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1. 发明申请

WO2014025514A1 METHOD OF MAKING AGGLOMERATED MICROBIOLOGICAL MEDIA AND COMPOSITIONS THEREOF 审中-公开
标题翻译：制备聚集微生物培养基的方法及其组合物
公开(公告)号：WO2014025514A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/051446
申请日：2013-07-22
申请人： 3M INNOVATIVE PROPERTIES COMPANY , LIU, Jie J. , XIA, Wensheng
发明人： LIU, Jie J. , XIA, Wensheng
IPC分类号： C12N1/20
CPC分类号： C12N1/20
摘要： A method of making a flowable, agglomerated nutrient medium is provided. The method comprises forming a nutrient medium composition by placing a powdered nutrient into a fluidized bed-type agglomeration chamber, flowing a fluidizing gas through the chamber, and contacting in the agglomeration chamber the powdered nutrient with an aerosol spray of an agglomeration liquid; and collecting the composition from the chamber. The nutrient component facilitates the growth of a microorganism. The composition formed by the method comprises a population of agglomerated nutrient medium particles and, optionally, nonagglomerated powdered nutrient. The population comprises at least about 30 weight percent agglomerated nutrient particles having an effective particle diameter of about 250-400 microns. Compositions, thin film culture devices, and kits comprising the flowable, dried agglomerated nutrient medium are also provided.
摘要翻译：提供了制备可流动的附聚营养培养基的方法。所述方法包括通过将粉状营养物放入流化床型附聚室中形成营养培养基组合物，使流化气体流过所述室，并使所述粉末状营养物与附聚液体的气溶胶喷雾接触; 并从室收集组合物。营养成分促进微生物的生长。通过该方法形成的组合物包含聚集的营养培养基颗粒群和任选的非团聚的粉状营养物。群体包含至少约30重量％的有效粒径为约250-400微米的附聚营养颗粒。还提供了组合物，薄膜培养装置和包含可流动，干燥的附聚营养培养基的试剂盒。

2. 发明申请

WO2014018433A1 AGGLOMERATED MICROBIOLOGICAL MEDIA 审中-公开
标题翻译：组织微生物培养基
公开(公告)号：WO2014018433A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051449
申请日：2013-07-22
申请人： 3M INNOVATIVE PROPERTIES COMPANY , LIU, Jie J. , XIA, Wensheng
发明人： LIU, Jie J. , XIA, Wensheng
IPC分类号： C12N1/20
CPC分类号： C12N1/20 , C12N1/14 , C12N1/16 , C12N2500/46 , C12N2500/60
摘要： A method of making a flowable, dried agglomerated nutrient medium is provided. The method comprises introducing a nutrient component comprising a powdered nutrient, and an agglomeration liquid, into an agglomerator comprising a flow-through-type agglomeration chamber, wet-massing the nutrient component with the agglomeration liquid in the agglomeration chamber for a predetermined period of time to form agglomerated nutrient medium particles, and exposing the agglomerated nutrient medium particles to drying conditions for a period of time to form the dried, agglomerated nutrient medium. The nutrient component facilitates the growth of a microorganism. Compositions, articles, and kits comprising the flowable, dried agglomerated nutrient medium are also provided.
摘要翻译：提供了制备可流动的，干燥的附聚营养培养基的方法。该方法包括将包含粉末状营养物和附聚液的营养成分引入包含流通型附聚室的附聚器中，将附聚液中的营养成分与附聚室湿式预定一段时间以形成附聚的营养培养基颗粒，并将附聚的营养培养基颗粒暴露于干燥条件下一段时间以形成干燥的聚集的营养培养基。营养成分促进微生物的生长。还提供了包含可流动，干燥的附聚营养培养基的组合物，制品和试剂盒。

3. 发明申请

WO2012092123A1 EFFERVESCENT COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：有效的组合物及其用途
公开(公告)号：WO2012092123A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/066820
申请日：2011-12-22
申请人： 3M INNOVATIVE PROPERTIES COMPANY , XIA, Wensheng , MACH, Patrick A. , BEAURLINE, Joseph M. , BJORK, Jason W. , LIU, Jie J.
发明人： XIA, Wensheng , MACH, Patrick A. , BEAURLINE, Joseph M. , BJORK, Jason W. , LIU, Jie J.
IPC分类号： C12Q1/04 , C12N1/00 , C12N1/20
CPC分类号： C12Q1/045 , C12N1/14 , C12N1/20 , C12N1/38 , C12Q1/04 , C12Q1/689
摘要： A latent effervescent body comprising a selective agent is disclosed. A method of using the latent effervescent body in a method to selectively enrich a target microorganism is also disclosed. The method comprises providing a sample, a culture medium, and the latent effervescent body. The method further comprises contacting the sample, the culture medium, and the latent effervescent body under conditions to facilitate growth of the target microorganism. The method further comprises releasing the selective agent from the latent effervescent body. Optionally, the method includes detecting a microorganism.
摘要翻译：公开了包含选择剂的潜伏泡腾体。还公开了在选择性富集目标微生物的方法中使用潜在泡腾体的方法。该方法包括提供样品，培养基和潜在泡腾体。该方法还包括在促进靶微生物生长的条件下使样品，培养基和潜在泡腾体接触。该方法还包括从潜在泡腾体释放选择剂。任选地，该方法包括检测微生物。

