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1. 发明申请

WO2009149259A3 PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES 审中-公开
公开(公告)号：WO2009149259A3
公开(公告)日：2009-12-10
申请号：PCT/US2009/046259
申请日：2009-06-04
申请人： BRISTOL-MYERS SQUIBB COMPANY , ALBANY MOLECULAR RESEARCH, INC. , LOBBEN, Paul , ZHAO, Rulin , WANG, Bei , CHEN, Bang-chi , LIU, Shuang , HU, Min , YANG, Yuh-Lin, Allen , ISHERWOOD, Matthew , AMIN, Rasidul , CUI, Wenge
发明人： LOBBEN, Paul , ZHAO, Rulin , WANG, Bei , CHEN, Bang-chi , LIU, Shuang , HU, Min , YANG, Yuh-Lin, Allen , ISHERWOOD, Matthew , AMIN, Rasidul , CUI, Wenge
IPC分类号： C07D401/04
摘要： Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form.

2. 发明申请

WO2005076990A2 PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-CARBOXAMIDES USEFUL AS KINASE INHIBITORS 审中-公开
标题翻译：制备用作激酶抑制剂的2-氨基噻唑-5-羧酰胺的方法
公开(公告)号：WO2005076990A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/003807
申请日：2005-02-04
申请人： BRISTOL-MYERS SQUIBB COMPANY , CHEN, Bang-Chi , ZHAO, Rulin , WANG, Bei
发明人： CHEN, Bang-Chi , ZHAO, Rulin , WANG, Bei
IPC分类号： C07D277/56 , C07D417/12
CPC分类号： C07D277/56 , C07D417/12
摘要： The invention is directed to processes for preparing 2-aminothiazole-5-carboxamides of formula (I), wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined as set forth in the specification herein.
摘要翻译：本发明涉及制备式（I）的2-氨基噻唑-5-甲酰胺的方法，其中R 1，R 2， R 3，R 4和R 5的定义如本文说明书中所述。

3. 发明申请

WO2006135425A2 PREPARATION OF 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRID-2-ONES 审中-公开
标题翻译： 4,5-二羟基 - 吡唑并[3,4-C]吡啶-2-酮的制备
公开(公告)号：WO2006135425A2
公开(公告)日：2006-12-21
申请号：PCT/US2005/034551
申请日：2005-09-27
申请人： BRISTOL-MYERS SQUIBB COMPANY , ZHAO, Rulin , CHEN, Bang-Chi , WANG, Bei , ZHANG, Huiping
发明人： ZHAO, Rulin , CHEN, Bang-Chi , WANG, Bei , ZHANG, Huiping
CPC分类号： C07D487/04 , C07D471/04
摘要： A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4 c]pyrid-2-ones of the type shown below, as well as the corresponding pyrazoles, from appropriate phenyl hydrazines is described. O (R2b) 0-2 R1 I I 1 1-a X 2 N N-, R a' IV These compounds can be useful as factor Xa inhibitors.
摘要翻译：描述了用于制备下列所示类型的4,5-二氢 - 吡唑并[3,4-C]吡啶-2-酮的新方法及其中间体，以及相应的吡唑。 O（R2b）0-2 R1 II 1 1-a X 2 N N - ， - - - SIPO - >这些化合物可用作因子Xa抑制剂。

4. 发明申请

WO2006036926A3 EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRID-2-ONES 审中-公开
公开(公告)号：WO2006036926A3
公开(公告)日：2006-04-06
申请号：PCT/US2005/034511
申请日：2005-09-27
申请人： BRISTOL-MYERS SQUIBB COMPANY , MUDRYK, Boguslaw, M. , CUNIERE, Nicolas , HSIEH, Dau-Ming , ROSSANO, Lucius , LIANG, Jing , CHEN, Bang-Chi , ZHANG, Huiping , ZHAO, Rulin , WANG, Bei , DAVID, Adrian
发明人： MUDRYK, Boguslaw, M. , CUNIERE, Nicolas , HSIEH, Dau-Ming , ROSSANO, Lucius , LIANG, Jing , CHEN, Bang-Chi , ZHANG, Huiping , ZHAO, Rulin , WANG, Bei , DAVID, Adrian
IPC分类号： C07D471/04 , A61K31/437 , A61P7/02
摘要： A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. Formula (I). These compounds can be useful as factor Xa inhibitors.

