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1. 发明申请

WO2006014349A3 METHOD OF PRODUCING FULLY CARBAMYLATED ERYTHROPOIETIN 审中-公开
标题翻译：生产完全氨基甲酰化红细胞生成素的方法
公开(公告)号：WO2006014349A3
公开(公告)日：2006-07-20
申请号：PCT/US2005023505
申请日：2005-07-01
申请人： KENNETH S WARREN INST INC , CERAMI ANTHONY , HAND CARLA CERAMI , XIE QIAO WEN , BRINES MICHAEL
发明人： BRINES MICHAEL
IPC分类号： A61K38/00
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to a method of carbamylating an erythropoietin such that the resulting carbamylated erythropoietin has less that about 10% free primary amines on the lysines and the N-terminal amino acids, is not digested when exposed to Lys-C proteolysis, exhibits no erythropoietic activity in a TF-1 or UT-7/EPOR cell viability assay at a concentration of 1 µg/ml, and demonstrates a static sciatic index of less than about .65 within a Sciatic Nerve Assay. Additionally, the invention is related to pharmaceutical compositions containing carbamylated erythropoietins of the invention and the use of the pharmaceutical compositions for the treatment of conditions and diseases of excitable tissues.
摘要翻译：本发明涉及使促红细胞生成素氨基甲酰化的方法，使得所得的氨基甲酰化促红细胞生成素具有少于赖氨酸上约10％的游离伯胺和N端氨基酸，当暴露于Lys-C蛋白水解时不被消化，在浓度为1μg/ ml的TF-1或UT-7 / EPOR细胞活力测定中的促红细胞生成活性，并且在坐骨神经分析中显示小于约.65的静态坐骨指数。此外，本发明涉及含有本发明的氨基甲酰化促红细胞生成素的药物组合物以及该药物组合物用于治疗可兴奋组织的病症和疾病的用途。

2. 发明申请

WO2006014466A2 NOVEL CARBAMYLATED EPO AND METHOD FOR ITS PRODUCTION 审中-公开
标题翻译：新型的CARBAMYLATED EPO及其生产方法
公开(公告)号：WO2006014466A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/023910
申请日：2005-07-01
申请人： THE KENNETH S. WARREN INSTITUTE, INC. , LUNDBECK, H., A/S , BRINES, Michael , CERAMI, Anthony , HAND, Carla, Cerami , XIE, Qiao-wen , CHRISTENSEN, Soren , FOLDAGER, J , VLABJORN, M., H. , THEUSEN, A., H. , PEDERSEN, M. , MUNK, M.
发明人： BRINES, Michael , CERAMI, Anthony , HAND, Carla, Cerami , XIE, Qiao-wen , CHRISTENSEN, Soren , FOLDAGER, J , VLABJORN, M., H. , THEUSEN, A., H. , PEDERSEN, M. , MUNK, M.
IPC分类号： C12N14/505
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention comprises an optimal process for carbamylation yielding a product with a low degree of polymerisation and aggregation. The fully carbamylated erythropoietin with all of the N-terminal and all lysine residues was obtained. The resulting fully carbamylated pure EPO is along with pharmaceutical compositions comprising the compound are part of the invention.
摘要翻译：本发明包括用于氨甲酰化产生具有低聚合度和聚集度的产物的最佳方法。获得具有所有N-末端和所有赖氨酸残基的完全氨基甲酰化促红细胞生成素。得到的完全氨基甲酰化的纯EPO与包含该化合物的药物组合物一起是本发明的一部分。

3. 发明申请

WO03020161A3 IMMUNE MODULATION DEVICE FOR USE IN ANIMALS 审中-公开
标题翻译：用于动物的免疫调节装置
公开(公告)号：WO03020161A3
公开(公告)日：2003-06-05
申请号：PCT/US0214759
申请日：2002-05-09
申请人： APPLIED VACCINE TECHNOLOGIES C , CERAMI ANTHONY , CERAMI CARLA , XIE QIAO-WEN , TENHUISEN KEVOR S , ROSENBLATT JOEL , KOYFMAN ILYA S
发明人： CERAMI ANTHONY , CERAMI CARLA , XIE QIAO-WEN , TENHUISEN KEVOR S , ROSENBLATT JOEL , KOYFMAN ILYA S
IPC分类号： A61K9/00 , A61K9/16 , A61K35/14 , A61K38/00 , A61K39/00 , C07K14/00 , C12N5/06 , C12Q1/06 , G01N33/53 , G01N33/543 , A61K45/05
CPC分类号： A61K9/0024 , A61K9/1641 , A61K9/1647 , Y10T442/2525
摘要： The present invention is directed to an implantable immune modulation device (Figure 1) that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell. The fiber filling is loaded with single or multiple antigens, and optionally one or more biologically active compounds such as cytokines (e.g. lymphokines, chemokines etc.), attachment factors, genes, peptides, proteins, nucleotides, carbohydrates or cells depending on the application.
摘要翻译：本发明涉及可用于在多孔壳内调节包含多种纤维的哺乳动物的免疫应答的可植入免疫调节装置（图1）。取决于应用，纤维填充物装载有单个或多个抗原，以及任选地一种或多种生物活性化合物，例如细胞因子（例如淋巴因子，趋化因子等），附着因子，基因，肽，蛋白质，核苷酸，碳水化合物或细胞。

