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1. 发明申请

WO2018170129A1 SPLICEOSOME MUTATIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2018170129A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022437
申请日：2018-03-14
申请人： EISAI CO., LTD , WARMUTH, Markus , PUYANG, Xiaoling , TENG, Teng , ZHU, Ping
发明人： WARMUTH, Markus , PUYANG, Xiaoling , TENG, Teng , ZHU, Ping
IPC分类号： C12Q1/6886 , A61K31/7105
摘要： Spliceosome mutations are described herein, including mutations in the PHF5A and SF3B1 subunits. This application also describes detecting the presence and/or absence of mutations in the spliceosome, as well as methods of diagnosing responsiveness to splice modulator treatment, methods of treating neoplastic disorders, and methods of monitoring or altering the treatment based on mutation status.

2. 发明申请

WO2017166106A1 COMPOSITE COMPRISING SEMICONDUCTOR NANOCRYSTALS AND PREPARING METHOD THEREFOR 审中-公开
标题翻译：包含半导体纳米晶体的复合材料及其制备方法
公开(公告)号：WO2017166106A1
公开(公告)日：2017-10-05
申请号：PCT/CN2016/077827
申请日：2016-03-30
申请人： DOW GLOBAL TECHNOLOGIES LLC , ROHM AND HAAS ELECTRONIC MATERIALS LLC , LV, Bo , WANG, Xiuyan , HUANG, Yan , REN, Xiaofan , JOO, Jake , ZHU, Ping
发明人： LV, Bo , WANG, Xiuyan , HUANG, Yan , REN, Xiaofan , JOO, Jake , ZHU, Ping
IPC分类号： C09K11/02
摘要： A method of preparing a semiconductor nanocrystal-silicate composite without significantly reducing the quantum yield of the semiconductor nanocrystal, a composite prepared from the method, and a film and an electronic device comprising the composite.
摘要翻译：制备半导体纳米晶 - 硅酸盐复合物而不显着降低半导体纳米晶的量子产率的方法，由该方法制备的复合物，以及包含该复合物的膜和电子器件。

3. 发明申请

WO2014130932A9 NOVEL ANDROGEN RECEPTOR MUTATION 审中-公开
公开(公告)号：WO2014130932A9
公开(公告)日：2014-08-28
申请号：PCT/US2014/017977
申请日：2014-02-24
申请人： NOVARTIS AG , COOKE, Vesselina , KORN, Joshua , KORPAL, Manav , ZHOU, Wenlai , ZHU, Ping , DELACH, Scott , CAPONIGRO, Giordano
发明人： COOKE, Vesselina , KORN, Joshua , KORPAL, Manav , ZHOU, Wenlai , ZHU, Ping , DELACH, Scott , CAPONIGRO, Giordano
IPC分类号： C12Q1/68 , C07K14/705 , G01N33/74 , A61K31/00 , C07K14/72
摘要： Compositions and methods are provided for diagnosis, prognosis and treatment of AR-related diseases, such as prostate diseases, such as prostate cancer, breast cancer, and many other diseases. In particular, a novel and clinically relevant mutation at position 876 of the androgen receptor (AR) has been identified. Drug sensitivity can be predicted and therapeutic regimens can be planned on the basis of the presence or absence of this mutation. Polypeptides comprising, antibodies to, and polynucleotides encoding the mutant AR can be used to identity novel treatments. A double mutation in AR at positions 741 and 877 is also shown to be useful for patient stratification.

4. 发明申请

WO2014130932A2 NOVEL ANDROGEN RECEPTOR MUTATION 审中-公开
标题翻译：新生儿受体突变
公开(公告)号：WO2014130932A2
公开(公告)日：2014-08-28
申请号：PCT/US2014017977
申请日：2014-02-24
申请人： NOVARTIS AG , COOKE VESSELINA , KORN JOSHUA , KORPAL MANAV , ZHOU WENLAI , ZHU PING , DELACH SCOTT , CAPONIGRO GIORDANO
发明人： COOKE VESSELINA , KORN JOSHUA , KORPAL MANAV , ZHOU WENLAI , ZHU PING , DELACH SCOTT , CAPONIGRO GIORDANO
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K31/275 , A61K31/4166 , A61K31/519 , C12Q2600/106 , C12Q2600/156 , G01N33/743 , G01N2333/723 , G01N2800/52
摘要： Compositions and methods are provided for diagnosis, prognosis and treatment of AR-related diseases, such as prostate diseases, such as prostate cancer, breast cancer, and many other diseases. In particular, a novel and clinically relevant mutation at position 876 of the androgen receptor (AR) has been identified. Drug sensitivity can be predicted and therapeutic regimens can be planned on the basis of the presence or absence of this mutation. Polypeptides comprising, antibodies to, and polynucleotides encoding the mutant AR can be used to identity novel treatments. A double mutation in AR at positions 741 and 877 is also shown to be useful for patient stratification.
摘要翻译：提供组合物和方法用于AR相关疾病如前列腺疾病如前列腺癌，乳腺癌和许多其他疾病的诊断，预后和治疗。特别地，已经鉴定了雄激素受体（AR）的876位的新颖和临床相关的突变。可以预测药物敏感性，并且可以基于这种突变的存在或不存在来规划治疗方案。包含编码突变AR的抗体和多核苷酸的多肽可用于鉴定新的治疗。在位置741和877的AR中的双重突变也显示可用于患者分层。

