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1. 发明申请

WO2012169973A1 A CORE-SHELL NANOPARTICLE 审中-公开
标题翻译：核心纳米粒子
公开(公告)号：WO2012169973A1
公开(公告)日：2012-12-13
申请号：PCT/SG2012/000210
申请日：2012-06-11
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie, Y , WANG, Yong , ERATHODIYIL, Nandanan , IBRAHIM, Nor Lizawati
发明人： YING, Jackie, Y , WANG, Yong , ERATHODIYIL, Nandanan , IBRAHIM, Nor Lizawati
IPC分类号： A61K9/51 , A61K31/704 , A61K49/06 , A61P35/00
CPC分类号： A61K31/704 , A61K9/5115 , A61K9/513 , A61K47/58 , A61K47/6923 , A61K47/6925 , A61K49/1854 , B82Y5/00
摘要： A core-shell nanoparticle for drug delivery comprising a polymeric shell encapsulating core comprising a drug and an imaging agent.
摘要翻译：用于药物递送的核 - 壳纳米颗粒，其包含包含药物和成像剂的聚合物壳包封芯。

2. 发明申请

WO2011043738A3 DELIVERY OF BMP-7 AND METHODS OF USE THEREOF 审中-公开
标题翻译： BMP-7的递送及其使用方法
公开(公告)号：WO2011043738A3
公开(公告)日：2011-06-03
申请号：PCT/SG2010000380
申请日：2010-10-06
申请人： AGENCY SCIENCE TECH & RES , ZINK DANIELE , YING JACKIE Y , CHOW EDWIN PEI YONG , TASNIM FARAH
发明人： ZINK DANIELE , YING JACKIE Y , CHOW EDWIN PEI YONG , TASNIM FARAH
IPC分类号： A61K38/18
CPC分类号： A61K38/1875 , A61M1/3489 , C12N5/0686 , C12N2501/155
摘要： The present invention generally relates to delivery of BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist and methods of use thereof. In some embodiments, methods and devices are provided for delivery of BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist to a patient. In some cases, the BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be released in controlled fashion from a device in fluid communication with a patient. In some embodiments, the BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be expressed by cells within a device. In other embodiments, methods are provided for improving the function of devices containing renal proximal tubule cells. For example, in some embodiments, exposure of renal proximal tubule cells to BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be used to inhibit disruption of cell layers comprising renal proximal tubule cells. In another embodiment, exposure of renal proximal tubule cells to BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be used to inhibit trans- and de-differentiation of renal proximal tubule cells. In another embodiment, exposure of renal proximal tubule cells to BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be used to improve renal proximal tubule cell functions.
摘要翻译：本发明一般涉及BMP-7或功能变体或其功能片段和/或BMP-7激动剂的递送及其使用方法。在一些实施方案中，提供方法和装置用于向患者递送BMP-7或功能变体或其功能性片段和/或BMP-7激动剂。在一些情况下，BMP-7或其功能变体或功能片段和/或BMP-7激动剂可以以受控的方式从与患者流体连通的装置释放。在一些实施方案中，BMP-7或其功能变体或功能片段和/或BMP-7激动剂可以由器件内的细胞表达。在其他实施方案中，提供了用于改善含有肾近端小管细胞的装置功能的方法。例如，在一些实施方案中，肾近端小管细胞暴露于BMP-7或功能变体或其功能性片段和/或BMP-7激动剂可用于抑制包含肾近端小管细胞的细胞层的破坏。在另一个实施方案中，肾近端小管细胞暴露于BMP-7或功能变体或其功能片段和/或BMP-7激动剂可用于抑制肾近端小管细胞的反式和去分化。在另一个实施方案中，肾近端小管细胞暴露于BMP-7或功能变体或其功能片段和/或BMP-7激动剂可用于改善肾近端小管细胞功能。

