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1. 发明申请

WO2006058185A2 DEVICE AND METHOD FOR ELECTROPORATION-BASED DELIVERY OF MOECULES INTO CELLS AND DYNAMIC MONITORING OF CELL RESPONSES 审中-公开
标题翻译：用于基于电导输送到细胞中的装置和方法以及细胞响应的动态监测
公开(公告)号：WO2006058185A2
公开(公告)日：2006-06-01
申请号：PCT/US2005/042684
申请日：2005-11-23
申请人： ABASSI, Yama A. , WANG, Xiaobo , ATIENZA, Josephine , XU, Xiao , XU, Junquan
发明人： ABASSI, Yama A. , WANG, Xiaobo , ATIENZA, Josephine , XU, Xiao , XU, Junquan
IPC分类号： G11C11/00
CPC分类号： G01N33/5008 , C12M35/02 , C12N15/87 , G01N15/12 , G01N33/48728
摘要： The present invention includes devices and methods for transfecting a cell or cell population and dynamic monitoring of cellular events. A variety of microelectronic devices are provide that incorporate functions such as electroporation, modulation of a transmembrane potential and dynamic monitoring of cellular functions and mechanisms.
摘要翻译：本发明包括用于转染细胞或细胞群的装置和方法以及细胞事件的动态监测。提供了多种微电子器件，其包括诸如电穿孔，跨膜电位的调节和细胞功能和机制的动态监测的功能。

2. 发明申请

WO2006036952A2 DYNAMIC MONITORING OF CELL ADHESION AND SPREADING USING THE RT-CES SYSTEM 审中-公开
标题翻译：细胞粘附的动态监测和使用RT-CES系统的扩散
公开(公告)号：WO2006036952A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/034561
申请日：2005-09-27
申请人： ABASSI, Yama, A. , ATIENZA, Josephine , XU, Xiao , WANG, Xiaobo
发明人： ABASSI, Yama, A. , ATIENZA, Josephine , XU, Xiao , WANG, Xiaobo
IPC分类号： G11C11/00 , C12M1/34 , H01M4/50
CPC分类号： G01N29/036 , G01N2291/0257
摘要： The present invention includes devices and methods for dynamically monitoring cell adhesion and cell spreading. Cells are added to a microelectronic cell sensor array operably connected to an impedance analyzer. The device also includes a coating including biological molecule or organic compound capable of interacting with the cell. Cell adhesion and cell mobility is determined by detecting changes in impedance and comparing impedance or cell index values between samples.
摘要翻译：本发明包括用于动态监测细胞粘附和细胞扩散的装置和方法。将细胞添加到可操作地连接到阻抗分析器的微电子单元传感器阵列。该装置还包括包含能够与细胞相互作用的生物分子或有机化合物的涂层。通过检测阻抗变化并比较样品之间的阻抗或细胞指数值来确定细胞粘附和细胞迁移率。

3. 发明申请

WO2006017762A2 DYNAMIC MONITORING OF ACTIVATION OF G-PROTEIN (GPCR) AND RECEPTOR TYROSINE KINASE (RTK) IN LIVING CELLS USING REAL-TIME MICROELECTRONIC CELL SENSING TECHNOLOGY 审中-公开
标题翻译：使用实时微电子细胞感测技术动态监测生活细胞中G蛋白（GPCR）和受体酪氨酸激酶（RTK）的活性
公开(公告)号：WO2006017762A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/027943
申请日：2005-08-04
申请人： ABASSI, Yama, A. , YU, Naichen , ATIENZA, Josephine , XU, Xiao , WANG, Xiaobo
发明人： ABASSI, Yama, A. , YU, Naichen , ATIENZA, Josephine , XU, Xiao , WANG, Xiaobo
IPC分类号： C12M1/34 , H01M4/50
CPC分类号： G01N33/4836
摘要： The present application includes systems and methods for identifying a compound capable of interacting with a G-Protein Coupled Receptor (GPCR) or Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance operably connected to an impedance analyzer, adding test cells expressing a GPCR or a RTK to wells of the device, monitoring the impedances of the wells before and after adding a compound of interest, determining the change in the impedance or cell index of a well, comparing the change in impedance or cell index between the compound and the control, and identifying the compound interacts with the GPCR or RTK if the comparison demonstrates a significant difference between the change in impedance or cell index.
摘要翻译：本申请包括用于鉴定能够与G-蛋白偶联受体（GPCR）或受体酪氨酸激酶（RTK）相互作用的化合物的系统和方法，包括提供能够测量可操作地连接到阻抗分析仪的细胞 - 基底阻抗的装置，测试细胞表达GPCR或RTK到设备的孔中，监测在添加感兴趣的化合物之前和之后孔的阻抗，确定孔的阻抗或细胞指数的变化，比较阻抗或细胞指数的变化在化合物和对照之间，并且如果比较显示阻抗或细胞指数的变化之间的显着差异，则鉴定化合物与GPCR或RTK相互作用。

