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1. 发明申请

WO2010036998A2 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
标题翻译：吲哚和吲哚衍生物及其使用方法
公开(公告)号：WO2010036998A2
公开(公告)日：2010-04-01
申请号：PCT/US2009/058553
申请日：2009-09-28
申请人： ABBOTT LABORATORIES , SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana , HU, Min
发明人： SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana , HU, Min
IPC分类号： A61K31/439 , C12Q1/02 , C07D471/08
CPC分类号： G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R 1 , R 2 , R 3 , R 4 , R 5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译：本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

2. 发明申请

WO2011008312A2 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
标题翻译：吲哚和吲哚啉衍生物及其使用方法
公开(公告)号：WO2011008312A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/027931
申请日：2010-03-19
申请人： ABBOTT LABORATORIES , SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana L. , HU, Min
发明人： SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana L. , HU, Min
IPC分类号： C07D487/18
CPC分类号： C07D471/18 , C07D487/18
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a , R 1 , R 2 , R 3 , R 4 , R 5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译：本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和吲哚啉衍生物， R 1，R 2，R 3，R 4，R 5，R 5，R 5，R 4， U，V，W，X，Y和Z如说明书中所定义。本申请还涉及包含此类化合物的组合物，以及使用此类化合物和组合物治疗疾病状况的方法以及鉴定此类化合物的方法。

3. 发明申请

WO2016008429A1 APPARATUS AND METHOD FOR AUTOMATICALLY OPENING VEHICLE TRUNK 审中-公开
标题翻译：装置和自动开启车辆的方法
公开(公告)号：WO2016008429A1
公开(公告)日：2016-01-21
申请号：PCT/CN2015/084231
申请日：2015-07-16
申请人： XIAO, Min , HU, Min , HU, Alicia X.
发明人： XIAO, Min , HU, Min , HU, Alicia X.
IPC分类号： E05F15/00
CPC分类号： E05F15/77 , E05Y2900/548
摘要： An apparatus and method for automatically opening a vehicle trunk are provided. The apparatus may include : a ranging device configured to measure a distance between a handheld device and the vehicle when receiving a first signal periodically transmitted from the handheld device, and to transmit a second signal instructing to open the trunk when the measured distance satisfies a predetermined condition; and a control device configured to control whether or not to open the trunk when receiving the second signal from the ranging device. According to some embodiments, the user is only required to approach the trunk to cause the trunk to automatically open. Thus, it is very convenient to automatically open the trunk with a relatively high success rate.
摘要翻译：提供了一种用于自动打开车辆行李箱的设备和方法。该装置可以包括：测距装置，其被配置为当接收到从手持设备周期性发送的第一信号时测量手持设备与车辆之间的距离，并且当所测量的距离满足预定的距离时发送指示打开干线的第二信号条件; 以及控制装置，被配置为当从所述测距装置接收到所述第二信号时，控制是否打开所述中继线。根据一些实施例，用户仅需要靠近中继线使得中继线自动打开。因此，以相对较高的成功率自动打开行李箱非常方便。

4. 发明申请

WO2011133143A1 MULTI-PILLAR STRUCTURE FOR MOLECULAR ANALYSIS 审中-公开
标题翻译：用于分子分析的多支架结构
公开(公告)号：WO2011133143A1
公开(公告)日：2011-10-27
申请号：PCT/US2010/031790
申请日：2010-04-20
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , LI, Zhiyong , HU, Min , OU, Fung Suong , WU, Wei , WILLIAMS, R. Stanley
发明人： LI, Zhiyong , HU, Min , OU, Fung Suong , WU, Wei , WILLIAMS, R. Stanley
IPC分类号： G01N21/65 , G01N33/483 , B82B1/00 , G01J3/44
CPC分类号： G01N21/658
摘要： A multi-pillar structure for molecular analysis is provided. The structure comprises at least two nanopoles, each nanopole attached at one end to a substrate and freely movable along its length. The opposite ends of the at least two nanopoles are each capable of movement toward each other to trap at least one analyte molecule at their opposite ends. Each nanopole is coated with a metal coating. An array of such multi-pillar structures is also provided. A method for preparing the multi-pillar structure is further provided.
摘要翻译：提供了一种用于分子分析的多支柱结构。该结构包括至少两个纳米微粒，每个纳米孔一端连接到基底上，并可沿其长度自由移动。至少两个纳米球的相对端各自能够相互移动以在其相对端捕获至少一种分析物分子。每个纳米孔涂有金属涂层。还提供了这种多支柱结构的阵列。还提供了一种制备多支柱结构的方法。