5. 发明申请

WO2010075149A1 LLRP-BASED FLEXIBLE READER SYSTEM AND METHOD 审中-公开
标题翻译：基于LLRP的灵活读取系统和方法
公开(公告)号：WO2010075149A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/068385
申请日：2009-12-17
申请人： SYMBOL TECHNOLOGIES, INC. , LIN, Lang, , MOLINA, Hugo, , ZHU, Ping,
发明人： LIN, Lang, , MOLINA, Hugo, , ZHU, Ping,
IPC分类号： H04L29/08
CPC分类号： H04L67/12 , H04L67/28
摘要： A system includes a host computing device (110), a first RFID transceiver (120), and at least one second RFID transceiver (130; 140). The host computing device (110) executes an application according to a predetermined RFID communication protocol. The predetermined RFID communication protocol supports communication only with a single RFID transceiver. The first RFID transceiver (120) communicates with the host computing device (110) according to the predetermined RFID communication protocol. The at least one second RFID transceiver (130; 140) communicates with the first RFID transceiver (120). The at least one second RFID transceiver (130; 140) provides data to the host computing device (110) only via the first RFID transceiverb (120).
摘要翻译：系统包括主计算设备（110），第一RFID收发器（120）和至少一个第二RFID收发器（130; 140）。主计算设备（110）根据预定的RFID通信协议执行应用。预定的RFID通信协议仅支持与单个RFID收发器的通信。第一RFID收发器（120）根据预定的RFID通信协议与主机计算设备（110）进行通信。所述至少一个第二RFID收发器（130; 140）与所述第一RFID收发器（120）通信。至少一个第二RFID收发器（130; 140）仅通过第一RFID收发器（120）向主计算设备（110）提供数据。

6. 发明申请

WO2005112434A2 NOISE FILTER FOR VIDEO PROCESSING 审中-公开
标题翻译：用于视频处理的噪声滤波器
公开(公告)号：WO2005112434A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/015402
申请日：2005-05-03
申请人： WIS TECHNOLOGIES, INC. , ZENG, Weimin , SHA, Li , ZHU, Ping
发明人： ZENG, Weimin , SHA, Li , ZHU, Ping
IPC分类号： H04N5/217
CPC分类号： H04N5/21 , H04N19/117 , H04N19/14
摘要： A noise filter for a video processing system includes a block selector, a cost calculator, a cost table, a cost comparator, and a coefficient filter. The block selector is coupled to receive data from the quantization unit and selects blocks for additional filtering. The selected blocks are provided to the cost calculator determines a cost for each of the coefficients in the block using the cost table and the costs are summed. The cost comparator compares the total to a threshold, and filters the coefficients using the coefficient filter if the total is greater a preset threshold. The noise filter to the VLC unit then outputs the filter data.
摘要翻译：用于视频处理系统的噪声滤波器包括块选择器，成本计算器，成本表，成本比较器和系数滤波器。块选择器被耦合以从量化单元接收数据并且选择用于额外滤波的块。所选择的块被提供给成本计算器使用成本表确定块中的每个系数的成本，并且将成本相加。成本比较器将总和比较为阈值，并且如果总数大于预设阈值，则使用系数滤波器对系数进行滤波。然后，VLC单元的噪声滤波器输出滤波器数据。

7. 发明申请

WO2019089641A1 COMBINATION COMPRISING AT LEAST ONE SPLICEOSOME MODULATOR AND AT LEAST ONE INHIBITOR CHOSEN FROM BCL2 INHIBITORS, BCL2/BCLXL INHIBITORS, AND BCLXL INHIBITORS AND METHODS OF USE 审中-公开
公开(公告)号：WO2019089641A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058277
申请日：2018-10-30
申请人： EISAI R&D MANAGEMENT CO., LTD. , AIRD, Daniel , CORSON, Laura , ZHU, Ping , WARMUTH, Markus , BUONAMICI, Silvia , SMITH, Peter Gerard , FEKKES, Peter
发明人： AIRD, Daniel , CORSON, Laura , ZHU, Ping , WARMUTH, Markus , BUONAMICI, Silvia , SMITH, Peter Gerard , FEKKES, Peter
IPC分类号： A61K45/00 , A61P35/00
摘要： The present disclosure provides pharmaceutical combinations comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors. Also provided are methods of treating cancer comprising administering a therapeutically effective amount of at least one spliceosome modulator and a therapeutically effective amount of at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors.