4. 发明申请

WO2010129725A1 SYSTEM AND METHOD FOR MONITORING CARDIOMYOCYTE BEATING, VIABILITY AND MORPHOLOGY AND FOR SCREENING FOR PHARMACOLOGICAL AGENTS WHICH MAY INDUCE CARDIOTOXICITY OR MODULATE CARDIOMYOCYTE FUNCTION 审中-公开
标题翻译：用于监测心脏病发作，病变和形态学以及可能引起心脏病毒或调节心肌细胞功能的药物代谢筛选的系统和方法
公开(公告)号：WO2010129725A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/033801
申请日：2010-05-05
申请人： ACEA BIOSCIENCES, INC. , WANG, Xiaobo , OUYANG, Wei , LI, Nan , XI, Biao , ABASSI, Yama A. , XU, Xiao
发明人： WANG, Xiaobo , OUYANG, Wei , LI, Nan , XI, Biao , ABASSI, Yama A. , XU, Xiao
IPC分类号： C12M1/34
CPC分类号： G01N33/48728
摘要： Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.
摘要翻译：提供了用于进行细胞的细胞外记录的装置和方法，例如可兴奋细胞，心肌细胞和心肌细胞前体细胞。示例性装置包括形成或提供为一个或多个孔的基底的非导电基底; 记录电极，其位于所述阱内的所述衬底上，其中当将细胞样品添加到所述装置时，所述记录电极可接近细胞; 以及位于无细胞区域内的阱内的参比电极，当将细胞样品添加到器件时，无细胞区域表征为不与细胞接触，从而防止细胞与参比电极之间的接触。

5. 发明申请

WO2008036375A2 USE OF IMPEDANCE-BASED CYTOLOGICAL PROFILING TO CLASSIFY CELLULAR RESPONSE PROFILES UPON EXPOSURE TO BIOLOGICALLY ACTIVE AGENTS 审中-公开
标题翻译：基于阻抗的细胞学分型技术在接触生物活性剂时对细胞反应特征进行分类
公开(公告)号：WO2008036375A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/020418
申请日：2007-09-20
申请人： ACEA BIOSCIENCES CORPORATION , WANG, Xiaobo , ABASSI, Yama, A. , ZHANG, Wenfu , XU, Xiao
发明人： WANG, Xiaobo , ABASSI, Yama, A. , ZHANG, Wenfu , XU, Xiao
IPC分类号： G06F19/00
CPC分类号： G01N33/54373 , G01N33/5005 , G01N33/5438 , G06F19/24
摘要： The present invention provides methods of multi-dimensional profiling of biologically active agents and determining their effects on biological systems. The methods of the present invention include real-time impedance monitoring of cellular responses to biologically active agents and categorization of cellular kinetic profiles into mechanism specific cellular response profile groups. The grouping of similar cellular response profiles allows the correlation between agent and mechanism, thus allowing for the identification of potential therapeutic applications of agents or further study of cellular responses or mechanisms.
摘要翻译：本发明提供了多维分析生物活性剂并确定其对生物系统的影响的方法。本发明的方法包括对生物活性剂的细胞响应的实时阻抗监测以及将细胞动力学曲线分类成机制特异性细胞响应曲线组。类似的细胞反应谱的分组允许药剂和机制之间的相关性，从而允许鉴定药剂的潜在治疗应用或进一步研究细胞应答或机制。

