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1. 发明申请

WO2008134146A1 CLOSED LOOP/SEMI-CLOSED LOOP THERAPY MODIFICATION SYSTEM 审中-公开
标题翻译：闭环/半闭环修复系统
公开(公告)号：WO2008134146A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/057807
申请日：2008-03-21
申请人： MEDTRONIC MINIMED, INC. , MASTROTOTARO, John J. , YOON, Richard K.
发明人： MASTROTOTARO, John J. , YOON, Richard K.
IPC分类号： A61B5/00 , A61M5/172
CPC分类号： A61M5/14244 , A61B5/14532 , A61B5/14865 , A61B5/4839 , A61B5/6848 , A61B5/6849 , A61M5/1582 , A61M5/1723 , A61M2205/3561 , A61M2205/3592
摘要： A closed loop/semi-closed loop infusion system provides therapy modification and safeguards against the over-delivery or under-delivery of insulin. A glucose sensor system is configured to obtain a measured blood glucose value. A controller is operationally connected with the glucose sensor system and configured to compare the measured blood glucose value to a target blood glucose value and adjust a therapy delivery parameter if the measured blood glucose value is not consistent with the target blood glucose value, wherein the adjusted therapy delivery parameter is limited to be within a boundary. Thereafter, a delivery system delivers therapy at the adjusted therapy delivery parameter.
摘要翻译：闭环/半闭环灌注系统提供治疗改变和防止胰岛素过量递送或递送不足的保护措施。葡萄糖传感器系统被配置为获得测量的血糖值。控制器与葡萄糖传感器系统可操作地连接，并且被配置为将所测量的血糖值与目标血糖值进行比较，并且如果所测量的血糖值与目标血糖值不一致则调整治疗递送参数，其中调整治疗传递参数被限制在边界内。此后，递送系统以调整的治疗递送参数递送治疗。

2. 发明申请

WO2008150633A2 WIRELESS MONITOR FOR A PERSONAL MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：用于个人医疗设备系统的无线监视器
公开(公告)号：WO2008150633A2
公开(公告)日：2008-12-11
申请号：PCT/US2008/063155
申请日：2008-05-09
申请人： MEDTRONIC MINIMED, INC. , RANKERS, Ulrich , ENEGREN, Bradley J. , GOTTLIEB, Rebecca K. , HAN, Jino , HOLTZCLAW, Kris R. , HONG, Peter I. , ISTOC, Emilian , MASTROTOTARO, John J. , MOBERG, Sheldon B. , TALBOT, Cary , WILLIAMS, Gary , HALPERN, Arieh S.
发明人： RANKERS, Ulrich , ENEGREN, Bradley J. , GOTTLIEB, Rebecca K. , HAN, Jino , HOLTZCLAW, Kris R. , HONG, Peter I. , ISTOC, Emilian , MASTROTOTARO, John J. , MOBERG, Sheldon B. , TALBOT, Cary , WILLIAMS, Gary , HALPERN, Arieh S.
IPC分类号： A61M5/00
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/411 , A61B5/7275 , A61M5/142 , A61M5/14244 , A61M5/172 , A61M2205/18 , A61M2205/3561 , A61M2205/3569 , A61M2205/3592 , A61M2205/502 , A61M2205/505 , A61M2209/01 , G06F19/00 , G06F19/3418 , G06F19/3468 , G16H40/63
摘要： A monitor device (200) for a fluid infusion system (100) and its operating, display, and data processing characteristics are described herein. One embodiment of the monitor device (200) is used in an insulin infusion system (100) having an insulin infusion pump (104) and a continuous glucose sensor transmitter (106). The monitor device (200) is configured as a wireless bedside monitor that wirelessly receives status data from a device in the fluid infusion system (100), such as the infusion pump (104) or the sensor transmitter (106). The monitor device (200) supports a number of user interface features, alarm/alert features, and graphical display features, where such features enhance the overall operation and user-friendliness of the monitor device (200). For example, the monitor device (200) can generate status icons that graphically indicate the time remaining for an exhaustible operating quantity of a device in the infusion system (e.g., a battery charge, a fluid reservoir volume, or a calibration or replacement period). The monitor device (200) can also estimate future measurements of a physiological characteristic of a monitored patient, based upon empirical measurement data received by the monitor device (200).
摘要翻译：本文描述了用于流体输注系统（100）的监视器装置（200）及其操作，显示和数据处理特性。监测装置（200）的一个实施例用于具有胰岛素输注泵（104）和连续葡萄糖传感器发射器（106）的胰岛素输注系统（100）中。监视器装置（200）被配置为从诸如输液泵（104）或传感器发射器（106）的流体输注系统（100）中的装置无线地接收状态数据的无线床旁监视器。监视器设备（200）支持许多用户界面特征，警报/警报特征和图形显示特征，其中这些特征增强了监视器设备（200）的整体操作和用户友好性。例如，监视设备（200）可以生成状态图标，其图形地指示输注系统中的设备的可耗费的操作量的剩余时间（例如，电池充电，流体存储器容积或校准或更换周期）。监视器装置（200）还可以基于由监视器装置（200）接收的经验测量数据来估计所监视患者的生理特征的未来测量。