8. 发明申请

WO2018098305A1 TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF BREAST CANCER 审中-公开
公开(公告)号：WO2018098305A1
公开(公告)日：2018-05-31
申请号：PCT/US2017/063047
申请日：2017-11-22
申请人： EISAI R&D MANAGEMENT CO., LTD. , BOCK, Mark , HAO, Ming-Hong , KORPAL, Manav , NYAVANANDI, Vijay Kumar , PUYANG, Xiaoling , SAMAJDAR, Susanta , SMITH, Peter Gerard , WANG, John , ZHENG, Guo Zhu , ZHU, Ping , MITCHELL, Lorna Helen , LARSEN, Nicholas , RIOUX, Nathalie , PRAJAPATI, Sudeep , REYNOLDS, Dominic , O'SHEA, Morgan , SAMARAKOON, Thiwanka
发明人： BOCK, Mark , HAO, Ming-Hong , KORPAL, Manav , NYAVANANDI, Vijay Kumar , PUYANG, Xiaoling , SAMAJDAR, Susanta , SMITH, Peter Gerard , WANG, John , ZHENG, Guo Zhu , ZHU, Ping , MITCHELL, Lorna Helen , LARSEN, Nicholas , RIOUX, Nathalie , PRAJAPATI, Sudeep , REYNOLDS, Dominic , O'SHEA, Morgan , SAMARAKOON, Thiwanka
IPC分类号： C07D403/12 , C07D401/14 , C07D231/56 , C07D401/06 , A61P35/00 , A61K31/416
摘要： Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.

9. 发明申请

WO2011073326A2 ORGANIC COMPOSITIONS TO TREAT HSF1-RELATED DISEASES 审中-公开
标题翻译：治疗HSF1相关疾病的有机组合物
公开(公告)号：WO2011073326A2
公开(公告)日：2011-06-23
申请号：PCT/EP2010069917
申请日：2010-12-16
申请人： NOVARTIS AG , HINKLE GREGORY , KUCHIMANCHI SATYANARAYANA , MILSTEIN STUART , WARMUTH MARKUS , ZHOU WENLAI , ZHU PING , ZIMMERMANN TRACY S
发明人： HINKLE GREGORY , KUCHIMANCHI SATYANARAYANA , MILSTEIN STUART , WARMUTH MARKUS , ZHOU WENLAI , ZHU PING , ZIMMERMANN TRACY S
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , A61K45/06 , C07H21/02 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2320/31 , C12N2320/51 , C12N2320/53 , C12N2310/3521
摘要： The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.
摘要翻译：本公开涉及使用治疗有效量的针对HSF的RNAi剂治疗热休克因子1（HSF1）相关疾病例如癌症和病毒性疾病的方法。

10. 发明申请

WO2005112434A3 NOISE FILTER FOR VIDEO PROCESSING 审中-公开
标题翻译：用于视频处理的噪声滤波器
公开(公告)号：WO2005112434A3
公开(公告)日：2007-09-27
申请号：PCT/US2005015402
申请日：2005-05-03
申请人： WIS TECHNOLOGIES INC , ZENG WEIMIN , SHA LI , ZHU PING
发明人： ZENG WEIMIN , SHA LI , ZHU PING
IPC分类号： G06K9/40 , H04N5/21 , H04N7/12 , H04N7/26 , H04N11/02
CPC分类号： H04N5/21 , H04N19/117 , H04N19/14
摘要： A noise filter for a video processing system includes a block selector, a cost calculator, a cost table, a cost comparator, and a coefficient filter. The block selector is coupled to receive data from the quantization unit and selects blocks for additional filtering. The selected blocks are provided to the cost calculator determines a cost for each of the coefficients in the block using the cost table and the costs are summed. The cost comparator compares the total to a threshold, and filters the coefficients using the coefficient filter if the total is greater a preset threshold. The noise filter to the VLC unit then outputs the filter data.
摘要翻译：用于视频处理系统的噪声滤波器包括块选择器，成本计算器，成本表，成本比较器和系数滤波器。块选择器被耦合以从量化单元接收数据并且选择用于额外滤波的块。所选择的块被提供给成本计算器使用成本表确定块中的每个系数的成本，并且将成本相加。成本比较器将总和比较为阈值，并且如果总数大于预设阈值，则使用系数滤波器对系数进行滤波。然后，VLC单元的噪声滤波器输出滤波器数据。

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