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1. 发明申请

WO2008086541A2 METHOD AND SYSTEM FOR PROVIDING SENSOR REDUNDANCY 审中-公开
标题翻译：用于提供传感器冗余的方法和系统
公开(公告)号：WO2008086541A2
公开(公告)日：2008-07-17
申请号：PCT/US2008/055437
申请日：2008-02-29
申请人： MEDTRONIC MINIMED, INC. , MASTROTOTARO, John , YOON, Richard , KEENAN, Desmond
发明人： MASTROTOTARO, John , YOON, Richard , KEENAN, Desmond
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6848 , A61B5/6849 , A61B2560/0276 , A61M5/14244 , A61M5/1723 , A61M2005/1726 , A61M2205/17 , A61M2230/201 , G06F19/00 , G16H50/50
摘要： A closed loop system or semi-closed loop system for infusing insulin using sensor values applies a redundant sensor system as a fail-safe method against sensor failure. The redundant glucose sensors are used corroborate each other and a failing sensor is detected if the sensors no longer corroborate each other. The use of redundant sensors has the additional benefit of producing better sensor signals compared to the use of a single sensor.
摘要翻译：用于使用传感器值输注胰岛素的闭环系统或半闭环系统应用冗余传感器系统作为防止传感器故障的故障安全方法。使用冗余的葡萄糖传感器相互证实，如果传感器不再相互证实，则检测到故障传感器。与使用单个传感器相比，使用冗余传感器具有产生更好的传感器信号的额外好处。

2. 发明申请

WO2005065542A2 REAL TIME SELF-ADJUSTING CALIBRATION ALGORITHM 审中-公开
标题翻译：实时自调整校准算法
公开(公告)号：WO2005065542A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/044086
申请日：2004-12-23
申请人： MEDTRONIC MINIMED, INC. , SHIN, John, J. , PATEL, Nandita, N. , KANDERIAN, Sami, Jr. , WANG, Lu , YOON, Richard
发明人： SHIN, John, J. , PATEL, Nandita, N. , KANDERIAN, Sami, Jr. , WANG, Lu , YOON, Richard
IPC分类号： A61B5/00
CPC分类号： A61B5/6849 , A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/6848 , A61B2560/0223 , A61M2005/1726 , G06F19/00
摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals. It also includes obtaining at least two reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals. Also included is calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data. And, calibrating the obtained glucose monitor data using the calibration characteristics is included. In preferred embodiments, the reference source is a blood glucose meter, and the at least two reference glucose values are obtained from blood tests. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered.
摘要翻译：校准葡萄糖监测数据的方法包括以预定间隔在一段时间内收集葡萄糖监测数据。它还包括从参考源获得至少两个参考葡萄糖值，所述参考源在时间上对应于以预定间隔获得的葡萄糖监测数据。还包括使用参考葡萄糖值和相应的葡萄糖监测数据计算校准特性以回收所获得的葡萄糖监测数据。并且包括使用校准特性来校准所获得的葡萄糖监测数据。在优选实施例中，参考源是血糖仪，并且从血液测试获得至少两个参考葡萄糖值。在另外的实施例中，校准特性的计算包括线性回归，并且在特定实施例中包括最小二乘线性回归。或者，校准特性的计算包括非线性回归。可以验证数据完整性，并且可以对数据进行过滤。

3. 发明申请

WO2008098261A3 METHOD AND SYSTEM FOR DETECTING THE AGE, HYDRATION, AND FUNCTIONAL STATES OF SENSORS USING ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY 审中-公开
标题翻译：使用电化学阻抗谱检测传感器的年龄，水合和功能状态的方法和系统
公开(公告)号：WO2008098261A3
公开(公告)日：2008-11-06
申请号：PCT/US2008055430
申请日：2008-02-29
申请人： MEDTRONIC MINIMED INC , WANG LU , SHAH RAJIV , COOPER KENNETH , YOON RICHARD , LEE HELEN
发明人： WANG LU , SHAH RAJIV , COOPER KENNETH , YOON RICHARD , LEE HELEN
IPC分类号： G01N27/416 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/15003 , A61B5/150389 , A61B5/150503 , A61B5/155 , A61B5/157 , A61B2560/0276 , A61M5/1723 , A61M2230/201
摘要： A method and program prevents a user from bypassing a limit placed on a specified operating life of a sensor by disconnecting and reconnecting the sensor. The present invention checks a characteristic of the sensor to see if the sensor is used prior to the connection of the sensor, and rejects the sensor if the sensor is determined to have been used before. The process of checking the characteristic of the sensor involves performing an Electrochemical Impedance Spectroscopy (EIS) procedure and calculating an impedance value. The impedance value can be compared to various threshold values for a variety of purposes including the determination of age, condition, hydration, and stabilization of the sensor.
摘要翻译：一种方法和程序通过断开并重新连接传感器来防止用户绕过传感器的指定工作寿命的限制。本发明在传感器连接之前检查传感器的特性以查看传感器是否被使用，并且如果确定传感器之前已被使用过，则拒绝传感器。检查传感器特性的过程涉及执行电化学阻抗谱（EIS）程序并计算阻抗值。可以将阻抗值与各种阈值进行比较，用于各种目的，包括确定传感器的年龄，状况，水合作用和稳定性。

