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1. 发明申请

WO2017036978A1 FUSED HETEROCYCLIC COMPOUNDS AS S1P MODULATORS 审中-公开
标题翻译：熔融杂环化合物作为S1P调节剂
公开(公告)号：WO2017036978A1
公开(公告)日：2017-03-09
申请号：PCT/EP2016/070225
申请日：2016-08-26
申请人： ABBVIE INC. , ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人： LANGE, Udo , OCHSE, Michael , VAN DER KAM, Elizabeth , VAN BERGEIJK, Jeroen , TURNER, Sean , OELLIEN, Frank , WALLESER, Patrick , AMBERG, Wilhelm , HORNBERGER, Wilfried , GENESTE, Herve , MEZLER, Mario , HUTCHINS, Charles
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61P25/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to heterocyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
摘要翻译：本发明涉及作为S1P调节剂的杂环化合物，包含这些化合物的药物组合物及其在治疗，缓解或预防S1P受体介导的疾病或病症中的用途。

2. 发明申请

WO2015091931A1 OXINDOLE DERIVATIVES CARRYING A PIPERIDYL-SUBSTITUTED AZETIDINYL SUBSTITUENT AND USE THEREOF FOR TREATING VASOPRESSINE-RELATED DISEASES 审中-公开
标题翻译：携带哌啶取代的亚胺基取代基的氧化衍生物及其用于治疗类风湿关节疾病的用途
公开(公告)号：WO2015091931A1
公开(公告)日：2015-06-25
申请号：PCT/EP2014/078699
申请日：2014-12-19
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG , ABBVIE INC.
发明人： GENESTE, Hervé , HORNBERGER, Wilfried , HUTCHINS, Charles W. , JANTOS, Katja , KLING, Andreas , LAPLANCHE, Loic , VAN GAALEN, Marcel
IPC分类号： C07D401/14 , C07D401/04 , A61K31/444 , A61P25/24 , A61P3/10
CPC分类号： C07D401/14 , C07B59/002 , C07B2200/05 , C07D401/04 , C07D405/14 , C07D491/107
摘要： The present invention relates to novel substituted oxindole derivatives of formula (I) wherein the variables are as defined in the claims and description; to pharmaceutical compositions comprising them, and to their use for treatment of vasopressin-related disorders.
摘要翻译：本发明涉及式（I）的新型取代的羟基吲哚衍生物，其中变量如权利要求和说明书所定义; 包含它们的药物组合物及其用于治疗加压素相关病症的用途。

3. 发明申请

WO2015091934A1 OXINDOLE DERIVATIVES CARRYING AN AMINE-SUBSTITUTED PIPERIDYL-AZETIDINYL SUBSTITUENT AND USE THEREOF FOR TREATING VASOPRESSINE-RELATED DISEASES 审中-公开
标题翻译：实施胺取代的哌嗪 - 亚胺基替代物的氧化衍生物及其用于治疗与维生素A相关的疾病的用途
公开(公告)号：WO2015091934A1
公开(公告)日：2015-06-25
申请号：PCT/EP2014/078702
申请日：2014-12-19
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG , ABBVIE INC.
发明人： GENESTE, Hervé , HORNBERGER, Wilfried , HUTCHINS, Charles, W. , JANTOS, Katja , KLING, Andreas , LAPLANCHE, Loic , VAN GAALEN, Marcel
IPC分类号： C07D401/14 , A61K31/4545 , A61P9/00
CPC分类号： C07D401/14
摘要： The present invention relates to novel substituted oxindole derivatives of formula (I) wherein the variables are as defined in the claims and description; to pharmaceutical compositions comprising them, and to their use for the treatment of vasopressin-related disorders.
摘要翻译：本发明涉及式（I）的新型取代的羟基吲哚衍生物，其中变量如权利要求和说明书所定义; 包含它们的药物组合物及其用于治疗加压素相关病症的用途。

