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1. 发明申请

WO2009018478A3 USE OF GENOMIC TESTING AND KETOGENIC COMPOUNDS FOR TREATMENT OF REDUCED COGNITIVE FUNCTION 审中-公开
标题翻译：用于治疗减少认知功能的基因测试和发酵化合物的使用
公开(公告)号：WO2009018478A3
公开(公告)日：2009-03-12
申请号：PCT/US2008071817
申请日：2008-07-31
申请人： ACCERA INC , HENDERSON SAMUEL T
发明人： HENDERSON SAMUEL T
IPC分类号： G01N33/48 , A61K31/12
CPC分类号： A61K31/23 , A61K31/7004 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： Methods of using genotyping to select patients for treatment with compounds capable of elevating ketone body concentrations in amounts effective to treat reduced neuronal metabolism associated with reduced neuronal metabolism are disclosed. Conditions include Alzheimer's disease, Parkinson's Disease, Friedreich's Ataxia, GLUTI-deficient Epilepsy, Leprechaunism, and Rabson- Mendenhall Syndrome, Coronary Arterial Bypass Graft, dementia, anesthesia-induced memory loss, and Huntington's Disease.
摘要翻译：公开了使用基因分型来选择患者治疗能够提高酮体浓度的化合物的方法，所述化合物有效治疗与减少的神经元代谢相关的减少的神经元代谢。病情包括阿尔茨海默病，帕金森病，弗里德里希共济失调，GLUTI缺陷性癫痫，妖精症，拉布森门多霍综合征，冠状动脉旁路移植术，痴呆，麻醉诱发的记忆丧失和亨廷顿疾病。

2. 发明申请

WO2006118665A3 METHOD FOR REDUCING LEVELS OF DISEASE ASSOCIATED PROTEINS 审中-公开
标题翻译：降低相关蛋白质水平的方法
公开(公告)号：WO2006118665A3
公开(公告)日：2008-12-18
申请号：PCT/US2006008668
申请日：2006-03-08
申请人： ACCERA INC , HENDERSON SAMUEL T
发明人： HENDERSON SAMUEL T
IPC分类号： A23L33/00 , A63D15/00 , A61K31/401 , A61K31/522
CPC分类号： A61K31/137 , A61K31/22 , A61K31/366 , A61K31/401 , A61K31/522
摘要： The subject invention concerns the reduction of protein aggregation in the neurons of a mammal through the use of a ketogenic treatment such as a ketogenic diet, a physical training regimen and/or administration of agents to increase fatty acid oxidation. Such ketogenic treatment can be useful in the reduction of certain aggregates including amyloid ß peptide, polyglutamine containing huntintin protein, polyglutamine containing androgen receptor, polyglutamine containing atrophin-1, polyglutamine containing ataxins, a-synclein, prion protein, tau and superoxide dismutase 1 (SOD1).
摘要翻译：本发明涉及通过使用酮生成治疗例如生酮饮食，身体训练方案和/或施用药物以增加脂肪酸氧化来减少哺乳动物的神经元中的蛋白质聚集。这种酮生成治疗可用于减少某些聚集体，包括淀粉样蛋白β肽，含有多聚谷氨酰胺的亨廷丁蛋白，含有多聚谷氨酰胺的雄激素受体，含聚谷氨酰胺的含萎缩蛋白-1，聚谷氨酰胺含ataxins，α-康普林，朊蛋白，tau和超氧化物歧化酶1 SOD1）。

3. 发明申请

WO2007115282A2 USE OF KETOGENIC COMPOUNDS FOR TREATMENT OF AGE-ASSOCIATED MEMORY IMPAIRMENT 审中-公开
标题翻译：用于治疗与年龄相关的记忆障碍的发酵化合物的使用
公开(公告)号：WO2007115282A2
公开(公告)日：2007-10-11
申请号：PCT/US2007065873
申请日：2007-04-03
申请人： ACCERA INC , HENDERSON SAMUEL T
发明人： HENDERSON SAMUEL T
IPC分类号： A61K31/22
CPC分类号： A61K31/22 , A23L2/52 , A23L33/10 , A61K9/0056 , A61K9/0095 , A61K31/19 , A61K31/23
摘要： This invention relates to the field of therapeutic agents for the treatment of Age-Associated Memory Impairment (AAMI). In particular, the present invention utilizes compositions comprising at least one compound capable of elevating ketone body concentrations in a mammal (e.g., ketogenic compounds), administered in an amount effective for treatment or prevention of loss of cognitive function caused by reduced neuronal metabolism in AAMI. In one embodiment, the composition includes medium chain triglycerides (MCT). In another embodiment, the compositions are administered in the presence of carbohydrate. The present invention also relates to oral dosage forms, in particular, a nutritional drink comprising at least one compound capable of elevating ketone body concentrations in a mammal.
摘要翻译：本发明涉及用于治疗年龄相关记忆障碍（AAMI）的治疗剂领域。特别地，本发明使用包含至少一种能够提高哺乳动物（例如致酮化合物）中酮体浓度的化合物的组合物，其以有效治疗或预防由AAMI中减少的神经元代谢引起的认知功能丧失的量施用。在一个实施方案中，组合物包括中链甘油三酸酯（MCT）。在另一个实施方案中，组合物在碳水化合物存在下给药。本发明还涉及口服剂型，特别是包含至少一种能够提高哺乳动物中酮体浓度的化合物的营养饮品。

