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1. 发明申请

WO2005095366A1 7-ARYL 1,5-DIHYDRO-4,1-BENZOXAZEPIN-2(3H)-ONE DERIVATIVES AND THEIR USE AS PROGESTERONE RECEPTOR MODULATORS 审中-公开
标题翻译： 7-ARYL 1,5-二氢-4,1-苯并恶嗪-2（3H） - 酮衍生物及其作为孕酮受体调节剂的用途
公开(公告)号：WO2005095366A1
公开(公告)日：2005-10-13
申请号：PCT/US2005/009756
申请日：2005-03-23
申请人： WYETH , ZHANG, Puwen , WROBEL, Jay, Edward , TEREFENKO, Eugene, Anthony , KERN, Jeffrey, Curtis
发明人： ZHANG, Puwen , WROBEL, Jay, Edward , TEREFENKO, Eugene, Anthony , KERN, Jeffrey, Curtis
IPC分类号： C07D267/14
CPC分类号： C07D267/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： This invention provides progesterone receptor modulators having the structure: wherein R 1 to R 7 , X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有以下结构的孕酮受体调节剂：其中R 1至R 7，X和Q如说明书中所定义; 或其药学上可接受的盐。

2. 发明申请

WO0066225A8 CONTRACEPTIVE COMPOSITIONS CONTAINING CYCLIC CARBAMATES AND AMIDE DERIVATIVES 审中-公开
标题翻译：含有环状碳酸酯和酰胺衍生物的合成组合物
公开(公告)号：WO0066225A8
公开(公告)日：2002-05-30
申请号：PCT/US0011846
申请日：2000-05-01
申请人： AMERICAN HOME PROD , LIGAND PHARM INC , GRUBB GARY S , ZHI LIN , JONES TODD K , SANTILLI ARTHUR A , TEGLEY CHRISTOPHER M , VIET ANDREW Q , ZHANG PUWEN , FENSOME ANDREW , WROBEL JAY E , EDWARDS JAMES P
发明人： GRUBB GARY S , ZHI LIN , JONES TODD K , SANTILLI ARTHUR A , TEGLEY CHRISTOPHER M , VIET ANDREW Q , ZHANG PUWEN , FENSOME ANDREW , WROBEL JAY E , EDWARDS JAMES P
IPC分类号： C07D498/04 , A61K31/40 , A61K31/445 , A61K31/535 , A61K31/5365 , A61K31/56 , A61K45/06 , A61P15/18 , A61K31/565 , A61K31/57
CPC分类号： A61K31/56 , A61K31/40 , A61K31/445 , A61K31/535 , A61K31/565 , A61K45/06 , A61K2300/00
摘要： This invention relates to cyclic combination therapies and regimens utilizing, in combination with progestins, estrogens, or both, substituted indoline derivative compounds which are antagonists of the progesterone receptor having general structure (I) wherein A and B are independent substituents selected from S, CH or N; provided that when A is S, B is CH or N; and when B is S, A is CH or N; and A and B cannot both be CH; and when A and B both equal N, one N may be optionally substituted with a C1 to C6 alkyl group; R1 and R2 are independent substituents selected from the group of H, C1 to C6 alkyl, substituted C1 to C6 alkyl, C2 to C6 alkenyl, substituted C2 to C6 alkenyl, C2 to C6 alkynyl, substituted C2 to C6 alkynyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, substituted aryl, heterocyclic, substituted heterocyclic, COR , or NR COR ; or R and R are fused to form optionally substituted 3 to 8 membered spirocyclic alkyl, alkenyl or heterocyclic ring, the heterocyclic ring containing one to three heteroatoms selected from the group of O, S and N; or pharmaceutically useful salts thereof. These methods of treatment may be used for contraception or for the treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minimization of side effects or cyclic menstrual bleeding. Additional uses of the invention include stimulation of food intake.
摘要翻译：本发明涉及利用与孕激素，雌激素或两者作为孕酮受体的拮抗剂的代用药物，其具有一般结构（I）的循环组合疗法和方案，其中A和B是选自S，CH 或N; 条件是当A为S时，B为CH或N; 当B为S时，A为CH或N; A和B不能同时为CH; 并且当A和B均等于N时，一个N可以任选地被C 1至C 6烷基取代; R1和R2是选自H，C1至C6烷基，取代C1至C6烷基，C2至C6烯基，取代C2至C6烯基，C2至C6炔基，取代C2至C6炔基，C3至C8环烷基的独立取代基取代的C 3至C 8环烷基，芳基，取代的芳基，杂环基，取代的杂环基，COR A或NR C CORA; 或R 1和R 2稠合形成任选取代的3至8元螺环烷基，烯基或杂环，所述杂环含有一至三个选自O，S和N的杂原子; 或其药学上有用的盐。这些治疗方法可用于避孕或治疗和/或预防继发性闭经，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症; 多囊卵巢综合征，子宫内膜，卵巢，乳腺，结肠，前列腺的癌和腺癌，或副作用最小化或周期性月经出血。本发明的额外用途包括刺激食物摄取。