5. 发明申请

WO2010104520A1 BROAD BAND STRUCTURES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY 审中-公开
标题翻译：表面增强拉曼光谱的宽带结构
公开(公告)号：WO2010104520A1
公开(公告)日：2010-09-16
申请号：PCT/US2009/037167
申请日：2009-03-13
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , LI, Zhiyong , HU, Min
发明人： LI, Zhiyong , HU, Min
IPC分类号： G01J3/44
CPC分类号： G01N21/554 , B82Y30/00 , G01N21/553 , G01N21/658
摘要： Broad band structures (10, 10', 10") for surface enhanced Raman spectroscopy are disclosed herein. Each embodiment of the structure (10, 10', 10") is made up of a metal layer, and a dielectric layer (16A, 16S, 16P) established on at least a portion of the metal layer. The dielectric layer (16A, 16S, 16P) has a controlled thickness that varies from at least one portion of the dielectric layer (16A, 16s, 16p) to at least another portion of the dielectric layer. Nanostructures are established on the dielectric layer (16A, 16S, 16P) at least at the portion and the other portion, the nanostructures thus being configured to exhibit variable plasmon resonances.
摘要翻译：本文公开了用于表面增强拉曼光谱的宽带结构（10,10'，10“）。结构（10,10'，10”）的每个实施例由金属层和电介质层（16A， 16S，16P）建立在金属层的至少一部分上。电介质层（16A，16S，16P）具有从电介质层（16A，16s，16p）的至少一部分至电介质层的至少另一部分变化的受控厚度。至少在部分和另一部分，在介电层（16A，16S，16P）上建立纳米结构，因此纳米结构被配置为展现可变的等离子体共振。

6. 发明申请

WO2012057701A1 TUBULAR FIBER MEMBRANE WITH NANOPOROUS SKIN 审中-公开
标题翻译：管状纤维膜与纳米皮肤
公开(公告)号：WO2012057701A1
公开(公告)日：2012-05-03
申请号：PCT/SG2010/000405
申请日：2010-10-25
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie, Y. , DENG, Rensheng , HU, Min , NI, Ming
发明人： YING, Jackie, Y. , DENG, Rensheng , HU, Min , NI, Ming
IPC分类号： B01D69/08 , A61M1/18 , A61F2/04 , B01D71/06
CPC分类号： B01D63/02 , A61M1/1621 , A61M1/1625 , A61M1/3689 , B01D63/06 , B01D67/0088 , B01D69/085 , B01D69/087 , B01D71/68 , B01D2313/44 , D01D5/06 , D01D5/247
摘要： A wet spinning process for forming a tubular fiber membrane is provided. The tubular fiber membrane has a nanoporous skin layer and a microporous lumen layer. The skin layer defines an outer surface of the fiber membrane and the lumen layer defines a lumen surface of the fiber membrane. The pores in the skin layer may have an average pore size of less than about 7 nm, and pores in the lumen layer may have an average pore size of from about 0.5 to about 3 μm. The fiber membranes may be used in artificial renal proximal tubules, artificial kidneys, bioreactors, or fiber cartridges.
摘要翻译：提供了一种用于形成管状纤维膜的湿式纺丝方法。管状纤维膜具有纳米孔表皮层和微孔腔层。表皮层限定纤维膜的外表面，内腔层限定纤维膜的内表面。表皮层中的孔可具有小于约7nm的平均孔径，并且管腔层中的孔可具有约0.5至约3μm的平均孔径。纤维膜可以用于人造肾近端小管，人造肾，生物反应器或纤维筒。

7. 发明申请

WO2009149259A3 PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES 审中-公开
公开(公告)号：WO2009149259A3
公开(公告)日：2009-12-10
申请号：PCT/US2009/046259
申请日：2009-06-04
申请人： BRISTOL-MYERS SQUIBB COMPANY , ALBANY MOLECULAR RESEARCH, INC. , LOBBEN, Paul , ZHAO, Rulin , WANG, Bei , CHEN, Bang-chi , LIU, Shuang , HU, Min , YANG, Yuh-Lin, Allen , ISHERWOOD, Matthew , AMIN, Rasidul , CUI, Wenge
发明人： LOBBEN, Paul , ZHAO, Rulin , WANG, Bei , CHEN, Bang-chi , LIU, Shuang , HU, Min , YANG, Yuh-Lin, Allen , ISHERWOOD, Matthew , AMIN, Rasidul , CUI, Wenge
IPC分类号： C07D401/04
摘要： Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form.

