , C07D333/70 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D495/04
摘要： The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/ or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease. Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.
摘要翻译：本发明提供式I的化合物和药学上可接受的盐，其中变量A1，A2，R1，R2，V，W，X，Y和Z在本文中定义。某些本文所述的具有强抗病毒活性的式I化合物。本发明特别提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式I化合物。本发明还提供含有一种或多种式I化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。本发明还包括通过向这些患者施用一定量的有效减少疾病或病症的体征或症状的式I化合物来治疗患有某些感染性疾病的患者的方法。这些传染病包括病毒感染，特别是HCV感染。本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。治疗方法包括给予式I化合物作为单一活性剂或将一种式I化合物与一种或多种其它治疗剂组合施用。

4. 发明申请

WO2012166716A3 SUBSITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR TREATING HCV INFECTIONS 审中-公开
公开(公告)号：WO2012166716A3
公开(公告)日：2012-12-06
申请号：PCT/US2012/039835
申请日：2012-05-29
申请人： ACHILLION PHARMACEUTICALS, INC. , WILES, Jason Allan , WANG, Qiuping , HASHIMOTO, Akihiro , PAIS, Godwin , CHEN, Dawei , WANG, Xiangzhu , GADHACHANDA, Venkat , PHADKE, Avinash , DESHPANDE, Milind
发明人： WILES, Jason Allan , WANG, Qiuping , HASHIMOTO, Akihiro , PAIS, Godwin , CHEN, Dawei , WANG, Xiangzhu , GADHACHANDA, Venkat , PHADKE, Avinash , DESHPANDE, Milind
IPC分类号： A61K31/4178 , A61K31/4164 , A61P31/12 , A61P31/00
摘要： The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula (I) D-M-D (Formula I) useful as antiviral agents. In certain embodiments disclosed herein M is a group -P-A-P- where A is (Formula I) Certain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/ and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure.

5. 发明申请

WO2010115184A2 HYDROXYTHIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译：羟肟酸和相关化合物作为抗感染剂
公开(公告)号：WO2010115184A2
公开(公告)日：2010-10-07
申请号：PCT/US2010/029938
申请日：2010-04-05
申请人： ACHILLION PHARMACEUTICALS, INC. , BRADBURY, Barton James , DESHPANDE, Milind , HASHIMOTO, Akihiro , KIM, Ha Young , LUCIEN, Edlaine , PAIS, Godwin , PUCCI, Michael , WANG, Qiuping , WILES, Jason Allan , PHADKE, Avinash
发明人： BRADBURY, Barton James , DESHPANDE, Milind , HASHIMOTO, Akihiro , KIM, Ha Young , LUCIEN, Edlaine , PAIS, Godwin , PUCCI, Michael , WANG, Qiuping , WILES, Jason Allan , PHADKE, Avinash
IPC分类号： C07D495/04 , C07D495/16 , C07D495/14 , A61P29/00
CPC分类号： A61K31/4743 , A61K31/496 , C07D495/04 , C07D498/16 , C07D519/00
摘要： Disclosed herein are hydroxythienoquinolones and related compounds and their pharmaceutically acceptable salts useful as antiviral agents and having the general formula (I) in which the variables R 2 , R 6 , and R 7 are defined herein. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity and are particularly efficacious for the treatment of MRSA infections. The invention also provides pharmaceutical compositions, pharmaceutical compositions containing a hydroxythienoquinolone in combination with one or more other active agent, and methods of treating microbial infections in animals by administering an effective amount of a hydroxythienoquinolone or related compound to an animal suffering from a microbial infection.
摘要翻译：本文公开了羟基噻吩并喹啉酮及其可药用盐，其可用作抗病毒剂，并具有通式（I），其中变量R2，R6和R7在本文中定义。本文提供的某些化合物具有有效的抗细菌，抗原生动物或抗真菌活性，并且对于治疗MRSA感染特别有效。本发明还提供药物组合物，含有羟基噻吩并喹啉酮与一种或多种其它活性剂的药物组合物，以及通过向有微生物感染的动物施用有效量的羟基噻吩并喹啉酮或相关化合物来治疗动物微生物感染的方法。