4. 发明申请

WO2007001883A3 METHOD TO REDUCE OXIDATIVE DAMAGE AND IMPROVE MITOCHONDRIAL EFFICIENCY 审中-公开
标题翻译：减少氧化损伤和改善线粒体效率的方法
公开(公告)号：WO2007001883A3
公开(公告)日：2007-05-31
申请号：PCT/US2006023342
申请日：2006-06-15
申请人： ACCERA INC , HENDERSON SAMUEL T
发明人： HENDERSON SAMUEL T
IPC分类号： A61K31/22 , A61K31/202 , A61K31/225 , A61K31/33 , A61K31/683 , A61K31/685
CPC分类号： A61K31/22 , A61K31/202 , A61K31/205 , A61K31/225 , A61K31/23 , A61K31/33 , A61K31/683 , A61K31/685 , A61K45/06 , A61K2300/00
摘要： Methods for the reduction of mitochondrial oxidative damage and improved mitochondrial efficiency in an animal by administration of medium chain triglycerides or prodrug of medium chain triglycerides to the animal are provided.
摘要翻译：提供了通过向动物施用中链甘油三酯或中链甘油三酯前药来减少动物线粒体氧化损伤和改善线粒体效率的方法。

5. 发明申请

WO0182928A9 USE OF MEDIUM CHAIN TRIGLYCERIDES FOR THE TREATMENT AND PREVENTION OF ALZHEIMER'S DISEASE AND OTHER DISEASES RESULTING FROM REDUCED NEURONAL METABOLISM 审中-公开
标题翻译：用于治疗和预防由减少的神经元代谢引起的阿尔茨海默病和其他疾病的中链链抗体的使用
公开(公告)号：WO0182928A9
公开(公告)日：2006-06-15
申请号：PCT/US0113955
申请日：2001-05-01
申请人： ACCERA INC , HENDERSON SAMUEL T
发明人： HENDERSON SAMUEL T
IPC分类号： A61K31/12 , A61K45/00 , A61K31/20 , A61K31/205 , A61K31/215 , A61K31/22 , A61K31/221 , A61K31/23 , A61K31/25 , A61K45/06 , A61P3/10 , A61P25/28 , A61P43/00
CPC分类号： A61K45/06 , A61K31/12 , A61K31/20 , A61K31/205 , A61K31/215 , A61K31/22 , A61K31/221 , A61K31/23 , A61K31/25 , A61K2300/00
摘要： Methods and compositions for treating or preventing, the occurrence of senile dementia of the Alzheimer's type, or other conditions arising from reduced neuronal metabolism and leading to lessened cognitive function are described. In a preferred embodiment the administration of triglicerides or fatty acids with chain lengths between 5 and 12, to said patient at a level produce an improvement in cognitive ability.
摘要翻译：描述了用于治疗或预防阿尔茨海默氏型老年性痴呆的发生或由减少的神经元代谢引起的导致认知功能降低的其它病症的方法和组合物。在优选的实施方案中，将链长度在5至12之间的三联体或脂肪酸以一定水平给予所述患者的认知能力的改善。

6. 发明申请

WO2004077938A3 NOVEL CHEMICAL ENTITIES AND METHODS FOR THEIR USE IN TREATMENT OF METABOLIC DISORDERS 审中-公开
标题翻译：用于治疗代谢性疾病的新型化学实验方法及其使用方法
公开(公告)号：WO2004077938A3
公开(公告)日：2005-06-09
申请号：PCT/US2004007191
申请日：2004-03-08
申请人： ACCERA INC , HENDERSON SAMUEL T , ORNDORFF STEVE , MELVIN LAWRENCE S
发明人： HENDERSON SAMUEL T , ORNDORFF STEVE , MELVIN LAWRENCE S
IPC分类号： A01K20060101 , A61K31/122 , A61K31/198 , A61K31/205 , A61K31/221 , A61K31/355 , A61K31/375 , A61K31/70 , A61K31/7024 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/16 , A61K33/18 , A61K33/24 , A61K33/26 , A61K33/32 , A61K33/42 , A61K45/06 , C07H13/06
CPC分类号： C07H13/06 , A61K31/122 , A61K31/198 , A61K31/205 , A61K31/221 , A61K31/355 , A61K31/375 , A61K31/7024 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/16 , A61K33/18 , A61K33/24 , A61K33/26 , A61K33/32 , A61K33/42 , A61K45/06
摘要： Methods and compositions for treating or preventing, the occurrence of senile dementia of the Alzheimer's type, or other conditions arising from reduced neuronal metabolism and leading to lessened cognitive function are described. In a preferred embodiment the administration of novel esterified saccharide compounds to said patient at a level to produce an improvement in cognitive ability.
摘要翻译：描述了用于治疗或预防阿尔茨海默氏型老年性痴呆的发生或由减少的神经元代谢引起的导致认知功能降低的其它病症的方法和组合物。在优选的实施方案中，向所述患者施用新的酯化糖化合物，以产生认知能力的改善。