5. 发明申请

WO2006036926A2 EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRID-2-ONES 审中-公开
标题翻译： 4,5-二羟基 - 吡唑并[3,4-C]吡啶-2-酮的有效合成
公开(公告)号：WO2006036926A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/034511
申请日：2005-09-27
申请人： BRISTOL-MYERS SQUIBB COMPANY , MUDRYK, Boguslaw, M. , CUNIERE, Nicolas , HSIEH, Dau-Ming , ROSSANO, Lucius , LIANG, Jing , CHEN, Bang-Chi , ZHANG, Huiping , ZHAO, Rulin , WANG, Bei , DAVID, Adrian
发明人： MUDRYK, Boguslaw, M. , CUNIERE, Nicolas , HSIEH, Dau-Ming , ROSSANO, Lucius , LIANG, Jing , CHEN, Bang-Chi , ZHANG, Huiping , ZHAO, Rulin , WANG, Bei , DAVID, Adrian
CPC分类号： C07D471/04
摘要： A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. Formula (I). These compounds can be useful as factor Xa inhibitors.
摘要翻译：描述了由合适的苯肼制备下列所示类型的4,5-二氢 - 吡唑并[3,4-c]吡啶-2-酮的新方法及其中间体。式（I）。这些化合物可用作因子Xa抑制剂。

6. 发明申请

WO2018017910A1 GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME 审中-公开
标题翻译：葡糖激酶活化剂及其使用方法
公开(公告)号：WO2018017910A1
公开(公告)日：2018-01-25
申请号：PCT/US2017/043199
申请日：2017-07-21
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： CHENG, Peter T. W. , MENG, Wei , LIU, Mark , WANG, Bei , ZHAO, Rulin
IPC分类号： C07F9/40 , A61K31/675 , A61P3/00
摘要： A compound, enantiomer, prodrug, diastereomer, or salt is provided which is an activator of the enzyme glucokinase and thus is believed to be useful in treating diabetes and related diseases, which compound has the structure (I). A method for treating diabetes and related disease employing the compound, enantiomer, prodrug, diastereomer, or salt is also provided.
摘要翻译：提供了一种化合物，对映体，前药，非对映体或盐，它是酶葡糖激酶的活化剂，因此被认为可用于治疗糖尿病和相关疾病，该化合物具有结构（I）。还提供了使用该化合物，对映异构体，前药，非对映异构体或盐治疗糖尿病和相关疾病的方法。

7. 发明申请

WO2021207433A2 EPITOPES OF SARS-COV-2 NEUTRALIZING ANTIBODIES 审中-公开
公开(公告)号：WO2021207433A2
公开(公告)日：2021-10-14
申请号：PCT/US2021/026286
申请日：2021-04-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , CHENG, Yifan , ASARNOW, Daniel , CRAIK, Charles , MANGLIK, Aashish , BOHN, Markus , WANG, Cheng-I , HU, Yuanyu , WANG, Bei
发明人： CHENG, Yifan , ASARNOW, Daniel , CRAIK, Charles , MANGLIK, Aashish , BOHN, Markus , WANG, Cheng-I , HU, Yuanyu , WANG, Bei
IPC分类号： C07K16/10 , C07K16/08 , A61P31/12 , A61K39/215 , A61P31/14 , C07K2317/21 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N33/53
摘要： The invention provides novel anti-SARS-CoV-2-Spike antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions.

