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1. 发明申请

WO2011059409A1 OBTAINING DATA FOR AUTOMATIC GLAUCOMA SCREENING, AND SCREENING AND DIAGNOSTIC TECHNIQUES AND SYSTEMS USING THE DATA 审中-公开
标题翻译：获取用于自动GLAUCOMA筛选的数据，以及使用数据的筛选和诊断技术和系统
公开(公告)号：WO2011059409A1
公开(公告)日：2011-05-19
申请号：PCT/SG2010/000434
申请日：2010-11-16
申请人： LIU, Jiang , ZHANG, Zhuo , WONG, Wing, Kee, Damon , TAN, Ngan, Meng , YIN, Fengshou , LEE, Beng Hai , LI, Huiqi , LIM, Joo, Hwee , CHEUNG, Carol , AUNG, Tin , WONG, Tien, Yin , LIANG, Ziyang , CHENG, Jun , MANI, Baskaran
发明人： LIU, Jiang , ZHANG, Zhuo , WONG, Wing, Kee, Damon , TAN, Ngan, Meng , YIN, Fengshou , LEE, Beng Hai , LI, Huiqi , LIM, Joo, Hwee , CHEUNG, Carol , AUNG, Tin , WONG, Tien, Yin , LIANG, Ziyang , CHENG, Jun , MANI, Baskaran
IPC分类号： A61B3/12
CPC分类号： A61B3/0025 , A61B3/12 , A61B5/02007 , A61B5/7264 , A61B5/7267 , A61B5/7275 , G06T7/0012 , G06T7/40 , G06T2207/30041
摘要： A non-stereo fundus image is used to obtain a plurality of glaucoma indicators. Additionally, genome data for the subject is used to obtain genetic marker data relating to one or more genes and/or SNPs associated with glaucoma. The glaucoma indicators and genetic marker data are input into an adaptive model operative to generate an output indicative of a risk of glaucoma in the subject. In combination, the genetic indicators and genome data are more informative about the risk of glaucoma than either of the two in isolation. The adaptive model may be a two-stage model, having a first stage in which individual genetic indicators are combined with respective portions of the genome data by first adaptive model modules to form respective first outputs, and a second stage in which the first outputs are combined by a second adaptive mode. Texture analysis is performed on the fundus images to classify them based on their quality, and only images which are determined to meet a quality criterion are subjected to an analysis to determine if they exhibit glaucoma indicators. Also, the images are put into a standard format. The system may include estimating the position of the optic cup by combining results from multiple optic cup segmentation techniques. The system may include estimating the position of the optic disc by applying edge detection to the funds image, excluding edge points that are unlikely to be optic disc boundary points, and estimating the position of an optic disc by fitting an ellipse to the remaining edge points.
摘要翻译：使用非立体眼底图像来获得多个青光眼指示符。此外，用于受试者的基因组数据用于获得与与青光眼相关的一个或多个基因和/或SNP相关的遗传标记数据。青光眼指标和遗传标记数据被输入到适应模型中，该模型用于产生指示受试者青光眼风险的输出。综合来看，遗传指标和基因组数据对于青光眼的风险比孤立的两者之一更有信息。自适应模型可以是两阶段模型，其具有第一阶段，其中通过第一自适应模型模块将个体遗传指标与基因组数据的相应部分组合以形成相应的第一输出，第二阶段中，第一输出是通过第二自适应模式组合。对眼底图像进行纹理分析，根据其质量对其进行分类，仅对满足质量标准的图像进行分析，以确定其是否呈现青光眼指标。此外，图像被放入标准格式。该系统可以包括通过组合来自多个光学杯分割技术的结果来估计光学杯的位置。该系统可以包括通过对资金图像应用边缘检测来估计视盘的位置，不包括不太可能是视盘边界点的边缘点，以及通过将椭圆拟合到剩余边缘点来估计视盘的位置。