3. 发明申请

WO0066564A8 BENZIMIDAZOLONES AND ANALOGUES AND THEIR USE AS PROGESTERONE RECEPTOR LIGANDS 审中-公开
标题翻译：苯并咪唑和类似物及其作为孕酮受体配体使用
公开(公告)号：WO0066564A8
公开(公告)日：2001-08-02
申请号：PCT/US0011824
申请日：2000-05-01
申请人： AMERICAN HOME PROD , LIGAND PHARM INC , ZHANG PUWEN , BENDER REINHOLD H W , ZHI LIN , JONES TODD K , TEGLEY CHRISTOPHER M , WROBEL JAY E , EDWARDS JAMES P
发明人： ZHANG PUWEN , BENDER REINHOLD H W , ZHI LIN , JONES TODD K , TEGLEY CHRISTOPHER M , WROBEL JAY E , EDWARDS JAMES P
IPC分类号： A61K31/136 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/498 , A61K31/4985 , A61K31/5415 , A61P5/00 , A61P5/24 , A61P13/08 , A61P15/00 , A61P35/00 , A61P43/00 , C07C215/76 , C07C229/18 , C07D235/26 , C07D235/28 , C07D241/44 , C07D263/58 , C07D277/68 , C07D279/16 , C07D409/04 , C07D487/04 , A61K31/429
CPC分类号： C07D263/58 , C07C215/76 , C07C229/18 , C07D235/26 , C07D235/28 , C07D241/44 , C07D277/68 , C07D279/16 , C07D409/04 , C07D487/04
摘要： The present invention provides compounds and pharmaceutical formulations useful as progesterone receptor agonists and antagonists and having general formula (a): wherein A is O, S, or NR ; B is a bond between A and C=Q, or the moiety CR R ; R , R , R are independently selected from H or optionally substituted C1 to C6 alkyl, C2 to C6 alkenyl, C2 to C6 alkynyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, or heteorcyclic groups, or cyclic alkyl constructed by fusing R and R to from a 5 to 7 membered ring; R is selected from H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituded C1 to C6 alkenyl, alkynyl, substituted alkynyl, -COH, or optionally substituted -CO(C1 to C3 alkyl), -CO(aryl), -CO(C1 to C3 alkoxy), or -CO(C1 toC3 aminoalkyl) groups; R is selected from H, halogen, CN, NO2, or optionally substituted C1 to C6 alkyl, C1 to C6 alkoxy, or C1 to C6 aminoalkyl groups; R is selected from a trisubstituted benzene ring; or a 5- or 6- membered heteroaromatic ring containing 1 or 2 substituents; Q is O, S, NR , or CR R ; or a pharmaceutically acceptable salt thereof. The invention also includes methods of contraception and methods of treating or preventing maladies associated with the progesterone receptor.
摘要翻译：本发明提供可用作孕酮受体激动剂和拮抗剂并具有通式（a）的化合物和药物制剂：其中A是O，S或NR 4; B是A和C = Q之间的键，或部分CR 5 R 6; R 4，R 5，R 6独立地选自H或任选取代的C 1 -C 6烷基，C 2至C 6烯基，C 2至C 6炔基，C 3至C 8环烷基，取代的C 3至C 8环烷基，芳基，或杂环基团，或通过将R 4和R 5与5至7元环稠合而构成的环状烷基; R 1选自H，OH，NH 2，C 1至C 6烷基，取代的C 1 -C 6烷基，C 3至C 6烯基，取代的C 1至C 6烯基，炔基，取代的炔基，-COH或任选取代的-CO 至C 3烷基），-CO（芳基），-CO（C 1至C 3烷氧基）或-CO（C 1至C 3氨基烷基） R 2选自H，卤素，CN，NO 2或任选取代的C 1至C 6烷基，C 1至C 6烷氧基或C 1至C 6氨基烷基; R 3选自三取代苯环; 或含有1或2个取代基的5-或6-元杂芳族环; Q是O，S，NR 8或CR 9 R 10; 或其药学上可接受的盐。本发明还包括避孕方法和治疗或预防与孕酮受体相关的疾病的方法。

