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1. 发明申请

WO2010129725A1 SYSTEM AND METHOD FOR MONITORING CARDIOMYOCYTE BEATING, VIABILITY AND MORPHOLOGY AND FOR SCREENING FOR PHARMACOLOGICAL AGENTS WHICH MAY INDUCE CARDIOTOXICITY OR MODULATE CARDIOMYOCYTE FUNCTION 审中-公开
标题翻译：用于监测心脏病发作，病变和形态学以及可能引起心脏病毒或调节心肌细胞功能的药物代谢筛选的系统和方法
公开(公告)号：WO2010129725A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/033801
申请日：2010-05-05
申请人： ACEA BIOSCIENCES, INC. , WANG, Xiaobo , OUYANG, Wei , LI, Nan , XI, Biao , ABASSI, Yama A. , XU, Xiao
发明人： WANG, Xiaobo , OUYANG, Wei , LI, Nan , XI, Biao , ABASSI, Yama A. , XU, Xiao
IPC分类号： C12M1/34
CPC分类号： G01N33/48728
摘要： Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.
摘要翻译：提供了用于进行细胞的细胞外记录的装置和方法，例如可兴奋细胞，心肌细胞和心肌细胞前体细胞。示例性装置包括形成或提供为一个或多个孔的基底的非导电基底; 记录电极，其位于所述阱内的所述衬底上，其中当将细胞样品添加到所述装置时，所述记录电极可接近细胞; 以及位于无细胞区域内的阱内的参比电极，当将细胞样品添加到器件时，无细胞区域表征为不与细胞接触，从而防止细胞与参比电极之间的接触。

2. 发明申请

WO2011146531A1 DATA ANALYSIS OF IMPEDANCE-BASED CARDIOMYOCYTE-BEATING SIGNALS AS DETECTED ON REAL-TIME CELL ANALYSIS (RTCA) CARDIO INSTRUMENTS 审中-公开
标题翻译：基于实时细胞分析（RTCA）心脏仪器检测的基于阻抗的心脏纤维化信号的数据分析
公开(公告)号：WO2011146531A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/036877
申请日：2011-05-17
申请人： ACEA BIOSCIENCES, INC , LI, Nan , WANG, Xiaobo , ABASSI, Yama, A. , XI, Biao , ZHANG, Wen, Fu , XU, Xiao
发明人： LI, Nan , WANG, Xiaobo , ABASSI, Yama, A. , XI, Biao , ZHANG, Wen, Fu , XU, Xiao
IPC分类号： C12Q1/02
CPC分类号： G01N33/48728 , G01N33/4836 , G01N33/5008 , G01N33/5014 , G01N33/5061 , G01N33/5073 , G01N2800/326 , G01N2800/52
摘要： A method of determining one or more beating parameters for use in cardiomyocyte beating analysis including: providing a cell analysis device including wells, each well including a sensor capable of monitoring beating of cardiomyoctes in millisecond time resolution; adding cardiomyocytes to the wells; monitoring the beating of the cardiomyocytes in millisecond time resolution to obtain a plurality of beating measurements; and calculating one or more beating parameters from the plurality of beating measurements.
摘要翻译：一种确定用于心肌细胞搏动分析的一个或多个跳动参数的方法，包括：提供包括孔的细胞分析装置，每个孔包括能以毫秒时间分辨率监测心脏跳动的传感器; 向心脏中加入心肌细胞; 以毫秒时间分辨率监测心肌细胞的搏动以获得多次打浆测量; 以及从所述多次跳动测量中计算一个或多个跳动参数。

3. 发明申请

WO2011146531A9 DATA ANALYSIS OF IMPEDANCE-BASED CARDIOMYOCYTE-BEATING SIGNALS AS DETECTED ON REAL-TIME CELL ANALYSIS (RTCA) CARDIO INSTRUMENTS 审中-公开
公开(公告)号：WO2011146531A9
公开(公告)日：2011-11-24
申请号：PCT/US2011/036877
申请日：2011-05-17
申请人： ACEA BIOSCIENCES, INC , LI, Nan , WANG, Xiaobo , ABASSI, Yama, A. , XI, Biao , ZHANG, Wen, Fu , XU, Xiao
发明人： LI, Nan , WANG, Xiaobo , ABASSI, Yama, A. , XI, Biao , ZHANG, Wen, Fu , XU, Xiao
IPC分类号： C12Q1/02
摘要： A method of determining one or more beating parameters for use in cardiomyocyte beating analysis including: providing a cell analysis device including wells, each well including a sensor capable of monitoring beating of cardiomyoctes in millisecond time resolution; adding cardiomyocytes to the wells; monitoring the beating of the cardiomyocytes in millisecond time resolution to obtain a plurality of beating measurements; and calculating one or more beating parameters from the plurality of beating measurements.