4. 发明申请

WO2012112915A1 DEVICE FOR COATING BONE PLATE 审中-公开
标题翻译：用于涂覆骨板的装置
公开(公告)号：WO2012112915A1
公开(公告)日：2012-08-23
申请号：PCT/US2012/025682
申请日：2012-02-17
申请人： LIPORACE, Frank, A. , YOON, Richard, S.
发明人： LIPORACE, Frank, A. , YOON, Richard, S.
IPC分类号： A61B17/58 , A61B17/80 , B05C21/00 , A61B19/02
CPC分类号： A61B17/80 , A61B17/82 , A61B2017/00004 , A61B2017/00526 , A61B2017/00893 , A61F2002/30677 , A61F2310/0097 , B05C13/02
摘要： An encasement for coating a bone plate with a substrate includes a sidewall structure having an upper edge and a cover disposed on the upper edge of the sidewall structure. The encasement includes a base from which the sidewall structure rises such that the sidewall structure, the cover and the base combine to create an open interior space of the encasement. An aperture in the sidewall structure provides access to the open interior space of the encasement and a plurality of cover protrusions extend from the cover into the open interior space. The encasement further includes a plurality of base protrusions extending from the base directly opposing the plurality of cover protrusions. A combined height of an individual cover protrusion and an opposing base protrusion is less than or equal to a height of the sidewall structure.
摘要翻译：用于用基材涂覆骨板的外壳包括具有上边缘和设置在侧壁结构的上边缘上的盖的侧壁结构。该包装件包括一个底座，侧壁结构从该基座上升，使得侧壁结构，盖子和底座相结合以形成包装的敞开的内部空间。侧壁结构中的孔提供了进入外壳的敞开的内部空间的通道，并且多个盖突起从盖延伸到开放的内部空间中。所述外壳还包括从所述底座延伸的多个基底突起，所述多个基底突起与所述多个覆盖突起直接相对。单个盖突起和相对的底部突起的组合高度小于或等于侧壁结构的高度。