4. 发明申请

WO2013149800A1 CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V 审中-公开
标题翻译：羧酰胺化合物及其作为钙抑制剂V
公开(公告)号：WO2013149800A1
公开(公告)日：2013-10-10
申请号：PCT/EP2013/055291
申请日：2013-03-14
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG , ABBVIE INC.
发明人： KLING, Andreas , JANTOS, Katja , MACK, Helmut , MÖLLER, Achim , HORNBERGER, Wilfried , BACKFISCH, Gisela , LAO, Yanbin , NIJSEN, Marjoleen
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D471/04 , C07D487/04 , A61K31/4439 , A61P25/00 , A61P31/00 , A61P33/00 , A61P35/00
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/107
摘要： The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R 1 , R 2 and n have the meanings mentioned in the claims and the description, Y is a radical of the formulae (Y1) or (Y2) where # indicates the point of attachment of Y to the pyridine ring, R 3 , R 4 , R 5 , R y and m have the meanings mentioned in the claims and the description, A is is (CH 2 ) p with p being 1, 2, 3 or 4, where one or two hydrogen atoms may be replaced by a radical R 6 , where A is attached to the 3-or 4-positon of the pyrazole radical and R 6 has the meaning mentioned in the claims and the description; A 1 is (CH 2 )q with q being 0, 1, 2 or 3, where one or two hydrogen atoms may be replaced by halogen or C 1 -C 4 -alkyl; and A 2 is (CH 2 )r with r being 0, 1, 2 or 3, where one or two hydrogen atoms may be replaced by halogen or C 1 -C 4 -alkyl, provided that that r + q is 2, 3, 4, 5 or 6; their tautomers, the hydrates thereof, the pharmaceutically suitable salts of the carbox-amide compounds (I), the prodrugs of (I) and the pharmaceutically suitable salts of the prodrugs, tautomers or hydrates of (I).
摘要翻译：本发明涉及新的羧酰胺化合物及其用于制备药物的用途。羧酰胺化合物是钙蛋白酶（钙依赖性半胱氨酸蛋白酶）的抑制剂。因此，本发明还涉及这些羧酰胺化合物用于治疗与升高的钙蛋白酶活性相关的病症的用途。羧酰胺化合物是通式（I）的化合物，其中R 1，R 2和n具有权利要求书和描述中所述的含义，Y是式（Y1）或（Y2）的基团，其中＃表示 Y连接到吡啶环，R3，R4，R5，Ry和m具有权利要求和说明书中提及的含义，A是（CH 2）p，其中p是1,2,3或4，其中一个或两个氢原子可以被基团R6代替，其中A连接到吡唑基的3-或4-位，R6具有权利要求书和说明书中提到的含义; A 1是（CH 2）q，其中q是0,1,2或3，其中一个或两个氢原子可以被卤素或C 1 -C 4 - 烷基取代; 并且A 2为（CH 2）r，其中r为0,1,2或3，其中一个或两个氢原子可被卤素或C 1 -C 4 - 烷基取代，条件是该r + q为2,3,4,5 或6; 其互变异构体，其水合物，羧酰胺化合物（I）的药学上合适的盐，（I）的前药和（I）的前药，互变异构体或水合物的药学上合适的盐。

5. 发明申请

WO2014140186A1 OXINDOLE DERIVATIVES CARRYING AN OXETANE SUBSTITUENT AND USE THEREOF FOR TREATING VASOPRESSINE-RELATED DISEASES 审中-公开
标题翻译：携带OXETANE取代物的OXINDOLE衍生物及其用于治疗类风湿性关节炎的用途
公开(公告)号：WO2014140186A1
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054973
申请日：2014-03-13
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人： JANTOS, Katja , BRAJE, Wilfried , GENESTE, Hervé , KLING, Andreas , UNGER, Liliane , BEHL, Berthold , VAN GAALEN, Marcel , HORNBERGER, Wilfried , LAPLANCHE, Loic , WEBER, Silke
IPC分类号： C07D405/14 , A61K31/4545 , A61P3/00 , A61P9/00 , A61P25/00 , A61P7/00
CPC分类号： C07D405/14 , C07D487/08
摘要： The present invention relates to novel substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-related disorders.
摘要翻译：本发明涉及新型取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素相关病症的用途。