4. 发明申请

WO2013066645A1 DEVICE FOR SPLITTING LIGHT INTO COMPONENTS HAVING DIFFERENT WAVELENGTH RANGES AND METHODS OF USE 审中-公开
标题翻译：将光分解成具有不同波长范围的组件的设备和使用方法
公开(公告)号：WO2013066645A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/061171
申请日：2012-10-19
申请人： ACEA BIOSCIENCES, INC. , LI, Nan , CHEN, Ye , WANG, Xiaobo
发明人： LI, Nan , CHEN, Ye , WANG, Xiaobo
IPC分类号： G02B27/10
CPC分类号： G02B27/1006 , G01J3/14 , G01J3/36 , G01J3/443 , G02B5/04 , G02B5/285 , G02B27/141 , G02B27/142
摘要： A prism including a substrate faceted to provide a plurality of flat surfaces, wherein at least two of the plurality of surfaces, each including a filter coating, form at least two filter surfaces, wherein each filter surface selectively permits passage of a predetermined wavelength and reflects remaining wavelengths along an optical path towards another of the plurality of surfaces, optionally another filter surface, wherein an angle of incidence of each of the plurality of surfaces along the optical path is equal or nearly equal. An apparatus incorporating the prism and its use for splitting a light spectrum into a plurality of wavelengths or wavelength ranges.
摘要翻译：一种棱镜，包括面以提供多个平坦表面的基板，其中，所述多个表面中的至少两个表面，每个包括过滤器涂层，形成至少两个过滤器表面，其中每个过滤器表面选择性地允许预定波长的通过并反射沿着光路的剩余波长朝向多个表面中的另一个，可选地另外的滤光器表面，其中沿着光路的多个表面中的每一个的入射角相等或接近相等。一种结合棱镜的装置及其用于将光谱分解成多个波长或波长范围的用途。

5. 发明申请

WO2013081651A1 CO-CULTURE DEVICE ASSEMBLY 审中-公开
标题翻译：文化设备组合
公开(公告)号：WO2013081651A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/023513
申请日：2012-02-01
申请人： ACEA BIOSCIENCES INC. , ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , THOMAS, Donald , LI, Wei , KE, Ning , LI, Nan , PAPAS, Adrian , WATZELE, Manfred , SEILER, Alexander , WANG, Tianxing , ABASSI, Yama , WANG, Xiaobo
发明人： THOMAS, Donald , LI, Wei , KE, Ning , LI, Nan , PAPAS, Adrian , WATZELE, Manfred , SEILER, Alexander , WANG, Tianxing , ABASSI, Yama , WANG, Xiaobo
IPC分类号： C12Q1/00
CPC分类号： C12M25/04 , C12Q1/02 , G01N21/253 , G01N21/6452 , G01N33/48735 , G01N33/54373
摘要： An insert device and co-culture device assembly incorporating the insert device, which includes an insert chamber with two fluid impermeable side walls that extend from a microporous bottom to an open top to form an inner cavity. The first side wall is shaped to form a convex arc that follows between about half of a circumference of the well and less than an entire circumference of the well. The second side wall joins ends of the first side wall and protrudes inward towards a center of the convex arc. A notched flange extends outward from or beneath the top and partially surrounds the perimeter of the insert chamber.
摘要翻译：包括插入装置的插入装置和共培养装置组件，其包括具有从微孔底部延伸到开口顶部以形成内腔的两个流体不可渗透侧壁的插入室。第一侧壁成形为形成沿着井的圆周的大约一半且小于井的整个圆周的凸弧。第二侧壁连接第一侧壁的端部并朝向凸弧的中心向内突出。凹口凸缘从顶部向下或从顶部向外延伸并且部分地围绕插入室的周边。

6. 发明申请

WO2013059835A1 SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL 审中-公开
标题翻译：用于检测流动通道中的多激发诱导光的系统和方法
公开(公告)号：WO2013059835A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/061399
申请日：2012-10-22
申请人： ACEA BIOSCIENCES, INC. , LI, Nan , WU, Jian , CHEN, Ye , WANG, Tianxing , WANG, Xiaobo
发明人： LI, Nan , WU, Jian , CHEN, Ye , WANG, Tianxing , WANG, Xiaobo
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , G01N15/1429 , G01N15/1434 , G01N15/1459 , G01N21/64 , G01N21/6428 , G01N2015/1006 , G01N2015/1438 , G01N2015/149 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6482 , G01N2201/06113 , G01N2201/0621
摘要： A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.
摘要翻译：一种用于检测由多个激发源引起的光的信号分量的系统，包括：流路，包括至少两个空间分离的光询问区; 非调制激励源，其将第一波长的光束以接近恒定的强度引导到第一光学询问区上; 调制激励源，其将以调制频率随时间调制的第二波长的光束引导到第二光学询问区上; 检测器子系统，包括一组检测器，其被配置为检测从流过所述至少两个光询问区的颗粒发射的光并将检测到的光转换成总电信号; 以及处理器，其根据从每个光询问区检测的光来确定信号分量。