6. 发明申请

WO2010068761A2 4-AMINO-4-OXOBUTANOYL PEPTIDE CYCLIC ANALOGUES, INHIBITORS OF VIRAL REPLICATION 审中-公开
标题翻译： 4-氨基-4-氧代丁酰基肽类环化类似物，病毒复制抑制剂
公开(公告)号：WO2010068761A2
公开(公告)日：2010-06-17
申请号：PCT/US2009/067507
申请日：2009-12-10
申请人： ACHILLION PHARMACEUTICALS, INC. , PHADKE, Avinash , WANG, Xiangzhu , PAIS, Godwin , HASHIMOTO, Akihiro , GADHACHANDA, Venkat , CHEN, Dawei , AGARWAL, Atul , ZHANG, Suoming , LIU, Cuixian , LI, Shouming , DESHPANDE, Milind
发明人： PHADKE, Avinash , WANG, Xiangzhu , PAIS, Godwin , HASHIMOTO, Akihiro , GADHACHANDA, Venkat , CHEN, Dawei , AGARWAL, Atul , ZHANG, Suoming , LIU, Cuixian , LI, Shouming , DESHPANDE, Milind
IPC分类号： C07D403/14 , C07D403/12 , C07D417/14
CPC分类号： C07K5/12 , A61K38/00 , C07K5/06165
摘要： The invention provides 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Formula I and the pharmaceutically salts thereof. The variables are defined herein. Certain compounds of Formula I are useful as antiviral agents. 4-amino-4-oxobutanoyl peptide cyclic analogues as disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptide cyclic analogues and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptide cyclic analogue as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptide cyclic analogue and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections, in patients.
摘要翻译：本发明提供式I的4-氨基-4-氧代丁酰基肽及其环状类似物及其药用盐。变量在此定义。式I的某些化合物可用作抗病毒剂。如本文所公开的4-氨基-4-氧代丁酰基肽环类似物是病毒复制的有效和/或选择性抑制剂，特别是丙型肝炎病毒复制。本发明还提供了含有一种或多种4-氨基-4-氧代丁酰基肽环类似物和一种或多种药学上可接受的载体的药物组合物。此类药物组合物可含有4-氨基-4-氧代丁酰基肽环状类似物作为唯一活性剂，或可含有4-氨基-4-氧代丁酰基肽环状类似物与一种或多种其他药物活性剂的组合。本发明还提供了用于治疗患者中的病毒感染（包括丙型肝炎感染）的方法。

7. 发明申请

WO2009042668A2 UREA-CONTAINING PEPTIDES AS INHIBITORS OF VIRAL REPLICATION 审中-公开
标题翻译：含有尿素的肽作为病毒复制的抑制剂
公开(公告)号：WO2009042668A2
公开(公告)日：2009-04-02
申请号：PCT/US2008/077497
申请日：2008-09-24
申请人： ACHILLION PHARMACEUTICALS, INC. , CHEN, Dawei , DESHPANDE, Milind , PHADKE, Avinash
发明人： CHEN, Dawei , DESHPANDE, Milind , PHADKE, Avinash
IPC分类号： C07K5/10 , C07K5/06 , C07F5/02 , A61K38/12 , A61K38/00 , A61K31/69
CPC分类号： C07K5/0823 , A61K38/00 , C07K5/06165
摘要： The invention provides compounds urea-containing peptide compounds of Formula I and the pharmaceutically salts and hydrates thereof. The variables T, R 1 -R 9 , J, L, M, Y, Z, m, n, and t are defined herein. Certain compounds of Formula I are useful as antiviral agents. Certain urea-containing peptide compounds disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more urea containing peptides compounds and one or more pharmaceutically acceptable carriers, excipients, or diluents. Such pharmaceutical compositions may contain a urea containing peptides compound as the only active agent or may contain a combination of a urea containing peptides compound and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections, in mammals.
摘要翻译：本发明提供了式I化合物的含脲的肽化合物及其药用盐和水合物。变量T，R1-R9，J，L，M，Y，Z，m，n和t在本文中定义。式I的某些化合物可用作抗病毒剂。本文公开的某些含脲肽化合物是病毒复制的有效和/或选择性抑制剂，特别是丙型肝炎病毒复制。本发明还提供了含有一种或多种含脲的肽化合物和一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。这样的药物组合物可以含有含脲的肽化合物作为唯一的活性剂，或者可以含有含脲的肽化合物和一种或多种其他药物活性剂的组合。本发明还提供了用于治疗哺乳动物中的病毒感染（包括丙型肝炎感染）的方法。