4. 发明申请

WO2003020161A2 IMMUNE MODULATION DEVICE FOR USE IN ANIMALS 审中-公开
标题翻译：用于动物的免疫调节装置
公开(公告)号：WO2003020161A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/014759
申请日：2002-05-09
申请人： APPLIED VACCINE TECHNOLOGIES CORP. , TENHUISEN, Kevor, S. , ROSENBLATT, Joel , KOYFMAN, Ilya, S. , CERAMI, Anthony , CERAMI, Carla , XIE, Qiao-wen
发明人： TENHUISEN, Kevor, S. , ROSENBLATT, Joel , KOYFMAN, Ilya, S. , CERAMI, Anthony , CERAMI, Carla , XIE, Qiao-wen
IPC分类号： A61D
CPC分类号： A61K9/0024 , A61K9/1641 , A61K9/1647 , Y02A50/475 , Y02A50/48 , Y10T442/2525
摘要： The present invention is directed to an implantable immune modulation device that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell. The fiber filling is loaded with single or multiple antigens, and optionally one or more biologically active compounds such as cytokines ( e.g. lymphokines, chemokines etc.), attachment factors, genes, peptides, proteins, nucleotides, carbohydrates or cells depending on the application.
摘要翻译：本发明涉及可植入免疫调节装置（图1），其可用于在多孔壳内调节包含多个纤维的哺乳动物中的免疫应答。根据应用，纤维填充物装载有单个或多个抗原，以及任选的一种或多种生物活性化合物，例如细胞因子（例如淋巴因子，趋化因子等），附着因子，基因，肽，蛋白质，核苷酸，碳水化合物或细胞。

5. 发明申请

WO2002062301A2 METHOD AND COMPOSITION FOR REJUVINATING CELLS, TISSUES, ORGANS, HAIR AND NAILS 审中-公开
标题翻译：用于增强细胞，组织，器官，毛发和钉的方法和组合物
公开(公告)号：WO2002062301A2
公开(公告)日：2002-08-15
申请号：PCT/US2002/003714
申请日：2002-02-07
申请人： FARRINGTON PHARMACEUTICALS, LLC , ULRICH, Peter, C. , FANG, Sheng, Ding , BRINES, Michael , XIE, Qiao, Wen , CERAMI, Anthony
发明人： ULRICH, Peter, C. , FANG, Sheng, Ding , BRINES, Michael , XIE, Qiao, Wen , CERAMI, Anthony
IPC分类号： A61K
CPC分类号： C07D213/20 , A61K8/49 , A61K8/4986 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61Q3/00 , A61Q3/02 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q19/08 , A61Q19/10 , C07D213/50 , C07D213/57 , C07D213/73 , C07D231/12 , C07D233/54 , C07D233/56 , C07D233/64 , C07D239/26 , C07D239/42 , C07D249/08 , C07D277/22 , C07D277/24 , C07D277/84 , C07D417/06 , C07D487/04 , C07D513/04
摘要： In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue fissuion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.
摘要翻译：在一个实施方案中，本发明涉及包含药物组合物的化合物和组合物，所述药物组合物包含解偶联蛋白质，脂质，核酸和其他生物材料的糖介导的偶联的化合物和相关方法，以及任何组合它们。在另一个实施方案中，当生物体内部暴露于化合物或组合物时，通过摄入，透皮施用或其他方式，组合物和相关方法在体内可用于减少糖介导的偶联过程在生物体中的有害作用。在又一个实施方案中，所述组合物和相关方法可用于器官，细胞和组织的离体治疗以及毛发，指甲和皮肤的外部治疗，以通过改变可变形性并增加组织裂隙系数来使它们复原。在另一个实施方案中，本发明涉及新化合物和药物组合物。