6. 发明申请

WO2011146531A9 DATA ANALYSIS OF IMPEDANCE-BASED CARDIOMYOCYTE-BEATING SIGNALS AS DETECTED ON REAL-TIME CELL ANALYSIS (RTCA) CARDIO INSTRUMENTS 审中-公开
公开(公告)号：WO2011146531A9
公开(公告)日：2011-11-24
申请号：PCT/US2011/036877
申请日：2011-05-17
申请人： ACEA BIOSCIENCES, INC , LI, Nan , WANG, Xiaobo , ABASSI, Yama, A. , XI, Biao , ZHANG, Wen, Fu , XU, Xiao
发明人： LI, Nan , WANG, Xiaobo , ABASSI, Yama, A. , XI, Biao , ZHANG, Wen, Fu , XU, Xiao
IPC分类号： C12Q1/02
摘要： A method of determining one or more beating parameters for use in cardiomyocyte beating analysis including: providing a cell analysis device including wells, each well including a sensor capable of monitoring beating of cardiomyoctes in millisecond time resolution; adding cardiomyocytes to the wells; monitoring the beating of the cardiomyocytes in millisecond time resolution to obtain a plurality of beating measurements; and calculating one or more beating parameters from the plurality of beating measurements.

7. 发明申请

WO2011146531A1 DATA ANALYSIS OF IMPEDANCE-BASED CARDIOMYOCYTE-BEATING SIGNALS AS DETECTED ON REAL-TIME CELL ANALYSIS (RTCA) CARDIO INSTRUMENTS 审中-公开
标题翻译：基于实时细胞分析（RTCA）心脏仪器检测的基于阻抗的心脏纤维化信号的数据分析
公开(公告)号：WO2011146531A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/036877
申请日：2011-05-17
申请人： ACEA BIOSCIENCES, INC , LI, Nan , WANG, Xiaobo , ABASSI, Yama, A. , XI, Biao , ZHANG, Wen, Fu , XU, Xiao
发明人： LI, Nan , WANG, Xiaobo , ABASSI, Yama, A. , XI, Biao , ZHANG, Wen, Fu , XU, Xiao
IPC分类号： C12Q1/02
CPC分类号： G01N33/48728 , G01N33/4836 , G01N33/5008 , G01N33/5014 , G01N33/5061 , G01N33/5073 , G01N2800/326 , G01N2800/52
摘要： A method of determining one or more beating parameters for use in cardiomyocyte beating analysis including: providing a cell analysis device including wells, each well including a sensor capable of monitoring beating of cardiomyoctes in millisecond time resolution; adding cardiomyocytes to the wells; monitoring the beating of the cardiomyocytes in millisecond time resolution to obtain a plurality of beating measurements; and calculating one or more beating parameters from the plurality of beating measurements.
摘要翻译：一种确定用于心肌细胞搏动分析的一个或多个跳动参数的方法，包括：提供包括孔的细胞分析装置，每个孔包括能以毫秒时间分辨率监测心脏跳动的传感器; 向心脏中加入心肌细胞; 以毫秒时间分辨率监测心肌细胞的搏动以获得多次打浆测量; 以及从所述多次跳动测量中计算一个或多个跳动参数。

8. 发明申请

WO2004010102A2 IMPEDANCE BASED APPARATUSES AND METHODS FOR ANALYZING CELLS AND PARTICLES 审中-公开
标题翻译：基于阻抗的设备和方法分析细胞和粒子
公开(公告)号：WO2004010102A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/022537
申请日：2003-07-18
申请人： ACEA BIOSCIENCES, INC. , WANG, Xiaobo , XU, Xiao
发明人： WANG, Xiaobo , XU, Xiao
IPC分类号： G01N
CPC分类号： G01N33/5005 , G01N15/12 , G01N33/54366 , G01N33/5438
摘要： A device for monitoring the migration or invasion of a biological particle such as a cell is disclosed. The device includes an upper chamber adapted to receive and retain a cell sample, a lower chamber having at least two electrodes, and a biocompatible porous membrane having a porosity sufficient to allow cells to migrate therethrough. The membrane is disposed in the device so as to separate the upper and lower chambers from one another. Migration of cells through the porous membrane permits contact between the migrating cells and one or more electrodes of the lower chamber. The contact provides a detectable change in impedance between or among the electrodes.
摘要翻译：公开了一种用于监测诸如细胞的生物颗粒的迁移或侵入的装置。该装置包括适于接收和保留细胞样品的上腔室，具有至少两个电极的下腔室，以及具有足以允许细胞通过其移动的孔隙度的生物相容性多孔膜。膜设置在装置中以便将上腔室和下腔室彼此分开。细胞通过多孔膜的迁移允许迁移细胞与下室的一个或多个电极之间的接触。接触在电极之间或之间提供可检测的阻抗变化。