8. 发明申请

WO2006122011A2 THIAZOLE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：噻唑化合物及其使用方法
公开(公告)号：WO2006122011A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/017692
申请日：2006-05-09
申请人： ACHILLION PHARMACEUTICALS, INC. , ZHANG, Suoming , PHADKE, Avinash , LIU, Cuixian , WANG, Xiangzhu , QUINN, Jesse , CHEN, Dawei , GADHACHANDA, Venkat , LI, Shouming , DESHPANDE, Milind
发明人： ZHANG, Suoming , PHADKE, Avinash , LIU, Cuixian , WANG, Xiangzhu , QUINN, Jesse , CHEN, Dawei , GADHACHANDA, Venkat , LI, Shouming , DESHPANDE, Milind
IPC分类号： A61K31/426 , A61K31/427 , A61P31/12 , C07D487/04
CPC分类号： C07D487/04 , C07D277/38 , C07D277/42 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention provides compounds, salts and hydrates of Formula I, wherein the variables Ar 1 R 2 , R 3 , R 4 , r, q, and t are defined herein. Certain compounds of Formula I described herein possess potent antiviral activity. The invention also provides compounds of Formula I that are potent and/ or selective inhibitors of Hepatitis C virus replication. Certain compounds described herein inhibit assembly of the HCV replication complex. The invention also provides pharmaceutical compositions containing one or more compounds of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease. Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.
摘要翻译：本发明提供式I的化合物，盐和水合物，其中变量Ar 1 R 2，R 3，R 4 本文中定义的是，r，q和t。某些本文所述的式I化合物具有有效的抗病毒活性。本发明还提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式I化合物。本文所述的某些化合物抑制HCV复制复合物的组装。本发明还提供含有一种或多种式I化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。本发明还包括通过向这些患者施用一定量的有效降低疾病体征或症状的式I化合物来治疗患有某些感染性疾病的患者的方法。这些传染病包括病毒感染，特别是HCV感染。本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。治疗方法包括给予式I化合物作为单一活性剂或将一种式I化合物与一种或多种其它治疗剂组合施用。