6. 发明申请

WO2018083171A1 SPIRO-COMPOUNDS AS S1P MODULATORS 审中-公开
标题翻译： SPIRO化合物作为S1P调节剂
公开(公告)号：WO2018083171A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/078043
申请日：2017-11-02
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG , ABBVIE PHARMACEUTICALS TRADING (SHANGHAI) CO., LTD.
发明人： AMBERG, Wilhelm , VAN BERGEIJK, Jeroen , GENESTE, Herve , HORNBERGER, Wilfried , VAN DER KAM, Elizabeth Louise , LANGE, Udo , MEZLER, Mario , OCHSE, Michael , OELLIEN, Frank , WALLESER, Patrick , TURNER, Sean C
IPC分类号： C07D221/20 , C07D205/12 , C07D491/107 , A61K31/397 , A61K31/438 , A61P25/00
摘要： The invention relates to heterocyclic compounds of formula (I) as SIP modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment or alleviation of diseases or disorders mediated by an SIP receptor.
摘要翻译：本发明涉及式（I）的杂环化合物作为SIP调节剂，包含此类化合物的药物组合物，以及它们在治疗或缓解由S1P受体介导的疾病或障碍中的用途。

7. 发明申请

WO2016034703A1 FUSED HETEROCYCLIC OR CARBOCYCLIC COMPOUNDS CARRYING A SUBSTITUTED CYCLOALIPHATIC RADICAL AND USE THEREOF FOR TREATING VASOPRESSIN-RELATED DISEASES 审中-公开
标题翻译：携带取代的循环系统的融合的杂环化合物或碳环化合物及其用于治疗与血管相关性疾病
公开(公告)号：WO2016034703A1
公开(公告)日：2016-03-10
申请号：PCT/EP2015/070223
申请日：2015-09-04
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人： BRAJE, Wilfried , FROGGETT, Jayne , GENESTE, Hervé , HORNBERGER, Wilfried , JANTOS, Katja , KLING, Andreas , VAN GAALEN, Marcel
IPC分类号： C07D239/91
CPC分类号： C07D239/91 , C07D401/12 , C07D403/12 , C07D455/02 , C07D491/107
摘要： The present invention relates to novel fused heterocyclic or carbocyclic compounds of formula (I) wherein the variables are as defined in the claims and the description. The invention further relates to pharmaceutical compositions comprising these compounds, and to their use for the treatment of vasopressin-related disorders.
摘要翻译：本发明涉及式（I）的新型稠合杂环或碳环化合物，其中变量如权利要求和说明书所定义。本发明还涉及包含这些化合物的药物组合物及其用于治疗加压素相关病症的用途。

8. 发明申请

WO2019016112A1 1,2,3,4-SUBSTITUTED QUINOLINE COMPOUNDS AS S1P MODULATORS 审中-公开
公开(公告)号：WO2019016112A1
公开(公告)日：2019-01-24
申请号：PCT/EP2018/069196
申请日：2018-07-16
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人： AMBERG, Wilhelm , GENESTE, Hervé , HORNBERGER, Wilfried , LANGE, Udo , MEZLER, Mario , OCHSE, Michael , OELLIEN, Frank , TURNER, Sean C , VAN BERGEIJK, Jeroen , VAN DER KAM, Elizabeth
IPC分类号： C07D217/04 , C07D401/06 , C07D405/06 , C07D409/06 , A61P25/28 , A61K31/4725
摘要： The invention relates to 1,2,3,4-substituted quinoline compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.