8. 发明申请

WO2009149258A2 CRYSTALLINE FORM OF 6-[(4S)-2-METHYL-4-(2-NAPHTHYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-7-YL]PYRIDAZIN-3-AMINE 审中-公开
标题翻译： 6 - [（4S）-2-甲基-4-（2-萘基）-1,2,3,4-四氢喹啉-7-YL]吡啶-3-胺的晶体形式
公开(公告)号：WO2009149258A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046256
申请日：2009-06-04
申请人： BRISTOL-MYERS SQUIBB COMPANY , ALBANY MOLECULAR RESEARCH, INC. , QIU, Jun , GAO, Qi , LIU, Shuang , HU, Min , YANG, Yuh-lin, Allen , ISHERWOOD, Matthew , AMIN, Rasidul
发明人： QIU, Jun , GAO, Qi , LIU, Shuang , HU, Min , YANG, Yuh-lin, Allen , ISHERWOOD, Matthew , AMIN, Rasidul
IPC分类号： C07D401/04 , A61K31/497 , A61P3/04
CPC分类号： C07F5/04 , C07C215/20 , C07C217/58 , C07C223/02 , C07D217/04 , C07D237/20 , C07D401/04 , C07D413/10 , C07F5/022 , C07F5/025
摘要： The present disclosure generally relates to a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form, as well of methods of using a crystalline form in the treatment of depression and other conditions and methods for obtaining such crystalline form.
摘要翻译：本公开内容通常涉及6 - [（4S）-2-甲基-4-（萘基）-1,2,3,4-四氢异喹啉-7-基]哒嗪-3-胺的结晶形式。本公开还通常涉及包含结晶形式的药物组合物，以及在治疗抑郁症和其它病症中使用结晶形式的方法以及获得这种结晶形式的方法。

9. 发明申请

WO2007041568A3 COMPOSITIONS AND METHOD FOR REGULATING UBIQUITIN-SPECIFIC PROCESSING PROTEASES 审中-公开
公开(公告)号：WO2007041568A3
公开(公告)日：2007-04-12
申请号：PCT/US2006/038601
申请日：2006-10-03
申请人： THE TRUSTEES OF THE UNIVERSITY OF PRINCETON , SHI, Yigong , HU, Min
发明人： SHI, Yigong , HU, Min
IPC分类号： C07K2/00 , C07K7/00 , C07K7/02
摘要： The disclosure contained herein provides compounds and methods for identification of compounds that agonize or antagonize the function of USP14, a member of the ubiquitin-specific processing protease (UBP) family. Over-expression or gain-of-function of UBP's contributes to a range of diseases such as cancer, thus inhibition of USP14 by antagonists may provide a strategy for therapeutic intervention. Loss-of-function or reduced expression of UBP's, or reduced expression of the proteasome, contributes to improper synaptic activity and neurodegenerative diseases, thus activation of USP14 by agonists may provide a strategy for therapeutic intervention.

10. 发明申请

WO2019213796A1 INDUCED REJUVENATED MESENCHYMAL STEM CELLS (irMSCs) AND USES THEREOF 审中-公开
公开(公告)号：WO2019213796A1
公开(公告)日：2019-11-14
申请号：PCT/CN2018/085752
申请日：2018-05-05
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HU, Min
发明人： HU, Min , SUN, Yi
IPC分类号： C12N5/07 , C12N5/071 , A61P19/00 , A61K35/36
摘要： Provided a method to produce induced rejuvenated mesenchymal stem cells(irMSCs) from a primary fibroblast. Also provided are pharmaceutical compositons comprising at least one irMSC, and methods to use irMSC for treating bone injury or promoting bone repair in a subject, or for eliciting cartilage regeneration.

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