9. 发明申请

WO2010068760A2 NEW 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION 审中-公开
标题翻译：作为病毒复制的新型4-氨基-4-氧代戊酸酯
公开(公告)号：WO2010068760A2
公开(公告)日：2010-06-17
申请号：PCT/US2009/067506
申请日：2009-12-10
申请人： ACHILLION PHARMACEUTICALS, INC. , PHADKE, Avinash , CHEN, Dawei , GADHACHANDA, Venkat , HASHIMOTO, Akihiro , PAIS, Godwin , WANG, Xiangzhu , AGARWAL, Atul , KIM, Ha Young , LI, Shouming , LIU, Cuixian , ZHANG, Suoming , DESHPANDE, Milind
发明人： PHADKE, Avinash , CHEN, Dawei , GADHACHANDA, Venkat , HASHIMOTO, Akihiro , PAIS, Godwin , WANG, Xiangzhu , AGARWAL, Atul , KIM, Ha Young , LI, Shouming , LIU, Cuixian , ZHANG, Suoming , DESHPANDE, Milind
IPC分类号： C07D403/14 , C07D413/14 , A61P31/12 , A61K31/437
CPC分类号： C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/08 , C07D487/08 , C07D487/18 , C07D491/113
摘要： The invention provides 4-amino-4-oxobutanoyl peptides of Formula I and the pharmaceutically salts and hydrates thereof. The variables R, R 1 , R 6 -R 8 , R 16 , R 18 , R 19 , M, n, T, Y, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. The 4-amino-4-oxobutanoyl peptides disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptides and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptides as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptides and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections.
摘要翻译：本发明提供式I的4-氨基-4-氧代丁酰基肽及其药学上可接受的盐和水合物。变量R，R1，R6-R8，R16，R18，R19，M，n，T，Y和Z在本文中定义。某些式I化合物可用作抗病毒剂。本文公开的4-氨基-4-氧代丁酰基肽是有效和/或选择性的病毒复制抑制剂，特别是丙型肝炎病毒复制。本发明还提供含有一种或多种4-氨基-4-氧代丁酰基肽和一种或多种药学上可接受的载体的药物组合物。这样的药物组合物可以含有4-氨基-4-氧代丁酰基肽作为唯一的活性剂，或者可以含有4-氨基-4-氧代丁酰基肽和一种或多种其它药学活性剂的组合。本发明还提供了治疗病毒感染的方法，包括丙型肝炎感染。

10. 发明申请

WO2010059937A1 CYCLIC CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF AS OF HEPATITIS C VIRUS 审中-公开
标题翻译：周期性羧酰胺化合物及其与乙型肝炎病毒的模拟物
公开(公告)号：WO2010059937A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/065328
申请日：2009-11-20
申请人： ACHILLION PHARMACEUTICALS, INC. , ZHANG, Suoming , PHADKE, Avinash , DESHPANDE, Milind , GADHACHANDA, Venkat
发明人： ZHANG, Suoming , PHADKE, Avinash , DESHPANDE, Milind , GADHACHANDA, Venkat
IPC分类号： C07K5/02 , A61K38/00
CPC分类号： C07K5/0808 , C07K5/0819
摘要： The invention provides cyclic carboxamide compounds and analogues thereof of Formula (I) and the pharmaceutically salts and hydrates thereof. The variables R, R 1 , R 6 -R 8 , R 16 , R 18 , R 19 , M, n, T, Y, and Z are defined herein. Certain compounds of Formula (I) are useful as antiviral agents. Certain cyclic carboxamide compounds and cyclic carboxamide analogues disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more cyclic carboxamide compounds or cyclic carboxamide analogues and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a cyclic carboxamide compound or cyclic carboxamide analogue as the only active agent or may contain a combination of a cyclic carboxamide compound or cyclic carboxamide analogue and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections.
摘要翻译：本发明提供式（I）的环状羧酰胺化合物及其类似物及其药学上可接受的盐和水合物。变量R，R1，R6-R8，R16，R18，R19，M，n，T，Y和Z在本文中定义。某些式（I）化合物可用作抗病毒剂。本文公开的某些环状羧酰胺化合物和环状羧酰胺类似物是有效和/或选择性的病毒复制抑制剂，特别是丙型肝炎病毒复制。本发明还提供含有一种或多种环状羧酰胺化合物或环状甲酰胺类似物和一种或多种药学上可接受的载体的药物组合物。这样的药物组合物可以含有环状羧酰胺化合物或环状羧酰胺类似物作为唯一的活性剂，或者可以含有环状甲酰胺化合物或环状甲酰胺类似物和一种或多种其它药学活性剂的组合。本发明还提供了治疗病毒感染的方法，包括丙型肝炎感染。

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