3. 发明申请

WO2010053443A1 APPARATUS FOR BIOPOLYMER SYNTHESIS 审中-公开
标题翻译：用于生物聚合物合成的装置
公开(公告)号：WO2010053443A1
公开(公告)日：2010-05-14
申请号：PCT/SG2008/000426
申请日：2008-11-06
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , LI, Mo-Huang , YING, Jackie Y. , KUAN, Yoke Kong , CHEONG, Wai Chye
发明人： LI, Mo-Huang , YING, Jackie Y. , KUAN, Yoke Kong , CHEONG, Wai Chye
IPC分类号： C40B60/14 , C40B80/00 , C12Q1/68
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00317 , B01J2219/00423 , B01J2219/00621 , B01J2219/00626 , B01J2219/00644 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/50255 , C40B60/14
摘要： The present invention relates to an apparatus for biopolymer synthesis wherein said apparatus comprises at least one support having a plurality of microwells and wherein said microwells comprise a porous substrate providing a surface area for biopolymer synthesis.
摘要翻译：本发明涉及用于生物聚合物合成的装置，其中所述装置包括具有多个微孔的至少一个支撑体，并且其中所述微孔包括提供用于生物聚合物合成的表面积的多孔基底。

4. 发明申请

WO2009108138A1 HYDRODYNAMIC SPINNING OF POLYMER FIBER IN COAXIAL LAMINAR FLOWS 审中-公开
标题翻译：聚合纤维在同轴层流中的水动力纺丝
公开(公告)号：WO2009108138A1
公开(公告)日：2009-09-03
申请号：PCT/SG2009/000078
申请日：2009-03-02
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie Y. , HU, Min , DENG, Rensheng , SCHUMACHER, Karl , KURISAWA, Motoichi
发明人： YING, Jackie Y. , HU, Min , DENG, Rensheng , SCHUMACHER, Karl , KURISAWA, Motoichi
IPC分类号： D01D5/06
CPC分类号： D01D5/28 , A61L27/52 , D01D5/24 , D01D5/38
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
摘要翻译：聚合物纤维通过流体动力纺丝形成。流体被迫流过导管以形成包括三层或更多层大体上同轴的流体流的层流，其各自的流速被选择为限定流体流的管状中间层的横截面。中间层包含可交联的聚合物前体。流体流的另一层包含交联剂。选择聚合物前体，交联剂和流体以防止聚合物前体远离中间层的实质性扩散，并且允许一部分交联剂从另一层扩散到中间层以促进交叉在中间层中连接聚合物前体以在聚合物纤维中形成管状聚合物层。聚合物层因此具有一般对应于中间层的横截面的横截面。

5. 发明申请

WO2009108125A1 GOLD NANOPARTICLES 审中-公开
标题翻译：黄金纳米粒子
公开(公告)号：WO2009108125A1
公开(公告)日：2009-09-03
申请号：PCT/SG2009/000063
申请日：2009-02-23
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , ZHANG, Yugen , YING, Jackie, Y. , ZHAO, Lan
发明人： ZHANG, Yugen , YING, Jackie, Y. , ZHAO, Lan
IPC分类号： B82B3/00 , B22F9/16 , C01G7/00 , C22B11/00
CPC分类号： C22B5/00 , B22F1/0022 , B22F9/24 , B22F2009/245 , B82Y30/00 , B82Y40/00 , C22B11/04 , C30B7/14 , C30B29/02 , C30B29/60
摘要： Gold nanoparticles are prepared by combining a gold salt, an N,N'-disubstituted imidazolium salt and a thiol.
摘要翻译：通过组合金盐，N，N'-二取代咪唑鎓盐和硫醇制备金纳米颗粒。