2. 发明申请

WO2012030304A1 A ROBOTIC DEVICE FOR USE IN IMAGE-GUIDED ROBOT ASSISTED SURGICAL TRAINING 审中-公开
标题翻译：用于图像引导机器人辅助手术训练的机器人装置
公开(公告)号：WO2012030304A1
公开(公告)日：2012-03-08
申请号：PCT/SG2011/000302
申请日：2011-09-01
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY HOSPITAL (S) PTE LTD , NATIONAL UNIVERSITY OF SINGAPORE , YANG, Tao , YANG, Liangjing , LIU, Jiang , CHUI, Chee Kong , HUANG, Weimin , ZHANG, Jing , ZHOU, Jiayin , LEE, Beng Hai , TAN, Ngan Meng , WONG, Wing Kee Damon , YIN, Fengshou , CHANG, Kin Yong , SU, Yi
发明人： YANG, Tao , YANG, Liangjing , LIU, Jiang , CHUI, Chee Kong , HUANG, Weimin , ZHANG, Jing , ZHOU, Jiayin , LEE, Beng Hai , TAN, Ngan Meng , WONG, Wing Kee Damon , YIN, Fengshou , CHANG, Kin Yong , SU, Yi
IPC分类号： G09B23/28 , B25J9/00 , B25J3/04 , B25J7/00 , A61B19/00 , G09B9/00
CPC分类号： G09B23/28 , A61B34/30 , B25J3/04 , B25J7/00 , G09B23/285
摘要： A robotic device for use in image-guided robot assisted surgical training, the robotic device comprising a manual interface structure configured to simulate handling of a surgical tool; a translational mechanism for translational motion of the manual interface structure; a rotational mechanism for rotational motion of the manual interface structure; and a spherical mechanism configured to decouple the orientation of the manual interface structure into spatial coordinates, wherein a linkage between the rotational mechanism, the rotational mechanism and the spherical mechanism, and the manual interface structure are disposed on opposing sides of an intersection of a pitch axis and a yaw axis of the spherical mechanism.
摘要翻译：一种用于图像引导机器人辅助外科手术训练的机器人装置，所述机器人装置包括被配置为模拟外科手术工具的处理的手动界面结构; 手动界面结构的平移运动的平移机制; 用于手动接口结构的旋转运动的旋转机构; 以及球面机构，被配置为将手动界面结构的取向分离成空间坐标，其中旋转机构，旋转机构和球面机构之间的联动以及手动界面结构设置在俯仰的交叉点的相对侧上轴和球面机构的偏转轴。

3. 发明申请

WO2011108994A1 ROBOT ASSISTED SURGICAL TRAINING 审中-公开
标题翻译：机器人辅助手术训练
公开(公告)号：WO2011108994A1
公开(公告)日：2011-09-09
申请号：PCT/SG2011/000087
申请日：2011-03-04
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , NATIONAL UNIVERSITY HOSPITAL (S) PTE LTD , HUANG, Weimin , LIU, Jiang , ZHOU, Jiayin , ZHANG, Jing , LEE, Beng Hai , WONG, Wing Kee, Damon , TAN, Ngan Meng , ZHANG, Zhou , YIN, Fengshou , CHANG, Stephen , CHUI, Chee Kong , SU, Yi
发明人： HUANG, Weimin , LIU, Jiang , ZHOU, Jiayin , ZHANG, Jing , LEE, Beng Hai , WONG, Wing Kee, Damon , TAN, Ngan Meng , ZHANG, Zhou , YIN, Fengshou , CHANG, Stephen , CHUI, Chee Kong , SU, Yi
IPC分类号： G09B9/00 , G09B23/28
CPC分类号： G09B23/28 , G06F19/00 , G09B23/30
摘要： A surgical training system and method. The system comprises means for recording reference data representing a reference manipulation of a computer generated model of an object by a master user; means for physically guiding a trainee user based on the recorded reference data during a training manipulation of the model of the object by the trainee user; and means for recording assessment data representing an assessment manipulation of the model of the object by the trainee user without guidance.
摘要翻译：外科手术训练系统及方法该系统包括用于记录表示由主用户计算机生成的对象的模型的参考操纵的参考数据的装置; 用于在由所述受训用户对所述对象的模型的训练操纵期间基于所记录的参考数据物理地引导所述受训用户的装置; 以及用于在没有指导的情况下记录代表对象的模型的评估操纵的评估数据的方法。

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