4. 发明申请

WO2008073958A3 SUBSTITUTED BENZOTHIADIAZINEDIOXIDE DERIVATIVES AND METHODS OF THEIR USE 审中-公开
公开(公告)号：WO2008073958A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/087180
申请日：2007-12-12
申请人： WYETH , GOLDBERG, Joel , FENSOME, Andrew , MCCOMAS, Casey Cameron , ZHANG, Puwen
发明人： GOLDBERG, Joel , FENSOME, Andrew , MCCOMAS, Casey Cameron , ZHANG, Puwen
IPC分类号： C07D285/16 , A61K31/5415 , A61K31/549 , A61P15/00 , A61P9/00 , A61P25/00 , A61P1/00
摘要： The present invention is directed to substituted benzothiadiazinedioxide derivatives of formula (I) :or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

5. 发明申请

WO2008073459A1 ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE 审中-公开
标题翻译： ARYL SULFAMIDE衍生物及其使用方法
公开(公告)号：WO2008073459A1
公开(公告)日：2008-06-19
申请号：PCT/US2007/025405
申请日：2007-12-12
申请人： WYETH , MC COMAS, Casey, Cameron , COHN, Stephen, Todd , CRAWLEY, Matthew, L. , FENSOME, Andrew , GOLDBERG, Joel, Adam , JENKINS, Douglas, John , KIM, Callain, Younghee , MAHANEY, Paige, Erin , MANN, Charles, William , MARELLA, Michael, Anthony , O'NEILL, David, John , SABATUCCI, Joseph, P. , TEREFENKO, Eugene, Anthony , TRYBULSKI, Eugene, John , VU, An, Thien , WOODWORTH, Richard, Page, Jr. , ZHANG, Puwen
发明人： MC COMAS, Casey, Cameron , COHN, Stephen, Todd , CRAWLEY, Matthew, L. , FENSOME, Andrew , GOLDBERG, Joel, Adam , JENKINS, Douglas, John , KIM, Callain, Younghee , MAHANEY, Paige, Erin , MANN, Charles, William , MARELLA, Michael, Anthony , O'NEILL, David, John , SABATUCCI, Joseph, P. , TEREFENKO, Eugene, Anthony , TRYBULSKI, Eugene, John , VU, An, Thien , WOODWORTH, Richard, Page, Jr. , ZHANG, Puwen
IPC分类号： C07D285/14 , C07D417/04 , C07D417/06
CPC分类号： C07D417/04 , C07D285/14 , C07D417/06
摘要： The present invention is directed to aryl sulfamide derivatives of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.
摘要翻译：本发明涉及式（I）的芳基磺酰胺衍生物：或其药学上可接受的盐，立体异构体或互变异构体，它们是单胺再摄取抑制剂，含有这些衍生物的组合物及其用于预防和治疗病症的方法，包括血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其他疾病或病症。

6. 发明申请

WO2004000801A2 USE OF CYCLOTHIOCARBAMATE DERIVATIVES IN TREATMENT OF HORMONE-RELATED CONDITIONS 审中-公开
标题翻译：环磷酰胺衍生物用于治疗与HORMONE相关的病症
公开(公告)号：WO2004000801A2
公开(公告)日：2003-12-31
申请号：PCT/US2003/019751
申请日：2003-06-23
申请人： WYETH , FENSOME, Andrew , GRUBB, Gary , HARRISON, Diane, Deborah , WINNEKER, Richard, Craig , ZHANG, Puwen , KERN, Jeffrey, Curtis , TEREFENKO, Eugene, Anthony
发明人： FENSOME, Andrew , GRUBB, Gary , HARRISON, Diane, Deborah , WINNEKER, Richard, Craig , ZHANG, Puwen , KERN, Jeffrey, Curtis , TEREFENKO, Eugene, Anthony
IPC分类号： C07D
CPC分类号： A61K31/426 , A61K31/536 , A61K31/54 , A61K31/554 , A61K31/565 , A61K2300/00
摘要： The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I, formula II, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I is: (I) and wherein R 1 -R 5 and Q 1 are defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I or formula II and a selective estrogen receptor modulator are also described.
摘要翻译：本发明提供诱导避孕的方法，其包括递送给女性包含式I，式II化合物或其互变异构体的组合物，其方案包括递送一种或多种选择性雌激素受体调节剂，其中式I为：（I）并且其中R 1 -R 5和Q 1如本文所述定义。提供了提供激素替代疗法和治疗癌症，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症和多囊卵巢综合征的方法，其包括递送式I或式II化合物和选择性雌激素受体调节剂。