9. 发明申请

WO2012097196A1 PYRAZOLOPYRIMIDINE DERIVATIVES AND USES AS ANTICANCER AGENTS 审中-公开
标题翻译：吡唑并嘧啶衍生物和作为抗原剂的用途
公开(公告)号：WO2012097196A1
公开(公告)日：2012-07-19
申请号：PCT/US2012/021144
申请日：2012-01-12
申请人： ACEA BIOSCIENCES INC. , MAO, Long , ZHAO, Li , LIU, Jia , WANG, Xiaobo , XU, Xiao
发明人： MAO, Long , ZHAO, Li , LIU, Jia , WANG, Xiaobo , XU, Xiao
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： Novel compounds having a fused pyrazolopyrimidine derivatives and related fused ring systems are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Pharmaceutical compositions, and methods of using these compounds and compositions to treat cancer and other diseases related to the dysregulation of kinase (such as Aurora A, Aurora B, Aurora C, cMet, JAK2, ROS1, but not limited to) pathways are disclosed. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.
摘要翻译：公开了具有稠合吡唑并嘧啶衍生物和相关稠环体系的新型化合物。这些化合物抑制多种类型的癌细胞的生长，因此可用于治疗癌症。公开了药物组合物和使用这些化合物和组合物治疗与激酶失调相关的癌症和其它疾病（如Aurora A，Aurora B，Aurora C，cMet，JAK2，ROS1但不限于）途径的方法。通过用于监测细胞生长/迁移的系统来证明这些化合物的功效，这表明它们是癌细胞的生长和/或迁移的有效抑制剂。公开了包含这些化合物的组合物，以及使用这些化合物和用于治疗癌症的组合物的方法。

10. 发明申请

WO2006015387A2 METHOD FOR ASSAYING FOR NATURAL KILLER, CYTOTOXIC T- LYMPHOCYTE AND NEUTROPHIL-MEDIATED KILLING OF TARGET CELLS USING REAL-TIME MICROELECTRONIC CELL SENSING TECHNOLOGY 审中-公开
标题翻译：使用实时微电解细胞感测技术测定天然杀伤剂，CYTOTOXIC T淋巴细胞和靶向细胞的中性粒细胞杀伤的方法
公开(公告)号：WO2006015387A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/027891
申请日：2005-08-04
申请人： XU, Xiao , ABASSI, Yama , WANG, Xiaobo
发明人： XU, Xiao , ABASSI, Yama , WANG, Xiaobo
IPC分类号： C12M1/34 , H01M4/50
CPC分类号： G01N33/4836
摘要： The present invention includes a method of measuring cytolytic activity including providing a device capable of monitoring cell-substrate impedance operably connected to an impedance analyzer, adding target cells to at least one well of the device, adding effector cells to the at least one well, monitoring impedance of the at least one well and optionally determining a cell index from the impedance, wherein monitoring impedance includes measuring impedance during at least one time point before and at least one time point after adding effector cells, and determining viability of said target cells after adding effector cells by comparing the impedance or optionally the cell index at the at least one time point after adding effector cells to the impedance or optionally the cell index at the at least one time point before adding effector cells.
摘要翻译：本发明包括测量细胞溶解活性的方法，包括提供能够监测可操作地连接到阻抗分析仪的细胞 - 基底阻抗的装置，将靶细胞添加到装置的至少一个孔中，将效应细胞添加到至少一个孔，监测所述至少一个井的阻抗并且可选地从所述阻抗确定细胞指数，其中监测阻抗包括在加入效应细胞之前和至少一个时间点之前的至少一个时间点之前测量阻抗，以及在确定所述靶细胞之后的存活力通过在添加效应细胞之前在至少一个时间点将效应细胞添加到阻抗或任选地在至少一个时间点的细胞指数之后，比较阻抗或任选地在至少一个时间点处的细胞指数来添加效应细胞。

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