5. 发明申请

WO2009134622A1 AUTOMOBILE PHYSIOLOGICAL MONITORING SYSTEM AND METHOD FOR USING THE SAME 审中-公开
标题翻译：汽车生理监测系统及其使用方法
公开(公告)号：WO2009134622A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/040772
申请日：2009-04-16
申请人： MEDTRONIC MINIMED, INC. , ENEGREN, Bradley, J. , PATEL, Himanshu , MADZAR, Bogdan , YOON, Richard, K. , NARANG, Ajit, S.
发明人： ENEGREN, Bradley, J. , PATEL, Himanshu , MADZAR, Bogdan , YOON, Richard, K.
IPC分类号： A61B5/00 , B60K28/06
CPC分类号： A61B5/14532 , A61B5/0031 , A61B5/1112 , A61B5/1468 , A61B5/1473 , A61B2560/045 , B60K28/063 , B60K28/066 , G06F19/00
摘要： An automobile monitoring system to monitor user body characteristics, includes at least one sensor to monitor at least one user body characteristic. The at least one sensor is operatively coupled to a body of a user to monitor the at least one user body characteristic while the user is operating an automobile. The at least one user body characteristic is at least a glucose level of the user's body. At least one transmitter is operatively coupled to the at least one sensor to communicate sensor data obtained from the at least one sensor while the user is operating the automobile. Automobile electronics are operatively coupled to the at least one transmitter to receive sensor data from the at least one sensor while the user is operating the automobile. The automobile electronics provide the sensor data to the user while the user is operating the automobile. A mobile telephone is operatively coupled to the automobile electronics, wherein the automobile electronics initiate a communication via the mobile telephone based on the sensor data received from the at least one sensor. An automobile monitoring system to monitor user body characteristics includes at least one sensor to monitor at least one user body characteristic. The at least one sensor is operatively coupled to a body of a user to monitor the at least one user body characteristic while the user is operating an automobile. The at least one user body characteristic is at least a glucose level of the user's body. At least one transmitter is operatively coupled to the at least one sensor to communicate sensor data obtained from the at least one sensor while the user is operating the automobile. Automobile electronics are operatively coupled to the at least one transmitter to receive sensor data from the at least one sensor while the user is operating the automobile. The automobile electronics provide the sensor data to the user while the user is operating the automobile. A global positioning system (GPS) is operatively coupled to the automobile electronics to determine a current location of the user. The automobile electronics limit the user from operating the automobile to travel beyond a distance based on the sensor data received from the at least one sensor. An automobile monitoring system to monitor user body characteristics includes at least one sensor to monitor at least one user body characteristic. The at least one sensor is operatively coupled to a body of a user to monitor the at least one user body characteristic while the user is operating an automobile. The at least one user body characteristic is at least a glucose level of the user's body. At least one transmitter is operatively coupled to the at least one sensor to communicate sensor data obtained from the at least one sensor while the user is operating the automobile. Automobile electronics are operatively coupled to the at least one transmitter to receive sensor data from the at least one sensor while the user is operating the automobile. The automobile electronics provide the sensor data to the user while the user is operating the automobile. A global positioning system (GPS) is operatively coupled to the automobile electronics to determine a current location of the user. The automobile electronics provide a nearest destination from the current location of the user for the user to travel to based on the sensor data received from the at least one sensor.
摘要翻译：监视用户身体特征的汽车监控系统包括至少一个用于监视至少一个用户身体特征的传感器。所述至少一个传感器可操作地联接到使用者的身体，以在用户操作汽车时监视所述至少一个用户身体的特征。所述至少一个使用者身体特征至少是使用者身体的葡萄糖水平。至少一个发射器可操作地耦合到所述至少一个传感器，以在用户操作汽车的同时传送从所述至少一个传感器获得的传感器数据。汽车电子设备可操作地耦合到至少一个发射器，以在用户操作汽车时从至少一个传感器接收传感器数据。汽车电子设备在用户操作汽车时向用户提供传感器数据。移动电话可操作地耦合到汽车电子设备，其中汽车电子设备基于从至少一个传感器接收的传感器数据，经由移动电话发起通信。监控用户身体特征的汽车监控系统包括至少一个用于监视至少一个用户身体特征的传感器。所述至少一个传感器可操作地联接到使用者的身体，以在用户操作汽车时监视所述至少一个用户身体的特征。所述至少一个使用者身体特征至少是使用者身体的葡萄糖水平。至少一个发射器可操作地耦合到所述至少一个传感器，以在用户操作汽车的同时传送从所述至少一个传感器获得的传感器数据。汽车电子设备可操作地耦合到至少一个发射器，以在用户操作汽车时从至少一个传感器接收传感器数据。汽车电子设备在用户操作汽车时向用户提供传感器数据。全球定位系统（GPS）可操作地耦合到汽车电子装置以确定用户的当前位置。基于从至少一个传感器接收的传感器数据，汽车电子设备限制用户操作汽车行驶超过一定距离。监控用户身体特征的汽车监控系统包括至少一个用于监视至少一个用户身体特征的传感器。所述至少一个传感器可操作地联接到使用者的身体，以在用户操作汽车时监视所述至少一个用户身体的特征。所述至少一个使用者身体特征至少是使用者身体的葡萄糖水平。至少一个发射器可操作地耦合到所述至少一个传感器，以在用户操作汽车的同时传送从所述至少一个传感器获得的传感器数据。汽车电子设备可操作地耦合到至少一个发射器，以在用户操作汽车时从至少一个传感器接收传感器数据。汽车电子设备在用户操作汽车时向用户提供传感器数据。全球定位系统（GPS）可操作地耦合到汽车电子装置以确定用户的当前位置。根据从至少一个传感器接收的传感器数据，汽车电子设备从用户的当前位置提供最近的目的地，供用户前往。

