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    • 3. 发明申请
    • SYSTEMS AND METHODS FOR TUNING PROPERTIES OF NANOPARTICLES
    • 用于调谐纳米粒子性质的系统和方法
    • WO2007035871A1
    • 2007-03-29
    • PCT/US2006/036829
    • 2006-09-21
    • MASSACHUSETTS INSTITUTE OF TECHNOLOGYZAHN, MarkusADALSTEINSSON, Elfar
    • ZAHN, MarkusADALSTEINSSON, Elfar
    • G01R33/28A61B5/05A61N1/40
    • G01R33/5601A61N1/406
    • Systems and methods for imaging include preparing a ferrofluid including magnetic nanoparticles (MNPs) in a liquid carrier, positioning the ferrofluid in a field region of a magnetic resonance imaging (MRI) system, and actuating a spin velocity or linear velocity of the magnetic nanoparticles to alter the scalar or tensor complex magnetic susceptibility (CMS) of the ferrofluid. Additional activation magnetic field generating apparatus can tune the magnetic field to change particle spin velocity or linear velocity. The method provides, inter alia, for using the spinning MNPs to: heat or cool a region of interest; acquire an improved image of the nanoparticles within a region of interest; alter local effective viscosity, diffusion coefficient, magnetic field, and/or other electromagnetic and/or physicochemical properties; cause local mixing; and enhance diffusion in drug delivery. Parallel methods with dielectric nanoparticles and electric fields are also disclosed.
    • 用于成像的系统和方法包括在液体载体中制备包括磁性纳米颗粒(MNP)的铁磁流体,将铁磁流体定位在磁共振成像(MRI)系统的场区域中,并且将磁性纳米颗粒的旋转速度或线速度驱动到 改变铁磁流体的标量或张量复磁化率(CMS)。 附加的激活磁场产生装置可调谐磁场以改变粒子的旋转速度或线速度。 该方法尤其提供了使用纺丝MNP:加热或冷却感兴趣的区域; 在感兴趣的区域内获得纳米颗粒的改进图像; 改变局部有效粘度,扩散系数,磁场和/或其他电磁和/或物理化学性质; 导致局部混合; 并增强药物传播的扩散。 还公开了具有介电纳米颗粒和电场的平行方法。