6. 发明申请

WO02062301A3 METHOD AND COMPOSITION FOR REJUVINATING CELLS, TISSUES, ORGANS, HAIR AND NAILS 审中-公开
标题翻译：重组细胞，组织，器官，头发和指甲的方法和组合
公开(公告)号：WO02062301A3
公开(公告)日：2002-10-17
申请号：PCT/US0203714
申请日：2002-02-07
申请人： FARRINGTON PHARMACEUTICALS LLC , ULRICH PETER C , FANG SHENG DING , BRINES MICHAEL , XIE QIAO WEN , CERAMI ANTHONY
发明人： ULRICH PETER C , FANG SHENG DING , BRINES MICHAEL , XIE QIAO WEN , CERAMI ANTHONY
IPC分类号： C07D233/60 , A61K8/49 , A61K31/415 , A61K31/4174 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/44 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/519 , A61K31/535 , A61K31/5377 , A61K31/5383 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/02 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/02 , A61P25/28 , A61P27/02 , A61P27/12 , A61P27/16 , A61P43/00 , A61Q3/00 , A61Q3/02 , A61Q5/00 , A61Q5/12 , A61Q19/00 , A61Q19/08 , C07D213/20 , C07D213/50 , C07D213/57 , C07D213/73 , C07D233/54 , C07D239/26 , C07D239/42 , C07D265/36 , C07D277/22 , C07D277/24 , C07D277/84 , C07D417/06 , C07D487/04 , C07D498/02 , C07D513/04 , C07D521/00 , C07D213/02 , C07D239/02 , C07D277/20 , C07D277/30 , C07D277/60 , C07D401/00 , C07D403/02 , C07D413/02 , C07D417/00
CPC分类号： C07D213/20 , A61K8/49 , A61K8/4986 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61Q3/00 , A61Q3/02 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q19/08 , A61Q19/10 , C07D213/50 , C07D213/57 , C07D213/73 , C07D231/12 , C07D233/54 , C07D233/56 , C07D233/64 , C07D239/26 , C07D239/42 , C07D249/08 , C07D277/22 , C07D277/24 , C07D277/84 , C07D417/06 , C07D487/04 , C07D513/04
摘要： In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue fissuion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.
摘要翻译：在一个实施方案中，本发明涉及包含药物组合物的化合物和组合物，所述药物组合物含有化合物和解离糖介导的蛋白质，脂质，核酸和其他生物材料偶联的相关方法及其任何组合。在另一个实施方案中，组合物和相关方法在体内通过摄入，经皮施用或其它方式在生物体内部暴露于化合物或组合物时，有效地降低糖介导的生物体中的偶联过程的有害作用。在另一个实施方案中，组合物和相关方法可用于器官，细胞和组织的离体处理以及毛发，指甲和皮肤的外部治疗，以通过改变变形性和增加组织裂隙系数来使其恢复活力。在另一个实施方案中，本发明涉及新化合物和药物组合物。

7. 发明申请

WO2006014466A3 NOVEL CARBAMYLATED EPO AND METHOD FOR ITS PRODUCTION 审中-公开
标题翻译：新型碳酸酯EPO及其生产方法
公开(公告)号：WO2006014466A3
公开(公告)日：2006-06-29
申请号：PCT/US2005023910
申请日：2005-07-01
申请人： KENNETH S WARREN INST INC , LUNDBECK H AS , BRINES MICHAEL , CERAMI ANTHONY , HAND CARLA CERAMI , XIE QIAO-WEN , CHRISTENSEN SOREN , FOLDAGER J , VLABJORN M H , THEUSEN A H , PEDERSEN M , MUNK M
发明人： BRINES MICHAEL , CERAMI ANTHONY , HAND CARLA CERAMI , XIE QIAO-WEN , CHRISTENSEN SOREN , FOLDAGER J , VLABJORN M H , THEUSEN A H , PEDERSEN M , MUNK M
IPC分类号： A61K38/00
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention comprises an optimal process for carbamylation yielding a product with a low degree of polymerisation and aggregation. The fully carbamylated erythropoietin with all of the N-terminal and all lysine residues was obtained. The resulting fully carbamylated pure EPO is along with pharmaceutical compositions comprising the compound are part of the invention.
摘要翻译：本发明包括氨基甲酰化的最佳方法，产生具有低聚合度和聚集度的产物。获得具有所有N-末端和所有赖氨酸残基的完全氨基甲酰化促红细胞生成素。所得完全氨基甲酰化的纯EPO以及包含该化合物的药物组合物是本发明的一部分。

8. 发明申请

WO2006014349A2 METHOD OF PRODUCING FULLY CARBAMYLATED ERYTHROPOIETIN 审中-公开
标题翻译：生产完全碳酸化红细胞生成素的方法
公开(公告)号：WO2006014349A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/023505
申请日：2005-07-01
申请人： THE KENNETH S. WARREN INSTITUTE, INC. , CERAMI, Anthony , HAND, Carla, Cerami , XIE, Qiao-wen , BRINES, Michael
发明人： BRINES, Michael
IPC分类号： C07K14/505
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to a method of carbamylating an erythropoietin such that the resulting carbamylated erythropoietin has less that about 10% free primary amines on the lysines and the N-terminal amino acids, is not digested when exposed to Lys-C proteolysis, exhibits no erythropoietic activity in a TF-1 or UT-7/EPOR cell viability assay at a concentration of 1 µg/ml, and demonstrates a static sciatic index of less than about .65 within a Sciatic Nerve Assay. Additionally, the invention is related to pharmaceutical compositions containing carbamylated erythropoietins of the invention and the use of the pharmaceutical compositions for the treatment of conditions and diseases of excitable tissues.
摘要翻译：本发明涉及一种氨基甲酰化促红细胞生成素的方法，使得所得到的氨基甲酰化促红细胞生成素在赖氨酸和N-末端氨基酸上具有少于约10％的游离伯胺，当暴露于Lys-C蛋白水解时不被消化，在1μg/ ml浓度的TF-1或UT-7 / EPOR细胞活力测定中的红细胞生成活性，并且在Sciatic Nerve Assay中证实静态坐骨指数小于约.65。另外，本发明涉及含有本发明的氨基甲酰化促红细胞生成素的药物组合物以及药物组合物用于治疗可兴奋组织的病症和疾病的用途。

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