6. 发明申请

WO2008134146A1 CLOSED LOOP/SEMI-CLOSED LOOP THERAPY MODIFICATION SYSTEM 审中-公开
标题翻译：闭环/半闭环修复系统
公开(公告)号：WO2008134146A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/057807
申请日：2008-03-21
申请人： MEDTRONIC MINIMED, INC. , MASTROTOTARO, John J. , YOON, Richard K.
发明人： MASTROTOTARO, John J. , YOON, Richard K.
IPC分类号： A61B5/00 , A61M5/172
CPC分类号： A61M5/14244 , A61B5/14532 , A61B5/14865 , A61B5/4839 , A61B5/6848 , A61B5/6849 , A61M5/1582 , A61M5/1723 , A61M2205/3561 , A61M2205/3592
摘要： A closed loop/semi-closed loop infusion system provides therapy modification and safeguards against the over-delivery or under-delivery of insulin. A glucose sensor system is configured to obtain a measured blood glucose value. A controller is operationally connected with the glucose sensor system and configured to compare the measured blood glucose value to a target blood glucose value and adjust a therapy delivery parameter if the measured blood glucose value is not consistent with the target blood glucose value, wherein the adjusted therapy delivery parameter is limited to be within a boundary. Thereafter, a delivery system delivers therapy at the adjusted therapy delivery parameter.
摘要翻译：闭环/半闭环灌注系统提供治疗改变和防止胰岛素过量递送或递送不足的保护措施。葡萄糖传感器系统被配置为获得测量的血糖值。控制器与葡萄糖传感器系统可操作地连接，并且被配置为将所测量的血糖值与目标血糖值进行比较，并且如果所测量的血糖值与目标血糖值不一致则调整治疗递送参数，其中调整治疗传递参数被限制在边界内。此后，递送系统以调整的治疗递送参数递送治疗。

7. 发明申请

WO2008086541A9 METHOD AND SYSTEM FOR PROVIDING SENSOR REDUNDANCY 审中-公开
标题翻译：用于提供传感器冗余的方法和系统
公开(公告)号：WO2008086541A9
公开(公告)日：2008-11-06
申请号：PCT/US2008055437
申请日：2008-02-29
申请人： MEDTRONIC MINIMED INC , MASTROTOTARO JOHN , YOON RICHARD , KEENAN DESMOND
发明人： MASTROTOTARO JOHN , YOON RICHARD , KEENAN DESMOND
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6848 , A61B5/6849 , A61B2560/0276 , A61M5/14244 , A61M5/1723 , A61M2005/1726 , A61M2205/17 , A61M2230/201 , G16H50/50
摘要： A closed loop system or semi-closed loop system for infusing insulin using sensor values applies a redundant sensor system as a fail-safe method against sensor failure. The redundant glucose sensors are used corroborate each other and a failing sensor is detected if the sensors no longer corroborate each other. The use of redundant sensors has the additional benefit of producing better sensor signals compared to the use of a single sensor.
摘要翻译：使用传感器值输入胰岛素的闭环系统或半闭环系统应用冗余传感器系统作为防止传感器故障的故障安全方法。使用冗余的葡萄糖传感器相互证实，如果传感器不再相互证实，则检测到故障传感器。与使用单个传感器相比，使用冗余传感器具有产生更好的传感器信号的额外好处。

8. 发明申请

WO2008086541A3 METHOD AND SYSTEM FOR PROVIDING SENSOR REDUNDANCY 审中-公开
标题翻译：提供传感器冗余的方法和系统
公开(公告)号：WO2008086541A3
公开(公告)日：2008-09-12
申请号：PCT/US2008055437
申请日：2008-02-29
申请人： MEDTRONIC MINIMED INC , MASTROTOTARO JOHN , YOON RICHARD , KEENAN DESMOND
发明人： MASTROTOTARO JOHN , YOON RICHARD , KEENAN DESMOND
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6848 , A61B5/6849 , A61B2560/0276 , A61M5/14244 , A61M5/1723 , A61M2005/1726 , A61M2205/17 , A61M2230/201 , G16H50/50
摘要： A closed loop system or semi-closed loop system for infusing insulin using sensor values applies a redundant sensor system as a fail-safe method against sensor failure. The redundant glucose sensors are used corroborate each other and a failing sensor is detected if the sensors no longer corroborate each other. The use of redundant sensors has the additional benefit of producing better sensor signals compared to the use of a single sensor.
摘要翻译：使用传感器值输入胰岛素的闭环系统或半闭环系统将冗余传感器系统作为防止传感器故障的故障安全方法。冗余葡萄糖传感器被使用相互抵触，如果传感器不再相互抵触，则会检测到故障传感器。与使用单个传感器相比，冗余传感器的使用具有产生更好的传感器信号的额外优点。