4. 发明申请

WO2006091720A3 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF IMMUNE RESPONSE MODIFIERS 审中-公开
公开(公告)号：WO2006091720A3
公开(公告)日：2006-08-31
申请号：PCT/US2006/006387
申请日：2006-02-23
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ALKAN, Sefik , KIEPER, William C. , VASILAKOS, John P. , BONK, Jason D. , GRIESGRABER, George W. , LIPSON, Kenneth E. , LIU, Jie J. , MENDOZA, James D. , STOERMER, Doris , WIGHTMAN, Paul D. , JING, Naiyong , SCHULTZ, William J.
发明人： ALKAN, Sefik , KIEPER, William C. , VASILAKOS, John P. , BONK, Jason D. , GRIESGRABER, George W. , LIPSON, Kenneth E. , LIU, Jie J. , MENDOZA, James D. , STOERMER, Doris , WIGHTMAN, Paul D. , JING, Naiyong , SCHULTZ, William J.
IPC分类号： A61K31/4745 , A61K31/4748 , A61K31/437 , A61K31/4738
摘要： The present invention provides immunomodulatory compositions include an immune response modifier moiety coupled to a targeting moiety. In another aspect, the invention provides methods of providing targeted delivery of an IRM, generating a localized immune response, and treating a condition in a subject. Generally, the methods include administering to the subject an immunomodulatory composition that includes an immune response modifier moiety coupled to a targeting moiety that recognizes a delivery target.

5. 发明申请

WO2009006131A1 AN INDICATING FIBER 审中-公开
标题翻译：指示纤维
公开(公告)号：WO2009006131A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068094
申请日：2008-06-25
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ZHANG, Yifan , LIU, Jie J. , MOORE, Eric M. , PORBENI, Francis E. , TUMAN, Scott J. , WOLK, Diane R.
发明人： ZHANG, Yifan , LIU, Jie J. , MOORE, Eric M. , PORBENI, Francis E. , TUMAN, Scott J. , WOLK, Diane R.
IPC分类号： D01F1/10 , G01N33/52
CPC分类号： D01F1/10 , G01N33/528 , Y10T436/143333
摘要： A fiber, an articles formed from a fiber and methods of making the fiber and associate article are disclosed. In one embodiment, the fiber comprises a synthetic polymer and a color-changing indicator. The color-changing indicator is dispersed throughout the synthetic polymer. The color-changing indicator reacts in the presence of a stimulus to produce a color change.
摘要翻译：公开了一种纤维，由纤维形成的制品和制造纤维和副制品的方法。在一个实施方案中，纤维包括合成聚合物和颜色变化指示剂。颜色变化指示剂分散在整个合成聚合物中。颜色变化指示器在存在刺激的情况下反应以产生颜色变化。

6. 发明申请

WO2009005936A1 ACCELERATING A NINHYDRIN REACTION 审中-公开
标题翻译：加速一种新的反应
公开(公告)号：WO2009005936A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/065774
申请日：2008-06-04
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ZHANG, Yifan , FRASER, Robert J. , JING, Naiyong , LIU, Jie J.
发明人： ZHANG, Yifan , FRASER, Robert J. , JING, Naiyong , LIU, Jie J.
IPC分类号： G01N31/22 , G01N33/50
CPC分类号： G01N31/22 , G01N33/6839
摘要： The present disclosure relates to accelerating a ninhydrin reaction within an indicator solution. The indicator solution comprises ninhydrin and an accelerant selected from the group consisting of at least 50% wt. isopropyl alcohol and a lithium salt. The indicator solution produces a color change in the presence of a protein or amine in less than 5 minutes under an ambient temperature condition.
摘要翻译：本公开涉及在指示剂溶液内加速茚三酮反应。指示剂溶液包括茚三酮和选自至少50重量％的促进剂。异丙醇和锂盐。指示剂溶液在环境温度条件下在不到5分钟的时间内在蛋白质或胺的存在下产生颜色变化。