3. 发明申请

WO2011084651A1 ANALYTE SENSORS COMPRISING BLENDED MEMBRANE COMPOSITIONS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：包含混合膜组合物的分析仪传感器及其制备和使用方法
公开(公告)号：WO2011084651A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060883
申请日：2010-12-16
申请人： MEDTRONIC MINIMED, INC. , WANG, Jenn-Hann Larry , DANG, Tri T. , COCHRAN, Brooks B. , MASTROTOTARO, John J. , SHAH, Rajiv
发明人： WANG, Jenn-Hann Larry , DANG, Tri T. , COCHRAN, Brooks B. , MASTROTOTARO, John J. , SHAH, Rajiv
IPC分类号： C12Q1/00
CPC分类号： G01N33/5438 , G01N27/307 , G01N33/54393
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a blended mixture of a linear polyurethane/polyurea polymer, and a branched acrylate polymer.
摘要翻译：本发明的实施方案提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。在本发明的某些实施方案中，传感器包括分析物调节膜，其包含线性聚氨酯/聚脲聚合物和支化丙烯酸酯聚合物的共混混合物。

4. 发明申请

WO2009058792A2 MODIFIED SENSOR CALIBRATION ALGORITHM 审中-公开
标题翻译：改进传感器校准算法
公开(公告)号：WO2009058792A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/081481
申请日：2008-10-28
申请人： MEDTRONIC MINIMED, INC. , MUELLER, John, C., Jr. , KEENAN, Desmond Barry , WANG, Lu , MASTROTOTARO, John J.
发明人： MUELLER, John, C., Jr. , KEENAN, Desmond Barry , WANG, Lu , MASTROTOTARO, John J.
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2560/0223
摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals, obtaining reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals, calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data, and calibrating the obtained glucose monitor data using the calibration characteristics. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered. Further, calibration techniques may be modified during a fast rate of change in the patient's blood glucose level to increase sensor accuracy.
摘要翻译：一种校准葡萄糖监测数据的方法包括以预定间隔在一段时间内收集葡萄糖监测数据，从参考源获取参考葡萄糖值，该参考源在时间上与以预定间隔获得的葡萄糖监测数据相对应，使用参考葡萄糖值和相应的葡萄糖监测数据，以回收所获得的葡萄糖监测数据，并使用校准特征校准获得的葡萄糖监测数据。在另外的实施例中，校准特性的计算包括线性回归，并且在特定实施例中包括最小二乘线性回归。或者，校准特性的计算包括非线性回归。可以验证数据完整性，并且可以对数据进行过滤。此外，可以在患者血糖水平的快速变化率期间修改校准技术以提高传感器精度。

5. 发明申请

WO2014035672A2 SAFEGUARDING TECHNIQUES FOR A CLOSED-LOOP INSULIN INFUSION SYSTEM 审中-公开
标题翻译：封闭式胰岛素输注系统的保护技术
公开(公告)号：WO2014035672A2
公开(公告)日：2014-03-06
申请号：PCT/US2013/054996
申请日：2013-08-14
申请人： MEDTRONIC MINIMED, INC.
发明人： MASTROTOTARO, John J. , GROSMAN, Benyamin , PARIKH, Neha J. , ROY, Anirban , KEENAN, Desmond Barry
IPC分类号： G06F19/00
CPC分类号： G06F19/3468 , A61B5/14532 , A61B5/1495 , A61B5/4839 , A61M5/14248 , A61M5/1723 , A61M2005/14208 , A61M2230/201 , G06F19/00
摘要： Processor-implemented methods of controlling an insulin infusion device for a user are provided here. A first method obtains and analyzes calibration factors (and corresponding timestamp data) for a continuous glucose sensor, and regulates entry into a closed-loop operating mode of the infusion device based on the calibration factors and timestamp data. A second method obtains a most recent sensor glucose value and a target glucose setpoint value for the user at the outset of the closed-loop mode. The second method adjusts the closed-loop insulin infusion rate over time, in response to the sensor glucose value and the setpoint value. A third method calculates an upper insulin limit that applies to the insulin infusion rate during the closed-loop mode. The insulin limit is calculated based on a fasting blood glucose value of the user, a total daily insulin value of the user, and fasting insulin delivery data for the user.
摘要翻译：这里提供了用于控制用户的胰岛素输注装置的处理器实现的方法。第一种方法获得和分析连续葡萄糖传感器的校准因子（和对应的时间戳数据），并且基于校准因子和时间戳数据来调节进入输注装置的闭环操作模式。第二种方法在闭环模式开始时获得用户最新的传感器葡萄糖值和目标葡萄糖设定值。第二种方法是响应于传感器葡萄糖值和设定点值来调整随时间推移的闭环胰岛素输注速率。第三种方法计算在闭环模式期间适用于胰岛素输注速率的胰岛素上限。基于用户的空腹血糖值，用户的总每日胰岛素值和用户的空腹胰岛素递送数据来计算胰岛素限制。