7. 发明申请

WO2007041257A3 SUBSTITUTED PROPYLAMINE DERIVATIVES AND METHODS OF THEIR USE 审中-公开
标题翻译：取代的丙胺衍生物及其使用方法
公开(公告)号：WO2007041257A3
公开(公告)日：2007-06-28
申请号：PCT/US2006037961
申请日：2006-09-27
申请人： WYETH CORP , MCCOMAS CASEY CAMERON , ZHANG PUWEN , TEREFENKO EUGENE ANTHONY , VU AN THIEN , COHN STEPHEN TODD
发明人： MCCOMAS CASEY CAMERON , ZHANG PUWEN , TEREFENKO EUGENE ANTHONY , VU AN THIEN , COHN STEPHEN TODD
IPC分类号： C07D209/34 , A61P25/00 , C07D209/96 , C07D235/26 , C07D235/30 , C07D277/68
CPC分类号： C07D209/96 , C07D209/08 , C07D209/34 , C07D235/26 , C07D235/30 , C07D277/68
摘要： The present invention is directed to substituted propylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
摘要翻译：本发明涉及式I的取代的丙胺衍生物：或其药学上可接受的盐，含有这些衍生物的组合物，以及它们用于预防和治疗由单胺再摄取改善的病症的用途，包括尤其是血管舒缩症状（VMS ），性功能障碍，胃肠和泌尿生殖系统疾病，慢性疲劳综合征，纤维化痛综合征，神经系统疾病及其组合，特别是选自重度抑郁症，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛，糖尿病性神经病，以及它们的组合。

8. 发明申请

WO2005097744A1 1-(1H-INDOL-1-YL)-3-(4-METHYLPIPERAZIN-1-YL)-1-PHENYL PROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE NOREPINEPHRINE (NE) AND THE SEROTONINE (5-HT) ACTIVITY AND THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) 审中-公开
标题翻译： 1-（1H-INDOL-1-YL）-3-（4-甲基哌嗪-1-基）-1-苯基丙-2-醇衍生物及其相关化合物作为肾上腺素（NE）和丝氨酸（5- HT）用于治疗VASOMOTOR症状（VMS）的活性和单胺类复发
公开(公告)号：WO2005097744A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010511
申请日：2005-03-29
申请人： WYETH , KIM, Callain, Younghee , MAHANEY, Paige, Erin , TRYBULSKI, Eugene, John , ZHANG, Puwen , TEREFENKO, Eugene, Anthony , MCCOMAS, Casey, Cameron , MARELLA, Michael, Anthony , COGHLAN, Richard, Dale , HEFFERNAN, Gavin, David , COHN, Stephen, Todd , VU, An, Thien , SABATUCCI, Joseph, Peter , YE, Fei
发明人： KIM, Callain, Younghee , MAHANEY, Paige, Erin , TRYBULSKI, Eugene, John , ZHANG, Puwen , TEREFENKO, Eugene, Anthony , MCCOMAS, Casey, Cameron , MARELLA, Michael, Anthony , COGHLAN, Richard, Dale , HEFFERNAN, Gavin, David , COHN, Stephen, Todd , VU, An, Thien , SABATUCCI, Joseph, Peter , YE, Fei
IPC分类号： C07D209/08
CPC分类号： C07D209/08 , C07D209/30 , C07D209/42 , C07D235/06 , C07D241/42 , C07D265/36 , C07D471/04
摘要： The present invention is directed to phenylaminopropanol derivatives of formula (I): or a pharmaceutically acceptable salt thereof; wherein: the dotted line between Y and Z represents an optional double bond; the dotted line between the two R 4 groups represents an optional heterocyclic ring of 4 to 6 ring atoms that may be formed between the two R 4 groups, together with the nitrogen through which they are attached; Y is N, CR 6 , or C=O; Z is N, CR 7 , CR 5 , or C(R 5 ) 2 ; R 2 is aryl substituted with 0-3 R 1 or heteroaryl substituted with 0-3 R 1 ; R 3 is H or C 1 -C 4 alkyl; n is an integer form 0 to 4; x is an integer from 1 to 2; and the other substituents are defined in the claims; compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia , vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected form the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
摘要翻译：本发明涉及式（I）的苯基氨基丙醇衍生物：或其药学上可接受的盐; 其中：Y和Z之间的虚线表示任选的双键; 两个R 4基团之间的虚线表示可以在两个R 4基团之间形成的任选的4至6个环原子的杂环，以及它们连接的氮原子; Y是N，CR6或C = O; Z是N，CR7，CR5或C（R5）2; R2是被0-3个R1取代的芳基或被0-3个R1取代的杂芳基; R3是H或C1-C4烷基; n为0〜4的整数; x是1到2的整数; 并且其它取代基在权利要求中限定; 含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS），性功能障碍，胃肠道和泌尿生殖器疾病，慢性疲劳综合征，纤维瘤病综合征，神经系统疾病特别是选自重度抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛，糖尿病性神经病变及其组合的那些条件。