8. 发明申请

WO2010122489A1 DISPLAYING VIDEO SEQUENCES 审中-公开
标题翻译：显示视频序列
公开(公告)号：WO2010122489A1
公开(公告)日：2010-10-28
申请号：PCT/IB2010/051717
申请日：2010-04-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZHANG, Huanhuan , CHEN, Xin , LIU, Yunqiang , WANG, Bei , TAN, Jingwei , SHI, Jun
发明人： ZHANG, Huanhuan , CHEN, Xin , LIU, Yunqiang , WANG, Bei , TAN, Jingwei , SHI, Jun
IPC分类号： H04N5/45
CPC分类号： H04N5/45 , H04N21/4316 , H04N21/44008 , H04N21/812
摘要： The present invention aims to provide a method, a system and an apparatus for displaying a first video sequence together with a second video sequence. A second video sequence is displayed on the device ( 110 ), a first unit (101) detects the start of an event within the second video sequence, the device (110) displays the first video sequence together with the second video sequence when the start of the event has been detected. By applying the method, the first video sequence having various content can be easily provided to people during the display of the second video sequence, so that people can enjoy two video sequences at the same time.
摘要翻译：本发明旨在提供一种用于与第二视频序列一起显示第一视频序列的方法，系统和装置。在设备（110）上显示第二视频序列，第一单元（101）检测第二视频序列内的事件的开始，当开始时，设备（110）与第二视频序列一起显示第一视频序列的事件已被检测到。通过应用该方法，可以在第二视频序列的显示期间容易地向人们提供具有各种内容的第一视频序列，使得人们可以同时欣赏两个视频序列。

9. 发明申请

WO2006070298A1 METHOD AND APPARATUS FOR ENABLING AN APPLICATION TO COOPERATE WITH RUNNING OFA PROGRAM 审中-公开
标题翻译：方法和设备，用于实现与运行程序的合作
公开(公告)号：WO2006070298A1
公开(公告)日：2006-07-06
申请号：PCT/IB2005/054252
申请日：2005-12-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HE, Dahua , LI, Mo , WANG, Jin , PENG, Yang , WANG, Bei
发明人： HE, Dahua , LI, Mo , WANG, Jin , PENG, Yang , WANG, Bei
IPC分类号： G11B27/00
CPC分类号： G11B27/329 , G11B27/105 , G11B2220/213 , G11B2220/2541 , H04N21/8545
摘要： The present invention provides a method and apparatus for enabling an application to cooperate with the running of a program. According to the invention, the playing control information of a program and the linking information of an application corresponding to the program are edited into a program playing control file. Through executing said playing control file, guided by the linking information and based on the running control information of the application, the application can download, run or stop to run cooperating with the playing of the optical disc program. The Solution of combining an application and a program into a playing control file will effectively cause the downloading and running of the application to cooperate with the playing of the program so as to ensure normal realization of corresponding functions.
摘要翻译：本发明提供了一种使应用程序能够与程序的运行相配合的方法和装置。根据本发明，将程序的播放控制信息和与该程序相对应的应用的链接信息编辑为程序播放控制文件。通过执行所述播放控制文件，由链接信息指导并且基于应用程序的运行控制信息，应用程序可以下载，运行或停止以与光盘程序的播放协同运行。将应用程序和程序组合到播放控制文件中的解决方案将有效地使应用程序的下载和运行与程序的播放配合，以确保相应功能的正常实现。

10. 发明申请

WO2005045842A1 PLAY BACK SYSTEM AND ITS PLAY BACK METHOD 审中-公开
标题翻译：回放系统及其回放方法
公开(公告)号：WO2005045842A1
公开(公告)日：2005-05-19
申请号：PCT/IB2004/052301
申请日：2004-11-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WANG, Bei , KELLY, Declan
发明人： WANG, Bei , KELLY, Declan
IPC分类号： G11B27/10
CPC分类号： G11B27/105 , G11B19/02 , G11B27/329 , G11B2220/2562
摘要： An optical disc playing system , comprises a selecting apparatus for receiving a command from a user, which requires to play a part of content of a program in the optical disc; a sending apparatus for sending a request which requires to provide the related information of said part of content; a receiving apparatus for receiving the related information; and a reading-out apparatus for reading out the received related information and said part of content. An optical disc playing method using said system comprises the steps of: receiving a command from a user, which requires to play a part of content of a program in the optical disc; sending a request which requires to provide the related information of said part of content; receiving the related information; and playing the disc in coordination with said part of content using the received related information.
摘要翻译：一种光盘播放系统，包括：用于从用户接收命令的选择装置，其需要播放光盘中节目内容的一部分; 发送装置，用于发送需要提供所述部分内容的相关信息的请求; 用于接收相关信息的接收装置; 以及用于读出所接收的相关信息和所述内容的一部分的读出装置。使用所述系统的光盘播放方法包括以下步骤：从用户接收需要播放光盘中节目内容的一部分的命令; 发送要求提供所述部分内容的相关信息的请求; 收到相关信息; 以及使用所接收的相关信息与所述部分内容一起播放光盘。

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