6. 发明申请

WO2014035570A2 SAFEGUARDING MEASURES FOR A CLOSED-LOOP INSULIN INFUSION SYSTEM 审中-公开
标题翻译：封闭式胰岛素输注系统的保护措施
公开(公告)号：WO2014035570A2
公开(公告)日：2014-03-06
申请号：PCT/US2013/051886
申请日：2013-07-24
申请人： MEDTRONIC MINIMED, INC.
发明人： KEENAN, Desmond Barry , MASTROTOTARO, John J. , GROSMAN, Benyamin , PARIKH, Neha J. , ROY, Anirban
IPC分类号： G06F19/00
CPC分类号： A61M5/1723 , A61B5/14503 , A61B5/14532 , A61B5/4839 , A61B5/746 , A61M5/172 , A61M2205/18 , A61M2205/502 , A61M2205/52 , A61M2205/582 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Processor-implemented methods of controlling an insulin infusion device for a user are provided here. A first method obtains a current insulin on board (IOB) value that estimates active insulin in the user, and compensates a calculated insulin infusion rate in response to the obtained IOB value. A second method supervises the operation of a glucose sensor by obtaining and processing insulin-delivered data and glucose sensor data for the user. An alert is generated if the second method determines that a current glucose sensor value has deviated from a predicted sensor glucose value by at least a threshold amount.
摘要翻译：这里提供了用于控制用户的胰岛素输注装置的处理器实现的方法。第一种方法获得当前用于估计用户中的活性胰岛素的船上胰岛素（IOB）值，并且根据获得的IOB值补偿计算的胰岛素输注速率。第二种方法通过获得和处理用户的胰岛素递送数据和葡萄糖传感器数据来监视葡萄糖传感器的操作。如果第二种方法确定当前的葡萄糖传感器值已经从预测的传感器葡萄糖值偏离了至少一个阈值量，则产生警报。

7. 发明申请

WO2015026579A1 MEDICAL DEVICES AND RELATED UPDATING METHODS AND SYSTEMS 审中-公开
标题翻译：医疗器械及相关更新方法与系统
公开(公告)号：WO2015026579A1
公开(公告)日：2015-02-26
申请号：PCT/US2014/050775
申请日：2014-08-12
申请人： MEDTRONIC MINIMED, INC.
发明人： MASTROTOTARO, John J. , KEENAN, Desmond Barry , GROSMAN, Benyamin , PARIKH, Neha J. , ROY, Anirban , KIM, Do
IPC分类号： G06F19/00
CPC分类号： G06F19/3468 , G06F19/00 , G16H40/40
摘要： Apparatus are provided for medical devices and related operating systems and methods. An exemplary medical device includes a motor, one or more data storage elements to maintain control information, and a control module coupled to the motor and the one or more data storage elements. The control module is configured to obtain updated control information via a peer-to-peer communication session over a network, store the updated control information in the one or more data storage elements, and thereafter operate the motor based at least in part on the updated control information.
摘要翻译：提供了用于医疗装置和相关操作系统和方法的装置。示例性医疗装置包括马达，用于维持控制信息的一个或多个数据存储元件，以及耦合到马达和一个或多个数据存储元件的控制模块。控制模块被配置为经由网络上的对等通信会话获得更新的控制信息，将更新的控制信息存储在一个或多个数据存储元件中，然后至少部分地基于更新的控制信息。

8. 发明申请

WO2006132899A2 VIRTUAL PATIENT SOFTWARE SYSTEM FOR EDUCATING AND TREATING INDIVIDUALS WITH DIABETES 审中-公开
标题翻译：用糖尿病教育和治疗个体的虚拟患者软件系统
公开(公告)号：WO2006132899A2
公开(公告)日：2006-12-14
申请号：PCT/US2006/021225
申请日：2006-06-01
申请人： MEDTRONIC MINIMED, INC.
发明人： STOCKER, David, N. , KANDERIAN, Jr., Sami , CORTINA, Gabriel J. , NITZAN, Tamir , PLUMMER, Jon , STEIL, Garry M. , MASTROTOTARO, John J.
CPC分类号： G16H50/50 , G06F19/00
摘要： A system to assist an individual in developing a therapy in diabetes treatment of a patient includes a user interface control module, a simulation engine, a charting and display module. The user interface control module receives an input related to the patient and captures a current time of the simulation. The simulation engine receives the input, generates a plurality of blood glucose readings for the patient up to the current time of the simulation based on the input, and to transfers the plurality of blood glucose readings. The charting and display module receives the plurality of blood glucose readings and display the plurality of blood glucose readings. The simulation engine receives patient parameters from a patient parameter library based on a selected patient model.
摘要翻译：帮助个体开发患者糖尿病治疗的治疗系统包括用户界面控制模块，模拟引擎，图表和显示模块。用户接口控制模块接收与患者相关的输入并捕捉模拟的当前时间。模拟引擎接收输入，基于输入，生成直到模拟的当前时间的患者的多个血糖读数，并传送多个血糖读数。制图和显示模块接收多个血糖读数并显示多个血糖读数。模拟引擎基于所选择的患者模型从患者参数库接收患者参数。

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