6. 发明申请

WO2009085017A1 MESOPOROUS NANOSTRUCTURES 审中-公开
标题翻译：多孔纳米结构
公开(公告)号：WO2009085017A1
公开(公告)日：2009-07-09
申请号：PCT/SG2009/000003
申请日：2009-01-05
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, JACKIE Y , HAN, YU , CHNG, LENG LENG , ZHAO, LAN
发明人： YING, JACKIE Y , HAN, YU , CHNG, LENG LENG , ZHAO, LAN
IPC分类号： C01B33/12 , C01B37/02
CPC分类号： C01B37/00 , C01B37/02
摘要： The invention provides a process for making a particulate mesoporous material. A solution comprising a surfactant and a base is combined with a hydrolysable precursor without agitating said solution. The resulting mixture is then allowed to stand without externally applied agitation for sufficient time for hydrolysis of the precursor to form the particulate mesoporous material.
摘要翻译：本发明提供一种制备颗粒介孔材料的方法。将包含表面活性剂和碱的溶液与可水解的前体组合而不搅拌所述溶液。然后将所得混合物在不经外部搅拌的情况下静置足够的时间用于水解前体以形成颗粒介孔材料。

7. 发明申请

WO2009072990A1 METHOD FOR EXTRACELLULAR MATRIX MEDIATED DIFFERENTIATION AND PROLIFERATION OF STEM CELLS 审中-公开
标题翻译：超细胞基质介导的分化和干细胞增殖的方法
公开(公告)号：WO2009072990A1
公开(公告)日：2009-06-11
申请号：PCT/SG2008/000467
申请日：2008-12-05
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie Y. , WAN, Andrew Chwee Aun , NARAYANAN, Karthikeyan , SCHUMACHER, Karl M.
发明人： YING, Jackie Y. , WAN, Andrew Chwee Aun , NARAYANAN, Karthikeyan , SCHUMACHER, Karl M.
IPC分类号： C12N5/08 , C12N5/02 , C12N5/06
CPC分类号： C12N5/0606 , C12N5/0663 , C12N2502/13 , C12N2502/22 , C12N2502/256 , C12N2533/90
摘要： There is provided a method of culturing a stem cell on extracellular matrix extracted from support cells and in a stem cell culture medium comprising medium conditioned by the support cells
摘要翻译：提供了一种培养从支持细胞提取的细胞外基质上的干细胞的方法，以及包含由支持细胞调节的培养基的干细胞培养基

8. 发明申请

WO2009072987A1 INTEGRATED APPARATUS FOR CONDUCTING AND MONITORING CHEMICAL REACTIONS 审中-公开
标题翻译：用于导电和监测化学反应的综合装置
公开(公告)号：WO2009072987A1
公开(公告)日：2009-06-11
申请号：PCT/SG2008/000425
申请日：2008-11-06
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie Y. , HSIEH, Tseng-Ming , LOH, Jeremy Ming Hock , ZHANG, Chunyan
发明人： YING, Jackie Y. , HSIEH, Tseng-Ming , LOH, Jeremy Ming Hock , ZHANG, Chunyan
IPC分类号： G01N21/75 , G01N21/03 , G01N35/00
CPC分类号： B01L3/50851 , B01J2219/00283 , B01J2219/00306 , B01J2219/00495 , B01J2219/00576 , B01J2219/00585 , B01J2219/00704 , B01J2219/00722 , B01L7/52 , B01L2300/0654 , B01L2300/1822 , B01L2300/1827 , G01N21/03 , G01N2021/0346
摘要： Apparatus for conducting and monitoring chemical reactions comprises a base and a thermal cycler mounted on the base. A plurality of heat-conducting receptacles are mounted on the thermal cycler and in heat-communication therewith. Each receptacle comprises an opaque body defining a bore having an open end, a first window, and a second window. A cartridge is removably mounted on the receptacles. The cartridge comprises a plurality of light-transmitting reaction vessels, and conduits connected to the reaction vessels for processing and transferring fluid. The reaction vessels are received in the bores of the receptacles through the open ends of the bores. A light emitter is mounted on the base for illuminating the reaction vessels through the first windows of the reaction vessels. A light detector is mounted on the base for selectively receiving and detecting light emitted from the reaction vessels through the second windows of the receptacles.
摘要翻译：用于进行和监测化学反应的装置包括安装在基座上的底座和热循环仪。多个导热容器安装在热循环仪上并与其热连通。每个容器包括限定具有开口端，第一窗口和第二窗口的孔的不透明体。容器可拆卸地安装在容器上。盒包括多个透光反应容器和连接到反应容器的管道，用于处理和传送流体。反应容器通过孔的开口端容纳在容器的孔中。光发射器安装在基座上，用于通过反应容器的第一窗口照亮反应容器。光检测器安装在基座上，用于通过容器的第二窗口选择性地接收和检测从反应容器发射的光。