7. 发明申请

WO0118549A8 METHOD FOR IDENTIFYING MODULATORS OF DAF-16 审中-公开
标题翻译：鉴定DAF-16调节剂的方法
公开(公告)号：WO0118549A8
公开(公告)日：2001-06-07
申请号：PCT/US0024487
申请日：2000-09-07
申请人： NEUROGENETICS INC , HENDERSON SAMUEL T , JOHNSON THOMAS E
发明人： HENDERSON SAMUEL T , JOHNSON THOMAS E
IPC分类号： C12N15/10 , C12Q1/68 , C40B40/02 , G01N33/68
CPC分类号： C40B40/02 , C12N15/10 , C12N15/1037 , C12Q1/68
摘要： The invention comprises methods for identifying agents that can activate C. elegans DAF-16 and human homologs thereof, or their corresponding genes, whereby cytoprotective effects in cells may be induced. Such cytoprotective effects can result in enhanced environmental stress resistance, increased life span and improved late life vigor without significant inhibition of insulin-signaling pathways. The invention also comprises the therapeutic agents identified and methods of treatment using the agents.
摘要翻译：本发明包括用于鉴定可以活化C的药剂的方法。秀丽隐杆线虫DAF-16及其人类同源物或其相应基因，由此可诱导细胞的细胞保护作用。这种细胞保护作用可导致增强的环境胁迫耐受性，延长寿命并改善晚期活力，而不显着抑制胰岛素信号传导途径。本发明还包括所鉴定的治疗剂和使用所述药剂的治疗方法。

8. 发明申请

WO2007070701A2 COMPOSITIONS AND METHODS FOR PRESERVING BRAIN FUNCTION 审中-公开
标题翻译：保护脑功能的组合物和方法
公开(公告)号：WO2007070701A2
公开(公告)日：2007-06-21
申请号：PCT/US2006048077
申请日：2006-12-15
申请人： NESTEC SA , LARSON BRIAN T , HENDERSON SAMUEL T , ROBERTS MATTHEW A
发明人： LARSON BRIAN T , HENDERSON SAMUEL T , ROBERTS MATTHEW A
CPC分类号： A61K31/19 , A23L33/115 , A23V2002/00 , A61K31/205 , A61K31/215 , A61K31/22 , A23V2200/322 , A23V2250/1944
摘要： Compositions and methods for preventing, reducing, or delaying decline in one or more of cognitive function, motor function, cerebrovascular function, or behavior in animals, particularly geriatric animals, are disclosed. The compositions and methods utilize medium chain triglycerides.
摘要翻译：公开了用于预防，减少或延迟一种或多种认知功能，运动功能，脑血管功能或动物，特别是老年动物中的行为的降低的组合物和方法。组合物和方法利用中链甘油三酯。

9. 发明申请

WO03028631A3 DRUG TARGETS FOR ALZHEIMER'S DISEASE AND OTHER DISEASES ASSOCIATED WITH DECREASED NEURONAL METABOLISM 审中-公开
标题翻译：阿尔茨海默病和其他与降低的神经元代谢相关的疾病的药物目标
公开(公告)号：WO03028631A3
公开(公告)日：2003-08-21
申请号：PCT/US0230145
申请日：2002-09-23
申请人： ACCERA INC
发明人： HENDERSON SAMUEL T
IPC分类号： C12Q1/25 , C12Q1/44 , C12Q1/48 , C12Q1/68 , G01N33/50 , G01N33/94 , G01N31/00 , G01N33/00 , G01N33/48 , G01N33/92
CPC分类号： G01N33/5044 , C12Q1/25 , C12Q1/44 , C12Q1/48 , C12Q1/485 , C12Q1/6883 , G01N33/5008 , G01N33/502 , G01N33/5038 , G01N33/5067 , G01N33/948 , G01N2333/91057 , G01N2333/91235 , G01N2500/20
摘要： Target molecules for the development of assays and screening of compound libraries, which will be used to develop therapeutics for the prevention and treatment of Alzheimer's disease and other diseases associated with decreased neuronal metabolism are provided. Also provided are methods of treatment for the diseases.
摘要翻译：提供了用于开发测定和筛选化合物文库的靶分子，其将用于开发用于预防和治疗阿尔茨海默病和与神经元代谢减少相关的其他疾病的治疗剂。还提供了治疗疾病的方法。

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