7. 发明申请

WO2009005884A1 PHYSICAL ENTRAPMENT OF A COLOR-CHANGING INDICATOR TO A SUBSTRATE 审中-公开
标题翻译：颜色变化指示器到基板的物理描述
公开(公告)号：WO2009005884A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/061990
申请日：2008-04-30
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ZHANG, Yifan , WRIGHT, Robin E. , WOLK, Diane R. , TUMAN, Scott J. , PORBENI, Francis E. , LIU, Jie J. , JING, Naiyong , ENDLER, Elizabeth E.
发明人： ZHANG, Yifan , WRIGHT, Robin E. , WOLK, Diane R. , TUMAN, Scott J. , PORBENI, Francis E. , LIU, Jie J. , JING, Naiyong , ENDLER, Elizabeth E.
IPC分类号： G01N31/22
CPC分类号： G01N31/22 , G01N21/78
摘要： A color changing indicator that is physically entrapped onto a substrate produces a reactive article. In one embodiment, the reactive article comprises a substrate, a color changing indicator that produces a color change in response to a stimulus, and a delivery mechanism containing the color changing indicator. The delivery mechanism is secured to the substrate. The stimulus is capable of penetrating the delivery mechanism to produce a visually discernable color change of the color changing indicator.
摘要翻译：物理地夹在基材上的变色指示剂产生反应性物品。在一个实施例中，反应性制品包括衬底，响应于刺激而产生颜色变化的变色指示器和包含颜色变化指示器的输送机构。输送机构固定在基板上。刺激能够穿透输送机构以产生颜色变化指示器的视觉上可辨别的颜色变化。

8. 发明申请

WO2018102484A1 BASIC CORE MATERIAL ENCAPSULATED IN AN INORGANIC SHELL SUITABLE FOR USE IN BIOLOGICAL CARRIER MATERIALS 审中-公开
公开(公告)号：WO2018102484A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/063829
申请日：2017-11-30
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： CHRISTENSEN, Randilynn B. , BUDD, Kenton D. , FALSAFI, Afshin , AKSIT, Mahmut , NINKOVIC, Jana , LIU, Jie J. , AGRE, Mark B. , NAKAMURA, Masayuki , BJORK, Jason W.
IPC分类号： A61K6/00 , A61K6/06 , A61K6/02 , A61K9/50
摘要： A (e.g. hardenable dental) composition is described comprising (e.g. a first part comprising) an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core; and (e.g. a second part comprising) water or an acidic component. Also described is an encapsulated material (e.g. suitable for use in a biological carrier material) comprising a basic core material and an inorganic shell material comprising a metal oxide surrounding the core.

9. 发明申请

WO2015038580A1 ORAL COMPOSITIONS, DENTAL STRUCTURES AND METHODS OF DELIVERING ORAL COMPOSITIONS 审中-公开
标题翻译：口腔组合物，牙科结构和递送口服组合物的方法
公开(公告)号：WO2015038580A1
公开(公告)日：2015-03-19
申请号：PCT/US2014/054901
申请日：2014-09-10
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： WANG, Yizhong , OXMAN, Joel D. , KLAIBER, Paul R. , LIU, Jie J. , FITCH, Joanne A. , TON, Tiffany T.
IPC分类号： A61Q11/00 , A61K8/81
CPC分类号： A61K8/8147 , A61K8/8152 , A61K2800/5424 , A61K2800/594 , A61K2800/92 , A61Q11/00
摘要： An oral composition and a method of delivering an oral composition to a dental structure are described. The oral composition can include a solvent; an acidic copolymer having acidic acrylate monomeric units, acidic methacrylate monomeric units, or a combination thereof; a neutral copolymer having neutral acrylate monomeric units, neutral methacrylate monomeric units, or a combination thereof; and optionally an active agent. The acidic and neutral copolymers can be dissolved in the oral composition and the oral composition can form a film on a surface when contacted with an aqueous solution.
摘要翻译：描述口腔组合物和将口腔组合物递送到牙科结构的方法。口服组合物可包括溶剂; 具有酸性丙烯酸酯单体单元，酸式甲基丙烯酸酯单体单元或其组合的酸性共聚物; 具有中性丙烯酸酯单体单元，中性甲基丙烯酸酯单体单元或其组合的中性共聚物; 和任选的活性剂。酸性和中性共聚物可以溶解在口腔组合物中，口服组合物可以在与水溶液接触时在表面上形成膜。

10. 发明申请

WO2020044230A1 AQUEOUS ORAL CARE SOLUTIONS, METHODS, KITS, AND TOOTH SURFACES HAVING A COATING DERIVED FROM THE ORAL CARE SOLUTION 审中-公开
公开(公告)号：WO2020044230A1
公开(公告)日：2020-03-05
申请号：PCT/IB2019/057203
申请日：2019-08-27
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： WANG, Yizhong , LIU, Jie J. , RUSIN, Richard P. , GUSTAFSON, Melinda B. , HAEBERLEIN, Ingo , CARRERA VIDAL, Carola A.
IPC分类号： A61K8/19 , A61K8/21 , A61Q11/00
摘要： An aqueous oral care solution, a kit that includes such solution, a method of making such solution, a method of using such solution (e.g., a method of providing fluoride to a patient's tooth surface), and a tooth surface having a coating derived from the aqueous oral care solution, wherein the oral care solution includes: silver cations; thiocyanate anions provided by a thiocyanate source comprising Ca(SCN)2; fluoride anions; and water; wherein the molar ratio of silver to thiocyanate ions is up to 0.40:1, and water is up to 57 wt-%, based on the total weight of the solution.

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