9. 发明申请

WO2008098261A2 METHOD AND SYSTEM FOR DETECTING THE AGE, HYDRATION, AND FUNCTIONAL STATES OF SENSORS USING ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY 审中-公开
标题翻译：使用电化学阻抗谱法检测传感器的年龄，水化和功能状态的方法和系统
公开(公告)号：WO2008098261A2
公开(公告)日：2008-08-14
申请号：PCT/US2008/055430
申请日：2008-02-29
申请人： MEDTRONIC MINIMED, INC. , WANG, Lu , SHAH, Rajiv , COOPER, Kenneth , YOON, Richard , LEE, Helen
发明人： WANG, Lu , SHAH, Rajiv , COOPER, Kenneth , YOON, Richard , LEE, Helen
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/15003 , A61B5/150389 , A61B5/150503 , A61B5/155 , A61B5/157 , A61B2560/0276 , A61M5/1723 , A61M2230/201
摘要： A method and program prevents a user from bypassing a limit placed on a specified operating life of a sensor by disconnecting and reconnecting the sensor. The present invention checks a characteristic of the sensor to see if the sensor is used prior to the connection of the sensor, and rejects the sensor if the sensor is determined to have been used before. The process of checking the characteristic of the sensor involves performing an Electrochemical Impedance Spectroscopy (EIS) procedure and calculating an impedance value. The impedance value can be compared to various threshold values for a variety of purposes including the determination of age, condition, hydration, and stabilization of the sensor.
摘要翻译：一种方法和程序通过断开和重新连接传感器来防止用户绕过传感器的指定使用寿命的限制。本发明检查传感器的特征，以便在传感器连接之前是否使用传感器，并且如果传感器被确定为已经被使用过，则拒绝传感器。检查传感器特性的过程包括执行电化学阻抗谱（EIS）程序并计算阻抗值。可以将阻抗值与各种阈值进行比较，包括确定传感器的年龄，状况，水合和稳定性。

10. 发明申请

WO2005065542A3 REAL TIME SELF-ADJUSTING CALIBRATION ALGORITHM 审中-公开
标题翻译：实时自调整校准算法
公开(公告)号：WO2005065542A3
公开(公告)日：2005-12-29
申请号：PCT/US2004044086
申请日：2004-12-23
申请人： MEDTRONIC MINIMED INC , SHIN JOHN J , PATEL NANDITA N , KANDERIAN SAMI JR , WANG LU , YOON RICHARD
发明人： SHIN JOHN J , PATEL NANDITA N , KANDERIAN SAMI JR , WANG LU , YOON RICHARD
IPC分类号： A61B5/00
CPC分类号： A61B5/6849 , A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/6848 , A61B2560/0223 , A61M2005/1726
摘要： A method and a system for verifying the integrity of sensor data. Values are received (2100) from a sensor. A parameter related to the values is compared to a threshold (2110). For example the second-order derivative of the values may be compared to a threshold. Additional threshold violations are monitored for further values received from the sensor (2130). The receipt of data is terminated when two parameters exceed the threshold (2170). A method and a system for filtering data based on a quantifier of a variance derived from sensor data. The quantifier being used as input to an adaptive filter for filtering the sensor data. A method and a system for calibrating a sensor by determining the reliability of the sensor data, discarding data values that are unreliable, filtering the data values that have not been discarded and adjusting the output of the sensor using the filtered data values.
摘要翻译：一种用于验证传感器数据完整性的方法和系统。从传感器接收（2100）的值。将与值相关的参数与阈值进行比较（2110）。例如，值的二阶导数可以与阈值进行比较。监视从传感器（2130）接收的更多值的附加阈值违反。当两个参数超过阈值时，数据的接收被终止（2170）。一种基于从传感器数据导出的方差的量词来过滤数据的方法和系统。量化器被用作用于过滤传感器数据的自适应滤波器的输入。一种用于通过确定传感器数据的可靠性，丢弃不可靠的数据值，过滤未被丢弃的数据值并使用滤波后的数据值来调整传感器的输出的校准传感器的方法和系统。

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