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1. 发明申请

WO2018237291A9 SIGNALING CENTERS OF ERYTHROID DIFFERENTIATION 审中-公开
公开(公告)号：WO2018237291A9
公开(公告)日：2018-12-27
申请号：PCT/US2018/039045
申请日：2018-06-22
申请人： THE CHILDREN'S MEDICAL CENTER CORPORATION , ZON, Leonard I. , CHOUDHURI, Avik
发明人： ZON, Leonard I. , CHOUDHURI, Avik , TROMPOUKI, Eirini
IPC分类号： A61K39/00 , A61K45/00 , C12N15/11 , C12N15/09 , C12N15/00
摘要： Described herein are methods, compounds, pharmaceutical compositions, and kits for modulating erythropoiesis by altering occupancy at genomic signaling-centers.

2. 发明申请

WO2010091049A3 DIAGNOSIS AND TREATMENT OF CANCER 审中-公开
标题翻译：癌症的诊断和治疗
公开(公告)号：WO2010091049A3
公开(公告)日：2011-04-07
申请号：PCT/US2010022994
申请日：2010-02-03
申请人： CHILDRENS MEDICAL CENTER , ZON LEONARD I , CEOL CRAIG , HOUVRAS YARIV J
发明人： ZON LEONARD I , CEOL CRAIG , HOUVRAS YARIV J
IPC分类号： C12Q1/68 , C07K16/18 , C12N15/12 , G01N33/574 , G01N33/68
CPC分类号： G01N33/5743 , A61K39/39558 , C07K16/40 , C12N15/1137 , C12N2310/14 , C12Q1/6886 , C12Q2600/158 , C12Y201/01043 , G01N33/574 , G01N2333/91011 , G01N2333/91017
摘要： Provided herein are methods for diagnosing cancer by determining the level of expression of SETDB1 in a biological sample. Also provided herein are methods for treating cancer by administering an inhibitor of SETDB1 to a subject in need thereof.
摘要翻译：本文提供了通过确定生物样品中SETDB1的表达水平来诊断癌症的方法。本文还提供了通过向有需要的受试者施用SETDB1抑制剂来治疗癌症的方法。

3. 发明申请

WO2009155041A3 METHOD TO MODULATE HEMATOPOIETIC STEM CELL GROWTH 审中-公开
标题翻译：调节HEMATOPOIETIC STEM CELL GROWTH的方法
公开(公告)号：WO2009155041A3
公开(公告)日：2010-03-11
申请号：PCT/US2009045442
申请日：2009-05-28
申请人： CHILDRENS MEDICAL CENTER , GEN HOSPITAL CORP , BETH ISRAEL HOSPITAL , BRIGHAM & WOMENS HOSPITAL , ZON LEONARD I , NORTH TRISTA E , GOESSLING WOLFRAM
发明人： ZON LEONARD I , NORTH TRISTA E , GOESSLING WOLFRAM
IPC分类号： C12N5/02 , A61K31/04 , A61P37/06 , C12N5/00
CPC分类号： A61K31/00 , A61K31/04 , C12N5/0647 , C12N2501/03 , C12N2506/02 , C12N2506/11 , C12N2506/45
摘要： Described herein are methods, compositions and kits related to manipulating hematopoietic stem cells (HSC) and more particularly to methods, compositions and kits related to increasing the number of hematopoietic stem cells in vitro, ex vivo and/or in vivo. Also described are methods, compositions and kits related to making an expanded population of HSC and methods, compositions and kits related to using the expanded population of HSC. For example, HSC growth may be enhanced by contacting the nascent stem cells or HSC with an agent that stimulates the nitric oxide signaling pathway.
摘要翻译：本文描述了与操纵造血干细胞（HSC）相关的方法，组合物和试剂盒，更具体地涉及与体外，离体和/或体内增加造血干细胞数量有关的方法，组合物和试剂盒。还描述了与制造HSC的扩大群体相关的方法，组合物和试剂盒以及与使用HSC的扩展群体相关的方法，组合物和试剂盒。例如，可通过使新生干细胞或HSC与刺激一氧化氮信号通路的药物接触来增强HSC生长。