9. 发明申请

WO2009054814A1 FUNCTIONALIZED POLY (3,4-ALKYLENEBRIDGEDTHIOPHENE) (PABT) 审中-公开
标题翻译：官能化聚（3,4-亚烷基二乙二醇）（PABT）
公开(公告)号：WO2009054814A1
公开(公告)日：2009-04-30
申请号：PCT/SG2008000412
申请日：2008-10-24
申请人： AGENCY SCIENCE TECH & RES , YING JACKIE Y , YU HSIAO-HUA , LUO SHYH-CHYANG , XIE HONG , KANTCHEV ERIC ASSEN B
发明人： YING JACKIE Y , YU HSIAO-HUA , LUO SHYH-CHYANG , XIE HONG , KANTCHEV ERIC ASSEN B
IPC分类号： C08G61/12 , C07D495/02 , C07D495/08 , C09C1/62 , C09C3/10 , C09D5/24 , G01N33/543
CPC分类号： C08G61/126 , B82Y30/00 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C09C1/3072 , C09C3/10 , G01N33/54346
摘要： A functionalized poly (3, 4-alkylenebridgedthiophene) (PABT) polymer of formula (I) : where Ai is a bridging alkylene chain; Y1 and Y2 J are, independently, O, S or N-R2, where R2 is hydrogen, an alkyl group, alkenyl group, alkynyl group, a cycloalkyl, an aryl or heterocycle; and R1 is a functional chain attached to the bridging alkylene chain, are described. In addition, a process for their preparation and a method for depositing functionalized PABT polymers on non-conductive support matrix or nanoparticle are described. These polymers are useful in the preparation of bionanointerfaces.
摘要翻译：式（I）的官能化聚（3,4-亚烷基亚乙烯基噻吩）（PABT）聚合物：其中A 1是桥连亚烷基链; Y 1和Y 2独立地是O，S或N-R 2，其中R 2是氢，烷基，烯基，炔基，环烷基，芳基或杂环; 并描述了R1是连接到桥连亚烷基链的功能链。此外，描述了其制备方法和在非导电载体基质或纳米颗粒上沉积官能化的PABT聚合物的方法。这些聚合物可用于制备生物纳米结构。

10. 发明申请

WO2009054813A1 METHOD OF DELIVERING AN ANTI-CANCER AGENT TO A CELL 审中-公开
标题翻译：将抗癌剂递送至细胞的方法
公开(公告)号：WO2009054813A1
公开(公告)日：2009-04-30
申请号：PCT/SG2008/000409
申请日：2008-10-23
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie Y. , CHUNG, Joo Eun , KURISAWA, Motoichi
发明人： YING, Jackie Y. , CHUNG, Joo Eun , KURISAWA, Motoichi
IPC分类号： A61K47/48 , A61K39/395 , C08B37/08 , A61K31/353 , C08G65/331
CPC分类号： A61K31/353 , A61K9/1075 , A61K39/39558 , A61K47/6919 , A61K2039/505 , B82Y5/00 , C08B37/0072 , C08G65/3317 , C08G65/3326 , C08L2203/02
摘要： There is provided a delivery vehicle comprising an anti-cancer agent together with a conjugate of a delivery agent containing a free aldehyde and a flavonoid, having the delivery agent conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. The resulting delivery vehicles may be used to deliver an anti-cancer agent to a cell.
摘要翻译：提供了一种递送载体，其包含抗癌剂以及含有游离醛和类黄酮的递送剂的缀合物，其具有在类黄酮的A环的C 6和/或C 8位缀合的递送剂。所得到的递送载体可用于将抗癌剂递送至细胞。

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