9. 发明申请

WO2015173393A1 OXINDOLE COMPOUNDS CARRYING A NITROGEN-BOUND SPIRO SUBSTITUENT AND USE THEREOF FOR TREATING VASOPRESSIN-RELATED DISEASES 审中-公开
标题翻译：携带氮离子螺旋体替代物的氧化合物及其用于治疗相关疾病的用途
公开(公告)号：WO2015173393A1
公开(公告)日：2015-11-19
申请号：PCT/EP2015/060763
申请日：2015-05-15
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人： GENESTE, Hervé , HORNBERGER, Wilfried , JANTOS, Katja , KLING, Andreas , VAN GAALEN, Marcel
IPC分类号： C07D471/10 , C07D487/10 , C07D295/135 , C07D305/08
CPC分类号： C07D471/10 , C07D295/135 , C07D305/08 , C07D487/10
摘要： The present invention relates to novel substituted oxindole derivatives of the formula I wherein A is a ring selected from phenyl and 6-membered hetaryl containing 1 or 2 nitrogen atoms as ring members, where ring A carries one substituent R 6 and optionally one substituent R 7 ;B is a ring selected from phenyland a monocyclic or bicyclic het- eroaromatic ring containing 1, 2 or 3 heteroatoms selected from O, N and S as ring members, where ring B may carry 1, 2 or 3 substituents R 8 ;X 1 , X 2 , X 3 and X 4 , independently of each other, are selected from -CH 2 -, -O-, -S(O) c -, -NH-, -C(O)-, -CH 2 CH 2 -,-CH 2 O-, -OCH 2 -, -S(O) c CH 2 -, -CH 2 S(O)c-, CH 2 NH-,-NHCH 2 -, -CH 2 C(O)-andC(O)CH 2 -;X 5 is NH,CH 2 or O,;and wherein c, R 1 , R 2 , (R 3 )a, (R 4 )b, R 5 , R 6 , R 7 , and R 8 are as defined in the claims. The present invention also relates to pharmaceutical compositions comprising the novel substituted oxindole derivatives of the formula I, and to their use for the treatment of vasopressin-related disorders.
摘要翻译：本发明涉及式I的新的取代的羟基吲哚衍生物，其中A是选自苯基和含有1或2个氮原子作为环成员的6元杂芳基的环，其中环A携带一个取代基R6和任选的一个取代基R7; B 是选自苯基和含有1,2或3个选自O，N和S作为环成员的杂原子的单环或双环环芳族环的环，其中环B可以带有1,2或3个取代基R8; X1，X2，X3 和X 4彼此独立地选自-CH 2 - ， - O - ， - S（O）c - ， - NH - ， - C（O） - ， - CH 2 CH 2 - ， - CH 2 O-，-OCH 2 - -S（O）cCH 2 - ， - CH 2 S（O）c - ，CH 2 NH-， - NHCH 2 - ， - CH 2 C（O） - 和C（O）CH 2 - ; X 5是NH，CH 2或O，并且其中c， R2，（R3）a，（R4）b，R5，R6，R7和R8如权利要求中所定义。本发明还涉及包含式I的新型取代的羟吲哚衍生物的药物组合物及其用于治疗加压素相关病症的用途。

10. 发明申请

WO2015173392A1 OXINDOLE COMPOUNDS CARRYING A CO-BOUND SPIRO SUBSTITUENT AND USE THEREOF FOR TREATING VASOPRESSIN-RELATED DISEASES 审中-公开
标题翻译：携带共轭螺旋体替代物的氧化物化合物及其用于治疗相关疾病的用途
公开(公告)号：WO2015173392A1
公开(公告)日：2015-11-19
申请号：PCT/EP2015/060761
申请日：2015-05-15
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人： BRAJE, Wilfried , GENESTE, Hervé , HORNBERGER, Wilfried , JANTOS, Katja , KLING, Andreas , KRACK, Claudia , VAN GAALEN, Marcel
IPC分类号： C07D471/10 , C07D487/10 , C07D295/135 , C07D305/08 , C07D209/40 , C07D213/64
CPC分类号： C07D487/10 , C07D209/40 , C07D213/64 , C07D295/135 , C07D305/08 , C07D401/14 , C07D471/10
摘要： The present invention relates to novel substituted oxindole derivativesof formula I, wherein the variables are as defined in the claims and the description. The invention further relates to pharmaceutical compositions comprising compounds I and their use for the treatment of vasopressin-related disorders.
摘要翻译：本发明涉及式I的新型取代羟吲哚衍生物，其中变量如权利要求和说明书所定义。本发明还涉及包含化合物I及其用于治疗加压素相关病症的用途的药物组合物。

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