9. 发明申请

WO2004000230A3 CYCLOTHIOCARBAMATIVE DERIVATIVES AS PR MODULATORS AND USE THEREOF FOR TREATMENT OF SKIN DISORDERS 审中-公开
标题翻译：作为调节剂的环磷酰胺衍生物及其用于治疗皮肤疾病的用途
公开(公告)号：WO2004000230A3
公开(公告)日：2004-04-29
申请号：PCT/US0319860
申请日：2003-06-23
申请人： WYETH CORP , FENSOME ANDREW , HARRISON DIANE DEBORAH , WINNEKER RICHARD CRAIG , ZHANG PUWEN , KERN JEFFREY CURTIS , TEREFENKO EUGENE ANTHONY
发明人： FENSOME ANDREW , HARRISON DIANE DEBORAH , WINNEKER RICHARD CRAIG , ZHANG PUWEN , KERN JEFFREY CURTIS , TEREFENKO EUGENE ANTHONY
IPC分类号： C07D265/18 , A61K8/49 , A61K31/535 , A61K31/536 , A61K31/538 , A61K31/565 , A61P5/24 , A61P15/00 , A61P15/18 , A61P17/00 , A61P35/00 , A61P43/00 , A61Q7/00 , A61Q7/02 , A61Q19/00 , C07D409/04 , C07D413/04 , A61K31/56
CPC分类号： A61Q7/02 , A61K8/49 , A61K31/536 , A61K31/565 , A61Q19/00 , A61K2300/00
摘要： The present invention provides for the use of a compound of formula (I) or formula (II) in treating skin disorders, wherein formula (I) is: and wherein R -R and Q are defined as described herein. Specifically, methods for treating acne, hirsutism, and conditioning the skin are described. Also provided are novel PR modulators of formula (II) and uses thereof.
摘要翻译：本发明提供了式（I）或式（II）化合物在治疗皮肤病中的用途，其中式（I）是：并且其中R 1 -R 5和Q 1被定义如本文所述。具体地说，描述了治疗痤疮，多毛症和调理皮肤的方法。还提供了式（II）的新型PR调节剂及其用途。

10. 发明申请

WO2008073958A2 SUBSTITUTED BENZOTHIADIAZINEDIOXIDE DERIVATIVES AND METHODS OF THEIR USE 审中-公开
标题翻译：取代的苯并二氮杂二恶英衍生物及其使用方法
公开(公告)号：WO2008073958A2
公开(公告)日：2008-06-19
申请号：PCT/US2007087180
申请日：2007-12-12
申请人： WYETH CORP , GOLDBERG JOEL , FENSOME ANDREW , MCCOMAS CASEY CAMERON , ZHANG PUWEN
发明人： GOLDBERG JOEL , FENSOME ANDREW , MCCOMAS CASEY CAMERON , ZHANG PUWEN
IPC分类号： C07D285/16 , A61K31/5415 , A61K31/549 , A61P1/00 , A61P9/00 , A61P15/00 , A61P25/00
CPC分类号： C07D285/16
摘要： The present invention is directed to substituted benzothiadiazinedioxide derivatives of formula (I) :or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.
摘要翻译：本发明涉及式（I）的取代的苯并二氮杂二环的衍生物：或其药学上可接受的盐，立体异构体或互变异构体，它们是单胺再摄取抑制剂，含有这些衍生物的组合物，及其用于预防和治疗病症的方法，包括血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其他疾病或病症。

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