4. 发明申请

WO2005110076A2 BRAF EXPRESSION IN ZEBRAFISH AND USES THEREOF 审中-公开
标题翻译： BRAF表达在ZEBRAFISH及其用途
公开(公告)号：WO2005110076A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/015987
申请日：2005-05-09
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , FISHER, David, E. , WIDLUNG, Hans , ZON, Leonard, I. , PATTON, E., Elizabeth
发明人： FISHER, David, E. , WIDLUNG, Hans , ZON, Leonard, I. , PATTON, E., Elizabeth
IPC分类号： A01K67/027
CPC分类号： A01K67/0278 , A01K2217/072 , A01K2227/40 , A01K2267/0331
摘要： The present invention discloses a transgenic zebrafish that express activated BRAF specifically in melanocytes and its uses in screening for agents that can be used to treat melanomas or screening for agents that aggravate or induce melanomas.
摘要翻译：本发明公开了一种在黑素细胞中特异性表达活化的BRAF的转基因斑马鱼及其用于筛选可用于治疗黑素瘤或筛选加重或诱导黑素瘤的药剂的用途。

5. 发明申请

WO2018237291A2 SIGNALING CENTERS OF ERYTHROID DIFFERENTIATION 审中-公开
公开(公告)号：WO2018237291A2
公开(公告)日：2018-12-27
申请号：PCT/US2018/039045
申请日：2018-06-22
申请人： THE CHILDREN'S MEDICAL CENTER CORPORATION , ZON, Leonard I. , CHOUDHURI, Avik
发明人： ZON, Leonard I. , CHOUDHURI, Avik , TROMPOUKI, Eirini
IPC分类号： A61K31/522
CPC分类号： C12N15/1138 , A61P35/02 , A61P37/00 , C12N5/0647 , C12N5/0696 , C12N2310/20
摘要： Described herein are methods, compounds, pharmaceutical compositions, and kits for modulating erythropoiesis by altering occupancy at genomic signaling-centers.

6. 发明申请

WO2012174522A1 COMBINED CHEMICAL MODIFICATION OF SPHINGOSINE-1-PHOSPHATE (S1P) AND CXCR4 SIGNALLING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND ENGRAFTMENT 审中-公开
标题翻译：联合化学改性磷脂酸1-磷酸（S1P）和CXCR4信号通路用于HEMATOPOIETIC干细胞（HSC）动员和放大
公开(公告)号：WO2012174522A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/042934
申请日：2012-06-18
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , ZON, Leonard, I. , TAMPLIN, Owen, J.
发明人： ZON, Leonard, I. , TAMPLIN, Owen, J.
IPC分类号： A61K31/137 , A61K31/381 , A61K31/395 , A61K31/4245 , A61K31/662 , A61K38/04 , A61P37/06 , A61P43/00
CPC分类号： A61K35/14 , A61K31/137 , A61K31/138 , A61K31/381 , A61K31/395 , A61K31/4245 , A61K31/662 , A61K35/28 , A61K38/04 , A61K45/06 , A61K2300/00
摘要： The present embodiments provide for combinations of modulators that increase hematopoietic stem cell engraftment or increase mobilization in vivo . Methods and compositions for modulating the mobilization of stem cells, particularly for promoting or increasing the mobilization of hematopoietic stem cells (HSCs) from the bone marrow to the peripheral blood are disclosed. One aspect of the invention relates to the use of a CXCR4 antagonist that act in concert with specific molar ratios of S1P receptor 1 (S1PR1) modulator agents to promote HSC mobilization. The invention also relates to methods of using these combinations of CXCR4 antagonists and S1PR1 modulator agents for enhancing the mobilization of hematopoietic stem cells when harvesting of the stem cells, for example for the treatment of diseases, disabilities or conditions whereby transplantation of such cells would be beneficial in ameliorating a symptom associated with such diseases, disabilities or conditions. Another aspect of the invention relates to the use of a CXCR4 antagonist that act in concert with different, but specific molar ratios of S1P receptor 1 (S1PR1) modulator agents to promote HSC engraftment and methods for promoting HSC engraftment in a subject in need thereof, e.g., a recipient subject of a bone marrow or HSC transplant. Methods of screening for novel agents and pharmaceutical compositions comprising these agents are also disclosed.
摘要翻译：本实施例提供了增加造血干细胞移植或增加体内动员的调节剂的组合。公开了用于调节干细胞动员的方法和组合物，特别是用于促进或增加造血干细胞（HSC）从骨髓到外周血的动员。本发明的一个方面涉及CXCR4拮抗剂的用途，其与S1P受体1（S1PR1）调节剂的特定摩尔比一致以促进HSC动员。本发明还涉及使用CXCR4拮抗剂和S1PR1调节剂的这些组合的方法，用于在收获干细胞时增强造血干细胞的动员，例如用于治疗疾病，残疾或这样的细胞的移植将是有利于改善与这种疾病，残疾或病症相关的症状。本发明的另一方面涉及CXCR4拮抗剂的用途，所述CXCR4拮抗剂与S1P受体1（S1PR1）调节剂的不同但特异性摩尔比一致以促进HSC植入以及在有需要的受试者中促进HSC植入的方法，例如，骨髓或HSC移植的接受者。还公开了包含这些试剂的新型试剂和药物组合物的筛选方法。