7. 发明申请

WO2018014013A1 OPTICAL DETECTION SYSTEM FOR FLOW CYTOMETER, FLOW CYTOMETER SYSTEM AND METHODS OF USE 审中-公开
标题翻译：流量计，流量计系统和使用方法的光学检测系统
公开(公告)号：WO2018014013A1
公开(公告)日：2018-01-18
申请号：PCT/US2017/042284
申请日：2017-07-15
申请人： ACEA BIOSCIENCES, INC.
发明人： LI, Nan , KONG, Lingbo , WU, Jian , CHENG, Tingting , QING, Yangde , WANG, Xiaobo
IPC分类号： G01N15/14 , G01N21/64
摘要： An optical engine its use in a bench top flow cytometer, the optical engine having a set of lasers, each focused horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same excitation plane of a flow cell, a set of optics that separate fluorescence of a same wavelength range into different locations in a focal plane of collection optics according to the different lasers by which the fluorescent light is excited; and a detector that selectively detects light from the different locations thereby distinguishing between fluorescence emitted within the same wavelength range as excited by the different lasers.
摘要翻译：光学引擎将其用于台式流式细胞仪中，该光学引擎具有一组激光器，每个激光器沿着x轴水平地聚焦到相同的水平位置并且垂直地沿着y轴聚焦到沿着流动池的同一激发平面的不同垂直位置，一组光学器件，根据荧光被激发的不同激光器将相同波长范围的荧光分离到收集光学器件的焦平面中的不同位置; 以及检测器，其选择性地检测来自不同位置的光，从而区分在由不同激光器激发的相同波长范围内发射的荧光。

8. 发明申请

WO2019028122A1 CELL-SUBSTRATE IMPEDANCE MONITORING OF CANCER CELLS OF DIFFERENT LINEAGE, ORIGIN, OR STAGE 审中-公开
公开(公告)号：WO2019028122A1
公开(公告)日：2019-02-07
申请号：PCT/US2018/044774
申请日：2018-08-01
申请人： ACEA BIOSCIENCES, INC.
发明人： LI, Nan , ABASSI, Yama , XU, Xiao , WANG, Xiaobo
IPC分类号： G01N33/00 , G01N33/48
摘要： A method of assessing cytolysis of cancer cells, the method including: providing a cellsubstrate impedance monitoring cartridge having a plurality of chambers, each chamber having an electrode array configured for measuring cell-substrate impedance, wherein different chambers are preloaded with different target cells embodied as cancer cells of different lineage, origin or stage; adding effector cells to the plurality chambers for interaction with the target cells, wherein the effector cells are immune cells; monitoring cellsubstrate impedance of the plurality of chambers before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedances; and determining effectiveness of effector cell killing of the different target cells by comparing the impedances or impedance-based parameters over time.

9. 发明申请

WO2018161063A1 METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES 审中-公开
公开(公告)号：WO2018161063A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/020817
申请日：2018-03-03
申请人： ACEA BIOSCIENCES, INC.
发明人： ZHANG, Xiaoyu , ABASSI, Yama A. , LI, Nan , WANG, Xiaobo
IPC分类号： A61K35/34 , C12N13/00 , C12N15/01 , G01N27/02
摘要： Methods of inducing functional maturation of immature cardiomyocytes derived from induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) by electrically pacing the immature cardiomyocytes according to a pulse profile that induces maturation until the immature cardiomyocytes mature into functionally adult cardiomyocytes.

10. 发明申请

WO2017087945A1 CELL-SUBSTRATE IMPEDANCE MONITORING OF CANCER CELLS 审中-公开
标题翻译：癌细胞的细胞 - 基质阻抗监测
公开(公告)号：WO2017087945A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/063066
申请日：2016-11-21
申请人： ACEA BIOSCIENCES, INC.
发明人： WANG, Xiaobo , ABASSI, Yama A. , LI, Nan , MUIR, Lincoln , XU, Xiao
IPC分类号： C12M1/00 , C12M1/34 , C12M1/42 , C12N13/00 , H01M4/00
CPC分类号： C12N13/00 , G01N33/5011 , G01N33/502 , G01N33/5047 , G01N2800/52
摘要： Methods of assessing cytolysis of cancer cells, including providing a cell-substrate impedance monitoring device operably connected to an impedance analyzer, wherein the device comprises a well for receiving cells and an electrode array at a base of the well; adding target cells characterized as cancer cells to the well; adding effector cells to the well to form a test well, wherein the effector cells are immune cells obtained or derived from a same patient as the target cells; monitoring cell-substrate impedance of the test well before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedance; and determining effectiveness of effector cell killing of the target cells by comparing the impedance or impedance based parameter over time.
摘要翻译：评估癌细胞的细胞溶解的方法，包括提供可操作地连接到阻抗分析仪的细胞 - 基底阻抗监测装置，其中所述装置包括用于接收细胞的孔和位于所述阻抗分析仪的底部的电极阵列好; 将表征为癌细胞的靶细胞加入孔中; 将效应细胞加入孔中以形成测试孔，其中效应细胞是从与靶细胞相同的患者获得或衍生的免疫细胞; 在添加所述效应细胞之前和之后监测所述测试孔的细胞 - 基底阻抗，并任选地从所述阻抗导出基于阻抗的参数; 并通过比较基于阻抗或阻抗的参数随时间的变化来确定效应细胞杀死靶细胞的效力。

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