7. 发明申请

WO2008070310A3 METHOD TO ENHANCE TISSUE REGENERATION 审中-公开
公开(公告)号：WO2008070310A3
公开(公告)日：2008-06-12
申请号：PCT/US2007/082093
申请日：2007-10-22
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , NORTH, Trista, E. , GOESSLING, Wolfram , ZON, Leonard, I.
发明人： ZON, Leonard, I.
IPC分类号： A61K31/00 , A61K31/352 , A61K31/201
摘要： The present invention provides for compositions and methods for modulating tissue growth using tissue growth modulators, which are agents that either enhance or inhibit tissue growth as desired by a particular indication by modulating the PG or Wnt signaling pathways, or employing modulators of both PG and Wnt signaling pathways for a synergistic effect or highly selective effect.

8. 发明申请

WO2007112084A9 METHOD TO MODULATE HEMATOPOIETIC STEM CELL GROWTH 审中-公开
标题翻译：调节HEMATOPOIETIC STEM CELL GROWTH的方法
公开(公告)号：WO2007112084A9
公开(公告)日：2007-11-22
申请号：PCT/US2007007419
申请日：2007-03-26
申请人： CHILDRENS MEDICAL CENTER , ZON LEONARD I , N RTH TRISTA E , GOESSLING WOLFRAM
发明人： ZON LEONARD I , N RTH TRISTA E , GOESSLING WOLFRAM
IPC分类号： C12N5/22 , A61K35/14 , C12N5/0789
CPC分类号： A61K35/14 , A61K35/28 , A61K45/06 , C12N5/0647 , C12N2501/02
摘要： The present invention provides for compositions and methods for modulating hematopoietic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
摘要翻译：本发明提供了通过使用HCS调节剂调节造血干细胞群体的组合物和方法，所述HCS调节剂是根据特定适应症所希望的增加HSC数量或降低HSC号的试剂。例如，发现增加HSC数量的HSC调节剂包括前列腺素E2（PGE2）和刺激PGE2途径的试剂。相反，防止PGE2合成的HSC调节剂降低HSC数量。 HCS调节剂可以在体外，体内或体外使用。

9. 发明申请

WO2005110076A3 BRAF EXPRESSION IN ZEBRAFISH AND USES THEREOF 审中-公开
标题翻译： BRAF表达在ZEBRAFISH及其用途
公开(公告)号：WO2005110076A3
公开(公告)日：2006-01-26
申请号：PCT/US2005015987
申请日：2005-05-09
申请人： CHILDRENS MEDICAL CENTER , FISHER DAVID E , WIDLUNG HANS , ZON LEONARD I , PATTON E ELIZABETH
发明人： FISHER DAVID E , WIDLUNG HANS , ZON LEONARD I , PATTON E ELIZABETH
IPC分类号： A01K67/027 , G01N33/00
CPC分类号： A01K67/0278 , A01K2217/072 , A01K2227/40 , A01K2267/0331
摘要： The present invention discloses a transgenic zebrafish that express activated BRAF specifically in melanocytes and its uses in screening for agents that can be used to treat melanomas or screening for agents that aggravate or induce melanomas.
摘要翻译：本发明公开了一种在黑素细胞中特异性表达活化的BRAF的转基因斑马鱼及其用于筛选可用于治疗黑素瘤或筛选加重或诱导黑素瘤的药剂的用途。

10. 发明申请

WO2001007598A1 EXPRESSION CLONING USING A TAGGED cDNA LIBRARY 审中-公开
标题翻译：使用标记的cDNA文库表达克隆
公开(公告)号：WO2001007598A1
公开(公告)日：2001-02-01
申请号：PCT/US2000/019960
申请日：2000-07-20
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , ZON, Leonard, I. , AGARWAL, Sadhana
发明人： ZON, Leonard, I. , AGARWAL, Sadhana
IPC分类号： C12N15/10
CPC分类号： C12N15/1065 , C07K2319/00 , C12N15/1037 , C12N15/1086 , C40B40/02
摘要： Methods of expression cloning where a cDNA construct expresses a tagged polypeptide for a biochemical activity of interest are described.
摘要翻译：描述了cDNA构建体表达用于感兴趣的生化活性的标记多肽的表达克隆方法。

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